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Found 341 hits Enz. Inhib. hit(s) with Target = 'mGluR2 and G alpha 16'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222990
PNG
(US9315518, 34-3)
Show SMILES CC1C(C1C(C)(C)O)c1ccc2N(CC3CC3(F)F)S(=O)(=O)N(C)c2n1
Show InChI InChI=1S/C17H23F2N3O3S/c1-9-13(14(9)16(2,3)23)11-5-6-12-15(20-11)21(4)26(24,25)22(12)8-10-7-17(10,18)19/h5-6,9-10,13-14,23H,7-8H2,1-4H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222972
PNG
(US9315518, 2-7 | US9315518, 5-2)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)c1ccon1
Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-19-8-7-17(24-20(19)26(4)22(28)30)16-11-15-6-5-14(16)12-27(15)21(29)18-9-10-31-25-18/h7-11,14-15H,5-6,12-13H2,1-4H3
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n/an/an/an/a 16.0n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222977
PNG
(US9315518, 8-38)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CN(CC2C1)C(=O)c1ncco1
Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-18-6-5-17(25-19(18)26(4)22(28)30)14-9-15-11-27(12-16(15)10-14)21(29)20-24-7-8-31-20/h5-9,15-16H,10-13H2,1-4H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222971
PNG
(US9315518, 2-34)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)c1ncco1
Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-18-8-7-17(25-19(18)26(4)22(28)30)16-11-15-6-5-14(16)12-27(15)21(29)20-24-9-10-31-20/h7-11,14-15H,5-6,12-13H2,1-4H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222967
PNG
(US9315518, 2-8)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)c1csnn1
Show InChI InChI=1S/C22H26N6O2S/c1-22(2,3)12-28-18-8-7-16(23-19(18)26(4)21(28)30)15-9-14-6-5-13(15)10-27(14)20(29)17-11-31-25-24-17/h7-9,11,13-14H,5-6,10,12H2,1-4H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222973
PNG
(US9315518, 6-4)
Show SMILES Cn1c2nc(ccc2n(CC2CC2(F)F)c1=O)C1=CC2CCC1CN2C(=O)c1ccon1
Show InChI InChI=1S/C22H21F2N5O3/c1-27-19-18(29(21(27)31)11-13-9-22(13,23)24)5-4-16(25-19)15-8-14-3-2-12(15)10-28(14)20(30)17-6-7-32-26-17/h4-8,12-14H,2-3,9-11H2,1H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222984
PNG
(US9315518, 18-200)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1CCC(C)(C)C(C1)NC(=O)c1cnsn1
Show InChI InChI=1S/C23H32N6O2S/c1-22(2,3)13-29-17-8-7-15(25-19(17)28(6)21(29)31)14-9-10-23(4,5)18(11-14)26-20(30)16-12-24-32-27-16/h7-8,12,14,18H,9-11,13H2,1-6H3,(H,26,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222987
PNG
(US9315518, 24-7)
Show SMILES CN1c2nc(ccc2N(CC2CC2(F)F)S1(=O)=O)C1=CC2CN(CC2C1)C(=O)C(C)(C)O
Show InChI InChI=1S/C21H26F2N4O4S/c1-20(2,29)19(28)26-9-13-6-12(7-14(13)10-26)16-4-5-17-18(24-16)25(3)32(30,31)27(17)11-15-8-21(15,22)23/h4-6,13-15,29H,7-11H2,1-3H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222970
PNG
(US9315518, 2-22)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)Cn1cncn1
Show InChI InChI=1S/C23H29N7O2/c1-23(2,3)12-30-19-8-7-18(26-21(19)27(4)22(30)32)17-9-16-6-5-15(17)10-29(16)20(31)11-28-14-24-13-25-28/h7-9,13-16H,5-6,10-12H2,1-4H3
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n/an/an/an/a 56.1n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222969
PNG
(US9315518, 2-16)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)C1CC1
Show InChI InChI=1S/C23H30N4O2/c1-23(2,3)13-27-19-10-9-18(24-20(19)25(4)22(27)29)17-11-16-8-7-15(17)12-26(16)21(28)14-5-6-14/h9-11,14-16H,5-8,12-13H2,1-4H3
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n/an/an/an/a 64.1n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222968
PNG
(US9315518, 2-9)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)c1cccnc1
Show InChI InChI=1S/C25H29N5O2/c1-25(2,3)15-30-21-10-9-20(27-22(21)28(4)24(30)32)19-12-18-8-7-17(19)14-29(18)23(31)16-6-5-11-26-13-16/h5-6,9-13,17-18H,7-8,14-15H2,1-4H3
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n/an/an/an/a 100n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222986
PNG
(US9315518, 19-62)
Show SMILES Cc1cccc(c1)S(=O)(=O)NC1CC(CCC1(C)C)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1
Show InChI InChI=1S/C27H38N4O3S/c1-18-9-8-10-20(15-18)35(33,34)29-23-16-19(13-14-27(23,5)6)21-11-12-22-24(28-21)30(7)25(32)31(22)17-26(2,3)4/h8-12,15,19,23,29H,13-14,16-17H2,1-7H3
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n/an/an/an/a 116n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222979
PNG
(US9315518, 14-6)
Show SMILES Cn1c2nc(ccc2n(CC2CC2(F)F)c1=O)C1=CC2CN(CC2C1)C(=O)c1ncco1
Show InChI InChI=1S/C22H21F2N5O3/c1-27-18-17(29(21(27)31)11-15-8-22(15,23)24)3-2-16(26-18)12-6-13-9-28(10-14(13)7-12)20(30)19-25-4-5-32-19/h2-6,13-15H,7-11H2,1H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222976
PNG
(US9315518, 8-14)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CN(CC2C1)C(=O)C1(O)CCC1
Show InChI InChI=1S/C24H32N4O3/c1-23(2,3)14-28-19-7-6-18(25-20(19)26(4)22(28)30)15-10-16-12-27(13-17(16)11-15)21(29)24(31)8-5-9-24/h6-7,10,16-17,31H,5,8-9,11-14H2,1-4H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222988
PNG
(US9315518, 24-20)
Show SMILES CN1c2nc(ccc2N(CC2CC2(F)F)S1(=O)=O)C1=CCN(C1)C(=O)c1ccon1
Show InChI InChI=1S/C18H17F2N5O4S/c1-23-16-15(25(30(23,27)28)10-12-8-18(12,19)20)3-2-13(21-16)11-4-6-24(9-11)17(26)14-5-7-29-22-14/h2-5,7,12H,6,8-10H2,1H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222975
PNG
(US9315518, 8-9)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CN(CC2C1)C(=O)CO
Show InChI InChI=1S/C21H28N4O3/c1-21(2,3)12-25-17-6-5-16(22-19(17)23(4)20(25)28)13-7-14-9-24(18(27)11-26)10-15(14)8-13/h5-7,14-15,26H,8-12H2,1-4H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222972
PNG
(US9315518, 2-7 | US9315518, 5-2)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)c1ccon1
Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-19-8-7-17(24-20(19)26(4)22(28)30)16-11-15-6-5-14(16)12-27(15)21(29)18-9-10-31-25-18/h7-11,14-15H,5-6,12-13H2,1-4H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222981
PNG
(US9315518, 17-20)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CCC(CC1)NC(=O)C1CCCO1
Show InChI InChI=1S/C23H32N4O3/c1-23(2,3)14-27-18-12-11-17(25-20(18)26(4)22(27)29)15-7-9-16(10-8-15)24-21(28)19-6-5-13-30-19/h7,11-12,16,19H,5-6,8-10,13-14H2,1-4H3,(H,24,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222989
PNG
(US9315518, 25-5)
Show SMILES CN1c2nc(ccc2N(CC2CC2(F)F)S1(=O)=O)C1CCCNC1
Show InChI InChI=1S/C15H20F2N4O2S/c1-20-14-13(5-4-12(19-14)10-3-2-6-18-8-10)21(24(20,22)23)9-11-7-15(11,16)17/h4-5,10-11,18H,2-3,6-9H2,1H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222978
PNG
(US9315518, 11-5)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1CC2CN(CC2C1)C(=O)c1ncco1
Show InChI InChI=1S/C23H29N5O3/c1-23(2,3)13-28-18-6-5-17(25-19(18)26(4)22(28)30)14-9-15-11-27(12-16(15)10-14)21(29)20-24-7-8-31-20/h5-8,14-16H,9-13H2,1-4H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222974
PNG
(US9315518, 8-6)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CN(CC2C1)C(=O)C1(O)CCN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H41N5O5/c1-27(2,3)16-34-22-9-8-21(30-23(22)31(7)25(34)36)18-12-19-14-33(15-20(19)13-18)24(35)29(38)10-11-32(17-29)26(37)39-28(4,5)6/h8-9,12,19-20,38H,10-11,13-17H2,1-7H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222980
PNG
(US9315518, 17-15)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CCC(CC1)C(=O)NCc1ncco1
Show InChI InChI=1S/C23H29N5O3/c1-23(2,3)14-28-18-10-9-17(26-20(18)27(4)22(28)30)15-5-7-16(8-6-15)21(29)25-13-19-24-11-12-31-19/h5,9-12,16H,6-8,13-14H2,1-4H3,(H,25,29)
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n/an/an/an/a 594n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222985
PNG
(US9315518, 19-4)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1CCCC(C1)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1
Show InChI InChI=1S/C21H30N6O3S/c1-21(2,3)13-27-17-9-8-16(23-19(17)25(5)20(27)28)15-7-6-10-26(11-15)31(29,30)18-12-24(4)14-22-18/h8-9,12,14-15H,6-7,10-11,13H2,1-5H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222983
PNG
(US9315518, 18-42)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1CCC(C)(C)C(C1)NC(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C28H35F3N4O3/c1-26(2,3)16-35-21-12-11-20(32-23(21)34(6)25(35)37)18-13-14-27(4,5)22(15-18)33-24(36)17-7-9-19(10-8-17)38-28(29,30)31/h7-12,18,22H,13-16H2,1-6H3,(H,33,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222991
PNG
(US9315518, 38-5)
Show SMILES Cn1cnc(c1)C(=O)NCCCCc1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1
Show InChI InChI=1S/C21H30N6O2/c1-21(2,3)13-27-17-10-9-15(24-18(17)26(5)20(27)29)8-6-7-11-22-19(28)16-12-25(4)14-23-16/h9-10,12,14H,6-8,11,13H2,1-5H3,(H,22,28)
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n/an/an/an/a 1.18E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM222982
PNG
(US9315518, 18-10)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1CCC(C)(C)C(C1)NC(=O)CCn1cncn1
Show InChI InChI=1S/C25H37N7O2/c1-24(2,3)14-32-19-8-7-18(28-22(19)30(6)23(32)34)17-9-11-25(4,5)20(13-17)29-21(33)10-12-31-16-26-15-27-31/h7-8,15-17,20H,9-14H2,1-6H3,(H,29,33)
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n/an/an/an/a 2.19E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...


US Patent US9315518 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P5C
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212837
PNG
(US9278960, 1-7)
Show SMILES Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C17H13FN2O/c1-10-2-7-13-14(11-3-5-12(18)6-4-11)9-16(17(19)21)20-15(13)8-10/h2-9H,1H3,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212838
PNG
(US9278960, 1-9)
Show SMILES NC(=O)c1cc(-c2c(F)cc(Cl)cc2F)c2ccccc2n1
Show InChI InChI=1S/C16H9ClF2N2O/c17-8-5-11(18)15(12(19)6-8)10-7-14(16(20)22)21-13-4-2-1-3-9(10)13/h1-7H,(H2,20,22)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212839
PNG
(US9278960, 1-10)
Show SMILES NC(=O)c1cc(-c2ccc(OC(F)F)cc2)c2ccccc2n1
Show InChI InChI=1S/C17H12F2N2O2/c18-17(19)23-11-7-5-10(6-8-11)13-9-15(16(20)22)21-14-4-2-1-3-12(13)14/h1-9,17H,(H2,20,22)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212840
PNG
(US9278960, 1-11)
Show SMILES NC(=O)c1cc(C2=CCCC2)c2ccccc2n1
Show InChI InChI=1S/C15H14N2O/c16-15(18)14-9-12(10-5-1-2-6-10)11-7-3-4-8-13(11)17-14/h3-5,7-9H,1-2,6H2,(H2,16,18)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212841
PNG
(US9278960, 1-12)
Show SMILES Cn1cc(cn1)-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C14H12N4O/c1-18-8-9(7-16-18)11-6-13(14(15)19)17-12-5-3-2-4-10(11)12/h2-8H,1H3,(H2,15,19)
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n/an/a 678n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212842
PNG
(US9278960, 1-13)
Show SMILES Cc1cscc1-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C15H12N2OS/c1-9-7-19-8-12(9)11-6-14(15(16)18)17-13-5-3-2-4-10(11)13/h2-8H,1H3,(H2,16,18)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212843
PNG
(US9278960, 1-14)
Show SMILES Cc1c(cnn1-c1ccccc1)-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C20H16N4O/c1-13-17(12-22-24(13)14-7-3-2-4-8-14)16-11-19(20(21)25)23-18-10-6-5-9-15(16)18/h2-12H,1H3,(H2,21,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212844
PNG
(US9278960, 1-15)
Show SMILES NC(=O)c1cc(-c2ccc(Br)cc2)c2ccccc2n1
Show InChI InChI=1S/C16H11BrN2O/c17-11-7-5-10(6-8-11)13-9-15(16(18)20)19-14-4-2-1-3-12(13)14/h1-9H,(H2,18,20)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212845
PNG
(US9278960, 1-16)
Show SMILES NC(=O)c1cc(-c2ccccc2Br)c2ccccc2n1
Show InChI InChI=1S/C16H11BrN2O/c17-13-7-3-1-5-10(13)12-9-15(16(18)20)19-14-8-4-2-6-11(12)14/h1-9H,(H2,18,20)
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n/an/a 681n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212846
PNG
(US9278960, 1-17)
Show SMILES Cc1cc(Cl)ccc1-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C17H13ClN2O/c1-10-8-11(18)6-7-12(10)14-9-16(17(19)21)20-15-5-3-2-4-13(14)15/h2-9H,1H3,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212847
PNG
(US9278960, 1-18)
Show SMILES NC(=O)c1cc(-c2ccc(Cl)cc2F)c2ccccc2n1
Show InChI InChI=1S/C16H10ClFN2O/c17-9-5-6-10(13(18)7-9)12-8-15(16(19)21)20-14-4-2-1-3-11(12)14/h1-8H,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212848
PNG
(US9278960, 1-19)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2Cl)c2ccccc2n1
Show InChI InChI=1S/C16H10ClFN2O/c17-13-7-9(18)5-6-10(13)12-8-15(16(19)21)20-14-4-2-1-3-11(12)14/h1-8H,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212849
PNG
(US9278960, 1-20)
Show SMILES COc1ccc(c(F)c1)-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C17H13FN2O2/c1-22-10-6-7-11(14(18)8-10)13-9-16(17(19)21)20-15-5-3-2-4-12(13)15/h2-9H,1H3,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212850
PNG
(US9278960, 1-21)
Show SMILES Cc1ccc(c(F)c1)-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C17H13FN2O/c1-10-6-7-11(14(18)8-10)13-9-16(17(19)21)20-15-5-3-2-4-12(13)15/h2-9H,1H3,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212851
PNG
(US9278960, 1-22)
Show SMILES NC(=O)c1cc(-c2cnn(c2)-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C19H14N4O/c20-19(24)18-10-16(15-8-4-5-9-17(15)22-18)13-11-21-23(12-13)14-6-2-1-3-7-14/h1-12H,(H2,20,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212852
PNG
(US9278960, 1-23)
Show SMILES Cc1ccc(c(c1)C#N)-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C18H13N3O/c1-11-6-7-13(12(8-11)10-19)15-9-17(18(20)22)21-16-5-3-2-4-14(15)16/h2-9H,1H3,(H2,20,22)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212853
PNG
(US9278960, 1-24)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccccc2n1
Show InChI InChI=1S/C16H11FN2O/c17-11-7-5-10(6-8-11)13-9-15(16(18)20)19-14-4-2-1-3-12(13)14/h1-9H,(H2,18,20)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212854
PNG
(US9278960, 1-25)
Show SMILES Cc1ccc(cc1)-c1cc(nc2cc(C)ccc12)C(N)=O
Show InChI InChI=1S/C18H16N2O/c1-11-3-6-13(7-4-11)15-10-17(18(19)21)20-16-9-12(2)5-8-14(15)16/h3-10H,1-2H3,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212855
PNG
(US9278960, 1-26)
Show SMILES COc1ccc(cc1)-c1cc(nc2cc(C)ccc12)C(N)=O
Show InChI InChI=1S/C18H16N2O2/c1-11-3-8-14-15(12-4-6-13(22-2)7-5-12)10-17(18(19)21)20-16(14)9-11/h3-10H,1-2H3,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212856
PNG
(US9278960, 1-27)
Show SMILES Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccccc1Cl
Show InChI InChI=1S/C17H13ClN2O/c1-10-6-7-12-13(11-4-2-3-5-14(11)18)9-16(17(19)21)20-15(12)8-10/h2-9H,1H3,(H2,19,21)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212857
PNG
(US9278960, 1-28)
Show SMILES Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccccc1F
Show InChI InChI=1S/C17H13FN2O/c1-10-6-7-12-13(11-4-2-3-5-14(11)18)9-16(17(19)21)20-15(12)8-10/h2-9H,1H3,(H2,19,21)
PDB

UniProtKB/SwissProt

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PC sid
UniChem
n/an/a 393n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212858
PNG
(US9278960, 1-29)
Show SMILES Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H13N3O/c1-11-2-7-14-15(13-5-3-12(10-19)4-6-13)9-17(18(20)22)21-16(14)8-11/h2-9H,1H3,(H2,20,22)
PDB

UniProtKB/SwissProt

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UniChem
n/an/a 190n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212859
PNG
(US9278960, 2-3)
Show SMILES CN1CC(=O)N(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C21H17FN4O3/c1-25-11-19(27)26(21(25)29)10-12-2-7-15-16(13-3-5-14(22)6-4-13)9-18(20(23)28)24-17(15)8-12/h2-9H,10-11H2,1H3,(H2,23,28)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
n/an/a 21n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
mGluR2 and G alpha 16


(Homo sapiens (Human))
BDBM212860
PNG
(US9278960, 2-7)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1
Show InChI InChI=1S/C21H16FN3O3/c22-14-4-2-13(3-5-14)16-10-18(21(23)28)24-17-9-12(1-6-15(16)17)11-25-19(26)7-8-20(25)27/h1-6,9-10H,7-8,11H2,(H2,23,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9278960 (2016)


BindingDB Entry DOI: 10.7270/Q2MK6BQW
More data for this
Ligand-Target Pair
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