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Compile Data Set for Download or QSAR

Found 516 hits Enz. Inhib. hit(s) with Target = '26S Proteasome regulatory subunit Rpn11 (Rpn11)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM83506
PNG
((5Z)-5-[[2-(3-isopropoxypropylamino)-4-keto-9-meth...)
Show SMILES CCCN1C(=S)S\C(=C/c2c(NCCCOC(C)C)nc3c(C)cccn3c2=O)C1=O
Show InChI InChI=1S/C22H28N4O3S2/c1-5-10-26-21(28)17(31-22(26)30)13-16-18(23-9-7-12-29-14(2)3)24-19-15(4)8-6-11-25(19)20(16)27/h6,8,11,13-14,23H,5,7,9-10,12H2,1-4H3/b17-13-
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n/an/a 90n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2PC30Z9
More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401033
PNG
(US10005735, Compound 31)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
Show InChI InChI=1S/C23H29N5O3S2/c29-19(8-2-1-7-18-21-16(13-33-18)27-23(31)28-21)24-9-4-10-25-22(30)15-11-14-5-3-6-17(32)20(14)26-12-15/h3,5-6,11-12,16,18,21,32H,1-2,4,7-10,13H2,(H,24,29)(H,25,30)(H2,27,28,31)/t16-,18-,21-/m0/s1
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US Patent
n/an/a 200n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264417
PNG
(CHEMBL4104719)
Show SMILES O=C(NCc1ccncc1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3ccncc3)cccc2c1
Show InChI InChI=1S/C32H24N6O2S2/c39-31(37-17-21-7-11-33-12-8-21)25-15-23-3-1-5-27(29(23)35-19-25)41-42-28-6-2-4-24-16-26(20-36-30(24)28)32(40)38-18-22-9-13-34-14-10-22/h1-16,19-20H,17-18H2,(H,37,39)(H,38,40)
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n/an/a 200n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264415
PNG
(CHEMBL4096289)
Show SMILES COc1ccc(CNC(=O)c2cnc3c(SSc4cccc5cc(cnc45)C(=O)NCc4ccc(OC)cc4)cccc3c2)cc1
Show InChI InChI=1S/C36H30N4O4S2/c1-43-29-13-9-23(10-14-29)19-39-35(41)27-17-25-5-3-7-31(33(25)37-21-27)45-46-32-8-4-6-26-18-28(22-38-34(26)32)36(42)40-20-24-11-15-30(44-2)16-12-24/h3-18,21-22H,19-20H2,1-2H3,(H,39,41)(H,40,42)
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n/an/a<200n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401008
PNG
(US10005735, Compound 17)
Show SMILES Fc1ccc(CNC(=O)c2cnc3c(S)cccc3c2)cc1
Show InChI InChI=1S/C17H13FN2OS/c18-14-6-4-11(5-7-14)9-20-17(21)13-8-12-2-1-3-15(22)16(12)19-10-13/h1-8,10,22H,9H2,(H,20,21)
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US Patent
n/an/a<200n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264457
PNG
(CHEMBL4080490)
Show SMILES Fc1ccc(CNC(=O)c2cnc3c(SSc4cccc5cc(cnc45)C(=O)NCc4ccc(F)cc4)cccc3c2)cc1
Show InChI InChI=1S/C34H24F2N4O2S2/c35-27-11-7-21(8-12-27)17-39-33(41)25-15-23-3-1-5-29(31(23)37-19-25)43-44-30-6-2-4-24-16-26(20-38-32(24)30)34(42)40-18-22-9-13-28(36)14-10-22/h1-16,19-20H,17-18H2,(H,39,41)(H,40,42)
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n/an/a<200n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401006
PNG
(US10005735, Compound 15)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCc1ccncc1
Show InChI InChI=1S/C16H13N3OS/c20-16(19-9-11-4-6-17-7-5-11)13-8-12-2-1-3-14(21)15(12)18-10-13/h1-8,10,21H,9H2,(H,19,20)
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US Patent
n/an/a 200n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401020
PNG
(US10005735, Compound 19)
Show SMILES COc1ccc(CNC(=O)c2cnc3c(S)cccc3c2)cc1
Show InChI InChI=1S/C18H16N2O2S/c1-22-15-7-5-12(6-8-15)10-20-18(21)14-9-13-3-2-4-16(23)17(13)19-11-14/h2-9,11,23H,10H2,1H3,(H,20,21)
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n/an/a<200n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM400998
PNG
(US10005735, Compound 11)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCCc1cccs1
Show InChI InChI=1S/C16H14N2OS2/c19-16(17-7-6-13-4-2-8-21-13)12-9-11-3-1-5-14(20)15(11)18-10-12/h1-5,8-10,20H,6-7H2,(H,17,19)
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n/an/a 300n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264482
PNG
(CHEMBL4086748)
Show SMILES COC(=O)CNC(=O)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCC(=O)OC)cccc2c1
Show InChI InChI=1S/C26H22N4O6S2/c1-35-21(31)13-29-25(33)17-9-15-5-3-7-19(23(15)27-11-17)37-38-20-8-4-6-16-10-18(12-28-24(16)20)26(34)30-14-22(32)36-2/h3-12H,13-14H2,1-2H3,(H,29,33)(H,30,34)
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n/an/a>300n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264420
PNG
(CHEMBL4100384)
Show SMILES O=C(NCCc1cccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCCc3cccs3)cccc2c1
Show InChI InChI=1S/C32H26N4O2S4/c37-31(33-13-11-25-7-3-15-39-25)23-17-21-5-1-9-27(29(21)35-19-23)41-42-28-10-2-6-22-18-24(20-36-30(22)28)32(38)34-14-12-26-8-4-16-40-26/h1-10,15-20H,11-14H2,(H,33,37)(H,34,38)
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n/an/a 300n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM224012
PNG
(Capzimin | US10005735, Compound 12)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1
Show InChI InChI=1S/C15H13N3OS2/c19-15(17-5-4-13-16-6-7-21-13)11-8-10-2-1-3-12(20)14(10)18-9-11/h1-3,6-9,20H,4-5H2,(H,17,19)
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n/an/a 340n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM224012
PNG
(Capzimin | US10005735, Compound 12)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1
Show InChI InChI=1S/C15H13N3OS2/c19-15(17-5-4-13-16-6-7-21-13)11-8-10-2-1-3-12(20)14(10)18-9-11/h1-3,6-9,20H,4-5H2,(H,17,19)
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PubMed
n/an/a 340n/an/an/an/a7.530



California Institute of Technology



Assay Description
Fluorescence polarization assays were performed in low-volume 384-well solid black plates (Molecular Devices) in quadruplicate. The assays were perfo...


Nat Chem Biol 13: 486-493 (2017)


Article DOI: 10.1038/nchembio.2326
BindingDB Entry DOI: 10.7270/Q24J0D0B
More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264419
PNG
(CHEMBL4073553)
Show SMILES O=C(NCCc1nccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCCc3nccs3)cccc2c1
Show InChI InChI=1S/C30H24N6O2S4/c37-29(33-9-7-25-31-11-13-39-25)21-15-19-3-1-5-23(27(19)35-17-21)41-42-24-6-2-4-20-16-22(18-36-28(20)24)30(38)34-10-8-26-32-12-14-40-26/h1-6,11-18H,7-10H2,(H,33,37)(H,34,38)
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n/an/a 390n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401034
PNG
(US10005735, Compound 32)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
Show InChI InChI=1S/C28H39N5O6S2/c34-24(7-2-1-6-23-26-21(18-41-23)32-28(36)33-26)29-8-10-37-12-14-39-15-13-38-11-9-30-27(35)20-16-19-4-3-5-22(40)25(19)31-17-20/h3-5,16-17,21,23,26,40H,1-2,6-15,18H2,(H,29,34)(H,30,35)(H2,32,33,36)/t21-,23-,26-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264515
PNG
(CHEMBL4070821)
Show SMILES O=C(Nc1nccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)Nc3nccs3)cccc2c1
Show InChI InChI=1S/C26H16N6O2S4/c33-23(31-25-27-7-9-35-25)17-11-15-3-1-5-19(21(15)29-13-17)37-38-20-6-2-4-16-12-18(14-30-22(16)20)24(34)32-26-28-8-10-36-26/h1-14H,(H,27,31,33)(H,28,32,34)
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n/an/a 400n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM400992
PNG
(US10005735, Compound 5)
Show SMILES Sc1cccc2cc(cnc12)C(=O)Nc1nccs1
Show InChI InChI=1S/C13H9N3OS2/c17-12(16-13-14-4-5-19-13)9-6-8-2-1-3-10(18)11(8)15-7-9/h1-7,18H,(H,14,16,17)
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n/an/a 450n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM400996
PNG
(US10005735, Compound 9)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCc1nccs1
Show InChI InChI=1S/C14H11N3OS2/c18-14(17-8-12-15-4-5-20-12)10-6-9-2-1-3-11(19)13(9)16-7-10/h1-7,19H,8H2,(H,17,18)
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n/an/a 500n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401029
PNG
(US10005735, Compound 27)
Show SMILES Cc1nc(CCNC(=O)c2cnc3c(S)cccc3c2)sc1C
Show InChI InChI=1S/C17H17N3OS2/c1-10-11(2)23-15(20-10)6-7-18-17(21)13-8-12-4-3-5-14(22)16(12)19-9-13/h3-5,8-9,22H,6-7H2,1-2H3,(H,18,21)
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n/an/a 500n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264471
PNG
(CHEMBL4093962)
Show SMILES O=C(NCc1nccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3nccs3)cccc2c1
Show InChI InChI=1S/C28H20N6O2S4/c35-27(33-15-23-29-7-9-37-23)19-11-17-3-1-5-21(25(17)31-13-19)39-40-22-6-2-4-18-12-20(14-32-26(18)22)28(36)34-16-24-30-8-10-38-24/h1-14H,15-16H2,(H,33,35)(H,34,36)
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n/an/a 500n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264419
PNG
(CHEMBL4073553)
Show SMILES O=C(NCCc1nccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCCc3nccs3)cccc2c1
Show InChI InChI=1S/C30H24N6O2S4/c37-29(33-9-7-25-31-11-13-39-25)21-15-19-3-1-5-23(27(19)35-17-21)41-42-24-6-2-4-20-16-22(18-36-28(20)24)30(38)34-10-8-26-32-12-14-40-26/h1-6,11-18H,7-10H2,(H,33,37)(H,34,38)
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n/an/a 600n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM88892
PNG
(MLS000401485 | N-(2-chlorophenyl)-2-[(2E)-2-[(2-mo...)
Show SMILES [O-][N+](=O)c1ccc(\[NH+]=N\[CH-]c2sc(nc2-c2ccccc2)N2CCOCC2)c(c1)S(=O)(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C26H22ClN6O5S2/c27-20-8-4-5-9-21(20)31-40(36,37)24-16-19(33(34)35)10-11-22(24)30-28-17-23-25(18-6-2-1-3-7-18)29-26(39-23)32-12-14-38-15-13-32/h1-11,16-17,31H,12-15H2/q-1/p+1/b30-28+
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Burnham Center for Chemical Genomics

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Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2PC30Z9
More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401030
PNG
(US10005735, Compound 28)
Show SMILES CCOC(=O)c1csc(CCNC(=O)c2cnc3c(S)cccc3c2)n1
Show InChI InChI=1S/C18H17N3O3S2/c1-2-24-18(23)13-10-26-15(21-13)6-7-19-17(22)12-8-11-4-3-5-14(25)16(11)20-9-12/h3-5,8-10,25H,2,6-7H2,1H3,(H,19,22)
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n/an/a 700n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401009
PNG
(US10005735, Compound 18)
Show SMILES FC(F)(F)c1ccc(CNC(=O)c2cnc3c(S)cccc3c2)cc1
Show InChI InChI=1S/C18H13F3N2OS/c19-18(20,21)14-6-4-11(5-7-14)9-23-17(24)13-8-12-2-1-3-15(25)16(12)22-10-13/h1-8,10,25H,9H2,(H,23,24)
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n/an/a 700n/an/an/an/an/an/a



California Institute of Technology

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Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401026
PNG
(US10005735, Compound 24)
Show SMILES Sc1cccc2c(ccnc12)C(=O)NCCc1cccs1
Show InChI InChI=1S/C16H14N2OS2/c19-16(18-8-6-11-3-2-10-21-11)13-7-9-17-15-12(13)4-1-5-14(15)20/h1-5,7,9-10,20H,6,8H2,(H,18,19)
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n/an/a 700n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM39775
PNG
((5E)-5-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enyl...)
Show SMILES CN(C)c1ccc(\C=C\C=C2\SC(=S)N(C2=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H18N2OS2/c1-21(2)16-13-11-15(12-14-16)7-6-10-18-19(23)22(20(24)25-18)17-8-4-3-5-9-17/h3-14H,1-2H3/b7-6+,18-10+
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n/an/a 703n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2PC30Z9
More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM46229
PNG
(4-chloranyl-N-(3,4-dihydro-2H-thiochromen-4-yl)-3-...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)C(=O)NC1CCSc2ccccc12
Show InChI InChI=1S/C16H15ClN2O3S2/c17-12-6-5-10(9-15(12)24(18,21)22)16(20)19-13-7-8-23-14-4-2-1-3-11(13)14/h1-6,9,13H,7-8H2,(H,19,20)(H2,18,21,22)
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n/an/a 763n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2PC30Z9
More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM4314
PNG
((2E)-2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-3-(3,4-...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)N2CCc3ccccc23)cc1O
Show InChI InChI=1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+
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n/an/a 798n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2PC30Z9
More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM400995
PNG
(US10005735, Compound 8)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCc1cccs1
Show InChI InChI=1S/C15H12N2OS2/c18-15(17-9-12-4-2-6-20-12)11-7-10-3-1-5-13(19)14(10)16-8-11/h1-8,19H,9H2,(H,17,18)
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n/an/a 800n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264483
PNG
(CHEMBL4105598)
Show SMILES O=C(NCc1cccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3cccs3)cccc2c1
Show InChI InChI=1S/C30H22N4O2S4/c35-29(33-17-23-7-3-11-37-23)21-13-19-5-1-9-25(27(19)31-15-21)39-40-26-10-2-6-20-14-22(16-32-28(20)26)30(36)34-18-24-8-4-12-38-24/h1-16H,17-18H2,(H,33,35)(H,34,36)
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n/an/a 800n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264416
PNG
(CHEMBL4069023)
Show SMILES FC(F)(F)c1ccc(CNC(=O)c2cnc3c(SSc4cccc5cc(cnc45)C(=O)NCc4ccc(cc4)C(F)(F)F)cccc3c2)cc1
Show InChI InChI=1S/C36H24F6N4O2S2/c37-35(38,39)27-11-7-21(8-12-27)17-45-33(47)25-15-23-3-1-5-29(31(23)43-19-25)49-50-30-6-2-4-24-16-26(20-44-32(24)30)34(48)46-18-22-9-13-28(14-10-22)36(40,41)42/h1-16,19-20H,17-18H2,(H,45,47)(H,46,48)
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n/an/a 800n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264453
PNG
(CHEMBL4088568)
Show SMILES O=C(NCc1ccc(cc1)N1CCCCC1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3ccc(cc3)N3CCOCC3)cccc2c1
Show InChI InChI=1S/C43H42N6O3S2/c50-42(46-26-30-10-14-36(15-11-30)48-18-2-1-3-19-48)34-24-32-6-4-8-38(40(32)44-28-34)53-54-39-9-5-7-33-25-35(29-45-41(33)39)43(51)47-27-31-12-16-37(17-13-31)49-20-22-52-23-21-49/h4-17,24-25,28-29H,1-3,18-23,26-27H2,(H,46,50)(H,47,51)
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n/an/a 800n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401023
PNG
(US10005735, Compound 21)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCc1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C21H21N3O2S/c25-21(17-12-16-2-1-3-19(27)20(16)22-14-17)23-13-15-4-6-18(7-5-15)24-8-10-26-11-9-24/h1-7,12,14,27H,8-11,13H2,(H,23,25)
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n/an/a 800n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401021
PNG
(US10005735, Compound 20)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCc1ccc2OCOc2c1
Show InChI InChI=1S/C18H14N2O3S/c21-18(13-7-12-2-1-3-16(24)17(12)19-9-13)20-8-11-4-5-14-15(6-11)23-10-22-14/h1-7,9,24H,8,10H2,(H,20,21)
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n/an/a 900n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264426
PNG
(CHEMBL4095913)
Show SMILES O=C(NCc1ccco1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3ccco3)cccc2c1
Show InChI InChI=1S/C30H22N4O4S2/c35-29(33-17-23-7-3-11-37-23)21-13-19-5-1-9-25(27(19)31-15-21)39-40-26-10-2-6-20-14-22(16-32-28(20)26)30(36)34-18-24-8-4-12-38-24/h1-16H,17-18H2,(H,33,35)(H,34,36)
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n/an/a 900n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264526
PNG
(CHEMBL4093473)
Show SMILES COC(=O)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)OC)cccc2c1
Show InChI InChI=1S/C22H16N2O4S2/c1-27-21(25)15-9-13-5-3-7-17(19(13)23-11-15)29-30-18-8-4-6-14-10-16(22(26)28-2)12-24-20(14)18/h3-12H,1-2H3
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n/an/a 900n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264491
PNG
(CHEMBL4101230)
Show SMILES Cc1cc(S)c2ncccc2c1
Show InChI InChI=1S/C10H9NS/c1-7-5-8-3-2-4-11-10(8)9(12)6-7/h2-6,12H,1H3
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n/an/a 900n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264455
PNG
(CHEMBL4060337)
Show SMILES O=C(NCc1ccc2OCOc2c1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3ccc4OCOc4c3)cccc2c1
Show InChI InChI=1S/C36H26N4O6S2/c41-35(39-15-21-7-9-27-29(11-21)45-19-43-27)25-13-23-3-1-5-31(33(23)37-17-25)47-48-32-6-2-4-24-14-26(18-38-34(24)32)36(42)40-16-22-8-10-28-30(12-22)46-20-44-28/h1-14,17-18H,15-16,19-20H2,(H,39,41)(H,40,42)
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n/an/a 900n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM400994
PNG
(US10005735, Compound 7)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCc1ccco1
Show InChI InChI=1S/C15H12N2O2S/c18-15(17-9-12-4-2-6-19-12)11-7-10-3-1-5-13(20)14(10)16-8-11/h1-8,20H,9H2,(H,17,18)
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n/an/a 900n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM88971
PNG
((2E)-2-[(2Z)-2-(3-bromanyl-5-methoxy-4-oxidanylide...)
Show SMILES COc1cc(C=Cc2nc3ccccc3c(=O)[nH]2)cc(Br)c1O
Show InChI InChI=1S/C17H13BrN2O3/c1-23-14-9-10(8-12(18)16(14)21)6-7-15-19-13-5-3-2-4-11(13)17(22)20-15/h2-9,21H,1H3,(H,19,20,22)/b7-6+
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n/an/a 914n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2PC30Z9
More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401028
PNG
(US10005735, Compound 26)
Show SMILES Sc1cccc2c(ccnc12)C(=O)NCCc1ccco1
Show InChI InChI=1S/C16H14N2O2S/c19-16(18-8-6-11-3-2-10-20-11)13-7-9-17-15-12(13)4-1-5-14(15)21/h1-5,7,9-10,21H,6,8H2,(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264426
PNG
(CHEMBL4095913)
Show SMILES O=C(NCc1ccco1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3ccco3)cccc2c1
Show InChI InChI=1S/C30H22N4O4S2/c35-29(33-17-23-7-3-11-37-23)21-13-19-5-1-9-25(27(19)31-15-21)39-40-26-10-2-6-20-14-22(16-32-28(20)26)30(36)34-18-24-8-4-12-38-24/h1-16H,17-18H2,(H,33,35)(H,34,36)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264422
PNG
(CHEMBL4091693)
Show SMILES O=C(NCC1CCCO1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCC3CCCO3)cccc2c1
Show InChI InChI=1/C30H30N4O4S2/c35-29(33-17-23-7-3-11-37-23)21-13-19-5-1-9-25(27(19)31-15-21)39-40-26-10-2-6-20-14-22(16-32-28(20)26)30(36)34-18-24-8-4-12-38-24/h1-2,5-6,9-10,13-16,23-24H,3-4,7-8,11-12,17-18H2,(H,33,35)(H,34,36)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264424
PNG
(CHEMBL4078891)
Show SMILES NC(=O)c1cnc2c(SSc3cccc4cc(cnc34)C(N)=O)cccc2c1
Show InChI InChI=1S/C20H14N4O2S2/c21-19(25)13-7-11-3-1-5-15(17(11)23-9-13)27-28-16-6-2-4-12-8-14(20(22)26)10-24-18(12)16/h1-10H,(H2,21,25)(H2,22,26)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264518
PNG
(CHEMBL4087722)
Show SMILES O=C(NCc1cccs1)c1ccnc2c(SSc3cccc4c(ccnc34)C(=O)NCc3cccs3)cccc12
Show InChI InChI=1S/C30H22N4O2S4/c35-29(33-17-19-5-3-15-37-19)23-11-13-31-27-21(23)7-1-9-25(27)39-40-26-10-2-8-22-24(12-14-32-28(22)26)30(36)34-18-20-6-4-16-38-20/h1-16H,17-18H2,(H,33,35)(H,34,36)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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KEGG
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UniChem

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PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM50264547
PNG
(CHEMBL4077883)
Show SMILES COC(=O)c1ccnc2c(SSc3cccc4c(ccnc34)C(=O)OC)cccc12
Show InChI InChI=1S/C22H16N2O4S2/c1-27-21(25)15-9-11-23-19-13(15)5-3-7-17(19)29-30-18-8-4-6-14-16(22(26)28-2)10-12-24-20(14)18/h3-12H,1-2H3
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...


J Med Chem 60: 1343-1361 (2017)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM400988
PNG
(US10005735, Compound 1)
Show SMILES NC(=O)c1cnc2c(S)cccc2c1
Show InChI InChI=1S/C10H8N2OS/c11-10(13)7-4-6-2-1-3-8(14)9(6)12-5-7/h1-5,14H,(H2,11,13)
PDB

UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM88962
PNG
((6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(c...)
Show SMILES Nc1nc(cs1)C(=N/OCC(O)=O)\C(=O)N[C@H]1[C@H]2SCC(C=C)=C(N2C1=O)C(O)=O
Show InChI InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9+/t10-,14-/m1/s1
PDB

UniProtKB/SwissProt
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GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/a 1.04E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2PC30Z9
More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401031
PNG
(US10005735, Compound 29)
Show SMILES Cc1nc(CCNC(=O)c2cnc3c(S)cccc3c2)sc1C(O)=O
Show InChI InChI=1S/C17H15N3O3S2/c1-9-15(17(22)23)25-13(20-9)5-6-18-16(21)11-7-10-3-2-4-12(24)14(10)19-8-11/h2-4,7-8,24H,5-6H2,1H3,(H,18,21)(H,22,23)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11)


(Homo sapiens (Human))
BDBM401007
PNG
(US10005735, Compound 16)
Show SMILES Sc1cccc2cc(cnc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H14N2OS/c20-17(19-10-12-5-2-1-3-6-12)14-9-13-7-4-8-15(21)16(13)18-11-14/h1-9,11,21H,10H2,(H,19,20)
PDB

UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



California Institute of Technology

US Patent


Assay Description
In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...


US Patent US10005735 (2018)

More data for this
Ligand-Target Pair
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