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Compile Data Set for Download or QSAR

Found 262 hits Enz. Inhib. hit(s) with Target = '15-hydroxyprostaglandin dehydrogenase [NAD+]'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50066953
PNG
(CHEMBL3403240)
Show SMILES Brc1cc(\C=C2/SC(=O)NC2=O)ccc1OCCc1ccccc1
Show InChI InChI=1S/C18H14BrNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h1-7,10-11H,8-9H2,(H,20,21,22)/b16-11-
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n/an/a 4n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of 15-PGDH (unknown origin) by fluorescence spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347953
PNG
(CHEMBL1800140 | US8637558, 15)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Br)c1
Show InChI InChI=1S/C18H20BrNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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US Patent
n/an/a 6.60n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347952
PNG
(CHEMBL1800139 | US8637558, 11)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C18H20ClNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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US Patent
n/an/a 7.20n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347952
PNG
(CHEMBL1800139 | US8637558, 11)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C18H20ClNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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n/an/a 8n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438415
PNG
(CHEMBL2414148)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCC2)c(Cl)c1
Show InChI InChI=1S/C15H14ClNO3S/c16-11-6-10(7-13-14(18)17-15(19)21-13)4-5-12(11)20-8-9-2-1-3-9/h4-7,9H,1-3,8H2,(H,17,18,19)
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n/an/a 9n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347956
PNG
(CHEMBL1800143 | US8637558, 32)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C19H22ClNO3S/c20-15-11-14(12-17-18(22)21-19(23)25-17)8-9-16(15)24-10-4-7-13-5-2-1-3-6-13/h8-9,11-13H,1-7,10H2,(H,21,22,23)
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n/an/a 10n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347956
PNG
(CHEMBL1800143 | US8637558, 32)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C19H22ClNO3S/c20-15-11-14(12-17-18(22)21-19(23)25-17)8-9-16(15)24-10-4-7-13-5-2-1-3-6-13/h8-9,11-13H,1-7,10H2,(H,21,22,23)
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US Patent
n/an/a 10.3n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438413
PNG
(CHEMBL2414150)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCC2)c(Cl)c1
Show InChI InChI=1S/C16H16ClNO3S/c17-12-7-11(8-14-15(19)18-16(20)22-14)5-6-13(12)21-9-10-3-1-2-4-10/h5-8,10H,1-4,9H2,(H,18,19,20)
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n/an/a 11n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445521
PNG
(CHEMBL3103033)
Show SMILES Clc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C19H18ClN3O/c20-15-5-4-6-16(12-15)23-13-21-17-11-14(7-8-18(17)23)19(24)22-9-2-1-3-10-22/h4-8,11-13H,1-3,9-10H2
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n/an/a 12n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438430
PNG
(CHEMBL2414240 | US8637558, 18)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)cc1Cl
Show InChI InChI=1S/C18H20ClNO3S/c19-15-11-14(23-9-8-12-4-2-1-3-5-12)7-6-13(15)10-16-17(21)20-18(22)24-16/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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n/an/a 13n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118019
PNG
(US8637558, 34)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(OCCC2CCCCC2)c1Cl
Show InChI InChI=1S/C18H20ClNO3S/c19-16-13(11-15-17(21)20-18(22)24-15)7-4-8-14(16)23-10-9-12-5-2-1-3-6-12/h4,7-8,11-12H,1-3,5-6,9-10H2,(H,20,21,22)
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US Patent
n/an/a 17.9n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM30884
PNG
(1-(3-methylphenyl)-5-(piperidin-1-ylcarbonyl)-1H-b...)
Show SMILES Cc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3
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n/an/a 19n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347953
PNG
(CHEMBL1800140 | US8637558, 15)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Br)c1
Show InChI InChI=1S/C18H20BrNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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n/an/a 19n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445516
PNG
(CHEMBL3103038)
Show SMILES Cc1ccc(cc1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O/c1-15-5-8-17(9-6-15)23-14-21-18-13-16(7-10-19(18)23)20(24)22-11-3-2-4-12-22/h5-10,13-14H,2-4,11-12H2,1H3
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n/an/a 19n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445514
PNG
(CHEMBL3103040)
Show SMILES COc1ccc(cc1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O2/c1-25-17-8-6-16(7-9-17)23-14-21-18-13-15(5-10-19(18)23)20(24)22-11-3-2-4-12-22/h5-10,13-14H,2-4,11-12H2,1H3
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n/an/a 19n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445520
PNG
(CHEMBL3103034)
Show SMILES COc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O2/c1-25-17-7-5-6-16(13-17)23-14-21-18-12-15(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3
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n/an/a 19n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438430
PNG
(CHEMBL2414240 | US8637558, 18)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)cc1Cl
Show InChI InChI=1S/C18H20ClNO3S/c19-15-11-14(23-9-8-12-4-2-1-3-5-12)7-6-13(15)10-16-17(21)20-18(22)24-16/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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US Patent
n/an/a 19.6n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438403
PNG
(CHEMBL2414160 | US8637558, 69)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C18H14ClNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h1-7,10-11H,8-9H2,(H,20,21,22)
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US Patent
n/an/a 19.8n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438416
PNG
(CHEMBL2414147)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCOC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C18H20ClNO4S/c19-14-10-12(11-16-17(21)20-18(22)25-16)6-7-15(14)24-9-8-23-13-4-2-1-3-5-13/h6-7,10-11,13H,1-5,8-9H2,(H,20,21,22)
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n/an/a 20n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438403
PNG
(CHEMBL2414160 | US8637558, 69)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C18H14ClNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h1-7,10-11H,8-9H2,(H,20,21,22)
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n/an/a 20n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118042
PNG
(US8637558, 66)
Show SMILES OCC(=O)C1CCC(COc2ccc(C=C3SC(O)=NC3=O)cc2)CC1
Show InChI InChI=1S/C19H21NO5S/c21-10-16(22)14-5-1-13(2-6-14)11-25-15-7-3-12(4-8-15)9-17-18(23)20-19(24)26-17/h3-4,7-9,13-14,21H,1-2,5-6,10-11H2,(H,20,23,24)
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US Patent
n/an/a 20.4n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445562
PNG
(CHEMBL3102994)
Show SMILES Cc1cc(c(C)n1-c1ccc(Cl)c(Cl)c1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C19H20Cl2N4/c1-12-10-15(19-23-22-18-6-4-3-5-9-24(18)19)13(2)25(12)14-7-8-16(20)17(21)11-14/h7-8,10-11H,3-6,9H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445537
PNG
(CHEMBL3103018)
Show SMILES CC1CCCN(C1)C(=O)c1ccc2n(cnc2c1)-c1cccc(C)c1
Show InChI InChI=1S/C21H23N3O/c1-15-5-3-7-18(11-15)24-14-22-19-12-17(8-9-20(19)24)21(25)23-10-4-6-16(2)13-23/h3,5,7-9,11-12,14,16H,4,6,10,13H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445523
PNG
(CHEMBL3103032)
Show SMILES O=C(N1CCCCC1)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H19N3O/c23-19(21-11-5-2-6-12-21)15-9-10-18-17(13-15)20-14-22(18)16-7-3-1-4-8-16/h1,3-4,7-10,13-14H,2,5-6,11-12H2
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n/an/a 22n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445515
PNG
(CHEMBL3103039)
Show SMILES Clc1ccc(cc1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C19H18ClN3O/c20-15-5-7-16(8-6-15)23-13-21-17-12-14(4-9-18(17)23)19(24)22-10-2-1-3-11-22/h4-9,12-13H,1-3,10-11H2
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n/an/a 22n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118056
PNG
(US8637558, 84)
Show SMILES COc1cc(C=C2SC(O)=NC2=O)ccc1OCCCC1CCCCC1
Show InChI InChI=1S/C20H25NO4S/c1-24-17-12-15(13-18-19(22)21-20(23)26-18)9-10-16(17)25-11-5-8-14-6-3-2-4-7-14/h9-10,12-14H,2-8,11H2,1H3,(H,21,22,23)
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US Patent
n/an/a 22.1n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118012
PNG
(US8637558, 8)
Show SMILES OCc1cc(C=C2SC(O)=NC2=O)ccc1OCCC1CCCCC1
Show InChI InChI=1S/C19H23NO4S/c21-12-15-10-14(11-17-18(22)20-19(23)25-17)6-7-16(15)24-9-8-13-4-2-1-3-5-13/h6-7,10-11,13,21H,1-5,8-9,12H2,(H,20,22,23)
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US Patent
n/an/a 23n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347957
PNG
(CHEMBL1800144 | US8637558, 33)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C20H24ClNO3S/c21-16-12-15(13-18-19(23)22-20(24)26-18)9-10-17(16)25-11-5-4-8-14-6-2-1-3-7-14/h9-10,12-14H,1-8,11H2,(H,22,23,24)
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n/an/a 24n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347950
PNG
(CHEMBL1800138)
Show SMILES COc1cc(C=C2SC(O)=NC2=O)ccc1OCCC1CCCCC1
Show InChI InChI=1S/C19H23NO4S/c1-23-16-11-14(12-17-18(21)20-19(22)25-17)7-8-15(16)24-10-9-13-5-3-2-4-6-13/h7-8,11-13H,2-6,9-10H2,1H3,(H,20,21,22)
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n/an/a 25n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347957
PNG
(CHEMBL1800144 | US8637558, 33)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C20H24ClNO3S/c21-16-12-15(13-18-19(23)22-20(24)26-18)9-10-17(16)25-11-5-4-8-14-6-2-1-3-7-14/h9-10,12-14H,1-8,11H2,(H,22,23,24)
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US Patent
n/an/a 26.3n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347955
PNG
(CHEMBL1800142 | US8637558, 31)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C17H18ClNO3S/c18-13-8-12(9-15-16(20)19-17(21)23-15)6-7-14(13)22-10-11-4-2-1-3-5-11/h6-9,11H,1-5,10H2,(H,19,20,21)
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US Patent
n/an/a 26.9n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445522
PNG
(CHEMBL3102860)
Show SMILES COc1ccccc1-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O2/c1-25-19-8-4-3-7-18(19)23-14-21-16-13-15(9-10-17(16)23)20(24)22-11-5-2-6-12-22/h3-4,7-10,13-14H,2,5-6,11-12H2,1H3
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n/an/a 27n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347955
PNG
(CHEMBL1800142 | US8637558, 31)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C17H18ClNO3S/c18-13-8-12(9-15-16(20)19-17(21)23-15)6-7-14(13)22-10-11-4-2-1-3-5-11/h6-9,11H,1-5,10H2,(H,19,20,21)
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n/an/a 28n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118057
PNG
(US8637558, 89)
Show SMILES CC(CC1CCC(C)=CC1)Oc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C20H23NO3S/c1-13-3-5-15(6-4-13)11-14(2)24-17-9-7-16(8-10-17)12-18-19(22)21-20(23)25-18/h3,7-10,12,14-15H,4-6,11H2,1-2H3,(H,21,22,23)
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US Patent
n/an/a 28.4n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50378619
PNG
(CHEMBL590265 | US8637558, 3)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCc2cccs2)cc1
Show InChI InChI=1S/C16H13NO3S2/c18-15-14(22-16(19)17-15)10-11-3-5-12(6-4-11)20-8-7-13-2-1-9-21-13/h1-6,9-10H,7-8H2,(H,17,18,19)
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n/an/a 31n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15PGDH expressed in Escherichia coli BL-21 by fluorescence spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118041
PNG
(US8637558, 65)
Show SMILES CC1CCC(COc2ccc(C=C3SC(O)=NC3=O)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C19H20F3NO3S/c1-11-2-4-12(5-3-11)10-26-15-7-6-13(8-14(15)19(20,21)22)9-16-17(24)23-18(25)27-16/h6-9,11-12H,2-5,10H2,1H3,(H,23,24,25)
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US Patent
n/an/a 31.4n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445561
PNG
(CHEMBL3102995)
Show SMILES Cc1cc(c(C)n1-c1cccc(Cl)c1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C19H21ClN4/c1-13-11-17(14(2)24(13)16-8-6-7-15(20)12-16)19-22-21-18-9-4-3-5-10-23(18)19/h6-8,11-12H,3-5,9-10H2,1-2H3
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n/an/a 34n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445511
PNG
(CHEMBL3103043)
Show SMILES CC(C)(C)n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C17H23N3O/c1-17(2,3)20-12-18-14-11-13(7-8-15(14)20)16(21)19-9-5-4-6-10-19/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 34n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445555
PNG
(CHEMBL3103000)
Show SMILES Cc1cc(c(C)n1-c1ccc(C)cc1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C20H24N4/c1-14-8-10-17(11-9-14)24-15(2)13-18(16(24)3)20-22-21-19-7-5-4-6-12-23(19)20/h8-11,13H,4-7,12H2,1-3H3
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n/an/a 34n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445560
PNG
(CHEMBL3102996)
Show SMILES Cc1cc(c(C)n1-c1ccc(Cl)cc1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C19H21ClN4/c1-13-12-17(14(2)24(13)16-9-7-15(20)8-10-16)19-22-21-18-6-4-3-5-11-23(18)19/h7-10,12H,3-6,11H2,1-2H3
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n/an/a 38n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445549
PNG
(CHEMBL3103006)
Show SMILES CCOC(=O)c1ccc(cc1)-n1c(C)cc(c1C)-c1nnc2CCCCCn12
Show InChI InChI=1S/C22H26N4O2/c1-4-28-22(27)17-9-11-18(12-10-17)26-15(2)14-19(16(26)3)21-24-23-20-8-6-5-7-13-25(20)21/h9-12,14H,4-8,13H2,1-3H3
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n/an/a 38n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438402
PNG
(CHEMBL2414161 | US8637558, 70)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H16ClNO3S/c20-15-11-14(12-17-18(22)21-19(23)25-17)8-9-16(15)24-10-4-7-13-5-2-1-3-6-13/h1-3,5-6,8-9,11-12H,4,7,10H2,(H,21,22,23)
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n/an/a 38n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438402
PNG
(CHEMBL2414161 | US8637558, 70)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H16ClNO3S/c20-15-11-14(12-17-18(22)21-19(23)25-17)8-9-16(15)24-10-4-7-13-5-2-1-3-6-13/h1-3,5-6,8-9,11-12H,4,7,10H2,(H,21,22,23)
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US Patent
n/an/a 38.1n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438426
PNG
(CHEMBL2414244)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCC2)cc1Cl
Show InChI InChI=1S/C17H18ClNO3S/c18-14-10-13(22-8-7-11-3-1-2-4-11)6-5-12(14)9-15-16(20)19-17(21)23-15/h5-6,9-11H,1-4,7-8H2,(H,19,20,21)
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Article
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n/an/a 42n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50378637
PNG
(CHEMBL84603 | US8637558, 35)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCC2)cc1
Show InChI InChI=1S/C16H17NO3S/c18-15-14(21-16(19)17-15)9-11-5-7-13(8-6-11)20-10-12-3-1-2-4-12/h5-9,12H,1-4,10H2,(H,17,18,19)
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US Patent
n/an/a 42.5n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118047
PNG
(US8637558, 75)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(OCCCc2ccccc2)c1Cl
Show InChI InChI=1S/C19H16ClNO3S/c20-17-14(12-16-18(22)21-19(23)25-16)9-4-10-15(17)24-11-5-8-13-6-2-1-3-7-13/h1-4,6-7,9-10,12H,5,8,11H2,(H,21,22,23)
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US Patent
n/an/a 44.9n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50378637
PNG
(CHEMBL84603 | US8637558, 35)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCC2)cc1
Show InChI InChI=1S/C16H17NO3S/c18-15-14(21-16(19)17-15)9-11-5-7-13(8-6-11)20-10-12-3-1-2-4-12/h5-9,12H,1-4,10H2,(H,17,18,19)
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n/an/a 45n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15PGDH expressed in Escherichia coli BL-21 by fluorescence spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347954
PNG
(CHEMBL1800141 | US8637558, 30)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C16H16ClNO3S/c17-12-8-10(9-14-15(19)18-16(20)22-14)6-7-13(12)21-11-4-2-1-3-5-11/h6-9,11H,1-5H2,(H,18,19,20)
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n/an/a 47n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


Citation and Details
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438404
PNG
(CHEMBL2414159 | US8637558, 68)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C17H12ClNO3S/c18-13-8-12(9-15-16(20)19-17(21)23-15)6-7-14(13)22-10-11-4-2-1-3-5-11/h1-9H,10H2,(H,19,20,21)
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US Patent
n/an/a 47.5n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438401
PNG
(CHEMBL2414162 | US8637558, 71)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C20H18ClNO3S/c21-16-12-15(13-18-19(23)22-20(24)26-18)9-10-17(16)25-11-5-4-8-14-6-2-1-3-7-14/h1-3,6-7,9-10,12-13H,4-5,8,11H2,(H,22,23,24)
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US Patent
n/an/a 47.5n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
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