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Compile Data Set for Download or QSAR

Found 494 hits Enz. Inhib. hit(s) with Target = 'α-glucosidase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108221
PNG
(5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)-c3ccccc3)cn12
Show InChI InChI=1S/C23H26N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-3,6-7,9-13,19-22,26-29H,4-5,8,14H2
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n/an/a 6n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108222
PNG
(2-[3-(4-cyclohexylphenyl)propyl]-5-(hydroxymethyl)...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)C3CCCCC3)cn12
Show InChI InChI=1S/C23H32N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h9-13,16,19-22,26-29H,1-8,14H2
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n/an/a 52n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM60585
PNG
(2-(3'-Fluorophenyl)-7-methyl-1H-benzo[d]imidazole ...)
Show SMILES Cc1cccc2nc([nH]c12)-c1cccc(F)c1
Show InChI InChI=1S/C14H11FN2/c1-9-4-2-7-12-13(9)17-14(16-12)10-5-3-6-11(15)8-10/h2-8H,1H3,(H,16,17)
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n/an/a 165n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM), Puncak Alam Campus



Assay Description
The 135 無 of 50 mM phosphate saline buffer pH (6.8), solution of enzyme (20 無), and 20 無 of test sample with 70% DMSO was added to 96-well plate. ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108219
PNG
(5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H...)
Show SMILES Cc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1
Show InChI InChI=1S/C18H24N2O4/c1-11-5-7-12(8-6-11)3-2-4-13-9-20-14(10-21)15(22)16(23)17(24)18(20)19-13/h5-9,14-17,21-24H,2-4,10H2,1H3
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n/an/a 280n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108220
PNG
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
Show SMILES COc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1
Show InChI InChI=1S/C18H24N2O5/c1-25-13-7-5-11(6-8-13)3-2-4-12-9-20-14(10-21)15(22)16(23)17(24)18(20)19-12/h5-9,14-17,21-24H,2-4,10H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108216
PNG
(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCc3ccccc3)cn12
Show InChI InChI=1S/C16H20N2O4/c19-9-12-13(20)14(21)15(22)16-17-11(8-18(12)16)7-6-10-4-2-1-3-5-10/h1-5,8,12-15,19-22H,6-7,9H2
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n/an/a 570n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108223
PNG
(2-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)- 5H...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(F)cc3)cn12
Show InChI InChI=1S/C17H21FN2O4/c18-11-6-4-10(5-7-11)2-1-3-12-8-20-13(9-21)14(22)15(23)16(24)17(20)19-12/h4-8,13-16,21-24H,1-3,9H2
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n/an/a 730n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108218
PNG
(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Show SMILES CCCCCCCCc1cn2C(CO)C(O)C(O)C(O)c2n1
Show InChI InChI=1S/C16H28N2O4/c1-2-3-4-5-6-7-8-11-9-18-12(10-19)13(20)14(21)15(22)16(18)17-11/h9,12-15,19-22H,2-8,10H2,1H3
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n/an/a 970n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108224
PNG
(N-phenyl-4-[6,7,8-trihydroxy-5-(hydroxymethyl)- 5H...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCC(=O)Nc3ccccc3)cn12
Show InChI InChI=1S/C18H23N3O5/c22-10-13-15(24)16(25)17(26)18-20-12(9-21(13)18)7-4-8-14(23)19-11-5-2-1-3-6-11/h1-3,5-6,9,13,15-17,22,24-26H,4,7-8,10H2,(H,19,23)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM178004
PNG
(2-(3-((3-(trifluoromethyl)benzyl)oxy)phenyl)-4H-ch...)
Show SMILES FC(F)(F)c1ccc(c(COc2cccc(c2)-c2cc(=O)c3ccccc3o2)c1)C(F)(F)F
Show InChI InChI=1S/C23H15F3O3/c24-23(25,26)17-7-3-5-15(11-17)14-28-18-8-4-6-16(12-18)22-13-20(27)19-9-1-2-10-21(19)29-22/h1-13H,14H2
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n/an/a 1.26E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The α-glucosidase inhibition assay had been carried out using baker窺 yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM152497
PNG
((E)-N'-(6-Bromo-2-oxoindolin-3-ylidene)-2-(2,4...)
Show SMILES Clc1ccc(CC(=O)N\N=C2\C(=O)Nc3cc(Br)ccc23)c(Cl)c1
Show InChI InChI=1S/C16H10BrCl2N3O2/c17-9-2-4-11-13(6-9)20-16(24)15(11)22-21-14(23)5-8-1-3-10(18)7-12(8)19/h1-4,6-7H,5H2,(H,21,23)(H,20,22,24)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Hazara University



Assay Description
10 無 of test samples (5 mg/mL DMSO solution) were reconstituted in 100 無 of 100 mM-phosphate buffer (pH6.8) in 96-well microplate and incubated wit...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173530
PNG
((E)-N'-(3,4,5-trihydroxybenzylidene)-1H-indole...)
Show SMILES Oc1cc(\C=N\NC(=O)c2cc3ccccc3[nH]2)cc(O)c1O
Show InChI InChI=1S/C16H13N3O4/c20-13-5-9(6-14(21)15(13)22)8-17-19-16(23)12-7-10-3-1-2-4-11(10)18-12/h1-8,18,20-22H,(H,19,23)/b17-8+
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n/an/a 2.30E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The 135 無 of 50 mM phosphate saline buffer pH (6.8) was added in the 96-well plate and 20 無 of test sample with 70% DMSO added into the wells. The ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50438504
PNG
(CHEMBL2414818)
Show SMILES OC[C@H]1O[C@@H](CNC(=O)\C=C\c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H21NO6/c18-9-12-15(21)16(22)14(20)11(23-12)8-17-13(19)7-6-10-4-2-1-3-5-10/h1-7,11-12,14-16,18,20-22H,8-9H2,(H,17,19)/b7-6+/t11-,12+,14-,15+,16+/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as 4-nitrophenol release from 4-nitrophenyl alpha-D-glucopyranoside preincubated fo...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150768
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(3-h...)
Show SMILES Oc1cccc(c1)C(=O)CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H12N4O2S/c22-11-5-3-4-10(8-11)14(23)9-24-17-19-16-15(20-21-17)12-6-1-2-7-13(12)18-16/h1-8,22H,9H2,(H,18,19,21)
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n/an/a 2.46E+3n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM222221
PNG
(3-(4-(4,5-diphenyl-1H-imidazol-2-yl)-1-phenyl-1H-p...)
Show SMILES O=c1oc2ccccc2cc1-c1nn(cc1-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C33H22N4O2/c38-33-26(20-24-16-10-11-19-28(24)39-33)31-27(21-37(36-31)25-17-8-3-9-18-25)32-34-29(22-12-4-1-5-13-22)30(35-32)23-14-6-2-7-15-23/h1-21H,(H,34,35)
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n/an/a 2.78E+3n/an/an/an/an/an/a



University of the Punjab; Kinnaird College for Women



Assay Description
At 37 蚓, after incubation of 10 min of a reaction mixture solution of 70 μL (50 mM) phosphate buffer of 6.8 pH, 10 μL (0.5 mM) of a test c...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM222222
PNG
(6-Bromo-3-(4-(4,5-diphenyl-1H-imidazol-2-yl)-1-phe...)
Show SMILES Brc1ccc2oc(=O)c(cc2c1)-c1nn(cc1-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C33H21BrN4O2/c34-24-16-17-28-23(18-24)19-26(33(39)40-28)31-27(20-38(37-31)25-14-8-3-9-15-25)32-35-29(21-10-4-1-5-11-21)30(36-32)22-12-6-2-7-13-22/h1-20H,(H,35,36)
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n/an/a 2.95E+3n/an/an/an/an/an/a



University of the Punjab; Kinnaird College for Women



Assay Description
At 37 蚓, after incubation of 10 min of a reaction mixture solution of 70 μL (50 mM) phosphate buffer of 6.8 pH, 10 μL (0.5 mM) of a test c...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM152499
PNG
((E)-N'-(2-oxoindolin-3-ylidene)dodecanehydrazi...)
Show SMILES CCCCCCCCCCCC(=O)N\N=C1\C(=O)Nc2ccccc12
Show InChI InChI=1S/C20H29N3O2/c1-2-3-4-5-6-7-8-9-10-15-18(24)22-23-19-16-13-11-12-14-17(16)21-20(19)25/h11-14H,2-10,15H2,1H3,(H,22,24)(H,21,23,25)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Hazara University



Assay Description
10 無 of test samples (5 mg/mL DMSO solution) were reconstituted in 100 無 of 100 mM-phosphate buffer (pH6.8) in 96-well microplate and incubated wit...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM152496
PNG
((E)-N'-(6-bromo-2-oxoindolin-3-ylidene)-2-(3,4...)
Show SMILES Clc1ccc(CC(=O)N\N=C2\C(=O)Nc3cc(Br)ccc23)cc1Cl
Show InChI InChI=1S/C16H10BrCl2N3O2/c17-9-2-3-10-13(7-9)20-16(24)15(10)22-21-14(23)6-8-1-4-11(18)12(19)5-8/h1-5,7H,6H2,(H,21,23)(H,20,22,24)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Hazara University



Assay Description
10 無 of test samples (5 mg/mL DMSO solution) were reconstituted in 100 無 of 100 mM-phosphate buffer (pH6.8) in 96-well microplate and incubated wit...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108217
PNG
(2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,...)
Show SMILES CC(C)(C)CCc1cn2C(CO)C(O)C(O)C(O)c2n1
Show InChI InChI=1S/C14H24N2O4/c1-14(2,3)5-4-8-6-16-9(7-17)10(18)11(19)12(20)13(16)15-8/h6,9-12,17-20H,4-5,7H2,1-3H3
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n/an/a 3.42E+3n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM178010
PNG
(2-(3-((2,3-difluorobenzyl)oxy)phenyl)-4H-chromen-4...)
Show SMILES Fc1cccc(COc2cccc(c2)-c2cc(=O)c3ccccc3o2)c1F
Show InChI InChI=1S/C22H14F2O3/c23-18-9-4-6-15(22(18)24)13-26-16-7-3-5-14(11-16)21-12-19(25)17-8-1-2-10-20(17)27-21/h1-12H,13H2
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n/an/a 3.49E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The α-glucosidase inhibition assay had been carried out using baker窺 yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM50308256
PNG
(1-O-Methyl-2,3-O-isopropylidene-5-(4-cyclohexene-1...)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(nn2)C2=CCCCC2)[C@H]2OC(C)(C)O[C@@H]12
Show InChI InChI=1S/C17H25N3O4/c1-17(2)23-14-13(22-16(21-3)15(14)24-17)10-20-9-12(18-19-20)11-7-5-4-6-8-11/h7,9,13-16H,4-6,8,10H2,1-3H3/t13-,14-,15-,16-/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Universidade Federal do Rio de Janeiro

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase MAL12 assessed as inhibition of p-nitrophenol release by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50335391
PNG
(CHEMBL1651629 | N-Pentoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H33NO5/c1-2-3-6-9-22-10-7-4-5-8-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14+,15-,16-/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50299749
PNG
((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20-,21-,22?/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50063756
PNG
(CHEMBL3397482)
Show SMILES OC(=O)CC1Oc2ccccc2-c2ccc3N(Cc4ccc(cc4)C(F)(F)F)C(=O)C(=O)c3c12
Show InChI InChI=1/C25H16F3NO5/c26-25(27,28)14-7-5-13(6-8-14)12-29-17-10-9-16-15-3-1-2-4-18(15)34-19(11-20(30)31)21(16)22(17)23(32)24(29)33/h1-10,19H,11-12H2,(H,30,31)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science and Technology)

Curated by ChEMBL


Assay Description
Inhibition of bakers yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate after 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50335390
PNG
(CHEMBL1651630 | N-Hexoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15+,16-,17-/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM50308259
PNG
(1-O-Methyl-2,3-O-isopropylidene-5-[4-(1-hydroxycyc...)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(nn2)C2(O)CCCCC2)[C@H]2OC(C)(C)O[C@@H]12
Show InChI InChI=1S/C17H27N3O5/c1-16(2)24-13-11(23-15(22-3)14(13)25-16)9-20-10-12(18-19-20)17(21)7-5-4-6-8-17/h10-11,13-15,21H,4-9H2,1-3H3/t11-,13-,14-,15-/m1/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



Universidade Federal do Rio de Janeiro

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase MAL12 assessed as inhibition of p-nitrophenol release by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM179781
PNG
(2-(2'-Chlorophenyl)-7-methyl-1H-benzo[d]imidaz...)
Show SMILES Cc1cccc2nc([nH]c12)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2/c1-9-5-4-8-12-13(9)17-14(16-12)10-6-2-3-7-11(10)15/h2-8H,1H3,(H,16,17)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM), Puncak Alam Campus



Assay Description
The 135 無 of 50 mM phosphate saline buffer pH (6.8), solution of enzyme (20 無), and 20 無 of test sample with 70% DMSO was added to 96-well plate. ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM178004
PNG
(2-(3-((3-(trifluoromethyl)benzyl)oxy)phenyl)-4H-ch...)
Show SMILES FC(F)(F)c1ccc(c(COc2cccc(c2)-c2cc(=O)c3ccccc3o2)c1)C(F)(F)F
Show InChI InChI=1S/C23H15F3O3/c24-23(25,26)17-7-3-5-15(11-17)14-28-18-8-4-6-16(12-18)22-13-20(27)19-9-1-2-10-21(19)29-22/h1-13H,14H2
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n/an/a 5.45E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The α-glucosidase inhibition assay had been carried out using baker窺 yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50438503
PNG
(CHEMBL2414819)
Show SMILES OC[C@H]1O[C@@H](CNC(=O)\C=C\c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H21NO7/c18-8-12-15(22)16(23)14(21)11(24-12)7-17-13(20)6-3-9-1-4-10(19)5-2-9/h1-6,11-12,14-16,18-19,21-23H,7-8H2,(H,17,20)/b6-3+/t11-,12+,14-,15+,16+/m0/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as 4-nitrophenol release from 4-nitrophenyl alpha-D-glucopyranoside preincubated fo...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM50308258
PNG
(1-O-Methyl-2,3-O-isopropylidene-5-(4-phenoxymethyl...)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(COc3ccccc3)nn2)[C@H]2OC(C)(C)O[C@@H]12
Show InChI InChI=1S/C18H23N3O5/c1-18(2)25-15-14(24-17(22-3)16(15)26-18)10-21-9-12(19-20-21)11-23-13-7-5-4-6-8-13/h4-9,14-17H,10-11H2,1-3H3/t14-,15-,16-,17-/m1/s1
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n/an/a 5.70E+3n/an/an/an/an/an/a



Universidade Federal do Rio de Janeiro

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase MAL12 assessed as inhibition of p-nitrophenol release by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM181062
PNG
((E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(...)
Show SMILES Oc1c(Cl)cc(Cl)cc1\C=N\NC(=O)c1nc(cs1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C20H11Cl2N3O4S/c21-12-5-11(17(26)14(22)7-12)8-23-25-18(27)19-24-15(9-30-19)13-6-10-3-1-2-4-16(10)29-20(13)28/h1-9,26H,(H,25,27)/b23-8+
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n/an/a 6.24E+3n/an/an/an/an/an/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50335389
PNG
(CHEMBL1651631 | N-Heptoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C18H37NO5/c1-2-3-4-5-8-11-24-12-9-6-7-10-19-13-16(21)18(23)17(22)15(19)14-20/h15-18,20-23H,2-14H2,1H3/t15-,16+,17-,18-/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM222219
PNG
(4-(4,5-Diphenyl-1H-imidazol-2-yl)-1-(4-nitrophenyl...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-n1cc(-c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)c(n1)-c1ccccc1
Show InChI InChI=1S/C30H21N5O2/c36-35(37)25-18-16-24(17-19-25)34-20-26(27(33-34)21-10-4-1-5-11-21)30-31-28(22-12-6-2-7-13-22)29(32-30)23-14-8-3-9-15-23/h1-20H,(H,31,32)
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n/an/a 7.81E+3n/an/an/an/an/an/a



University of the Punjab; Kinnaird College for Women



Assay Description
At 37 蚓, after incubation of 10 min of a reaction mixture solution of 70 μL (50 mM) phosphate buffer of 6.8 pH, 10 μL (0.5 mM) of a test c...


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM18357
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Show SMILES CCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,2-10H2,1H3/t11-,12+,13-,14-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM18358
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-...)
Show SMILES CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50335392
PNG
(CHEMBL1651628 | N-Butoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO5/c1-2-3-8-21-9-6-4-5-7-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM181064
PNG
((E)-N'-(5-Chloro-2-hydroxybenzylidene)-4-(2-ox...)
Show SMILES Oc1ccc(Cl)cc1\C=N\NC(=O)c1nc(cs1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C20H12ClN3O4S/c21-13-5-6-16(25)12(7-13)9-22-24-18(26)19-23-15(10-29-19)14-8-11-3-1-2-4-17(11)28-20(14)27/h1-10,25H,(H,24,26)/b22-9+
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n/an/a 8.23E+3n/an/an/an/an/an/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84968
PNG
(Urea derivative, 12)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(F)cc3F)cc2)cc1O
Show InChI InChI=1S/C21H16F2N2O3/c22-15-6-9-18(17(23)12-15)25-21(28)24-16-7-3-13(4-8-16)1-2-14-5-10-19(26)20(27)11-14/h1-12,26-27H,(H2,24,25,28)/b2-1+
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3.20E+3n/a 8.40E+3n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175324
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C23H20N4O4/c1-12-7-17-18(8-13(12)2)26-22(25-17)15-3-5-16(6-4-15)23(31)27-24-11-14-9-19(28)21(30)20(29)10-14/h3-11,28-30H,1-2H3,(H,25,26)(H,27,31)/b24-11+
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n/an/a 8.40E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175315
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c(O)c1
Show InChI InChI=1S/C24H22N4O3/c1-14-10-20-21(11-15(14)2)27-23(26-20)16-4-6-17(7-5-16)24(30)28-25-13-18-8-9-19(31-3)12-22(18)29/h4-13,29H,1-3H3,(H,26,27)(H,28,30)/b25-13+
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n/an/a 8.44E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175317
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1ccc(O)c(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c1
Show InChI InChI=1S/C24H22N4O3/c1-14-10-20-21(11-15(14)2)27-23(26-20)16-4-6-17(7-5-16)24(30)28-25-13-18-12-19(31-3)8-9-22(18)29/h4-13,29H,1-3H3,(H,26,27)(H,28,30)/b25-13+
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n/an/a 8.44E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM178007
PNG
(2-(3-((3-((trifluoromethyl)thio)benzyl)oxy)phenyl)...)
Show SMILES FC(F)(F)Sc1cccc(COc2cccc(c2)-c2cc(=O)c3ccccc3o2)c1
Show InChI InChI=1S/C23H15F3O3S/c24-23(25,26)30-18-8-3-5-15(11-18)14-28-17-7-4-6-16(12-17)22-13-20(27)19-9-1-2-10-21(19)29-22/h1-13H,14H2
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n/an/a 8.66E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The α-glucosidase inhibition assay had been carried out using baker窺 yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175311
PNG
((E)-N'-(2,4-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)cc1O
Show InChI InChI=1S/C23H20N4O3/c1-13-9-19-20(10-14(13)2)26-22(25-19)15-3-5-16(6-4-15)23(30)27-24-12-17-7-8-18(28)11-21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
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n/an/a 8.74E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


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More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175309
PNG
((E)-N'-(2,5-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cc(O)ccc1O
Show InChI InChI=1S/C23H20N4O3/c1-13-9-19-20(10-14(13)2)26-22(25-19)15-3-5-16(6-4-15)23(30)27-24-12-17-11-18(28)7-8-21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
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n/an/a 8.74E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM23406
PNG
((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
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n/an/a 9.37E+3n/an/an/an/an/an/a



King Abdulaziz University



Assay Description
α-Glucosidase inhibitory activity was evaluated at 37 蚓, by using 0.1M phosphatebuffer (pH6.8) [28]. The enzyme(EC3.2.1.20, Saccharomyces cerev...


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More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM243075
PNG
(α-Gl inhibitor, C3)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)N1c2[nH]c(=O)[nH]c(=O)c2C(C(O)C(O)C(O)C(O)CO)c2c1[nH]c(=O)[nH]c2=O
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n/an/a 9.60E+3n/an/an/an/an/an/a



Shiraz University



Assay Description
In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25蚓 with minor changes, according to the meth...


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More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175310
PNG
((E)-N'-(2,3-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cccc(O)c1O
Show InChI InChI=1S/C23H20N4O3/c1-13-10-18-19(11-14(13)2)26-22(25-18)15-6-8-16(9-7-15)23(30)27-24-12-17-4-3-5-20(28)21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
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n/an/a 9.99E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50335399
PNG
(CHEMBL1651549 | N-Pentyl-1-deoxynojirimycin)
Show SMILES CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23NO4/c1-2-3-4-5-12-6-9(14)11(16)10(15)8(12)7-13/h8-11,13-16H,2-7H2,1H3/t8-,9+,10-,11-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50335388
PNG
(CHEMBL1651632 | N-Octoxypentyl-1-deoxynojirimycin)
Show SMILES CCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C19H39NO5/c1-2-3-4-5-6-9-12-25-13-10-7-8-11-20-14-17(22)19(24)18(23)16(20)15-21/h16-19,21-24H,2-15H2,1H3/t16-,17+,18-,19-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of maltase in mouse intestinal input by glucose release assay


Citation and Details
More data for this
Ligand-Target Pair
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