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Found 327 Enz. Inhib. hit(s) with Target = 'Thrombopoietin receptor'
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327452(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)
Affinity DataEC50:  3nMAssay Description:Inhibition of human TPOR expressed in human BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327451(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Affinity DataEC50:  6nMAssay Description:Inhibition of human TPOR expressed in human BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219622(CHEMBL429295 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219622(CHEMBL429295 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219613(CHEMBL248218 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248023(1-(2,6-dichloro-4-(4-(2-fluoro-3-(trifluoromethyl)...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219644(CHEMBL248390 | N-(5-chloro-4-(4-fluoro-3-(trifluor...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219670(CHEMBL249471 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105970(4-{N'-[1-(4-tert-Butyl-phenyl)-3-methyl-5-oxo-1,5-...)
Affinity DataEC50:  20nMAssay Description:Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265150(2-(7-(4-butylphenyl)-6-fluoro-5,10-dihydroindeno[1...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327455(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Affinity DataEC50:  22nMAssay Description:Inhibition of human TPOR expressed in human BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219654(CHEMBL440231 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219633(4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-f...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265108(CHEMBL498581 | N-(7-(4-butylphenyl)-6-fluoro-5,10-...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50264952(6-fluoro-7-(4-fluoro-3-methylphenyl)-5,10-dihydroi...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263454(9-(4-butylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327457(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Affinity DataEC50:  26nMAssay Description:Inhibition of human TPOR expressed in human BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219621(4-(pyrimidin-4-ylamino)-N-(7-trifluoromethyl-4,5-d...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248580(6-(4-carbamoylpiperidin-1-yl)-5-chloro-N-(4-(2-flu...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219659((Z)-N-(4-(3,4-difluorophenyl)thiazol-2-yl)-4-((2,4...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219614(CHEMBL249672 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219619(CHEMBL248428 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327456(CHEMBL1257847 | N'-(1-(1-(3,4-dimethylphenyl)-3-me...)
Affinity DataEC50:  31nMAssay Description:Inhibition of human TPOR expressed in human BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219625(CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at TPO receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219625(CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50377376(CHEMBL408853)
Affinity DataEC50:  32nMAssay Description:Agonist activity at TPO receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248531(1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human TPO receptor expressed in rat BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219679(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248531(1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219679(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at TPO receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248581(5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)...)
Affinity DataEC50:  34nMAssay Description:Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263334(9-(4-fluoro-3-methylphenyl)-2-hydroxy-6,11-dihydro...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327454(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)
Affinity DataEC50:  35nMAssay Description:Inhibition of human TPOR expressed in human BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219650(CHEMBL247041 | N-(4-(2-fluoro-3-isobutylphenyl)thi...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50264951(6-fluoro-7-(4-propylphenyl)-5,10-dihydroindeno[1,2...)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219643(CHEMBL246847 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105947(3-Hydroxy-4-{N'-[3-methyl-5-oxo-1-(3-trifluorometh...)
Affinity DataEC50:  40nMAssay Description:Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105963(4-{N'-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-...)
Affinity DataEC50:  40nMAssay Description:Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263455(2-hydroxy-9-(4-propoxyphenyl)-6,11-dihydro-5H-benz...)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327458(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Affinity DataEC50:  42nMAssay Description:Inhibition of human TPOR expressed in human BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219715(CHEMBL245794 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248582((4R)-1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263457(2-hydroxy-9-(3-propoxyphenyl)-6,11-dihydro-5H-benz...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219698(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(3-(4-f...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325421(4-(2-(1-(5-fluoro-2-oxo-1-p-tolylindolin-3-ylidene...)
Affinity DataEC50:  44nMAssay Description:Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50219675(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(4-f...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human TPOr expressed in BaF3 cells by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50327459(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)
Affinity DataEC50:  46nMAssay Description:Inhibition of human TPOR expressed in human BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThrombopoietin receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248024(1-(3-bromo-5-(4-(2-fluoro-3-(trifluoromethyl)pheny...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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