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Found 8240 hits Enz. Inhib. hit(s) with Target = '3',5'-cyclic phosphodiesterase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00100n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146672
PNG
(US8957073, 4.6 | US9718803, 4.6)
Show SMILES COc1ccc(c(OC)n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H21N5O2/c1-29-20-10-8-17(23(27-20)30-2)22-21(24-11-12-25-22)16-13-28(14-16)19-9-7-15-5-3-4-6-18(15)26-19/h3-12,16H,13-14H2,1-2H3
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n/an/a 0.00100n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00100n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146708
PNG
(US8957073, 4.42)
Show SMILES CC1(C)CC(=CCO1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H24N4O/c1-23(2)13-17(9-12-28-23)21-22(25-11-10-24-21)18-14-27(15-18)20-8-7-16-5-3-4-6-19(16)26-20/h3-11,18H,12-15H2,1-2H3
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n/an/a 0.00100n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146707
PNG
(US8957073, 4.41 | US9718803, 4.41)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1C1=CCOCC1
Show InChI InChI=1S/C21H20N4O/c1-2-4-18-15(3-1)5-6-19(24-18)25-13-17(14-25)21-20(22-9-10-23-21)16-7-11-26-12-8-16/h1-7,9-10,17H,8,11-14H2
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n/an/a 0.00100n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM267012
PNG
(2-(3-(3-(2,2-dimethyl-3,6- dihydro-2H-pyran-4-yl)p...)
Show SMILES CC1(C)OCCC(=C1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H24N4O/c1-23(2)13-17(9-12-28-23)21-22(25-11-10-24-21)18-14-27(15-18)20-8-7-16-5-3-4-6-19(16)26-20/h3-8,10-11,13,18H,9,12,14-15H2,1-2H3
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n/an/a 0.00100n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146707
PNG
(US8957073, 4.41 | US9718803, 4.41)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1C1=CCOCC1
Show InChI InChI=1S/C21H20N4O/c1-2-4-18-15(3-1)5-6-19(24-18)25-13-17(14-25)21-20(22-9-10-23-21)16-7-11-26-12-8-16/h1-7,9-10,17H,8,11-14H2
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n/an/a 0.00110n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00120n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00120n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47147
PNG
(US8957073, 4.28 | US8957073, 4.44 | US9718803, 4.4...)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16F4N4/c24-18-10-15(9-17(11-18)23(25,26)27)21-22(29-8-7-28-21)16-12-31(13-16)20-6-5-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.00122n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146672
PNG
(US8957073, 4.6 | US9718803, 4.6)
Show SMILES COc1ccc(c(OC)n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H21N5O2/c1-29-20-10-8-17(23(27-20)30-2)22-21(24-11-12-25-22)16-13-28(14-16)19-9-7-15-5-3-4-6-18(15)26-19/h3-12,16H,13-14H2,1-2H3
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n/an/a 0.00135n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146667
PNG
(US8957073, 4.1 | US9718803, 4.1)
Show SMILES COc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-22-17(6-4-10-25-22)21-20(23-11-12-24-21)16-13-27(14-16)19-9-8-15-5-2-3-7-18(15)26-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00200n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146687
PNG
(US8957073, 4.21 | US9718803, 4.21)
Show SMILES Cc1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00200n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146689
PNG
(US8957073, 4.23 | US9718803, 4.23)
Show SMILES Oc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H17ClN4O/c23-17-11-15(5-7-19(17)28)21-22(25-10-9-24-21)16-12-27(13-16)20-8-6-14-3-1-2-4-18(14)26-20/h1-11,16,28H,12-13H2
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n/an/a 0.00200n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146687
PNG
(US8957073, 4.21 | US9718803, 4.21)
Show SMILES Cc1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00230n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146689
PNG
(US8957073, 4.23 | US9718803, 4.23)
Show SMILES Oc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H17ClN4O/c23-17-11-15(5-7-19(17)28)21-22(25-10-9-24-21)16-12-27(13-16)20-8-6-14-3-1-2-4-18(14)26-20/h1-11,16,28H,12-13H2
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n/an/a 0.00230n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146667
PNG
(US8957073, 4.1 | US9718803, 4.1)
Show SMILES COc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-22-17(6-4-10-25-22)21-20(23-11-12-24-21)16-13-27(14-16)19-9-8-15-5-2-3-7-18(15)26-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00234n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146677
PNG
(US8957073, 4.11 | US9718803, 4.11)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H20N4O2S/c1-30(28,29)19-9-6-17(7-10-19)22-23(25-13-12-24-22)18-14-27(15-18)21-11-8-16-4-2-3-5-20(16)26-21/h2-13,18H,14-15H2,1H3
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n/an/a 0.00262n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146678
PNG
(US8957073, 4.12 | US9718803, 4.12)
Show SMILES Nc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2,(H2,22,25)
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n/an/a 0.00278n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146668
PNG
(US8957073, 4.2 | US9718803, 4.2)
Show SMILES Cc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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n/an/a 0.00279n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146668
PNG
(US8957073, 4.2 | US9718803, 4.2)
Show SMILES Cc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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n/an/a 0.00300n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146678
PNG
(US8957073, 4.12 | US9718803, 4.12)
Show SMILES Nc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2,(H2,22,25)
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n/an/a 0.00300n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146677
PNG
(US8957073, 4.11 | US9718803, 4.11)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H20N4O2S/c1-30(28,29)19-9-6-17(7-10-19)22-23(25-13-12-24-22)18-14-27(15-18)21-11-8-16-4-2-3-5-20(16)26-21/h2-13,18H,14-15H2,1H3
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n/an/a 0.00300n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50397973
PNG
(CHEMBL2180441)
Show SMILES Cc1nc2ccc(cc2nc1\C=C\c1nc(N[C@@H]2CCS(=O)(=O)C2)cc(n1)N1CCCC1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N6O2S/c1-15-18(30-20-12-16(24(25,26)27)4-5-19(20)28-15)6-7-21-31-22(29-17-8-11-36(34,35)14-17)13-23(32-21)33-9-2-3-10-33/h4-7,12-13,17H,2-3,8-11,14H2,1H3,(H,29,31,32)/b7-6+/t17-/m1/s1
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n/an/a 0.00330n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146695
PNG
(US8957073, 4.29 | US9718803, 4.29)
Show SMILES COc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4O/c1-16-13-18(7-9-21(16)29-2)23-24(26-12-11-25-23)19-14-28(15-19)22-10-8-17-5-3-4-6-20(17)27-22/h3-13,19H,14-15H2,1-2H3
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n/an/a 0.00350n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146679
PNG
(US8957073, 4.13 | US9718803, 4.13)
Show SMILES Nc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13,22H2
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n/an/a 0.00376n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146698
PNG
(US8957073, 4.32 | US9718803, 4.32)
Show SMILES Fc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16ClFN4/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00400n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146688
PNG
(US8957073, 4.22 | US9718803, 4.22)
Show SMILES Cc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00400n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146679
PNG
(US8957073, 4.13 | US9718803, 4.13)
Show SMILES Nc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13,22H2
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n/an/a 0.00400n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146695
PNG
(US8957073, 4.29 | US9718803, 4.29)
Show SMILES COc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4O/c1-16-13-18(7-9-21(16)29-2)23-24(26-12-11-25-23)19-14-28(15-19)22-10-8-17-5-3-4-6-20(17)27-22/h3-13,19H,14-15H2,1-2H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146670
PNG
(US8957073, 4.4 | US9718803, 4.4)
Show SMILES Fc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2
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n/an/a 0.00400n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146698
PNG
(US8957073, 4.32 | US9718803, 4.32)
Show SMILES Fc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16ClFN4/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00410n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146670
PNG
(US8957073, 4.4 | US9718803, 4.4)
Show SMILES Fc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2
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n/an/a 0.00418n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146688
PNG
(US8957073, 4.22 | US9718803, 4.22)
Show SMILES Cc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00420n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146701
PNG
(US8957073, 4.35 | US9718803, 4.35)
Show SMILES Cc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4/c1-16-7-8-19(13-17(16)2)23-24(26-12-11-25-23)20-14-28(15-20)22-10-9-18-5-3-4-6-21(18)27-22/h3-13,20H,14-15H2,1-2H3
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n/an/a 0.00500n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146697
PNG
(US8957073, 4.31 | US9718803, 4.31)
Show SMILES Cc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00500n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146697
PNG
(US8957073, 4.31 | US9718803, 4.31)
Show SMILES Cc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00510n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146701
PNG
(US8957073, 4.35 | US9718803, 4.35)
Show SMILES Cc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4/c1-16-7-8-19(13-17(16)2)23-24(26-12-11-25-23)20-14-28(15-20)22-10-9-18-5-3-4-6-21(18)27-22/h3-13,20H,14-15H2,1-2H3
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n/an/a 0.00550n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146669
PNG
(US8957073, 4.3 | US9718803, 4.3)
Show SMILES Cc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-18(6-4-10-23-15)22-21(24-11-12-25-22)17-13-27(14-17)20-9-8-16-5-2-3-7-19(16)26-20/h2-12,17H,13-14H2,1H3
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n/an/a 0.00600n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146704
PNG
(US8957073, 4.38 | US9718803, 4.38)
Show SMILES Cc1cc(ccc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146691
PNG
(US8957073, 4.25 | US9718803, 4.25)
Show SMILES CCOc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21FN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.00600n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146691
PNG
(US8957073, 4.25 | US9718803, 4.25)
Show SMILES CCOc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21FN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.00620n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146704
PNG
(US8957073, 4.38 | US9718803, 4.38)
Show SMILES Cc1cc(ccc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00640n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146669
PNG
(US8957073, 4.3 | US9718803, 4.3)
Show SMILES Cc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-18(6-4-10-23-15)22-21(24-11-12-25-22)17-13-27(14-17)20-9-8-16-5-2-3-7-19(16)26-20/h2-12,17H,13-14H2,1H3
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n/an/a 0.00648n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146702
PNG
(US8957073, 4.36 | US9718803, 4.36)
Show SMILES Cc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00670n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146709
PNG
(US8957073, 4.43 | US9718803, 4.43)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cn[nH]c1
Show InChI InChI=1S/C19H16N6/c1-2-4-16-13(3-1)5-6-17(24-16)25-11-15(12-25)19-18(20-7-8-21-19)14-9-22-23-10-14/h1-10,15H,11-12H2,(H,22,23)
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n/an/a 0.00700n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146709
PNG
(US8957073, 4.43 | US9718803, 4.43)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cn[nH]c1
Show InChI InChI=1S/C19H16N6/c1-2-4-16-13(3-1)5-6-17(24-16)25-11-15(12-25)19-18(20-7-8-21-19)14-9-22-23-10-14/h1-10,15H,11-12H2,(H,22,23)
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n/an/a 0.00700n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146703
PNG
(US8957073, 4.37 | US9718803, 4.37)
Show SMILES Cc1cc(Cl)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00700n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146702
PNG
(US8957073, 4.36 | US9718803, 4.36)
Show SMILES Cc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00700n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146703
PNG
(US8957073, 4.37 | US9718803, 4.37)
Show SMILES Cc1cc(Cl)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00720n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
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