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Compile Data Set for Download or QSAR

Found 699 hits Enz. Inhib. hit(s) with Target = 'p110α/p85α'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365506
PNG
(CHEMBL1957497)
Show SMILES CS(=O)(=O)N1CCN(Cc2cn3cc(nc(N4CCOCC4)c3n2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C23H28N8O3S/c1-35(32,33)31-7-5-28(6-8-31)14-17-15-30-16-21(18-3-2-4-20-19(18)13-24-27-20)26-23(22(30)25-17)29-9-11-34-12-10-29/h2-4,13,15-16H,5-12,14H2,1H3,(H,24,27)
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n/an/an/an/a 93n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365517
PNG
(CHEMBL1957508)
Show SMILES COCCCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C22H25N7O3/c1-31-9-3-6-23-22(30)19-14-29-13-18(15-4-2-5-17-16(15)12-24-27-17)25-20(21(29)26-19)28-7-10-32-11-8-28/h2,4-5,12-14H,3,6-11H2,1H3,(H,23,30)(H,24,27)
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n/an/an/an/a 114n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365510
PNG
(CHEMBL1957501)
Show SMILES NC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C18H17N7O2/c19-16(26)15-10-25-9-14(11-2-1-3-13-12(11)8-20-23-13)21-17(18(25)22-15)24-4-6-27-7-5-24/h1-3,8-10H,4-7H2,(H2,19,26)(H,20,23)
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n/an/an/an/a 138n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365516
PNG
(CHEMBL1957507)
Show SMILES COCCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H23N7O3/c1-30-8-5-22-21(29)18-13-28-12-17(14-3-2-4-16-15(14)11-23-26-16)24-19(20(28)25-18)27-6-9-31-10-7-27/h2-4,11-13H,5-10H2,1H3,(H,22,29)(H,23,26)
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n/an/an/an/a 200n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365508
PNG
(CHEMBL1957499)
Show SMILES CS(=O)(=O)N1CCN(Cc2cn3c(C#N)c(nc(N4CCOCC4)c3n2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C24H27N9O3S/c1-37(34,35)32-7-5-30(6-8-32)15-17-16-33-21(13-25)22(18-3-2-4-20-19(18)14-26-29-20)28-23(24(33)27-17)31-9-11-36-12-10-31/h2-4,14,16H,5-12,15H2,1H3,(H,26,29)
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n/an/an/an/a 203n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365507
PNG
(CHEMBL1957498)
Show SMILES CS(=O)(=O)N1CCN(Cc2nc3c(nc(cn3c2Br)-c2cccc3[nH]ncc23)N2CCOCC2)CC1
Show InChI InChI=1S/C23H27BrN8O3S/c1-36(33,34)31-7-5-29(6-8-31)14-20-21(24)32-15-19(16-3-2-4-18-17(16)13-25-28-18)26-22(23(32)27-20)30-9-11-35-12-10-30/h2-4,13,15H,5-12,14H2,1H3,(H,25,28)
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n/an/an/an/a 208n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365514
PNG
(CHEMBL1957505)
Show SMILES CN(C)CCCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C23H28N8O2/c1-29(2)8-4-7-24-23(32)20-15-31-14-19(16-5-3-6-18-17(16)13-25-28-18)26-21(22(31)27-20)30-9-11-33-12-10-30/h3,5-6,13-15H,4,7-12H2,1-2H3,(H,24,32)(H,25,28)
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n/an/an/an/a 429n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365513
PNG
(CHEMBL1957504)
Show SMILES O=C(NCCN1CCOCC1)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C24H28N8O3/c33-24(25-4-5-30-6-10-34-11-7-30)21-16-32-15-20(17-2-1-3-19-18(17)14-26-29-19)27-22(23(32)28-21)31-8-12-35-13-9-31/h1-3,14-16H,4-13H2,(H,25,33)(H,26,29)
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n/an/an/an/a 452n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365509
PNG
(CHEMBL1957500)
Show SMILES CS(=O)(=O)N1CCN(Cc2cn3c(Cl)c(nc(N4CCOCC4)c3n2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C23H27ClN8O3S/c1-36(33,34)31-7-5-29(6-8-31)14-16-15-32-21(24)20(17-3-2-4-19-18(17)13-25-28-19)27-22(23(32)26-16)30-9-11-35-12-10-30/h2-4,13,15H,5-12,14H2,1H3,(H,25,28)
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n/an/an/an/a 495n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365511
PNG
(CHEMBL1957502)
Show SMILES CNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C19H19N7O2/c1-20-19(27)16-11-26-10-15(12-3-2-4-14-13(12)9-21-24-14)22-17(18(26)23-16)25-5-7-28-8-6-25/h2-4,9-11H,5-8H2,1H3,(H,20,27)(H,21,24)
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n/an/an/an/a 600n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365512
PNG
(CHEMBL1957503)
Show SMILES CCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C20H21N7O2/c1-2-21-20(28)17-12-27-11-16(13-4-3-5-15-14(13)10-22-25-15)23-18(19(27)24-17)26-6-8-29-9-7-26/h3-5,10-12H,2,6-9H2,1H3,(H,21,28)(H,22,25)
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n/an/an/an/a 713n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50365515
PNG
(CHEMBL1957506)
Show SMILES CN(C)CCNC(=O)c1cn2cc(nc(N3CCOCC3)c2n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C22H26N8O2/c1-28(2)7-6-23-22(31)19-14-30-13-18(15-4-3-5-17-16(15)12-24-27-17)25-20(21(30)26-19)29-8-10-32-11-9-29/h3-5,12-14H,6-11H2,1-2H3,(H,23,31)(H,24,27)
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n/an/an/an/a 976n/an/an/an/a



Spanish National Cancer Research Centre (CNIO). C/Melchor Fern£ndez Almagro 3

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cells


Bioorg Med Chem Lett 22: 1874-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.074
BindingDB Entry DOI: 10.7270/Q29Z95DX
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207061
PNG
(US9260439, 38)
Show SMILES CNS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C19H27N9O3S/c1-21-32(29,30)27-4-2-14(12-27)28-5-3-15-16(13-10-22-18(20)23-11-13)24-19(25-17(15)28)26-6-8-31-9-7-26/h10-11,14,21H,2-9,12H2,1H3,(H2,20,22,23)/t14-/m0/s1
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0.228n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207095
PNG
(US9260439, 72)
Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)C1CN(C1)S(N)(=O)=O)N1CCOCC1
Show InChI InChI=1S/C17H23N9O3S/c18-16-20-7-11(8-21-16)14-13-1-2-26(12-9-25(10-12)30(19,27)28)15(13)23-17(22-14)24-3-5-29-6-4-24/h7-8,12H,1-6,9-10H2,(H2,18,20,21)(H2,19,27,28)
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207169
PNG
(US9260439, 146)
Show SMILES CC1(CCN(C1)S(C)(=O)=O)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C20H28N8O3S/c1-20(4-6-27(13-20)32(2,29)30)28-5-3-15-16(14-11-22-18(21)23-12-14)24-19(25-17(15)28)26-7-9-31-10-8-26/h11-12H,3-10,13H2,1-2H3,(H2,21,22,23)
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207102
PNG
(US9260439, 79)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@H]1CCN(C1)S(C)(=O)=O
Show InChI InChI=1S/C20H28N8O3S/c1-13-12-31-8-7-27(13)20-24-17(14-9-22-19(21)23-10-14)16-4-6-28(18(16)25-20)15-3-5-26(11-15)32(2,29)30/h9-10,13,15H,3-8,11-12H2,1-2H3,(H2,21,22,23)/t13-,15-/m0/s1
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207088
PNG
(US9260439, 65)
Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)[C@H]1C[C@H](F)C1)N1CCOCC1
Show InChI InChI=1S/C18H22FN7O/c19-12-7-13(8-12)26-2-1-14-15(11-9-21-17(20)22-10-11)23-18(24-16(14)26)25-3-5-27-6-4-25/h9-10,12-13H,1-8H2,(H2,20,21,22)/t12-,13-
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207082
PNG
(US9260439, 59)
Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)[C@H]1C[C@@H](C1)C#N)N1CCOCC1
Show InChI InChI=1S/C19H22N8O/c20-9-12-7-14(8-12)27-2-1-15-16(13-10-22-18(21)23-11-13)24-19(25-17(15)27)26-3-5-28-6-4-26/h10-12,14H,1-8H2,(H2,21,22,23)/t12-,14-
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207054
PNG
(US9260439, 31)
Show SMILES CC(C)[C@@H](O)C(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H32N8O3/c1-14(2)19(32)21(33)30-5-3-16(13-30)31-6-4-17-18(15-11-25-22(24)26-12-15)27-23(28-20(17)31)29-7-9-34-10-8-29/h11-12,14,16,19,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t16-,19+/m0/s1
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207048
PNG
(US9260439, 25)
Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)[C@H]1CCN(C1)C(=O)CO)N1CCOCC1
Show InChI InChI=1S/C20H26N8O3/c21-19-22-9-13(10-23-19)17-15-2-4-28(14-1-3-27(11-14)16(30)12-29)18(15)25-20(24-17)26-5-7-31-8-6-26/h9-10,14,29H,1-8,11-12H2,(H2,21,22,23)/t14-/m0/s1
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207045
PNG
(US9260439, 22)
Show SMILES CN([C@H]1C[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1)S(C)(=O)=O
Show InChI InChI=1S/C20H28N8O3S/c1-26(32(2,29)30)14-9-15(10-14)28-4-3-16-17(13-11-22-19(21)23-12-13)24-20(25-18(16)28)27-5-7-31-8-6-27/h11-12,14-15H,3-10H2,1-2H3,(H2,21,22,23)/t14-,15-
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207043
PNG
(US9260439, 20)
Show SMILES CS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C19H26N8O3S/c1-31(28,29)26-4-2-14(12-26)27-5-3-15-16(13-10-21-18(20)22-11-13)23-19(24-17(15)27)25-6-8-30-9-7-25/h10-11,14H,2-9,12H2,1H3,(H2,20,21,22)/t14-/m0/s1
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207025
PNG
(US9260439, 1)
Show SMILES CC(C)S(=O)(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C21H30N8O3S/c1-13(2)33(30,31)27-10-16(11-27)29-5-4-17-18(15-8-23-20(22)24-9-15)25-21(26-19(17)29)28-6-7-32-12-14(28)3/h8-9,13-14,16H,4-7,10-12H2,1-3H3,(H2,22,23,24)/t14-/m0/s1
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207118
PNG
(US9260439, 95)
Show SMILES CNS(=O)(=O)O[C@H]1C[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C19H26N8O4S/c1-21-32(28,29)31-14-8-13(9-14)27-3-2-15-16(12-10-22-18(20)23-11-12)24-19(25-17(15)27)26-4-6-30-7-5-26/h10-11,13-14,21H,2-9H2,1H3,(H2,20,22,23)/t13-,14-
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207123
PNG
(US9260439, 100)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@H]1CCN(C1)S(N)(=O)=O
Show InChI InChI=1S/C19H27N9O3S/c1-12-11-31-7-6-27(12)19-24-16(13-8-22-18(20)23-9-13)15-3-5-28(17(15)25-19)14-2-4-26(10-14)32(21,29)30/h8-9,12,14H,2-7,10-11H2,1H3,(H2,20,22,23)(H2,21,29,30)/t12-,14-/m0/s1
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207124
PNG
(US9260439, 101)
Show SMILES CCS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C20H28N8O3S/c1-2-32(29,30)27-5-3-15(13-27)28-6-4-16-17(14-11-22-19(21)23-12-14)24-20(25-18(16)28)26-7-9-31-10-8-26/h11-12,15H,2-10,13H2,1H3,(H2,21,22,23)/t15-/m0/s1
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207125
PNG
(US9260439, 102)
Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)[C@H]1CCN(C1)S(=O)(=O)C1CC1)N1CCOCC1
Show InChI InChI=1S/C21H28N8O3S/c22-20-23-11-14(12-24-20)18-17-4-6-29(15-3-5-28(13-15)33(30,31)16-1-2-16)19(17)26-21(25-18)27-7-9-32-10-8-27/h11-12,15-16H,1-10,13H2,(H2,22,23,24)/t15-/m0/s1
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207127
PNG
(US9260439, 104)
Show SMILES CNS(=O)(=O)O[C@H]1C[C@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C19H26N8O4S/c1-21-32(28,29)31-14-8-13(9-14)27-3-2-15-16(12-10-22-18(20)23-11-12)24-19(25-17(15)27)26-4-6-30-7-5-26/h10-11,13-14,21H,2-9H2,1H3,(H2,20,22,23)/t13-,14+
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207129
PNG
(US9260439, 106)
Show SMILES CC(C)S(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C21H30N8O3S/c1-14(2)33(30,31)28-5-3-16(13-28)29-6-4-17-18(15-11-23-20(22)24-12-15)25-21(26-19(17)29)27-7-9-32-10-8-27/h11-12,14,16H,3-10,13H2,1-2H3,(H2,22,23,24)/t16-/m0/s1
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207131
PNG
(US9260439, 108)
Show SMILES CCS(=O)(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C19H26N8O3S/c1-2-31(28,29)26-11-14(12-26)27-4-3-15-16(13-9-21-18(20)22-10-13)23-19(24-17(15)27)25-5-7-30-8-6-25/h9-10,14H,2-8,11-12H2,1H3,(H2,20,21,22)
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Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207132
PNG
(US9260439, 109)
Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)C1CN(C1)S(=O)(=O)C1CC1)N1CCOCC1
Show InChI InChI=1S/C20H26N8O3S/c21-19-22-9-13(10-23-19)17-16-3-4-28(14-11-27(12-14)32(29,30)15-1-2-15)18(16)25-20(24-17)26-5-7-31-8-6-26/h9-10,14-15H,1-8,11-12H2,(H2,21,22,23)
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207134
PNG
(US9260439, 111)
Show SMILES CC(C)S(=O)(=O)N1CC[C@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C21H30N8O3S/c1-14(2)33(30,31)28-5-3-16(13-28)29-6-4-17-18(15-11-23-20(22)24-12-15)25-21(26-19(17)29)27-7-9-32-10-8-27/h11-12,14,16H,3-10,13H2,1-2H3,(H2,22,23,24)/t16-/m1/s1
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207136
PNG
(US9260439, 113)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)C1CN(C1)S(C)(=O)=O
Show InChI InChI=1S/C19H26N8O3S/c1-12-11-30-6-5-26(12)19-23-16(13-7-21-18(20)22-8-13)15-3-4-27(17(15)24-19)14-9-25(10-14)31(2,28)29/h7-8,12,14H,3-6,9-11H2,1-2H3,(H2,20,21,22)/t12-/m0/s1
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207138
PNG
(US9260439, 115)
Show SMILES CCS(=O)(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C20H28N8O3S/c1-3-32(29,30)26-10-15(11-26)28-5-4-16-17(14-8-22-19(21)23-9-14)24-20(25-18(16)28)27-6-7-31-12-13(27)2/h8-9,13,15H,3-7,10-12H2,1-2H3,(H2,21,22,23)/t13-/m0/s1
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207141
PNG
(US9260439, 118)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)C1CN(C1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C21H28N8O3S/c1-13-12-32-7-6-28(13)21-25-18(14-8-23-20(22)24-9-14)17-4-5-29(19(17)26-21)15-10-27(11-15)33(30,31)16-2-3-16/h8-9,13,15-16H,2-7,10-12H2,1H3,(H2,22,23,24)/t13-/m0/s1
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207142
PNG
(US9260439, 119)
Show SMILES CCS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C21H30N8O3S/c1-3-33(30,31)27-6-4-16(12-27)29-7-5-17-18(15-10-23-20(22)24-11-15)25-21(26-19(17)29)28-8-9-32-13-14(28)2/h10-11,14,16H,3-9,12-13H2,1-2H3,(H2,22,23,24)/t14-,16-/m0/s1
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207143
PNG
(US9260439, 120)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)C1CN(C1)S(=O)(=O)N(C)C
Show InChI InChI=1S/C20H29N9O3S/c1-13-12-32-7-6-28(13)20-24-17(14-8-22-19(21)23-9-14)16-4-5-29(18(16)25-20)15-10-27(11-15)33(30,31)26(2)3/h8-9,13,15H,4-7,10-12H2,1-3H3,(H2,21,22,23)/t13-/m0/s1
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207144
PNG
(US9260439, 121)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@H]1CCN(C1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C22H30N8O3S/c1-14-13-33-9-8-29(14)22-26-19(15-10-24-21(23)25-11-15)18-5-7-30(20(18)27-22)16-4-6-28(12-16)34(31,32)17-2-3-17/h10-11,14,16-17H,2-9,12-13H2,1H3,(H2,23,24,25)/t14-,16-/m0/s1
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US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207145
PNG
(US9260439, 122)
Show SMILES CNS(=O)(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C19H27N9O3S/c1-12-11-31-6-5-27(12)19-24-16(13-7-22-18(20)23-8-13)15-3-4-28(17(15)25-19)14-9-26(10-14)32(29,30)21-2/h7-8,12,14,21H,3-6,9-11H2,1-2H3,(H2,20,22,23)/t12-/m0/s1
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207146
PNG
(US9260439, 123)
Show SMILES COC(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C21H28N8O3/c1-13-12-32-8-7-28(13)20-25-17(14-9-23-19(22)24-10-14)16-4-6-29(18(16)26-20)15-3-5-27(11-15)21(30)31-2/h9-10,13,15H,3-8,11-12H2,1-2H3,(H2,22,23,24)/t13-,15-/m0/s1
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207148
PNG
(US9260439, 125)
Show SMILES CCOC(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C22H30N8O3/c1-3-33-22(31)28-6-4-16(12-28)30-7-5-17-18(15-10-24-20(23)25-11-15)26-21(27-19(17)30)29-8-9-32-13-14(29)2/h10-11,14,16H,3-9,12-13H2,1-2H3,(H2,23,24,25)/t14-,16-/m0/s1
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207149
PNG
(US9260439, 126)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)C1CN(C1)S(N)(=O)=O
Show InChI InChI=1S/C18H25N9O3S/c1-11-10-30-5-4-26(11)18-23-15(12-6-21-17(19)22-7-12)14-2-3-27(16(14)24-18)13-8-25(9-13)31(20,28)29/h6-7,11,13H,2-5,8-10H2,1H3,(H2,19,21,22)(H2,20,28,29)/t11-/m0/s1
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207151
PNG
(US9260439, 128)
Show SMILES CNS(=O)(=O)N1C[C@@H](O)[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C20H29N9O4S/c1-12-11-33-6-5-28(12)20-25-17(13-7-23-19(21)24-8-13)14-3-4-29(18(14)26-20)15-9-27(10-16(15)30)34(31,32)22-2/h7-8,12,15-16,22,30H,3-6,9-11H2,1-2H3,(H2,21,23,24)/t12-,15+,16+/m0/s1
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207154
PNG
(US9260439, 131)
Show SMILES CC(C)S(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C22H32N8O3S/c1-14(2)34(31,32)28-6-4-17(12-28)30-7-5-18-19(16-10-24-21(23)25-11-16)26-22(27-20(18)30)29-8-9-33-13-15(29)3/h10-11,14-15,17H,4-9,12-13H2,1-3H3,(H2,23,24,25)/t15-,17-/m0/s1
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<0.229n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207155
PNG
(US9260439, 132)
Show SMILES CC(C)(C)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C18H25N7O/c1-18(2,3)25-5-4-13-14(12-10-20-16(19)21-11-12)22-17(23-15(13)25)24-6-8-26-9-7-24/h10-11H,4-9H2,1-3H3,(H2,19,20,21)
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PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207159
PNG
(US9260439, 136)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@@H]1CCN(C1)C(=O)OC1CN(C1)C(C)=O
Show InChI InChI=1S/C25H33N9O4/c1-15-14-37-8-7-33(15)24-29-21(17-9-27-23(26)28-10-17)20-4-6-34(22(20)30-24)18-3-5-31(11-18)25(36)38-19-12-32(13-19)16(2)35/h9-10,15,18-19H,3-8,11-14H2,1-2H3,(H2,26,27,28)/t15-,18+/m0/s1
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PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207084
PNG
(US9260439, 61)
Show SMILES COC(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C19H24N8O3/c1-29-19(28)26-10-13(11-26)27-3-2-14-15(12-8-21-17(20)22-9-12)23-18(24-16(14)27)25-4-6-30-7-5-25/h8-9,13H,2-7,10-11H2,1H3,(H2,20,21,22)
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0.234n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207105
PNG
(US9260439, 82)
Show SMILES CN(C)S(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C20H29N9O3S/c1-26(2)33(30,31)28-5-3-15(13-28)29-6-4-16-17(14-11-22-19(21)23-12-14)24-20(25-18(16)29)27-7-9-32-10-8-27/h11-12,15H,3-10,13H2,1-2H3,(H2,21,22,23)/t15-/m0/s1
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PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207140
PNG
(US9260439, 117)
Show SMILES CNS(=O)(=O)N1C[C@@H](OC)[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C21H31N9O4S/c1-13-12-34-7-6-29(13)21-26-18(14-8-24-20(22)25-9-14)15-4-5-30(19(15)27-21)16-10-28(11-17(16)33-3)35(31,32)23-2/h8-9,13,16-17,23H,4-7,10-12H2,1-3H3,(H2,22,24,25)/t13-,16+,17+/m0/s1
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PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM207108
PNG
(US9260439, 85 | US9260439, 92)
Show SMILES CNS(=O)(=O)N1CC[C@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C
Show InChI InChI=1S/C20H29N9O3S/c1-13-12-32-8-7-28(13)20-25-17(14-9-23-19(21)24-10-14)16-4-6-29(18(16)26-20)15-3-5-27(11-15)33(30,31)22-2/h9-10,13,15,22H,3-8,11-12H2,1-2H3,(H2,21,23,24)/t13-,15+/m0/s1
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0.283n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair
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