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Compile Data Set for Download or QSAR

Found 11373 hits Enz. Inhib. hit(s) with Target = 'Somatostatin receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50227385
PNG
(CHEMBL424915)
Show SMILES CC(C)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@@H]2C(=O)N1)C(O)=O
Show InChI InChI=1S/C58H85N17O14S2/c1-29(2)45-54(86)71-40(24-31-15-17-33(76)18-16-31)50(82)69-39(13-8-22-65-58(62)63)55(87)75-23-9-14-43(75)53(85)72-42(28-91-90-27-35(59)47(79)67-37(48(80)73-45)12-7-21-64-57(60)61)52(84)70-41(25-32-26-66-36-11-6-5-10-34(32)36)51(83)68-38(19-20-44(77)78)49(81)74-46(30(3)4)56(88)89/h5-6,10-11,15-18,26,29-30,35,37-43,45-46,66,76H,7-9,12-14,19-25,27-28,59H2,1-4H3,(H,67,79)(H,68,83)(H,69,82)(H,70,84)(H,71,86)(H,72,85)(H,73,80)(H,74,81)(H,77,78)(H,88,89)(H4,60,61,64)(H4,62,63,65)/t35-,37-,38-,39+,40-,41+,42-,43-,45+,46-/m1/s1
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n/an/an/an/a 0.0000100n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Melanin concentrating hormone(MCH) activity, causes melanosome aggregation within integumental fish melanocytes and lightening of the skin


J Med Chem 31: 949-54 (1988)


Article DOI: 10.1021/jm00400a010
BindingDB Entry DOI: 10.7270/Q2794582
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50227386
PNG
(CHEMBL385370)
Show SMILES CC(C)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@@H]2C(=O)N1)C(O)=O
Show InChI InChI=1S/C47H64N12O12S2/c1-24(2)38(46(70)71)58-40(64)31(15-16-37(61)62)53-42(66)34(20-26-21-52-30-8-4-3-7-28(26)30)56-43(67)35-23-73-72-22-29(48)39(63)55-33(19-25-11-13-27(60)14-12-25)41(65)54-32(9-5-17-51-47(49)50)45(69)59-18-6-10-36(59)44(68)57-35/h3-4,7-8,11-14,21,24,29,31-36,38,52,60H,5-6,9-10,15-20,22-23,48H2,1-2H3,(H,53,66)(H,54,65)(H,55,63)(H,56,67)(H,57,68)(H,58,64)(H,61,62)(H,70,71)(H4,49,50,51)/t29-,31-,32+,33-,34-,35-,36-,38-/m1/s1
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n/an/an/an/a 0.0000910n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Melanin concentrating hormone(MCH) activity, causes melanosome aggregation within integumental fish melanocytes and lightening of the skin


J Med Chem 31: 949-54 (1988)


Article DOI: 10.1021/jm00400a010
BindingDB Entry DOI: 10.7270/Q2794582
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50227387
PNG
(CHEMBL437651)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C71H108N20O17S3/c1-35(2)54-66(104)85-48(30-39-19-21-41(92)22-20-39)61(99)83-47(17-12-27-78-71(75)76)68(106)91-28-13-18-52(91)65(103)86-50(64(102)84-49(31-40-32-79-43-15-10-9-14-42(40)43)62(100)82-45(23-24-53(93)94)59(97)90-56(37(5)6)69(107)108)33-110-111-34-51(63(101)81-44(58(96)88-54)16-11-26-77-70(73)74)87-67(105)55(36(3)4)89-60(98)46(25-29-109-8)80-57(95)38(7)72/h9-10,14-15,19-22,32,35-38,44-52,54-56,79,92H,11-13,16-18,23-31,33-34,72H2,1-8H3,(H,80,95)(H,81,101)(H,82,100)(H,83,99)(H,84,102)(H,85,104)(H,86,103)(H,87,105)(H,88,96)(H,89,98)(H,90,97)(H,93,94)(H,107,108)(H4,73,74,77)(H4,75,76,78)/t38-,44-,45+,46-,47+,48-,49+,50-,51-,52-,54+,55-,56+/m0/s1
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n/an/an/an/a 0.000800n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Melanin concentrating hormone(MCH) activity, causes melanosome aggregation within integumental fish melanocytes and lightening of the skin


J Med Chem 31: 949-54 (1988)


Article DOI: 10.1021/jm00400a010
BindingDB Entry DOI: 10.7270/Q2794582
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311970
PNG
(US10166214, Example 106)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H21ClN4O/c1-17(2,20-16(23)13-10-7-19-8-11(10)13)15-9-5-4-6-12(18)14(9)22(3)21-15/h4-6,10-11,13,19H,7-8H2,1-3H3,(H,20,23)/t10-,11+,13+
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n/an/an/an/a 0.100n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM81767
PNG
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1
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n/an/an/an/a 0.100n/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst2 receptor


Bioorg Med Chem Lett 15: 3555-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311957
PNG
(US10166214, Example 93)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
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n/an/an/an/a 0.100n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM81767
PNG
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1
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n/an/an/an/a 0.190n/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst5 receptor


Bioorg Med Chem Lett 15: 3555-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311971
PNG
(US10166214, Example 107)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C18H24N4O/c1-10-6-5-7-11-15(10)22(4)21-16(11)18(2,3)20-17(23)14-12-8-19-9-13(12)14/h5-7,12-14,19H,8-9H2,1-4H3,(H,20,23)/t12-,13+,14+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM50352489
PNG
(CHEMBL1824052)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C78H105N17O19S2/c1-43(81)66(101)83-39-63(100)84-60-41-115-116-42-61(78(113)114)93-74(109)59(40-96)92-77(112)65(45(3)98)95-73(108)56(36-48-23-11-6-12-24-48)91-76(111)64(44(2)97)94-68(103)53(28-16-18-32-80)85-69(104)57(37-49-29-30-50-25-13-14-26-51(50)33-49)89-71(106)54(34-46-19-7-4-8-20-46)87-70(105)55(35-47-21-9-5-10-22-47)88-72(107)58(38-62(82)99)90-67(102)52(86-75(60)110)27-15-17-31-79/h4-14,19-26,29-30,33,43-45,52-61,64-65,96-98H,15-18,27-28,31-32,34-42,79-81H2,1-3H3,(H2,82,99)(H,83,101)(H,84,100)(H,85,104)(H,86,110)(H,87,105)(H,88,107)(H,89,106)(H,90,102)(H,91,111)(H,92,112)(H,93,109)(H,94,103)(H,95,108)(H,113,114)/t43-,44+,45+,52-,53-,54-,55-,56-,57+,58-,59-,60-,61-,64-,65-/m0/s1
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n/an/an/an/a 0.230n/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311994
PNG
(US10166214, Example 130)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C18H24N4O/c1-10-6-5-7-22-15(10)11(2)20-17(22)18(3,4)21-16(23)14-12-8-19-9-13(12)14/h5-7,12-14,19H,8-9H2,1-4H3,(H,21,23)/t12-,13+,14+
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n/an/an/an/a 0.300n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311973
PNG
(US10166214, Example 109)
Show SMILES CC(C)(NC(=O)[C@@H]1[C@H]2CNC[C@@H]12)c1n[nH]c2c(F)cccc12
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311944
PNG
(US10166214, Example 80)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C19H23N3O/c1-11-12-6-4-5-7-13(12)16(10-21-11)19(2,3)22-18(23)17-14-8-20-9-15(14)17/h4-7,10,14-15,17,20H,8-9H2,1-3H3,(H,22,23)/t14-,15+,17+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM312007
PNG
(US10166214, Example 143)
Show SMILES CC(C)(NC(=O)[C@@H]1[C@H]2CNC[C@@H]12)c1ncc2c(Cl)cccn12
Show InChI InChI=1S/C16H19ClN4O/c1-16(2,20-14(22)13-9-6-18-7-10(9)13)15-19-8-12-11(17)4-3-5-21(12)15/h3-5,8-10,13,18H,6-7H2,1-2H3,(H,20,22)/t9-,10+,13+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311967
PNG
(US10166214, Example 103)
Show SMILES CC(C)(NC(=O)[C@@H]1[C@H]2CNC[C@@H]12)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C16H18ClN3O2/c1-16(2,19-15(21)12-9-6-18-7-10(9)12)14-8-4-3-5-11(17)13(8)22-20-14/h3-5,9-10,12,18H,6-7H2,1-2H3,(H,19,21)/t9-,10+,12+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM50352480
PNG
(CHEMBL1824051)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C78H105N17O19S2/c1-43(81)66(101)83-39-63(100)84-60-41-115-116-42-61(78(113)114)93-74(109)59(40-96)92-77(112)65(45(3)98)95-73(108)56(36-48-23-11-6-12-24-48)91-76(111)64(44(2)97)94-68(103)53(28-16-18-32-80)85-69(104)57(37-49-29-30-50-25-13-14-26-51(50)33-49)89-71(106)54(34-46-19-7-4-8-20-46)87-70(105)55(35-47-21-9-5-10-22-47)88-72(107)58(38-62(82)99)90-67(102)52(86-75(60)110)27-15-17-31-79/h4-14,19-26,29-30,33,43-45,52-61,64-65,96-98H,15-18,27-28,31-32,34-42,79-81H2,1-3H3,(H2,82,99)(H,83,101)(H,84,100)(H,85,104)(H,86,110)(H,87,105)(H,88,107)(H,89,106)(H,90,102)(H,91,111)(H,92,112)(H,93,109)(H,94,103)(H,95,108)(H,113,114)/t43-,44+,45+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1
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n/an/an/an/a 0.350n/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294254
PNG
((4R,7S,10S,13R,16S,19R)-19-((R)-2-amino-3-(4-hydro...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)NC(=O)[C@H](N)Cc2ccc(O)cc2)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C64H75N11O11S2/c1-37(2)67-34-43-21-19-42(20-22-43)32-50-58(80)68-49(30-39-13-7-5-8-14-39)59(81)72-53(62(84)73-54(38(3)76)55(66)78)36-88-87-35-52(71-57(79)48(65)29-41-23-27-47(77)28-24-41)61(83)69-51(31-40-15-9-6-10-16-40)60(82)74-56(63(85)70-50)75(4)64(86)46-26-25-44-17-11-12-18-45(44)33-46/h5-28,33,37-38,48-54,56,67,76-77H,29-32,34-36,65H2,1-4H3,(H2,66,78)(H,68,80)(H,69,83)(H,70,85)(H,71,79)(H,72,81)(H,73,84)(H,74,82)/t38-,48-,49+,50+,51+,52+,53+,54+,56-/m1/s1
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n/an/an/an/a 0.370n/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Agonist activity at human sst1 receptor expressed in Chinese hamster CCL39 cells by luciferase reporter gene assay relative to somatostatin-14


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311969
PNG
(US10166214, Example 105)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H21FN4O/c1-17(2,20-16(23)13-10-7-19-8-11(10)13)15-9-5-4-6-12(18)14(9)22(3)21-15/h4-6,10-11,13,19H,7-8H2,1-3H3,(H,20,23)/t10-,11+,13+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50081058
PNG
(CHEMBL3421842 | US10166214, Example 22)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C19H23N3O/c1-11-8-12-6-4-5-7-13(12)17(21-11)19(2,3)22-18(23)16-14-9-20-10-15(14)16/h4-8,14-16,20H,9-10H2,1-3H3,(H,22,23)/t14-,15+,16+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311939
PNG
(US10166214, Example 75)
Show SMILES Cn1nc(c2ccc(F)cc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H21FN4O/c1-17(2,20-16(23)14-11-7-19-8-12(11)14)15-10-5-4-9(18)6-13(10)22(3)21-15/h4-6,11-12,14,19H,7-8H2,1-3H3,(H,20,23)/t11-,12+,14+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM312048
PNG
(US10166214, Example 184)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C18H23N3O/c1-11-5-4-8-21-14(11)6-7-15(21)18(2,3)20-17(22)16-12-9-19-10-13(12)16/h4-8,12-13,16,19H,9-10H2,1-3H3,(H,20,22)/t12-,13+,16+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50081055
PNG
(CHEMBL3421843 | US10166214, Example 49)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H22N4O/c1-17(2,19-16(22)14-11-8-18-9-12(11)14)15-10-6-4-5-7-13(10)21(3)20-15/h4-7,11-12,14,18H,8-9H2,1-3H3,(H,19,22)/t11-,12+,14+
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n/an/an/an/a 0.400n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human somatostatin 4 receptor expressed in H4 cells assessed as inhibition of forskolin-induced intracellular cAMP accumulation i...


ACS Med Chem Lett 6: 110-1 (2015)


Article DOI: 10.1021/ml500538a
BindingDB Entry DOI: 10.7270/Q2MC91RP
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50081058
PNG
(CHEMBL3421842 | US10166214, Example 22)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C19H23N3O/c1-11-8-12-6-4-5-7-13(12)17(21-11)19(2,3)22-18(23)16-14-9-20-10-15(14)16/h4-8,14-16,20H,9-10H2,1-3H3,(H,22,23)/t14-,15+,16+
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n/an/an/an/a 0.400n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human somatostatin 4 receptor expressed in H4 cells assessed as inhibition of forskolin-induced intracellular cAMP accumulation i...


ACS Med Chem Lett 6: 110-1 (2015)


Article DOI: 10.1021/ml500538a
BindingDB Entry DOI: 10.7270/Q2MC91RP
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311956
PNG
(US10166214, Example 92)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H21N3O2/c1-9-5-4-6-10-14(9)22-20-15(10)17(2,3)19-16(21)13-11-7-18-8-12(11)13/h4-6,11-13,18H,7-8H2,1-3H3,(H,19,21)/t11-,12+,13+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311992
PNG
(US10166214, Example 128)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C20H26N4O/c1-11-5-4-8-24-17(11)16(12-6-7-12)22-19(24)20(2,3)23-18(25)15-13-9-21-10-14(13)15/h4-5,8,12-15,21H,6-7,9-10H2,1-3H3,(H,23,25)/t13-,14+,15+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311990
PNG
(US10166214, Example 126)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H22N4O/c1-10-5-4-6-21-13(10)9-19-16(21)17(2,3)20-15(22)14-11-7-18-8-12(11)14/h4-6,9,11-12,14,18H,7-8H2,1-3H3,(H,20,22)/t11-,12+,14+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50081055
PNG
(CHEMBL3421843 | US10166214, Example 49)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H22N4O/c1-17(2,19-16(22)14-11-8-18-9-12(11)14)15-10-6-4-5-7-13(10)21(3)20-15/h4-7,11-12,14,18H,8-9H2,1-3H3,(H,19,22)/t11-,12+,14+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
SSTR3


(MOUSE)
BDBM50021063
PNG
(CHEMBL3287613)
Show SMILES Fc1ccc(cc1)C(=O)N[C@@H]1CCCC[C@@H]1NCc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H24FN3O/c23-17-11-9-15(10-12-17)22(27)26-21-8-4-3-7-20(21)25-14-16-13-24-19-6-2-1-5-18(16)19/h1-2,5-6,9-13,20-21,24-25H,3-4,7-8,14H2,(H,26,27)/t20-,21+/m0/s1
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n/an/an/an/a 0.460n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at mouse SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay


ACS Med Chem Lett 5: 690-5 (2014)


Article DOI: 10.1021/ml500079u
BindingDB Entry DOI: 10.7270/Q22N53V4
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM50154508
PNG
(CHEMBL3775042)
Show SMILES Cc1nc(no1)[C@@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccccc1)c1cnn(C)c1
Show InChI InChI=1S/C27H24N8O/c1-16-30-26(34-36-16)27(18-13-29-35(2)15-18)24-20(19-10-6-7-11-21(19)31-24)12-22(33-27)25-28-14-23(32-25)17-8-4-3-5-9-17/h3-11,13-15,22,31,33H,12H2,1-2H3,(H,28,32)/t22-,27-/m1/s1
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n/an/an/an/a 0.460n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels


Bioorg Med Chem Lett 26: 1529-35 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.022
BindingDB Entry DOI: 10.7270/Q2ZG6V4J
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311888
PNG
(US10166214, Example 24)
Show SMILES CC(C)(NC(=O)[C@@H]1[C@H]2CNC[C@@H]12)c1nccc2ccccc12
Show InChI InChI=1S/C18H21N3O/c1-18(2,21-17(22)15-13-9-19-10-14(13)15)16-12-6-4-3-5-11(12)7-8-20-16/h3-8,13-15,19H,9-10H2,1-2H3,(H,21,22)/t13-,14+,15+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311941
PNG
(US10166214, Example 77)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C18H22N4O/c1-10-11-6-4-5-7-12(11)16(22-21-10)18(2,3)20-17(23)15-13-8-19-9-14(13)15/h4-7,13-15,19H,8-9H2,1-3H3,(H,20,23)/t13-,14+,15+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM50021074
PNG
(CHEMBL3287628)
Show SMILES Clc1ccc(CN[C@H]2CCCC[C@H]2NC(=O)c2ccc3ccccc3c2)cc1Cl
Show InChI InChI=1S/C24H24Cl2N2O/c25-20-12-9-16(13-21(20)26)15-27-22-7-3-4-8-23(22)28-24(29)19-11-10-17-5-1-2-6-18(17)14-19/h1-2,5-6,9-14,22-23,27H,3-4,7-8,15H2,(H,28,29)/t22-,23+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay


ACS Med Chem Lett 5: 690-5 (2014)


Article DOI: 10.1021/ml500079u
BindingDB Entry DOI: 10.7270/Q22N53V4
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM50352483
PNG
(CHEMBL1824056)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C56H67N9O10S2/c1-34(66)48-55(73)63-45(30-37-19-9-4-10-20-37)54(72)64-47(56(74)75)33-77-76-32-41(58)49(67)60-43(28-35-15-5-2-6-16-35)52(70)61-44(29-36-17-7-3-8-18-36)53(71)62-46(31-38-24-25-39-21-11-12-22-40(39)27-38)51(69)59-42(50(68)65-48)23-13-14-26-57/h2-12,15-22,24-25,27,34,41-48,66H,13-14,23,26,28-33,57-58H2,1H3,(H,59,69)(H,60,67)(H,61,70)(H,62,71)(H,63,73)(H,64,72)(H,65,68)(H,74,75)/t34-,41+,42+,43+,44+,45+,46-,47+,48+/m1/s1
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n/an/an/an/a 0.530n/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM312004
PNG
(US10166214, Example 140)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H22N4O2/c1-17(2,20-15(22)14-10-7-18-8-11(10)14)16-19-9-12-13(23-3)5-4-6-21(12)16/h4-6,9-11,14,18H,7-8H2,1-3H3,(H,20,22)/t10-,11+,14+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311946
PNG
(BDBM311964 | US10166214, Example 82)
Show SMILES Cc1cc(c2ccccn12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C18H23N3O/c1-11-8-14(15-6-4-5-7-21(11)15)18(2,3)20-17(22)16-12-9-19-10-13(12)16/h4-8,12-13,16,19H,9-10H2,1-3H3,(H,20,22)/t12-,13+,16+
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n/an/an/an/a 0.600n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311876
PNG
(US10166214, Example 12)
Show SMILES CC(C)(COc1ccccc1C(F)(F)F)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H21F3N2O2/c1-16(2,22-15(23)14-10-7-21-8-11(10)14)9-24-13-6-4-3-5-12(13)17(18,19)20/h3-6,10-11,14,21H,7-9H2,1-2H3,(H,22,23)/t10-,11+,14+
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n/an/an/an/a 0.600n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM312015
PNG
(US10166214, Example 151)
Show SMILES Cc1nc(n2cccc(F)c12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H21FN4O/c1-9-14-12(18)5-4-6-22(14)16(20-9)17(2,3)21-15(23)13-10-7-19-8-11(10)13/h4-6,10-11,13,19H,7-8H2,1-3H3,(H,21,23)/t10-,11+,13+
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n/an/an/an/a 0.600n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM82547
PNG
(SRIF-D-Trp8)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55+,56-,57-,58-,59-,62-,63-/m0/s1
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n/an/an/an/a 0.630n/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311885
PNG
(US10166214, Example 21)
Show SMILES CC(C)(NC(=O)[C@@H]1[C@H]2CNC[C@@H]12)c1ccnc2ccccc12
Show InChI InChI=1S/C18H21N3O/c1-18(2,21-17(22)16-12-9-19-10-13(12)16)14-7-8-20-15-6-4-3-5-11(14)15/h3-8,12-13,16,19H,9-10H2,1-2H3,(H,21,22)/t12-,13+,16+
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n/an/an/an/a 0.700n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275929
PNG
(US10071974, Example 40 | US10071974, Example 41 | ...)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-15-6-4-5-7-16(15)17(11-21-13)19(2,3)22-18(23)14-10-20-8-9-24-12-14/h4-7,11,14,20H,8-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 0.700n/an/a7.425



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311974
PNG
(US10166214, Example 110)
Show SMILES CC(C)(NC(=O)[C@@H]1[C@H]2CNC[C@@H]12)c1n[nH]c2c(cccc12)C(F)(F)F
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n/an/an/an/a 0.700n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM81767
PNG
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1
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n/an/an/an/a 0.780n/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM312022
PNG
(US10166214, Example 158)
Show SMILES Cc1cc(F)cn2c(ncc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H21FN4O/c1-9-4-10(18)8-22-13(9)7-20-16(22)17(2,3)21-15(23)14-11-5-19-6-12(11)14/h4,7-8,11-12,14,19H,5-6H2,1-3H3,(H,21,23)/t11-,12+,14+
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Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311940
PNG
(US10166214, Example 76)
Show SMILES Cn1nc(c2cccc(c12)C(F)(F)F)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C18H21F3N4O/c1-17(2,23-16(26)13-10-7-22-8-11(10)13)15-9-5-4-6-12(18(19,20)21)14(9)25(3)24-15/h4-6,10-11,13,22H,7-8H2,1-3H3,(H,23,26)/t10-,11+,13+
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n/an/an/an/a 0.800n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM311952
PNG
(US10166214, Example 88)
Show SMILES Cc1cccc2c(ncnc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C18H22N4O/c1-10-5-4-6-11-15(10)20-9-21-16(11)18(2,3)22-17(23)14-12-7-19-8-13(12)14/h4-6,9,12-14,19H,7-8H2,1-3H3,(H,22,23)/t12-,13+,14+
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n/an/an/an/a 0.800n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275929
PNG
(US10071974, Example 40 | US10071974, Example 41 | ...)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-15-6-4-5-7-16(15)17(11-21-13)19(2,3)22-18(23)14-10-20-8-9-24-12-14/h4-7,11,14,20H,8-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 0.800n/an/a7.425



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM312001
PNG
(US10166214, Example 137)
Show SMILES Cc1cccn2c(ncc12)C1(CCC1)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C18H22N4O/c1-11-4-2-7-22-14(11)10-20-17(22)18(5-3-6-18)21-16(23)15-12-8-19-9-13(12)15/h2,4,7,10,12-13,15,19H,3,5-6,8-9H2,1H3,(H,21,23)/t12-,13+,15+
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n/an/an/an/a 0.800n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM50352481
PNG
(CHEMBL1824050)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H](C)O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N
Show InChI InChI=1S/C74H103N17O20S2/c1-40(77)62(98)79-36-59(97)80-56-38-112-113-39-57(74(110)111)89-70(106)55(37-92)88-73(109)61(42(3)94)91-69(105)53(33-45-21-11-6-12-22-45)87-72(108)60(41(2)93)90-64(100)49(24-14-16-30-76)81-65(101)52(34-46-25-27-47(95)28-26-46)84-66(102)50(31-43-17-7-4-8-18-43)83-67(103)51(32-44-19-9-5-10-20-44)85-68(104)54(35-58(78)96)86-63(99)48(82-71(56)107)23-13-15-29-75/h4-12,17-22,25-28,40-42,48-57,60-61,92-95H,13-16,23-24,29-39,75-77H2,1-3H3,(H2,78,96)(H,79,98)(H,80,97)(H,81,101)(H,82,107)(H,83,103)(H,84,102)(H,85,104)(H,86,99)(H,87,108)(H,88,109)(H,89,106)(H,90,100)(H,91,105)(H,110,111)/t40-,41+,42+,48-,49-,50-,51-,52+,53-,54-,55-,56-,57-,60-,61-/m0/s1
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n/an/an/an/a 0.870n/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM312014
PNG
(US10166214, Example 150)
Show SMILES Cc1cccn2c(cnc12)C(C)(C)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H22N4O/c1-10-5-4-6-21-13(9-19-15(10)21)17(2,3)20-16(22)14-11-7-18-8-12(11)14/h4-6,9,11-12,14,18H,7-8H2,1-3H3,(H,20,22)/t11-,12+,14+
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n/an/an/an/a 0.900n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM312009
PNG
(US10166214, Example 145)
Show SMILES Cc1cccn2c(ncc12)C1(CC1)NC(=O)[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C17H20N4O/c1-10-3-2-6-21-13(10)9-19-16(21)17(4-5-17)20-15(22)14-11-7-18-8-12(11)14/h2-3,6,9,11-12,14,18H,4-5,7-8H2,1H3,(H,20,22)/t11-,12+,14+
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n/an/an/an/a 0.900n/an/an/an/a



Centrexion Therapeutics Corporation

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10166214 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294255
PNG
((4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-31...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)c1c[nH]c2ccccc12)[C@@H](C)O
Show InChI InChI=1S/C75H102N18O19S2/c1-40(78)63(99)81-36-59(98)82-56-38-113-114-39-57(75(111)112)90-70(106)55(37-94)89-73(109)61(42(3)96)92-68(104)53(33-45-23-11-6-12-24-45)88-72(108)60(41(2)95)91-65(101)50(28-16-18-30-77)84-74(110)62(47-35-80-48-26-14-13-25-46(47)48)93-69(105)52(32-44-21-9-5-10-22-44)86-66(102)51(31-43-19-7-4-8-20-43)85-67(103)54(34-58(79)97)87-64(100)49(83-71(56)107)27-15-17-29-76/h4-14,19-26,35,40-42,49-57,60-62,80,94-96H,15-18,27-34,36-39,76-78H2,1-3H3,(H2,79,97)(H,81,99)(H,82,98)(H,83,107)(H,84,110)(H,85,103)(H,86,102)(H,87,100)(H,88,108)(H,89,109)(H,90,106)(H,91,101)(H,92,104)(H,93,105)(H,111,112)/t40-,41+,42+,49-,50-,51-,52-,53-,54-,55-,56-,57-,60-,61-,62-/m0/s1
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n/an/an/an/a 0.930n/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Agonist activity at human sst1 receptor expressed in Chinese hamster CCL39 cells by luciferase reporter gene assay relative to somatostatin-14


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
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