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Compile Data Set for Download or QSAR

Found 1381 hits Enz. Inhib. hit(s) with Target = 'p110α/p85α'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110α/p85α


(Homo sapiens (Human))
BDBM92862
PNG
(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Show SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
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n/an/an/an/a 40n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50315213
PNG
(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)
Show SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
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n/an/an/an/a 50n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50315213
PNG
(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)
Show SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
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Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365506
PNG
(CHEMBL1957497)
Show SMILES CS(=O)(=O)N1CCN(Cc2cn3cc(nc(N4CCOCC4)c3n2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C23H28N8O3S/c1-35(32,33)31-7-5-28(6-8-31)14-17-15-30-16-21(18-3-2-4-20-19(18)13-24-27-20)26-23(22(30)25-17)29-9-11-34-12-10-29/h2-4,13,15-16H,5-12,14H2,1H3,(H,24,27)
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n/an/an/an/a 93n/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468940
PNG
(CHEMBL4291904)
Show SMILES Fc1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H12BrFN2O2/c23-15-12-18-17(11-14(15)13-5-1-2-6-16(13)24)25-21(19-7-3-9-27-19)22(26-18)20-8-4-10-28-20/h1-12H
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n/an/an/an/a 93n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468968
PNG
(CHEMBL4294052)
Show SMILES FC(F)(F)c1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C23H12BrF3N2O2/c24-16-12-18-17(11-14(16)13-5-1-2-6-15(13)23(25,26)27)28-21(19-7-3-9-30-19)22(29-18)20-8-4-10-31-20/h1-12H
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Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365517
PNG
(CHEMBL1957508)
Show SMILES COCCCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C22H25N7O3/c1-31-9-3-6-23-22(30)19-14-29-13-18(15-4-2-5-17-16(15)12-24-27-17)25-20(21(29)26-19)28-7-10-32-11-8-28/h2,4-5,12-14H,3,6-11H2,1H3,(H,23,30)(H,24,27)
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Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468940
PNG
(CHEMBL4291904)
Show SMILES Fc1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H12BrFN2O2/c23-15-12-18-17(11-14(15)13-5-1-2-6-16(13)24)25-21(19-7-3-9-27-19)22(26-18)20-8-4-10-28-20/h1-12H
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Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365510
PNG
(CHEMBL1957501)
Show SMILES NC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C18H17N7O2/c19-16(26)15-10-25-9-14(11-2-1-3-13-12(11)8-20-23-13)21-17(18(25)22-15)24-4-6-27-7-5-24/h1-3,8-10H,4-7H2,(H2,19,26)(H,20,23)
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n/an/an/an/a 138n/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468968
PNG
(CHEMBL4294052)
Show SMILES FC(F)(F)c1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C23H12BrF3N2O2/c24-16-12-18-17(11-14(16)13-5-1-2-6-15(13)23(25,26)27)28-21(19-7-3-9-30-19)22(29-18)20-8-4-10-31-20/h1-12H
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Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365516
PNG
(CHEMBL1957507)
Show SMILES COCCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H23N7O3/c1-30-8-5-22-21(29)18-13-28-12-17(14-3-2-4-16-15(14)11-23-26-16)24-19(20(28)25-18)27-6-9-31-10-7-27/h2-4,11-13H,5-10H2,1H3,(H,22,29)(H,23,26)
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Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365508
PNG
(CHEMBL1957499)
Show SMILES CS(=O)(=O)N1CCN(Cc2cn3c(C#N)c(nc(N4CCOCC4)c3n2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C24H27N9O3S/c1-37(34,35)32-7-5-30(6-8-32)15-17-16-33-21(13-25)22(18-3-2-4-20-19(18)14-26-29-20)28-23(24(33)27-17)31-9-11-36-12-10-31/h2-4,14,16H,5-12,15H2,1H3,(H,26,29)
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Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365507
PNG
(CHEMBL1957498)
Show SMILES CS(=O)(=O)N1CCN(Cc2nc3c(nc(cn3c2Br)-c2cccc3[nH]ncc23)N2CCOCC2)CC1
Show InChI InChI=1S/C23H27BrN8O3S/c1-36(33,34)31-7-5-29(6-8-31)14-20-21(24)32-15-19(16-3-2-4-18-17(16)13-25-28-18)26-22(23(32)27-20)30-9-11-35-12-10-30/h2-4,13,15H,5-12,14H2,1H3,(H,25,28)
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Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365514
PNG
(CHEMBL1957505)
Show SMILES CN(C)CCCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C23H28N8O2/c1-29(2)8-4-7-24-23(32)20-15-31-14-19(16-5-3-6-18-17(16)13-25-28-18)26-21(22(31)27-20)30-9-11-33-12-10-30/h3,5-6,13-15H,4,7-12H2,1-2H3,(H,24,32)(H,25,28)
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Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365513
PNG
(CHEMBL1957504)
Show SMILES O=C(NCCN1CCOCC1)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C24H28N8O3/c33-24(25-4-5-30-6-10-34-11-7-30)21-16-32-15-20(17-2-1-3-19-18(17)14-26-29-19)27-22(23(32)28-21)31-8-12-35-13-9-31/h1-3,14-16H,4-13H2,(H,25,33)(H,26,29)
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Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365509
PNG
(CHEMBL1957500)
Show SMILES CS(=O)(=O)N1CCN(Cc2cn3c(Cl)c(nc(N4CCOCC4)c3n2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C23H27ClN8O3S/c1-36(33,34)31-7-5-29(6-8-31)14-16-15-32-21(24)20(17-3-2-4-19-18(17)13-25-28-19)27-22(23(32)26-16)30-9-11-35-12-10-30/h2-4,13,15H,5-12,14H2,1H3,(H,25,28)
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Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468963
PNG
(CHEMBL4279307)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C23H12BrF3N2O2/c24-16-12-18-17(11-15(16)13-5-7-14(8-6-13)23(25,26)27)28-21(19-3-1-9-30-19)22(29-18)20-4-2-10-31-20/h1-12H
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Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365511
PNG
(CHEMBL1957502)
Show SMILES CNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C19H19N7O2/c1-20-19(27)16-11-26-10-15(12-3-2-4-14-13(12)9-21-24-14)22-17(18(26)23-16)25-5-7-28-8-6-25/h2-4,9-11H,5-8H2,1H3,(H,20,27)(H,21,24)
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Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365512
PNG
(CHEMBL1957503)
Show SMILES CCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C20H21N7O2/c1-2-21-20(28)17-12-27-11-16(13-4-3-5-15-14(13)10-22-25-15)23-18(19(27)24-17)26-6-8-29-9-7-26/h3-5,10-12H,2,6-9H2,1H3,(H,21,28)(H,22,25)
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n/an/an/an/a 713n/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50365515
PNG
(CHEMBL1957506)
Show SMILES CN(C)CCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C22H26N8O2/c1-28(2)7-6-23-22(31)19-14-30-13-18(15-4-3-5-17-16(15)12-24-27-17)25-20(21(30)26-19)29-8-10-32-11-9-29/h3-5,12-14H,6-11H2,1-2H3,(H,23,31)(H,24,27)
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n/an/an/an/a 976n/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468965
PNG
(CHEMBL4285976)
Show SMILES Brc1cc2nc(-c3ccco3)c(nc2cc1-c1cc2ccccc2s1)-c1ccco1
Show InChI InChI=1S/C24H13BrN2O2S/c25-16-13-18-17(12-15(16)22-11-14-5-1-2-8-21(14)30-22)26-23(19-6-3-9-28-19)24(27-18)20-7-4-10-29-20/h1-13H
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n/an/an/an/a 1.20E+3n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468959
PNG
(CHEMBL4281931)
Show SMILES Fc1ccc(cc1)-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H12BrFN2O2/c23-16-12-18-17(11-15(16)13-5-7-14(24)8-6-13)25-21(19-3-1-9-27-19)22(26-18)20-4-2-10-28-20/h1-12H
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n/an/an/an/a 1.90E+3n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468936
PNG
(CHEMBL4292219)
Show SMILES Fc1cccc(c1)-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H12BrFN2O2/c23-16-12-18-17(11-15(16)13-4-1-5-14(24)10-13)25-21(19-6-2-8-27-19)22(26-18)20-7-3-9-28-20/h1-12H
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n/an/an/an/a 2.90E+3n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468960
PNG
(CHEMBL4277828)
Show SMILES Fc1ccc(c(F)c1)-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H11BrF2N2O2/c23-15-11-18-17(10-14(15)13-6-5-12(24)9-16(13)25)26-21(19-3-1-7-28-19)22(27-18)20-4-2-8-29-20/h1-11H
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n/an/an/an/a 3.20E+3n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468948
PNG
(CHEMBL4285769)
Show SMILES Fc1cccc(c1F)-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H11BrF2N2O2/c23-14-11-17-16(10-13(14)12-4-1-5-15(24)20(12)25)26-21(18-6-2-8-28-18)22(27-17)19-7-3-9-29-19/h1-11H
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n/an/an/an/a 7.30E+3n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468964
PNG
(CHEMBL4289392)
Show SMILES Brc1cc2nc(-c3ccco3)c(nc2cc1-c1ccncc1)-c1ccco1
Show InChI InChI=1S/C21H12BrN3O2/c22-15-12-17-16(11-14(15)13-5-7-23-8-6-13)24-20(18-3-1-9-26-18)21(25-17)19-4-2-10-27-19/h1-12H
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n/an/an/an/a 1.08E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468957
PNG
(CHEMBL4290817)
Show SMILES FC(F)(F)c1ccccc1-c1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C23H13F3N2O2/c24-23(25,26)16-6-2-1-5-15(16)14-9-10-17-18(13-14)28-22(20-8-4-12-30-20)21(27-17)19-7-3-11-29-19/h1-13H
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n/an/an/an/a 1.18E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468949
PNG
(CHEMBL4281353)
Show SMILES c1coc(c1)-c1nc2ccc(cc2nc1-c1ccco1)-c1ccccc1
Show InChI InChI=1S/C22H14N2O2/c1-2-6-15(7-3-1)16-10-11-17-18(14-16)24-22(20-9-5-13-26-20)21(23-17)19-8-4-12-25-19/h1-14H
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n/an/an/an/a 1.24E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468955
PNG
(CHEMBL4286987)
Show SMILES Fc1ccccc1-c1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C22H13FN2O2/c23-16-6-2-1-5-15(16)14-9-10-17-18(13-14)25-22(20-8-4-12-27-20)21(24-17)19-7-3-11-26-19/h1-13H
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n/an/an/an/a 1.27E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468957
PNG
(CHEMBL4290817)
Show SMILES FC(F)(F)c1ccccc1-c1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C23H13F3N2O2/c24-23(25,26)16-6-2-1-5-15(16)14-9-10-17-18(13-14)28-22(20-8-4-12-30-20)21(27-17)19-7-3-11-29-19/h1-13H
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n/an/an/an/a 1.28E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468966
PNG
(CHEMBL4293875)
Show SMILES Brc1cc2nc(-c3ccco3)c(nc2cc1-c1cncnc1)-c1ccco1
Show InChI InChI=1S/C20H11BrN4O2/c21-14-8-16-15(7-13(14)12-9-22-11-23-10-12)24-19(17-3-1-5-26-17)20(25-16)18-4-2-6-27-18/h1-11H
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n/an/an/an/a 1.35E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468952
PNG
(CHEMBL4288551)
Show SMILES Clc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C16H9ClN2O2/c17-10-5-6-11-12(9-10)19-16(14-4-2-8-21-14)15(18-11)13-3-1-7-20-13/h1-9H
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n/an/an/an/a 1.81E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468931
PNG
(CHEMBL4282598)
Show SMILES CC(C)(C)OC(=O)n1cccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C25H20BrN3O4/c1-25(2,3)33-24(30)29-10-4-7-19(29)15-13-17-18(14-16(15)26)28-23(21-9-6-12-32-21)22(27-17)20-8-5-11-31-20/h4-14H,1-3H3
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n/an/an/an/a 1.86E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468939
PNG
(CHEMBL4284050)
Show SMILES Brc1cc2nc(-c3ccco3)c(nc2cc1-c1ccccc1)-c1ccco1
Show InChI InChI=1S/C22H13BrN2O2/c23-16-13-18-17(12-15(16)14-6-2-1-3-7-14)24-21(19-8-4-10-26-19)22(25-18)20-9-5-11-27-20/h1-13H
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n/an/an/an/a 2.05E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468932
PNG
(CHEMBL4285204)
Show SMILES Brc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C16H9BrN2O2/c17-10-5-6-11-12(9-10)19-16(14-4-2-8-21-14)15(18-11)13-3-1-7-20-13/h1-9H
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n/an/an/an/a 2.76E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468932
PNG
(CHEMBL4285204)
Show SMILES Brc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C16H9BrN2O2/c17-10-5-6-11-12(9-10)19-16(14-4-2-8-21-14)15(18-11)13-3-1-7-20-13/h1-9H
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n/an/an/an/a 3.35E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468953
PNG
(CHEMBL4291974)
Show SMILES Brc1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C16H8Br2N2O2/c17-9-7-11-12(8-10(9)18)20-16(14-4-2-6-22-14)15(19-11)13-3-1-5-21-13/h1-8H
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n/an/an/an/a 3.93E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468935
PNG
(CHEMBL4290402)
Show SMILES Oc1ccccc1-c1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C22H14N2O3/c25-18-6-2-1-5-15(18)14-9-10-16-17(13-14)24-22(20-8-4-12-27-20)21(23-16)19-7-3-11-26-19/h1-13,25H
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n/an/an/an/a 4.35E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468949
PNG
(CHEMBL4281353)
Show SMILES c1coc(c1)-c1nc2ccc(cc2nc1-c1ccco1)-c1ccccc1
Show InChI InChI=1S/C22H14N2O2/c1-2-6-15(7-3-1)16-10-11-17-18(14-16)24-22(20-9-5-13-26-20)21(23-17)19-8-4-12-25-19/h1-14H
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n/an/an/an/a 4.78E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468950
PNG
(CHEMBL4277029)
Show SMILES Clc1cc(Cl)c2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C16H8Cl2N2O2/c17-9-7-10(18)14-11(8-9)19-15(12-3-1-5-21-12)16(20-14)13-4-2-6-22-13/h1-8H
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n/an/an/an/a 5.46E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468950
PNG
(CHEMBL4277029)
Show SMILES Clc1cc(Cl)c2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C16H8Cl2N2O2/c17-9-7-10(18)14-11(8-9)19-15(12-3-1-5-21-12)16(20-14)13-4-2-6-22-13/h1-8H
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n/an/an/an/a 7.60E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468956
PNG
(CHEMBL4282528)
Show SMILES COc1ccccc1-c1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C23H16N2O3/c1-26-19-7-3-2-6-16(19)15-10-11-17-18(14-15)25-23(21-9-5-13-28-21)22(24-17)20-8-4-12-27-20/h2-14H,1H3
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n/an/an/an/a 8.73E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468942
PNG
(2,3-Diphenyl-Quinoxaline | CHEMBL302245)
Show SMILES c1ccc(cc1)-c1nc2ccccc2nc1-c1ccccc1
Show InChI InChI=1S/C20H14N2/c1-3-9-15(10-4-1)19-20(16-11-5-2-6-12-16)22-18-14-8-7-13-17(18)21-19/h1-14H
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468961
PNG
(CHEMBL4289578)
Show SMILES Oc1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H13BrN2O3/c23-15-12-17-16(11-14(15)13-5-1-2-6-18(13)26)24-21(19-7-3-9-27-19)22(25-17)20-8-4-10-28-20/h1-12,26H
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468962
PNG
(CHEMBL4284548)
Show SMILES COc1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C23H15BrN2O3/c1-27-19-7-3-2-6-14(19)15-12-17-18(13-16(15)24)26-23(21-9-5-11-29-21)22(25-17)20-8-4-10-28-20/h2-13H,1H3
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468941
PNG
(CHEMBL4293032)
Show SMILES Fc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C16H9FN2O2/c17-10-5-6-11-12(9-10)19-16(14-4-2-8-21-14)15(18-11)13-3-1-7-20-13/h1-9H
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468938
PNG
(CHEMBL4280775)
Show SMILES COc1ccc(cc1)-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C23H15BrN2O3/c1-27-15-8-6-14(7-9-15)16-12-18-19(13-17(16)24)26-23(21-5-3-11-29-21)22(25-18)20-4-2-10-28-20/h2-13H,1H3
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468937
PNG
(CHEMBL4286147)
Show SMILES Clc1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H12BrClN2O2/c23-15-12-18-17(11-14(15)13-5-1-2-6-16(13)24)25-21(19-7-3-9-27-19)22(26-18)20-8-4-10-28-20/h1-12H
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468934
PNG
(CHEMBL1578104)
Show SMILES C1CN(CCO1)c1nc2ccccc2nc1N1CCOCC1
Show InChI InChI=1S/C16H20N4O2/c1-2-4-14-13(3-1)17-15(19-5-9-21-10-6-19)16(18-14)20-7-11-22-12-8-20/h1-4H,5-12H2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM50468967
PNG
(CHEMBL4278726)
Show SMILES Brc1cc2nc(-c3ccco3)c(nc2cc1-c1cc2ccccc2o1)-c1ccco1
Show InChI InChI=1S/C24H13BrN2O3/c25-16-13-18-17(12-15(16)22-11-14-5-1-2-6-19(14)30-22)26-23(20-7-3-9-28-20)24(27-18)21-8-4-10-29-21/h1-13H
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
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