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Found 2363 hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 5 subunit alpha'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
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US Patent
n/an/an/an/a 5.80E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM60414
PNG
(US9051311, 4)
Show SMILES FC(F)(F)c1cc(Br)c(c(c1)C1=CCNCC1)-c1cccc2CN(CCc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C23H21BrF3N5O2S2/c24-20-11-16(23(25,26)27)10-19(14-4-7-28-8-5-14)21(20)18-3-1-2-15-12-32(9-6-17(15)18)36(33,34)31-22-29-13-30-35-22/h1-4,10-11,13,28H,5-9,12H2,(H,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
293 cells stably transfected with human Navl .7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9051311 (2015)


BindingDB Entry DOI: 10.7270/Q25B0175
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145227
PNG
(US8952169, 6 | US9771376, Example 6)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-18(23)14-5-15(20)17(6-16(14)21)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23)
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US Patent
n/an/a 1.90E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145229
PNG
(US8952169, 8 | US9771376, Example 8)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)CC2
Show InChI InChI=1S/C18H23ClFNO4S/c1-18(2)11-5-4-10(13(18)6-11)9-25-16-8-15(20)12(7-14(16)19)17(22)21-26(3,23)24/h7-8,10-11,13H,4-6,9H2,1-3H3,(H,21,22)/t10-,11+,13+/m1/s1
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n/an/a 1.07E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145247
PNG
(US8952169, 26 | US9771376, Example 26)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-19(25)15-6-16(21)18(7-17(15)22)28-11-20-8-12-3-13(9-20)5-14(4-12)10-20/h6-7,12-14H,3-5,8-11H2,1-2H3,(H,23,25)
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n/an/a 772n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145264
PNG
(US8952169, 43)
Show SMILES CS(=O)(=O)NC(=O)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C21H28N2O4S/c1-28(25,26)23-19(24)17-7-18(16-2-3-16)20(22-11-17)27-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16H,2-6,8-10,12H2,1H3,(H,23,24)
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n/an/a 2.58E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145268
PNG
(US8952169, 47)
Show SMILES OC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H31FN2O5S/c25-21-7-22(32-13-24-8-14-3-15(9-24)5-16(4-14)10-24)19(17-1-2-17)6-20(21)23(29)26-33(30,31)27-11-18(28)12-27/h6-7,14-18,28H,1-5,8-13H2,(H,26,29)
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n/an/a 60.6n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145270
PNG
(US8952169, 49)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-23(27)20-9-19(18-2-3-18)22(10-21(20)25)31-14-24-11-15-6-16(12-24)8-17(7-15)13-24/h9-10,15-18H,2-8,11-14H2,1H3,(H,26,27)
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n/an/a 101n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145278
PNG
(US8952169, 57 | US9771376, Example 57)
Show SMILES CC1(C)CCc2cc(OCc3cc(F)c(cc3Cl)C(=O)NS(=O)(=O)N3CCC3)ccc2O1
Show InChI InChI=1S/C22H24ClFN2O5S/c1-22(2)7-6-14-10-16(4-5-20(14)31-22)30-13-15-11-19(24)17(12-18(15)23)21(27)25-32(28,29)26-8-3-9-26/h4-5,10-12H,3,6-9,13H2,1-2H3,(H,25,27)
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n/an/a 653n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145281
PNG
(US8952169, 60 | US9771376, Example 60)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-21(25)18-7-17(16-2-3-16)20(8-19(18)23)28-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16H,2-6,9-12H2,1H3,(H,24,25)
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n/an/a 159n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145282
PNG
(US8952169, 61)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(Br)c1
Show InChI InChI=1S/C19H24BrNO4S/c1-26(23,24)21-18(22)15-2-3-17(16(20)7-15)25-11-19-8-12-4-13(9-19)6-14(5-12)10-19/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,21,22)
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n/an/a 1.95E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145285
PNG
(US8952169, 64 | US9771376, Example 64)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)
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n/an/a 51.5n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145307
PNG
(US8952169, 86 | US9771376, Example 86)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)
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n/an/a 700n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145313
PNG
(US8952169, 92)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F
Show InChI InChI=1S/C20H24ClF3N2O4S/c1-26(2)31(28,29)25-18(27)14-5-15(21)17(6-16(14)22)30-10-19-7-11-3-12(8-19)20(23,24)13(4-11)9-19/h5-6,11-13H,3-4,7-10H2,1-2H3,(H,25,27)
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n/an/a 3.76E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145356
PNG
(US8952169, 135 | US9771376, Example 135)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC2CC3CC2C2CCCC32)cc1F
Show InChI InChI=1S/C19H24ClFN2O4S/c1-23(2)28(25,26)22-19(24)14-8-15(20)18(9-16(14)21)27-17-7-10-6-13(17)12-5-3-4-11(10)12/h8-13,17H,3-7H2,1-2H3,(H,22,24)
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n/an/a 7.82E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 743n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145367
PNG
(US8952169, 146 | US9771376, Example 146)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C21H25ClFNO4S/c22-17-6-16(20(25)24-29(26,27)15-1-2-15)18(23)7-19(17)28-11-21-8-12-3-13(9-21)5-14(4-12)10-21/h6-7,12-15H,1-5,8-11H2,(H,24,25)
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n/an/a 427n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145368
PNG
(US8952169, 147 | US9771376, Example 147)
Show SMILES O[C@H]1CCN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H33FN2O5S/c26-22-9-23(33-14-25-10-15-5-16(11-25)7-17(6-15)12-25)20(18-1-2-18)8-21(22)24(30)27-34(31,32)28-4-3-19(29)13-28/h8-9,15-19,29H,1-7,10-14H2,(H,27,30)/t15?,16?,17?,19-,25?/m0/s1
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n/an/a 110n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145369
PNG
(US8952169, 148 | US9771376, Example 148)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C24H30FNO4S/c25-21-9-22(30-13-24-10-14-5-15(11-24)7-16(6-14)12-24)19(17-1-2-17)8-20(21)23(27)26-31(28,29)18-3-4-18/h8-9,14-18H,1-7,10-13H2,(H,26,27)
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n/an/a 26n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145371
PNG
(US8952169, 150 | US9771376, Example 150)
Show SMILES FC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H30F2N2O4S/c25-18-11-28(12-18)33(30,31)27-23(29)20-6-19(17-1-2-17)22(7-21(20)26)32-13-24-8-14-3-15(9-24)5-16(4-14)10-24/h6-7,14-18H,1-5,8-13H2,(H,27,29)
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US Patent
n/an/a 422n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145374
PNG
(US8952169, 153)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F
Show InChI InChI=1S/C22H26F3NO4S/c1-31(28,29)26-20(27)17-6-16(13-2-3-13)19(7-18(17)23)30-11-21-8-12-4-14(9-21)22(24,25)15(5-12)10-21/h6-7,12-15H,2-5,8-11H2,1H3,(H,26,27)
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n/an/a 714n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145376
PNG
(US8952169, 155)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCOCC1)C1CC1
Show InChI InChI=1S/C25H33FN2O5S/c26-22-11-23(33-15-25-12-16-7-17(13-25)9-18(8-16)14-25)20(19-1-2-19)10-21(22)24(29)27-34(30,31)28-3-5-32-6-4-28/h10-11,16-19H,1-9,12-15H2,(H,27,29)
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n/an/a 14n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145380
PNG
(US8952169, 159 | US8952169, 444)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CC(F)(F)C1)C1CC1
Show InChI InChI=1S/C24H29F3N2O4S/c25-20-7-21(33-13-23-8-14-3-15(9-23)5-16(4-14)10-23)18(17-1-2-17)6-19(20)22(30)28-34(31,32)29-11-24(26,27)12-29/h6-7,14-17H,1-5,8-13H2,(H,28,30)
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n/an/a 326n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145387
PNG
(US8952169, 166 | US9771376, Example 166)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC(F)(F)CC2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-8-13(12-2-3-12)16(9-15(14)19)26-10-11-4-6-18(20,21)7-5-11/h8-9,11-12H,2-7,10H2,1H3,(H,22,23)
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n/an/a 5.23E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145389
PNG
(US8952169, 168 | US9771376, Example 168)
Show SMILES OCCCNS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H33FN2O5S/c25-21-10-22(32-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(29)27-33(30,31)26-4-1-5-28/h9-10,15-18,26,28H,1-8,11-14H2,(H,27,29)
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n/an/a 22n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145390
PNG
(US8952169, 169 | US9771376, Example 169)
Show SMILES COC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H33FN2O5S/c1-32-19-12-28(13-19)34(30,31)27-24(29)21-7-20(18-2-3-18)23(8-22(21)26)33-14-25-9-15-4-16(10-25)6-17(5-15)11-25/h7-8,15-19H,2-6,9-14H2,1H3,(H,27,29)
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n/an/a 144n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM47139
PNG
(US8952169, 175 | US8952169, 295)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C18H24FNO4S/c1-25(22,23)20-18(21)15-9-14(13-7-8-13)17(10-16(15)19)24-11-12-5-3-2-4-6-12/h9-10,12-13H,2-8,11H2,1H3,(H,20,21)
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n/an/a 670n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM47141
PNG
(US8952169, 185 | US8952169, 297)
Show SMILES Fc1cc(OCC2CCCCC2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C20H27FN2O4S/c21-18-12-19(27-13-14-5-2-1-3-6-14)16(15-7-8-15)11-17(18)20(24)22-28(25,26)23-9-4-10-23/h11-12,14-15H,1-10,13H2,(H,22,24)
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n/an/a 40n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145407
PNG
(US8952169, 186)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C20H28FNO5S/c1-26-9-10-28(24,25)22-20(23)17-11-16(15-7-8-15)19(12-18(17)21)27-13-14-5-3-2-4-6-14/h11-12,14-15H,2-10,13H2,1H3,(H,22,23)
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n/an/a 140n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145412
PNG
(US8952169, 191)
Show SMILES Fc1cc(OCC2C3CC4CC(C3)CC2C4)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C24H31FN2O4S/c25-22-12-23(31-13-21-17-7-14-6-15(9-17)10-18(21)8-14)19(16-2-3-16)11-20(22)24(28)26-32(29,30)27-4-1-5-27/h11-12,14-18,21H,1-10,13H2,(H,26,28)
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n/an/a 130n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145419
PNG
(US8952169, 198)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H25F4NO4S/c1-32(29,30)27-18(28)15-4-14(13-2-3-13)17(5-16(15)23)31-12-19-6-20(24)9-21(25,7-19)11-22(26,8-19)10-20/h4-5,13H,2-3,6-12H2,1H3,(H,27,28)
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n/an/a 3.50E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145438
PNG
(US8952169, 217)
Show SMILES Fc1cc(OCC2CCC(F)(F)CC2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C20H24F3NO4S/c21-17-10-18(28-11-12-5-7-20(22,23)8-6-12)15(13-1-2-13)9-16(17)19(25)24-29(26,27)14-3-4-14/h9-10,12-14H,1-8,11H2,(H,24,25)
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n/an/a 630n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145440
PNG
(US8952169, 219)
Show SMILES Fc1cc(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C24H28F4N2O4S/c25-18-7-19(34-14-21-8-22(26)11-23(27,9-21)13-24(28,10-21)12-22)16(15-2-3-15)6-17(18)20(31)29-35(32,33)30-4-1-5-30/h6-7,15H,1-5,8-14H2,(H,29,31)
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n/an/a 950n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145442
PNG
(US8952169, 221)
Show SMILES Fc1cc(OCC2(CCCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C21H26F4N2O4S/c22-17-12-18(31-13-20(21(23,24)25)7-2-1-3-8-20)15(14-5-6-14)11-16(17)19(28)26-32(29,30)27-9-4-10-27/h11-12,14H,1-10,13H2,(H,26,28)
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n/an/a 350n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145454
PNG
(US8952169, 233)
Show SMILES Fc1cc(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C24H27F4NO4S/c25-18-6-19(16(14-1-2-14)5-17(18)20(30)29-34(31,32)15-3-4-15)33-13-21-7-22(26)10-23(27,8-21)12-24(28,9-21)11-22/h5-6,14-15H,1-4,7-13H2,(H,29,30)
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n/an/a 430n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145470
PNG
(US8952169, 249)
Show SMILES Fc1cc(OCC2(CCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C20H24F4N2O4S/c21-16-11-17(30-12-19(20(22,23)24)6-1-2-7-19)14(13-4-5-13)10-15(16)18(27)25-31(28,29)26-8-3-9-26/h10-11,13H,1-9,12H2,(H,25,27)
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n/an/a 90n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145481
PNG
(US8952169, 262)
Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C24H28F3NO4S/c25-20-8-21(32-12-23-9-13-5-15(10-23)24(26,27)16(6-13)11-23)18(14-1-2-14)7-19(20)22(29)28-33(30,31)17-3-4-17/h7-8,13-17H,1-6,9-12H2,(H,28,29)
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n/an/a 130n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145485
PNG
(US8952169, 269)
Show SMILES Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C21H27FN2O4S/c22-18-11-19(28-13-21-7-2-1-4-15(21)12-21)16(14-5-6-14)10-17(18)20(25)23-29(26,27)24-8-3-9-24/h10-11,14-15H,1-9,12-13H2,(H,23,25)
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n/an/a 160n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145487
PNG
(US8952169, 280)
Show SMILES O=C(NS(=O)(=O)N1CCC1)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C23H31N3O4S/c27-21(25-31(28,29)26-4-1-5-26)19-9-20(18-2-3-18)22(24-13-19)30-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h9,13,15-18H,1-8,10-12,14H2,(H,25,27)
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n/an/a 7.50E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145488
PNG
(US8952169, 281)
Show SMILES COCCS(=O)(=O)NC(=O)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C23H32N2O5S/c1-29-4-5-31(27,28)25-21(26)19-9-20(18-2-3-18)22(24-13-19)30-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h9,13,15-18H,2-8,10-12,14H2,1H3,(H,25,26)
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n/an/a 1.53E+4n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145490
PNG
(US8952169, 283)
Show SMILES Fc1cc(O[C@H]2C3CC4CC2C[C@](Cl)(C4)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C23H28ClFN2O4S/c24-23-10-13-6-15(11-23)21(16(7-13)12-23)31-20-9-19(25)18(8-17(20)14-2-3-14)22(28)26-32(29,30)27-4-1-5-27/h8-9,13-16,21H,1-7,10-12H2,(H,26,28)/t13?,15?,16?,21-,23-
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n/an/a 2.16E+4n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145635
PNG
(US8952169, 440)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CN(C2)C(c2ccccc2)c2ccccc2)cc1F
Show InChI InChI=1S/C28H29FN2O4S/c1-36(33,34)30-28(32)24-14-23(20-12-13-20)26(15-25(24)29)35-18-19-16-31(17-19)27(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-11,14-15,19-20,27H,12-13,16-18H2,1H3,(H,30,32)
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n/an/a 2.54E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145380
PNG
(US8952169, 159 | US8952169, 444)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CC(F)(F)C1)C1CC1
Show InChI InChI=1S/C24H29F3N2O4S/c25-20-7-21(33-13-23-8-14-3-15(9-23)5-16(4-14)10-23)18(17-1-2-17)6-19(20)22(30)28-34(31,32)29-11-24(26,27)12-29/h6-7,14-17H,1-5,8-13H2,(H,28,30)
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n/an/a 326n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 743n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145641
PNG
(US8952169, 446)
Show SMILES Fc1cc(OCC2(CCCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H25F4NO4S/c22-17-11-18(30-12-20(21(23,24)25)8-2-1-3-9-20)15(13-4-5-13)10-16(17)19(27)26-31(28,29)14-6-7-14/h10-11,13-14H,1-9,12H2,(H,26,27)
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n/an/a 160n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145643
PNG
(US8952169, 448)
Show SMILES Fc1cc(OCC2CCC(F)(F)CC2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C20H25F3N2O4S/c21-17-11-18(29-12-13-4-6-20(22,23)7-5-13)15(14-2-3-14)10-16(17)19(26)24-30(27,28)25-8-1-9-25/h10-11,13-14H,1-9,12H2,(H,24,26)
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n/an/a 940n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM154167
PNG
(US9012443, 175)
Show SMILES COc1cc(C)ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H17N3O3S2/c1-13-3-5-17(18(11-13)26-2)19-16-6-4-15(12-14(16)7-8-21-19)28(24,25)23-20-22-9-10-27-20/h3-12H,1-2H3,(H,22,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...


US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM154169
PNG
(US9012443, 177)
Show SMILES COc1cc(Cl)c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H13Cl2N3O3S2/c1-27-17-10-16(21)15(20)9-14(17)18-13-3-2-12(8-11(13)4-5-22-18)29(25,26)24-19-23-6-7-28-19/h2-10H,1H3,(H,23,24)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...


US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM154183
PNG
(US9012443, 192)
Show SMILES Fc1ccc(c(OCC#N)c1)-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H13FN4O3S2/c21-14-1-3-17(18(12-14)28-9-6-22)19-16-4-2-15(11-13(16)5-7-23-19)30(26,27)25-20-24-8-10-29-20/h1-5,7-8,10-12H,9H2,(H,24,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...


US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM154186
PNG
(US9012443, 195)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-9-12(19(20,21)22)2-4-15(16)17-14-5-3-13(8-11(14)6-7-23-17)31(27,28)26-18-24-10-25-30-18/h2-10H,1H3,(H,24,25,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...


US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
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