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Found 257 hits Enz. Inhib. hit(s) with Target = '4-hydroxyphenylpyruvate dioxygenase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403921
PNG
(CHEMBL309664)
Show SMILES ClC1=C(CCCC1=O)OC(=O)C1CC1
Show InChI InChI=1S/C10H11ClO3/c11-9-7(12)2-1-3-8(9)14-10(13)6-4-5-6/h6H,1-5H2
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PC sid
UniChem
PubMed
n/an/a 15n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of pig liver HPPD using 4-hydroxyphenylpyruvic acid as substrate after 15 mins by spectrophotometric analysis


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Arabidopsis thaliana)
BDBM50264344
PNG
(CHEMBL4082652)
Show SMILES CCCCCCCCCC(=O)C1C(=O)C(C)(C)C(=O)C(C)(C)C1=O
Show InChI InChI=1S/C20H32O4/c1-6-7-8-9-10-11-12-13-14(21)15-16(22)19(2,3)18(24)20(4,5)17(15)23/h15H,6-13H2,1-5H3
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n/an/a 19n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of Arabidopsis thaliana HPPD expressed in Escherichia coli JM105 using 4-HPP as substrate preincubated for 15 mins followed by substrate a...


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403921
PNG
(CHEMBL309664)
Show SMILES ClC1=C(CCCC1=O)OC(=O)C1CC1
Show InChI InChI=1S/C10H11ClO3/c11-9-7(12)2-1-3-8(9)14-10(13)6-4-5-6/h6H,1-5H2
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n/an/a 20n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403921
PNG
(CHEMBL309664)
Show SMILES ClC1=C(CCCC1=O)OC(=O)C1CC1
Show InChI InChI=1S/C10H11ClO3/c11-9-7(12)2-1-3-8(9)14-10(13)6-4-5-6/h6H,1-5H2
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n/an/a 20n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072265
PNG
(CHEMBL3408320)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C16H18N4O3/c1-4-19-12-7-6-10(8-13(12)20(5-2)16(19)23)14(21)11-9-17-18(3)15(11)22/h6-9,22H,4-5H2,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072237
PNG
(CHEMBL3408314)
Show SMILES CCn1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C15H16N4O3/c1-4-19-12-7-9(5-6-11(12)17(2)15(19)22)13(20)10-8-16-18(3)14(10)21/h5-8,21H,4H2,1-3H3
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n/an/a 22n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072264
PNG
(CHEMBL3408319)
Show SMILES CCCn1c2cc(ccc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-4-8-21-14-9-11(6-7-13(14)20(5-2)17(21)24)15(22)12-10-18-19(3)16(12)23/h6-7,9-10,23H,4-5,8H2,1-3H3
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n/an/a 22n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403929
PNG
(CHEMBL76394)
Show SMILES BrC1=C(CCCC1=O)OC(=O)C1CC1
Show InChI InChI=1S/C10H11BrO3/c11-9-7(12)2-1-3-8(9)14-10(13)6-4-5-6/h6H,1-5H2
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n/an/a 28n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of pig liver HPPD using 4-hydroxyphenylpyruvic acid as substrate after 15 mins by spectrophotometric analysis


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403929
PNG
(CHEMBL76394)
Show SMILES BrC1=C(CCCC1=O)OC(=O)C1CC1
Show InChI InChI=1S/C10H11BrO3/c11-9-7(12)2-1-3-8(9)14-10(13)6-4-5-6/h6H,1-5H2
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n/an/a 30n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50089165
PNG
(CHEMBL23622 | Cyclopropanecarboxylic acid 3-oxo-cy...)
Show SMILES O=C(OC1=CC(=O)CCC1)C1CC1
Show InChI InChI=1S/C10H12O3/c11-8-2-1-3-9(6-8)13-10(12)7-4-5-7/h6-7H,1-5H2
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n/an/a 30n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403929
PNG
(CHEMBL76394)
Show SMILES BrC1=C(CCCC1=O)OC(=O)C1CC1
Show InChI InChI=1S/C10H11BrO3/c11-9-7(12)2-1-3-8(9)14-10(13)6-4-5-6/h6H,1-5H2
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n/an/a 30n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50089165
PNG
(CHEMBL23622 | Cyclopropanecarboxylic acid 3-oxo-cy...)
Show SMILES O=C(OC1=CC(=O)CCC1)C1CC1
Show InChI InChI=1S/C10H12O3/c11-8-2-1-3-9(6-8)13-10(12)7-4-5-7/h6-7H,1-5H2
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n/an/a 30n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50089165
PNG
(CHEMBL23622 | Cyclopropanecarboxylic acid 3-oxo-cy...)
Show SMILES O=C(OC1=CC(=O)CCC1)C1CC1
Show InChI InChI=1S/C10H12O3/c11-8-2-1-3-9(6-8)13-10(12)7-4-5-7/h6-7H,1-5H2
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n/an/a 30n/an/an/an/an/an/a



Tunghai Christian University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against HPPD(4-hydroxyphenylpyruvate Dioxygenase) from pig liver using enol borate assay method


Bioorg Med Chem Lett 10: 1297-8 (2000)


Article DOI: 10.1016/s0960-894x(00)00228-6
BindingDB Entry DOI: 10.7270/Q2DR2TQ1
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50089165
PNG
(CHEMBL23622 | Cyclopropanecarboxylic acid 3-oxo-cy...)
Show SMILES O=C(OC1=CC(=O)CCC1)C1CC1
Show InChI InChI=1S/C10H12O3/c11-8-2-1-3-9(6-8)13-10(12)7-4-5-7/h6-7H,1-5H2
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n/an/a 30n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of pig liver HPPD using 4-hydroxyphenylpyruvic acid as substrate after 15 mins by spectrophotometric analysis


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50089165
PNG
(CHEMBL23622 | Cyclopropanecarboxylic acid 3-oxo-cy...)
Show SMILES O=C(OC1=CC(=O)CCC1)C1CC1
Show InChI InChI=1S/C10H12O3/c11-8-2-1-3-9(6-8)13-10(12)7-4-5-7/h6-7H,1-5H2
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n/an/a 30n/an/an/an/an/an/a



Tunghai University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration required against 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) taken from pig liver


Bioorg Med Chem Lett 13: 927-30 (2003)


Article DOI: 10.1016/s0960-894x(02)01071-5
BindingDB Entry DOI: 10.7270/Q2NP23SQ
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Arabidopsis thaliana)
BDBM50487120
PNG
(CHEMBL2251430)
Show SMILES Cc1nc(C)n(O)c1C(=O)c1ccc(c(C2=NOCC2)c1Cl)S(C)(=O)=O
Show InChI InChI=1S/C16H16ClN3O5S/c1-8-15(20(22)9(2)18-8)16(21)10-4-5-12(26(3,23)24)13(14(10)17)11-6-7-25-19-11/h4-5,22H,6-7H2,1-3H3
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n/an/a 36n/an/an/an/an/an/a



BASF SE

Curated by ChEMBL


Assay Description
Inhibition of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase


Bioorg Med Chem 17: 4221-9 (2009)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Rattus norvegicus)
BDBM50264347
PNG
(CHEMBL4092919)
Show SMILES CC1(C)CC(=O)C(C(=O)c2ccc(cc2Cl)[N+]([O-])=O)C(=O)C1
Show InChI InChI=1S/C15H14ClNO5/c1-15(2)6-11(18)13(12(19)7-15)14(20)9-4-3-8(17(21)22)5-10(9)16/h3-5,13H,6-7H2,1-2H3
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Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Rattus norvegicus)
BDBM50264337
PNG
(CHEBI:38321 | MESOTRIONE)
Show SMILES CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H13NO7S/c1-23(21,22)8-5-6-9(10(7-8)15(19)20)14(18)13-11(16)3-2-4-12(13)17/h5-7,13H,2-4H2,1H3
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Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072269
PNG
(CHEMBL3408324)
Show SMILES CCCn1c2ccc(cc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-4-8-21-13-7-6-11(9-14(13)20(5-2)17(21)24)15(22)12-10-18-19(3)16(12)23/h6-7,9-10,23H,4-5,8H2,1-3H3
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n/an/a 39n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50124366
PNG
(4-Cyclopropanecarbonyl-3-cyclopropanecarbonyloxy-5...)
Show SMILES CCOC(=O)C1CC(=O)C(C(=O)C2CC2)=C(C1)OC(=O)C1CC1
Show InChI InChI=1/C17H20O6/c1-2-22-16(20)11-7-12(18)14(15(19)9-3-4-9)13(8-11)23-17(21)10-5-6-10/h9-11H,2-8H2,1H3
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Tunghai University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration required against 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) taken from pig liver


Bioorg Med Chem Lett 13: 927-30 (2003)


Article DOI: 10.1016/s0960-894x(02)01071-5
BindingDB Entry DOI: 10.7270/Q2NP23SQ
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50075319
PNG
(2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHY...)
Show SMILES [O-]C1=C(C(=[OH+])c2ccc(cc2[N+]([O-])=O)C(F)(F)F)C(=O)CCC1
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,19H,1-3H2
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Tunghai University

Curated by ChEMBL


Assay Description
Inhibition of pig liver 4-Hydroxyphenylpyruvate dioxygenase (4-HPPD) enzyme


J Med Chem 45: 2222-8 (2002)


Article DOI: 10.1021/jm010568y
BindingDB Entry DOI: 10.7270/Q2FT8KBG
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50088804
PNG
(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Show SMILES [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
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n/an/a 40n/an/an/an/an/an/a



Tunghai Christian University

Curated by ChEMBL


Assay Description
Inhibition of 4-hydroxyphenylpyruvate dioxygenase of purified pig liver by enol-borate method


Bioorg Med Chem Lett 10: 843-5 (2000)


Article DOI: 10.1016/s0960-894x(00)00115-3
BindingDB Entry DOI: 10.7270/Q2S75FK2
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50075319
PNG
(2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHY...)
Show SMILES [O-]C1=C(C(=[OH+])c2ccc(cc2[N+]([O-])=O)C(F)(F)F)C(=O)CCC1
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,19H,1-3H2
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n/an/a 40n/an/an/an/an/an/a



Tunghai Christian University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against HPPD(4-hydroxyphenylpyruvate Dioxygenase) from pig liver using enol borate assay method


Bioorg Med Chem Lett 10: 1297-8 (2000)


Article DOI: 10.1016/s0960-894x(00)00228-6
BindingDB Entry DOI: 10.7270/Q2DR2TQ1
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50075319
PNG
(2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHY...)
Show SMILES [O-]C1=C(C(=[OH+])c2ccc(cc2[N+]([O-])=O)C(F)(F)F)C(=O)CCC1
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,19H,1-3H2
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n/an/a 40n/an/an/an/an/an/a



Tunghai Christian University

Curated by ChEMBL


Assay Description
The inhibitory activity of the compound on pig liver 4-hydroxyphenylpyruvate dioxygenase (HPPD) was evaluated.


Bioorg Med Chem Lett 9: 551-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00036-0
BindingDB Entry DOI: 10.7270/Q2XD10VQ
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50124366
PNG
(4-Cyclopropanecarbonyl-3-cyclopropanecarbonyloxy-5...)
Show SMILES CCOC(=O)C1CC(=O)C(C(=O)C2CC2)=C(C1)OC(=O)C1CC1
Show InChI InChI=1/C17H20O6/c1-2-22-16(20)11-7-12(18)14(15(19)9-3-4-9)13(8-11)23-17(21)10-5-6-10/h9-11H,2-8H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50075319
PNG
(2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHY...)
Show SMILES [O-]C1=C(C(=[OH+])c2ccc(cc2[N+]([O-])=O)C(F)(F)F)C(=O)CCC1
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,19H,1-3H2
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n/an/a 40n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072270
PNG
(CHEMBL3408325)
Show SMILES CCCn1c2ccc(cc2n(CCC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-4-8-21-14-7-6-12(10-15(14)22(9-5-2)18(21)25)16(23)13-11-19-20(3)17(13)24/h6-7,10-11,24H,4-5,8-9H2,1-3H3
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Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Rattus norvegicus)
BDBM50088804
PNG
(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Show SMILES [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
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Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Rattus norvegicus)
BDBM50088804
PNG
(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Show SMILES [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
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Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat liver HPPD using 4-Hydroxyphenylpyruvate as substrate assessed as reduction in oxygen consumption preincubated for 3 mins fo...


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50124366
PNG
(4-Cyclopropanecarbonyl-3-cyclopropanecarbonyloxy-5...)
Show SMILES CCOC(=O)C1CC(=O)C(C(=O)C2CC2)=C(C1)OC(=O)C1CC1
Show InChI InChI=1/C17H20O6/c1-2-22-16(20)11-7-12(18)14(15(19)9-3-4-9)13(8-11)23-17(21)10-5-6-10/h9-11H,2-8H2,1H3
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Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50075319
PNG
(2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHY...)
Show SMILES [O-]C1=C(C(=[OH+])c2ccc(cc2[N+]([O-])=O)C(F)(F)F)C(=O)CCC1
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,19H,1-3H2
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Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Arabidopsis thaliana)
BDBM50487119
PNG
(CHEMBL2251439)
Show SMILES CCOc1c(Cl)c(ccc1S(=O)(=O)CC)C(=O)c1c(C)nc(C(C)C)n1O
Show InChI InChI=1S/C18H23ClN2O5S/c1-6-26-17-13(27(24,25)7-2)9-8-12(14(17)19)16(22)15-11(5)20-18(10(3)4)21(15)23/h8-10,23H,6-7H2,1-5H3
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n/an/a 43n/an/an/an/an/an/a



BASF SE

Curated by ChEMBL


Assay Description
Inhibition of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase


Bioorg Med Chem 17: 4221-9 (2009)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50075318
PNG
(2-(2-Chloro-4-methanesulfonyl-benzoyl)-3-hydroxy-c...)
Show SMILES CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1
Show InChI InChI=1S/C14H13ClO5S/c1-21(19,20)8-5-6-9(10(15)7-8)14(18)13-11(16)3-2-4-12(13)17/h5-7,13H,2-4H2,1H3
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n/an/a 45n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50075318
PNG
(2-(2-Chloro-4-methanesulfonyl-benzoyl)-3-hydroxy-c...)
Show SMILES CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1
Show InChI InChI=1S/C14H13ClO5S/c1-21(19,20)8-5-6-9(10(15)7-8)14(18)13-11(16)3-2-4-12(13)17/h5-7,13H,2-4H2,1H3
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Tunghai Christian University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound on pig liver 4-hydroxyphenylpyruvate dioxygenase (HPPD) was evaluated


Bioorg Med Chem Lett 9: 551-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00036-0
BindingDB Entry DOI: 10.7270/Q2XD10VQ
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Arabidopsis thaliana)
BDBM50487126
PNG
(CHEMBL2251437)
Show SMILES CCOc1c(Cl)c(ccc1S(=O)(=O)CC)C(=O)c1c(C)nc(C)n1O
Show InChI InChI=1S/C16H19ClN2O5S/c1-5-24-16-12(25(22,23)6-2)8-7-11(13(16)17)15(20)14-9(3)18-10(4)19(14)21/h7-8,21H,5-6H2,1-4H3
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n/an/a 48n/an/an/an/an/an/a



BASF SE

Curated by ChEMBL


Assay Description
Inhibition of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase


Bioorg Med Chem 17: 4221-9 (2009)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50075318
PNG
(2-(2-Chloro-4-methanesulfonyl-benzoyl)-3-hydroxy-c...)
Show SMILES CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1
Show InChI InChI=1S/C14H13ClO5S/c1-21(19,20)8-5-6-9(10(15)7-8)14(18)13-11(16)3-2-4-12(13)17/h5-7,13H,2-4H2,1H3
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Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072230
PNG
(CHEMBL3408157)
Show SMILES CCCn1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C16H18N4O3/c1-4-7-20-13-8-10(5-6-12(13)18(2)16(20)23)14(21)11-9-17-19(3)15(11)22/h5-6,8-9,22H,4,7H2,1-3H3
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n/an/a 59n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072236
PNG
(CHEMBL3408313)
Show SMILES CC(C)n1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C16H18N4O3/c1-9(2)20-13-7-10(5-6-12(13)18(3)16(20)23)14(21)11-8-17-19(4)15(11)22/h5-9,22H,1-4H3
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Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072266
PNG
(CHEMBL3408321)
Show SMILES CCn1c2ccc(cc2n(C(C)C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-5-20-13-7-6-11(8-14(13)21(10(2)3)17(20)24)15(22)12-9-18-19(4)16(12)23/h6-10,23H,5H2,1-4H3
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n/an/a 64n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072223
PNG
(CHEMBL3408156)
Show SMILES CCC(=O)C(C(C)=O)C(=O)c1ccc(cc1[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1/C14H12F3NO5/c1-3-11(20)12(7(2)19)13(21)9-5-4-8(14(15,16)17)6-10(9)18(22)23/h4-6,12H,3H2,1-2H3
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Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Arabidopsis thaliana)
BDBM50056923
PNG
((+)-usnic acid | (9bR)-2,6-diacetyl-3,7,9-trihydro...)
Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)c(C)c(O)c3C(C)=O)[C@@]2(C)C1=O
Show InChI InChI=1/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,11,22-23H,1-4H3/t11?,18-/s2
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Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of Arabidopsis thaliana HPPD expressed in Escherichia coli JM105 using HPPA as substrate after preincubated for 15 min followed by substra...


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403933
PNG
(CHEMBL72081)
Show SMILES O=C(OC1=CC(=O)CC1)C1CC1
Show InChI InChI=1S/C9H10O3/c10-7-3-4-8(5-7)12-9(11)6-1-2-6/h5-6H,1-4H2
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Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403933
PNG
(CHEMBL72081)
Show SMILES O=C(OC1=CC(=O)CC1)C1CC1
Show InChI InChI=1S/C9H10O3/c10-7-3-4-8(5-7)12-9(11)6-1-2-6/h5-6H,1-4H2
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Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of pig liver HPPD using 4-hydroxyphenylpyruvic acid as substrate after 15 mins by spectrophotometric analysis


J Med Chem 60: 4101-4125 (2017)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403933
PNG
(CHEMBL72081)
Show SMILES O=C(OC1=CC(=O)CC1)C1CC1
Show InChI InChI=1S/C9H10O3/c10-7-3-4-8(5-7)12-9(11)6-1-2-6/h5-6H,1-4H2
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Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Arabidopsis thaliana)
BDBM50487132
PNG
(CHEMBL2251438)
Show SMILES CCOc1c(Cl)c(ccc1S(=O)(=O)CC)C(=O)c1c(C)nc(CC)n1O
Show InChI InChI=1S/C17H21ClN2O5S/c1-5-13-19-10(4)15(20(13)22)16(21)11-8-9-12(26(23,24)7-3)17(14(11)18)25-6-2/h8-9,22H,5-7H2,1-4H3
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n/an/a 71n/an/an/an/an/an/a



BASF SE

Curated by ChEMBL


Assay Description
Inhibition of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase


Bioorg Med Chem 17: 4221-9 (2009)

More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072271
PNG
(CHEMBL3408326)
Show SMILES CCCn1c2ccc(cc2n(c1=O)C(C)(C)C)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C19H24N4O3/c1-6-9-22-14-8-7-12(16(24)13-11-20-21(5)17(13)25)10-15(14)23(18(22)26)19(2,3)4/h7-8,10-11,25H,6,9H2,1-5H3
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n/an/a 77n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403928
PNG
(CHEMBL307048)
Show SMILES CCOC(=O)C1CC(=O)C=C(C1)OC(=O)C1CC1
Show InChI InChI=1/C13H16O5/c1-2-17-12(15)9-5-10(14)7-11(6-9)18-13(16)8-3-4-8/h7-9H,2-6H2,1H3
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n/an/a 89n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Sus scrofa)
BDBM50403928
PNG
(CHEMBL307048)
Show SMILES CCOC(=O)C1CC(=O)C=C(C1)OC(=O)C1CC1
Show InChI InChI=1/C13H16O5/c1-2-17-12(15)9-5-10(14)7-11(6-9)18-13(16)8-3-4-8/h7-9H,2-6H2,1H3
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n/an/a 90n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver


Bioorg Med Chem Lett 12: 2271-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00432-8
BindingDB Entry DOI: 10.7270/Q25H7GS3
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072238
PNG
(CHEMBL3408315)
Show SMILES Cn1ncc(C(=O)c2ccc3n(C)c(=O)n(c3c2)C(C)(C)C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-17(2,3)21-13-8-10(6-7-12(13)19(4)16(21)24)14(22)11-9-18-20(5)15(11)23/h6-9,23H,1-5H3
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n/an/a 100n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072263
PNG
(CHEMBL3408318)
Show SMILES Cn1ncc(C(=O)c2ccc3n(C)c(=O)n(C4CC4)c3c2)c1O
Show InChI InChI=1S/C16H16N4O3/c1-18-12-6-3-9(14(21)11-8-17-19(2)15(11)22)7-13(12)20(16(18)23)10-4-5-10/h3,6-8,10,22H,4-5H2,1-2H3
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Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
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