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Compile Data Set for Download or QSAR

Found 471 hits Enz. Inhib. hit(s) with Target = 'Soluble guanylate cyclase (sGC)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233881
PNG
(US9353090, 9)
Show SMILES Cc1c(COc2ccccc2-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)ccc2CN(C[C@H]3COCCO3)CCc12
Show InChI InChI=1S/C34H39N3O5/c1-23-25(10-9-24-18-36(13-11-28(23)24)20-27-22-40-15-16-41-27)21-42-31-7-3-2-5-29(31)30-6-4-8-32(35-30)37-14-12-34(33(38)39)17-26(34)19-37/h2-10,26-27H,11-22H2,1H3,(H,38,39)/t26-,27-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233970
PNG
(US9353090, 98)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CC3COCCO3)CCc2c1C
Show InChI InChI=1S/C34H41N3O5S/c1-21-5-4-6-28(30-20-43-33(35-30)37-10-8-34(32(38)39)14-25(34)15-37)31(21)42-18-24-13-22(2)29-17-36(9-7-27(29)23(24)3)16-26-19-40-11-12-41-26/h4-6,13,20,25-26H,7-12,14-19H2,1-3H3,(H,38,39)/t25-,26?,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234193
PNG
(US9353090, 326)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CCN(CC(C)(C)c2c1)C1COC1
Show InChI InChI=1S/C35H43N3O5/c1-23-7-5-8-27(30-9-6-10-32(36-30)37-16-14-28(34(39)40)31(18-37)41-4)33(23)43-19-24-11-12-25-13-15-38(26-20-42-21-26)22-35(2,3)29(25)17-24/h5-12,17,26,28,31H,13-16,18-22H2,1-4H3,(H,39,40)/t28-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234168
PNG
(US9353090, 301)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CCN(CCc2c1C)[C@H]1CCOC1
Show InChI InChI=1S/C35H43N3O5/c1-23-6-4-7-29(31-8-5-9-33(36-31)38-18-14-30(35(39)40)32(20-38)41-3)34(23)43-21-26-11-10-25-12-16-37(27-15-19-42-22-27)17-13-28(25)24(26)2/h4-11,27,30,32H,12-22H2,1-3H3,(H,39,40)/t27-,30-,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234186
PNG
(US9353090, 319)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(Cl)c1OCc1ccc2CCN(C[C@H](C)c2c1)C1CCOCC1
Show InChI InChI=1S/C33H40ClN3O5S/c1-21-17-36(24-10-14-41-15-11-24)12-8-23-7-6-22(16-27(21)23)19-42-31-25(4-3-5-28(31)34)29-20-43-33(35-29)37-13-9-26(32(38)39)30(18-37)40-2/h3-7,16,20-21,24,26,30H,8-15,17-19H2,1-2H3,(H,38,39)/t21-,26+,30-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234162
PNG
(US9353090, 293)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1cc(C)c2CCN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C36H45N3O5/c1-24-6-4-7-30(32-8-5-9-34(37-32)39-17-12-31(36(40)41)33(22-39)42-3)35(24)44-23-26-20-25(2)29-11-16-38(15-10-27(29)21-26)28-13-18-43-19-14-28/h4-9,20-21,28,31,33H,10-19,22-23H2,1-3H3,(H,40,41)/t31-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233887
PNG
(US9353090, 15)
Show SMILES Cc1cccc(-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C35H41N3O4/c1-23-5-3-6-29(31-7-4-8-32(36-31)38-14-12-35(34(39)40)19-27(35)20-38)33(23)42-22-25-17-24(2)30-21-37(13-9-26(30)18-25)28-10-15-41-16-11-28/h3-8,17-18,27-28H,9-16,19-22H2,1-2H3,(H,39,40)/t27-,35+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234195
PNG
(US9353090, 328 | US9353090, 330)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1nc(cs1)-c1cc(F)cc(C)c1OCc1ccc2CCN(C[C@H](C)c2c1)C1CCOCC1
Show InChI InChI=1S/C34H42FN3O5S/c1-21-14-25(35)16-29(30-20-44-34(36-30)38-11-7-27(33(39)40)31(18-38)41-3)32(21)43-19-23-4-5-24-6-10-37(17-22(2)28(24)15-23)26-8-12-42-13-9-26/h4-5,14-16,20,22,26-27,31H,6-13,17-19H2,1-3H3,(H,39,40)/t22-,27-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233906
PNG
(US9353090, 34)
Show SMILES Cc1cccc(-c2cccc(n2)N2C[C@@H]3C[C@@]3(C2)C(O)=O)c1OCc1ccc2CCN(CCc2c1C)C1COC1
Show InChI InChI=1S/C33H37N3O4/c1-21-5-3-6-28(29-7-4-8-30(34-29)36-16-25-15-33(25,20-36)32(37)38)31(21)40-17-24-10-9-23-11-13-35(26-18-39-19-26)14-12-27(23)22(24)2/h3-10,25-26H,11-20H2,1-2H3,(H,37,38)/t25-,33-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233958
PNG
(US9353090, 86)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CN(CC3COCCO3)CCc2c1C
Show InChI InChI=1S/C33H39N3O5S/c1-21-4-3-5-28(29-20-42-32(34-29)36-11-9-33(31(37)38)14-25(33)16-36)30(21)41-18-24-7-6-23-15-35(10-8-27(23)22(24)2)17-26-19-39-12-13-40-26/h3-7,20,25-26H,8-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233959
PNG
(US9353090, 87)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CN(CCc2c1C)C1CCCOC1
Show InChI InChI=1S/C33H39N3O4S/c1-21-5-3-7-28(29-20-41-32(34-29)36-13-11-33(31(37)38)15-25(33)17-36)30(21)40-18-24-9-8-23-16-35(12-10-27(23)22(24)2)26-6-4-14-39-19-26/h3,5,7-9,20,25-26H,4,6,10-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233964
PNG
(US9353090, 92 | US9353090, 93)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CC3COCCO3)CCc2c1
Show InChI InChI=1S/C33H39N3O5S/c1-21-4-3-5-27(29-20-42-32(34-29)36-9-7-33(31(37)38)14-25(33)15-36)30(21)41-18-23-12-22(2)28-17-35(8-6-24(28)13-23)16-26-19-39-10-11-40-26/h3-5,12-13,20,25-26H,6-11,14-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233967
PNG
(US9353090, 95)
Show SMILES Cc1cc(COc2c(C)cccc2-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)cc2CCN(Cc12)C1CCOC1
Show InChI InChI=1S/C32H37N3O4S/c1-20-4-3-5-26(28-19-40-31(33-28)35-10-8-32(30(36)37)14-24(32)15-35)29(20)39-17-22-12-21(2)27-16-34(9-6-23(27)13-22)25-7-11-38-18-25/h3-5,12-13,19,24-25H,6-11,14-18H2,1-2H3,(H,36,37)/t24-,25?,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233968
PNG
(US9353090, 96)
Show SMILES Cc1cc(COc2c(C)cccc2-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)cc2CCN(Cc12)C1CCOCC1
Show InChI InChI=1S/C33H39N3O4S/c1-21-4-3-5-27(29-20-41-32(34-29)36-11-9-33(31(37)38)16-25(33)17-36)30(21)40-19-23-14-22(2)28-18-35(10-6-24(28)15-23)26-7-12-39-13-8-26/h3-5,14-15,20,25-26H,6-13,16-19H2,1-2H3,(H,37,38)/t25-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233969
PNG
(US9353090, 97)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CCc2c1)C1COC1
Show InChI InChI=1S/C31H35N3O4S/c1-19-4-3-5-25(27-18-39-30(32-27)34-9-7-31(29(35)36)12-23(31)13-34)28(19)38-15-21-10-20(2)26-14-33(24-16-37-17-24)8-6-22(26)11-21/h3-5,10-11,18,23-24H,6-9,12-17H2,1-2H3,(H,35,36)/t23-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233977
PNG
(US9353090, 105)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CCN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C34H41N3O4S/c1-22-4-3-5-29(30-21-42-33(35-30)37-15-12-34(32(38)39)18-26(34)19-37)31(22)41-20-25-7-6-24-8-13-36(14-9-28(24)23(25)2)27-10-16-40-17-11-27/h3-7,21,26-27H,8-20H2,1-2H3,(H,38,39)/t26-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233984
PNG
(US9353090, 112)
Show SMILES Cc1ccc(OCc2ccc3CN(CC4COCCO4)CCc3c2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C32H37N3O5S/c1-21-2-5-29(27(12-21)28-20-41-31(33-28)35-9-7-32(30(36)37)14-25(32)16-35)40-18-22-3-4-24-15-34(8-6-23(24)13-22)17-26-19-38-10-11-39-26/h2-5,12-13,20,25-26H,6-11,14-19H2,1H3,(H,36,37)/t25-,26?,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233989
PNG
(US9353090, 117)
Show SMILES Cc1ccc(OCc2ccc3CN(CC4COCCO4)CCc3c2C)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C33H39N3O5S/c1-21-3-6-30(28(13-21)29-20-42-32(34-29)36-10-8-33(31(37)38)14-25(33)16-36)41-18-24-5-4-23-15-35(9-7-27(23)22(24)2)17-26-19-39-11-12-40-26/h3-6,13,20,25-26H,7-12,14-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234111
PNG
(US9353090, 241)
Show SMILES CCO[C@@H]1CN(CC[C@@H]1C(O)=O)c1nc(cs1)-c1cccc(C)c1OCc1cc(C)c2CN(CCc2c1F)C1CCOCC1
Show InChI InChI=1S/C34H42FN3O5S/c1-4-42-30-18-38(13-9-27(30)33(39)40)34-36-29(20-44-34)26-7-5-6-21(2)32(26)43-19-23-16-22(3)28-17-37(12-8-25(28)31(23)35)24-10-14-41-15-11-24/h5-7,16,20,24,27,30H,4,8-15,17-19H2,1-3H3,(H,39,40)/t27-,30+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234122
PNG
(US9353090, 252)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(C)c1OCc1cc(OC)c2CN(CCc2c1F)C1CCOCC1
Show InChI InChI=1S/C33H40FN3O6S/c1-20-5-4-6-24(27-19-44-33(35-27)37-12-8-25(32(38)39)29(17-37)41-3)31(20)43-18-21-15-28(40-2)26-16-36(11-7-23(26)30(21)34)22-9-13-42-14-10-22/h4-6,15,19,22,25,29H,7-14,16-18H2,1-3H3,(H,38,39)/t25-,29+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234139
PNG
(US9353090, 270)
Show SMILES CCO[C@@H]1CN(CC[C@@H]1C(O)=O)c1nc(cs1)-c1cccc(C)c1OCc1cc(OC)c2CN(CCc2c1F)C1CCOCC1
Show InChI InChI=1S/C34H42FN3O6S/c1-4-43-30-18-38(13-9-26(30)33(39)40)34-36-28(20-45-34)25-7-5-6-21(2)32(25)44-19-22-16-29(41-3)27-17-37(12-8-24(27)31(22)35)23-10-14-42-15-11-23/h5-7,16,20,23,26,30H,4,8-15,17-19H2,1-3H3,(H,39,40)/t26-,30+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234141
PNG
(US9353090, 272)
Show SMILES CCO[C@@H]1CN(CC[C@@H]1C(O)=O)c1nc(cs1)-c1cc(C)ccc1OCc1cc(OC)c2CN(CCc2c1F)C1CCOCC1
Show InChI InChI=1S/C34H42FN3O6S/c1-4-43-31-18-38(12-8-25(31)33(39)40)34-36-28(20-45-34)26-15-21(2)5-6-29(26)44-19-22-16-30(41-3)27-17-37(11-7-24(27)32(22)35)23-9-13-42-14-10-23/h5-6,15-16,20,23,25,31H,4,7-14,17-19H2,1-3H3,(H,39,40)/t25-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234160
PNG
(US9353090, 291)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1cc(C)c2CCN(CCc2c1)C1COC1
Show InChI InChI=1S/C34H41N3O5/c1-22-6-4-7-28(30-8-5-9-32(35-30)37-15-12-29(34(38)39)31(18-37)40-3)33(22)42-19-24-16-23(2)27-11-14-36(26-20-41-21-26)13-10-25(27)17-24/h4-9,16-17,26,29,31H,10-15,18-21H2,1-3H3,(H,38,39)/t29-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234170
PNG
(US9353090, 303)
Show SMILES Cc1cc(COc2c(C)cccc2-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)cc2CCN(Cc12)C1CCC(F)(F)CC1
Show InChI InChI=1S/C34H39F2N3O3S/c1-21-4-3-5-27(29-20-43-32(37-29)39-13-11-33(31(40)41)16-25(33)17-39)30(21)42-19-23-14-22(2)28-18-38(12-8-24(28)15-23)26-6-9-34(35,36)10-7-26/h3-5,14-15,20,25-26H,6-13,16-19H2,1-2H3,(H,40,41)/t25-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234190
PNG
(US9353090, 323)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(C)c1OCc1ccc2CCN(CC(C)(C)c2c1)C1CCOCC1
Show InChI InChI=1S/C35H45N3O5S/c1-23-6-5-7-27(30-21-44-34(36-30)37-15-11-28(33(39)40)31(19-37)41-4)32(23)43-20-24-8-9-25-10-14-38(26-12-16-42-17-13-26)22-35(2,3)29(25)18-24/h5-9,18,21,26,28,31H,10-17,19-20,22H2,1-4H3,(H,39,40)/t28-,31+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234191
PNG
(US9353090, 324)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CCN(CC(C)(C)c2c1)C1CCOCC1
Show InChI InChI=1S/C37H47N3O5/c1-25-7-5-8-29(32-9-6-10-34(38-32)39-18-14-30(36(41)42)33(22-39)43-4)35(25)45-23-26-11-12-27-13-17-40(28-15-19-44-20-16-28)24-37(2,3)31(27)21-26/h5-12,21,28,30,33H,13-20,22-24H2,1-4H3,(H,41,42)/t30-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233890
PNG
(US9353090, 18)
Show SMILES Cc1ccc(OCc2ccc3CN(CCc3c2C)C2CCOCC2)c(c1)-c1cccc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C35H41N3O4/c1-23-6-9-32(30(18-23)31-4-3-5-33(36-31)38-15-13-35(34(39)40)19-27(35)21-38)42-22-26-8-7-25-20-37(14-10-29(25)24(26)2)28-11-16-41-17-12-28/h3-9,18,27-28H,10-17,19-22H2,1-2H3,(H,39,40)/t27-,35+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233875
PNG
(US9353090, 3)
Show SMILES Cc1c(COc2ccccc2-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)ccc2CN(CCc12)C1CCOCC1
Show InChI InChI=1S/C34H39N3O4/c1-23-25(10-9-24-20-36(15-11-28(23)24)27-12-17-40-18-13-27)22-41-31-7-3-2-5-29(31)30-6-4-8-32(35-30)37-16-14-34(33(38)39)19-26(34)21-37/h2-10,26-27H,11-22H2,1H3,(H,38,39)/t26-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234188
PNG
(US9353090, 321)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(Cl)c1OCc1ccc2CCN(C[C@H](C)c2c1)C1COC1
Show InChI InChI=1S/C31H36ClN3O5S/c1-19-13-34(22-16-39-17-22)10-8-21-7-6-20(12-25(19)21)15-40-29-23(4-3-5-26(29)32)27-18-41-31(33-27)35-11-9-24(30(36)37)28(14-35)38-2/h3-7,12,18-19,22,24,28H,8-11,13-17H2,1-2H3,(H,36,37)/t19-,24+,28-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233878
PNG
(US9353090, 6)
Show SMILES Cc1c(COc2ccccc2-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)ccc2CN(CCc12)C1CCOCC1
Show InChI InChI=1S/C34H39N3O4/c1-23-25(10-9-24-20-36(15-11-28(23)24)27-12-17-40-18-13-27)22-41-31-7-3-2-5-29(31)30-6-4-8-32(35-30)37-16-14-34(33(38)39)19-26(34)21-37/h2-10,26-27H,11-22H2,1H3,(H,38,39)/t26-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233886
PNG
(US9353090, 14)
Show SMILES Cc1cccc(-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C35H41N3O4/c1-23-5-3-6-30(31-7-4-8-32(36-31)38-16-14-35(34(39)40)19-27(35)21-38)33(23)42-22-26-10-9-25-20-37(15-11-29(25)24(26)2)28-12-17-41-18-13-28/h3-10,27-28H,11-22H2,1-2H3,(H,39,40)/t27-,35+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233963
PNG
(US9353090, 91)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CC3COCCO3)CCc2c1
Show InChI InChI=1S/C33H39N3O5S/c1-21-4-3-5-27(29-20-42-32(34-29)36-9-7-33(31(37)38)14-25(33)15-36)30(21)41-18-23-12-22(2)28-17-35(8-6-24(28)13-23)16-26-19-39-10-11-40-26/h3-5,12-13,20,25-26H,6-11,14-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233966
PNG
(US9353090, 94)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CCc2c1)C1CCCOC1
Show InChI InChI=1S/C33H39N3O4S/c1-21-5-3-7-27(29-20-41-32(34-29)36-11-9-33(31(37)38)15-25(33)16-36)30(21)40-18-23-13-22(2)28-17-35(10-8-24(28)14-23)26-6-4-12-39-19-26/h3,5,7,13-14,20,25-26H,4,6,8-12,15-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233971
PNG
(US9353090, 99)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CCc2c1C)C1CCCOC1
Show InChI InChI=1S/C34H41N3O4S/c1-21-6-4-8-28(30-20-42-33(35-30)37-12-10-34(32(38)39)15-25(34)16-37)31(21)41-18-24-14-22(2)29-17-36(11-9-27(29)23(24)3)26-7-5-13-40-19-26/h4,6,8,14,20,25-26H,5,7,9-13,15-19H2,1-3H3,(H,38,39)/t25-,26?,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233972
PNG
(US9353090, 100)
Show SMILES Cc1cc(COc2c(C)cccc2-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c(C)c2CCN(Cc12)C1CCOC1
Show InChI InChI=1S/C33H39N3O4S/c1-20-5-4-6-27(29-19-41-32(34-29)36-11-9-33(31(37)38)14-24(33)15-36)30(20)40-17-23-13-21(2)28-16-35(25-8-12-39-18-25)10-7-26(28)22(23)3/h4-6,13,19,24-25H,7-12,14-18H2,1-3H3,(H,37,38)/t24-,25?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233973
PNG
(US9353090, 101)
Show SMILES Cc1cc(COc2c(C)cccc2-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c(C)c2CCN(Cc12)C1CCOCC1
Show InChI InChI=1S/C34H41N3O4S/c1-21-5-4-6-28(30-20-42-33(35-30)37-12-10-34(32(38)39)16-25(34)17-37)31(21)41-19-24-15-22(2)29-18-36(11-7-27(29)23(24)3)26-8-13-40-14-9-26/h4-6,15,20,25-26H,7-14,16-19H2,1-3H3,(H,38,39)/t25-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233974
PNG
(US9353090, 102)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CCc2c1C)C1COC1
Show InChI InChI=1S/C32H37N3O4S/c1-19-5-4-6-26(28-18-40-31(33-28)35-10-8-32(30(36)37)12-23(32)13-35)29(19)39-15-22-11-20(2)27-14-34(24-16-38-17-24)9-7-25(27)21(22)3/h4-6,11,18,23-24H,7-10,12-17H2,1-3H3,(H,36,37)/t23-,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233991
PNG
(US9353090, 119)
Show SMILES Cc1ccc(OCc2ccc3CN(CCc3c2C)C2CCOC2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C32H37N3O4S/c1-20-3-6-29(27(13-20)28-19-40-31(33-28)35-11-9-32(30(36)37)14-24(32)16-35)39-17-23-5-4-22-15-34(25-8-12-38-18-25)10-7-26(22)21(23)2/h3-6,13,19,24-25H,7-12,14-18H2,1-2H3,(H,36,37)/t24-,25?,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233999
PNG
(US9353090, 127)
Show SMILES Cc1ccc(OCc2cc(C)c3CN(CC4COCCO4)CCc3c2C)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C34H41N3O5S/c1-21-4-5-31(28(12-21)30-20-43-33(35-30)37-9-7-34(32(38)39)14-25(34)15-37)42-18-24-13-22(2)29-17-36(8-6-27(29)23(24)3)16-26-19-40-10-11-41-26/h4-5,12-13,20,25-26H,6-11,14-19H2,1-3H3,(H,38,39)/t25-,26?,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234068
PNG
(US9353090, 196)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CCN(CCc2c1C)C1COC1
Show InChI InChI=1S/C34H41N3O5/c1-22-6-4-7-28(30-8-5-9-32(35-30)37-17-14-29(34(38)39)31(18-37)40-3)33(22)42-19-25-11-10-24-12-15-36(26-20-41-21-26)16-13-27(24)23(25)2/h4-11,26,29,31H,12-21H2,1-3H3,(H,38,39)/t29-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234113
PNG
(US9353090, 243)
Show SMILES COC[C@H]1N(C[C@@H]2C[C@]12C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1cc(F)c2CCN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C36H42FN3O5/c1-23-5-3-6-29(31-7-4-8-33(38-31)40-20-26-19-36(26,35(41)42)32(40)22-43-2)34(23)45-21-24-17-25-9-13-39(27-11-15-44-16-12-27)14-10-28(25)30(37)18-24/h3-8,17-18,26-27,32H,9-16,19-22H2,1-2H3,(H,41,42)/t26-,32+,36+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234126
PNG
(US9353090, 256)
Show SMILES CCO[C@H]1CN(CC[C@H]1C(O)=O)c1cccc(n1)-c1cccc(Cl)c1OCc1cc(C)c2CN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C35H42ClN3O5/c1-3-43-32-21-39(15-11-28(32)35(40)41)33-9-5-8-31(37-33)27-6-4-7-30(36)34(27)44-22-24-18-23(2)29-20-38(14-10-25(29)19-24)26-12-16-42-17-13-26/h4-9,18-19,26,28,32H,3,10-17,20-22H2,1-2H3,(H,40,41)/t28-,32+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234127
PNG
(US9353090, 257)
Show SMILES CCO[C@H]1CN(CC[C@H]1C(O)=O)c1cccc(n1)-c1cccc(Cl)c1OCc1cc2CCN(Cc2c(OC)c1)C1CCOCC1
Show InChI InChI=1S/C35H42ClN3O6/c1-3-44-32-21-39(15-11-27(32)35(40)41)33-9-5-8-30(37-33)26-6-4-7-29(36)34(26)45-22-23-18-24-10-14-38(25-12-16-43-17-13-25)20-28(24)31(19-23)42-2/h4-9,18-19,25,27,32H,3,10-17,20-22H2,1-2H3,(H,40,41)/t27-,32+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234130
PNG
(US9353090, 261)
Show SMILES CCO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(Cl)c1OCc1cc2CCN(Cc2c(OC)c1)C1CCOCC1
Show InChI InChI=1S/C33H40ClN3O6S/c1-3-42-30-18-37(12-8-25(30)32(38)39)33-35-28(20-44-33)24-5-4-6-27(34)31(24)43-19-21-15-22-7-11-36(23-9-13-41-14-10-23)17-26(22)29(16-21)40-2/h4-6,15-16,20,23,25,30H,3,7-14,17-19H2,1-2H3,(H,38,39)/t25-,30+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234131
PNG
(US9353090, 262)
Show SMILES COC[C@H]1N(C[C@@H]2C[C@]12C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CCN(CCc2c1F)C1CCOCC1
Show InChI InChI=1S/C36H42FN3O5/c1-23-5-3-6-29(30-7-4-8-32(38-30)40-20-26-19-36(26,35(41)42)31(40)22-43-2)34(23)45-21-25-10-9-24-11-15-39(16-12-28(24)33(25)37)27-13-17-44-18-14-27/h3-10,26-27,31H,11-22H2,1-2H3,(H,41,42)/t26-,31+,36+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234161
PNG
(US9353090, 292)
Show SMILES Cc1c(COc2ccccc2-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)ccc2CN(CCc12)C1CCC1
Show InChI InChI=1S/C33H37N3O3/c1-22-24(13-12-23-19-35(16-14-27(22)23)26-6-4-7-26)21-39-30-10-3-2-8-28(30)29-9-5-11-31(34-29)36-17-15-33(32(37)38)18-25(33)20-36/h2-3,5,8-13,25-26H,4,6-7,14-21H2,1H3,(H,37,38)/t25-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234169
PNG
(US9353090, 302)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CCN(CCc2c1C)[C@@H]1CCOC1
Show InChI InChI=1S/C35H43N3O5/c1-23-6-4-7-29(31-8-5-9-33(36-31)38-18-14-30(35(39)40)32(20-38)41-3)34(23)43-21-26-11-10-25-12-16-37(27-15-19-42-22-27)17-13-28(25)24(26)2/h4-11,27,30,32H,12-22H2,1-3H3,(H,39,40)/t27-,30+,32-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234173
PNG
(US9353090, 306)
Show SMILES CC(N1CCc2c(C)c(COc3ccccc3-c3cccc(n3)N3CC[C@]4(C[C@H]4C3)C(O)=O)ccc2C1)c1ccccn1
Show InChI InChI=1S/C36H38N4O3/c1-24-27(14-13-26-21-39(18-15-29(24)26)25(2)31-9-5-6-17-37-31)23-43-33-11-4-3-8-30(33)32-10-7-12-34(38-32)40-19-16-36(35(41)42)20-28(36)22-40/h3-14,17,25,28H,15-16,18-23H2,1-2H3,(H,41,42)/t25?,28-,36+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234178
PNG
(US9353090, 311)
Show SMILES Cc1cc(CN2CCc3c(C2)ccc(COc2ccccc2-c2cccc(n2)N2CC[C@]4(C[C@H]4C2)C(O)=O)c3C)no1
Show InChI InChI=1S/C34H36N4O4/c1-22-16-27(36-42-22)20-37-14-12-28-23(2)25(11-10-24(28)18-37)21-41-31-8-4-3-6-29(31)30-7-5-9-32(35-30)38-15-13-34(33(39)40)17-26(34)19-38/h3-11,16,26H,12-15,17-21H2,1-2H3,(H,39,40)/t26-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234179
PNG
(US9353090, 312)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(C)c1OCc1ccc2CCN(C[C@H](C)c2c1)C1CCOCC1
Show InChI InChI=1S/C34H43N3O5S/c1-22-5-4-6-27(30-21-43-34(35-30)37-14-10-28(33(38)39)31(19-37)40-3)32(22)42-20-24-7-8-25-9-13-36(18-23(2)29(25)17-24)26-11-15-41-16-12-26/h4-8,17,21,23,26,28,31H,9-16,18-20H2,1-3H3,(H,38,39)/t23-,28+,31-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


US Patent US9353090 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T31
More data for this
Ligand-Target Pair
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