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Found 533 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 4 (5-HT4)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM198005
PNG
(US9221790, 15)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCNC(Cc2c[nH]c3ccccc23)C1
Show InChI InChI=1/C23H27ClN4O2/c1-30-22-11-20(25)19(24)10-18(22)23(29)28-12-14-6-7-26-16(8-14)9-15-13-27-21-5-3-2-4-17(15)21/h2-5,10-11,13-14,16,26-27H,6-9,12,25H2,1H3,(H,28,29)
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US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197995
PNG
(US9221790, 5)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCn2ccc3ccccc23)CC1
Show InChI InChI=1S/C27H35ClN4O2/c1-34-26-18-24(29)23(28)17-22(26)27(33)30-19-20-9-14-31(15-10-20)12-5-2-6-13-32-16-11-21-7-3-4-8-25(21)32/h3-4,7-8,11,16-18,20H,2,5-6,9-10,12-15,19,29H2,1H3,(H,30,33)
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n/an/a 0.00500n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197993
PNG
(US9221790, 3)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccc3ccccc23)CC1
Show InChI InChI=1S/C25H31ClN4O2/c1-32-24-16-22(27)21(26)15-20(24)25(31)28-17-18-7-12-29(13-8-18)10-4-11-30-14-9-19-5-2-3-6-23(19)30/h2-3,5-6,9,14-16,18H,4,7-8,10-13,17,27H2,1H3,(H,28,31)
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n/an/a 0.0390n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197997
PNG
(US9221790, 7)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1
Show InChI InChI=1S/C19H27ClN6O2/c1-28-18-12-17(21)16(20)11-15(18)19(27)22-13-14-3-8-25(9-4-14)6-2-7-26-10-5-23-24-26/h5,10-12,14H,2-4,6-9,13,21H2,1H3,(H,22,27)
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n/an/a 0.0670n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM198000
PNG
(US9221790, 10)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cn(C)c3ccccc23)CC1
Show InChI InChI=1S/C24H29ClN4O2/c1-28-14-17(18-5-3-4-6-22(18)28)15-29-9-7-16(8-10-29)13-27-24(30)19-11-20(25)21(26)12-23(19)31-2/h3-6,11-12,14,16H,7-10,13,15,26H2,1-2H3,(H,27,30)
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n/an/a 0.0760n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197996
PNG
(US9221790, 6)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCn2ccnn2)CC1
Show InChI InChI=1S/C21H31ClN6O2/c1-30-20-14-19(23)18(22)13-17(20)21(29)24-15-16-5-10-27(11-6-16)8-3-2-4-9-28-12-7-25-26-28/h7,12-14,16H,2-6,8-11,15,23H2,1H3,(H,24,29)
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n/an/a 0.103n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM198003
PNG
(US9221790, 13)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H25ClFN3O2/c1-28-20-11-19(24)18(22)10-17(20)21(27)25-12-14-6-8-26(9-7-14)13-15-2-4-16(23)5-3-15/h2-5,10-11,14H,6-9,12-13,24H2,1H3,(H,25,27)
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n/an/a 0.134n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197992
PNG
(US9221790, 2)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cnnn2)CC1
Show InChI InChI=1S/C18H26ClN7O2/c1-28-17-10-16(20)15(19)9-14(17)18(27)21-11-13-3-7-25(8-4-13)5-2-6-26-12-22-23-24-26/h9-10,12-13H,2-8,11,20H2,1H3,(H,21,27)
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n/an/a 0.164n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197998
PNG
(US9221790, 8)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2nccn2)CC1
Show InChI InChI=1S/C19H27ClN6O2/c1-28-18-12-17(21)16(20)11-15(18)19(27)22-13-14-3-9-25(10-4-14)7-2-8-26-23-5-6-24-26/h5-6,11-12,14H,2-4,7-10,13,21H2,1H3,(H,22,27)
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n/an/a 0.182n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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n/an/a 0.210n/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT4ER expressed in CHO cells assessed as reduction in cAMP levels


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197991
PNG
(US9221790, 1)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cncn2)CC1
Show InChI InChI=1S/C19H27ClN6O2/c1-28-18-10-17(21)16(20)9-15(18)19(27)23-11-14-3-7-25(8-4-14)5-2-6-26-13-22-12-24-26/h9-10,12-14H,2-8,11,21H2,1H3,(H,23,27)
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n/an/a 0.226n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197994
PNG
(US9221790, 4)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnc2C)CC1
Show InChI InChI=1S/C21H30ClN5O2/c1-15-24-6-11-27(15)8-3-7-26-9-4-16(5-10-26)14-25-21(28)17-12-18(22)19(23)13-20(17)29-2/h6,11-13,16H,3-5,7-10,14,23H2,1-2H3,(H,25,28)
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n/an/a 0.229n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM197999
PNG
(US9221790, 9)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C20H25ClN4O2/c1-27-19-10-18(22)17(21)9-16(19)20(26)24-12-14-4-7-25(8-5-14)13-15-3-2-6-23-11-15/h2-3,6,9-11,14H,4-5,7-8,12-13,22H2,1H3,(H,24,26)
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n/an/a 0.267n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50005836
PNG
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
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n/an/a 0.362n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM198004
PNG
(US9221790, 14)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(O)cc2)CC1
Show InChI InChI=1S/C21H26ClN3O3/c1-28-20-11-19(23)18(22)10-17(20)21(27)24-12-14-6-8-25(9-7-14)13-15-2-4-16(26)5-3-15/h2-5,10-11,14,26H,6-9,12-13,23H2,1H3,(H,24,27)
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n/an/a 0.375n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM198002
PNG
(US9221790, 12)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccn2C)CC1
Show InChI InChI=1S/C20H27ClN4O2/c1-24-7-3-4-15(24)13-25-8-5-14(6-9-25)12-23-20(26)16-10-17(21)18(22)11-19(16)27-2/h3-4,7,10-11,14H,5-6,8-9,12-13,22H2,1-2H3,(H,23,26)
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n/an/a 0.421n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM198001
PNG
(US9221790, 11)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ncc[nH]2)CC1
Show InChI InChI=1S/C18H24ClN5O2/c1-26-16-9-15(20)14(19)8-13(16)18(25)23-10-12-2-6-24(7-3-12)11-17-21-4-5-22-17/h4-5,8-9,12H,2-3,6-7,10-11,20H2,1H3,(H,21,22)(H,23,25)
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n/an/a 0.454n/an/an/an/an/an/a



Dong-A Pharm. Co., Ltd.

US Patent


Assay Description
The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...


US Patent US9221790 (2015)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM85026
PNG
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)
Show SMILES CCCCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
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n/an/a 0.630n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity was determined against 5-hydroxytryptamine 3 receptor


J Med Chem 38: 4760-3 (1996)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50398963
PNG
(CHEMBL2179674)
Show SMILES Cn1cc2c(OCC3CCN(CCc4ccc(cc4)C(O)=O)CC3)nc3ccccc3c2c1
Show InChI InChI=1S/C27H29N3O3/c1-29-16-23-22-4-2-3-5-25(22)28-26(24(23)17-29)33-18-20-11-14-30(15-12-20)13-10-19-6-8-21(9-7-19)27(31)32/h2-9,16-17,20H,10-15,18H2,1H3,(H,31,32)
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n/an/a 2.80n/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT4ER expressed in CHO cells assessed as reduction in cAMP levels


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50398964
PNG
(CHEMBL2179707)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(cc3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N4O3/c1-18(2)30-23-6-4-3-5-22(23)24(28-30)25(31)27-17-20-12-15-29(16-13-20)14-11-19-7-9-21(10-8-19)26(32)33/h3-10,18,20H,11-17H2,1-2H3,(H,27,31)(H,32,33)
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n/an/a 9.80n/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT4ER expressed in CHO cells assessed as reduction in cAMP levels


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301927
PNG
(CHEMBL1748 | Norcisapride)
Show SMILES COC1CNCCC1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C14H20ClN3O3/c1-20-12-6-10(16)9(15)5-8(12)14(19)18-11-3-4-17-7-13(11)21-2/h5-6,11,13,17H,3-4,7,16H2,1-2H3,(H,18,19)
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n/an/a 19n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50056415
PNG
(2-piperidinopropyl 4-amino-5-chloro-2-methoxybenzo...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCCCC1
Show InChI InChI=1S/C16H23ClN2O3/c1-21-15-11-14(18)13(17)10-12(15)16(20)22-9-5-8-19-6-3-2-4-7-19/h10-11H,2-9,18H2,1H3
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n/an/a 49n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Partial agonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as effect on serotonin-induced receptor/Gbeta1 coupling...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50019523
PNG
(CHEMBL3291078)
Show SMILES COc1cc2C(=O)N(CCCN3CCCCC3)C(=O)c3cccc(n1)c23
Show InChI InChI=1S/C20H23N3O3/c1-26-17-13-15-18-14(7-5-8-16(18)21-17)19(24)23(20(15)25)12-6-11-22-9-3-2-4-10-22/h5,7-8,13H,2-4,6,9-12H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Antagonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as inhibition of serotonin-induced receptor/Gbeta1 coupling ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50019524
PNG
(CHEMBL3291079)
Show SMILES Clc1cc2C(=O)N(CCCN3CCCCC3)Cc3cccc(n1)c23
Show InChI InChI=1S/C19H22ClN3O/c20-17-12-15-18-14(6-4-7-16(18)21-17)13-23(19(15)24)11-5-10-22-8-2-1-3-9-22/h4,6-7,12H,1-3,5,8-11,13H2
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n/an/a 195n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Partial agonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as effect on serotonin-induced receptor/Gbeta1 coupling...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50019520
PNG
(CHEMBL3291075)
Show SMILES COc1cc(C(=O)OCCCN2CCCCC2)c2ccccc2n1
Show InChI InChI=1S/C19H24N2O3/c1-23-18-14-16(15-8-3-4-9-17(15)20-18)19(22)24-13-7-12-21-10-5-2-6-11-21/h3-4,8-9,14H,2,5-7,10-13H2,1H3
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n/an/a 203n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Antagonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as inhibition of serotonin-induced receptor/Gbeta1 coupling ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50019525
PNG
(CHEMBL3291080)
Show SMILES Clc1cc2C(=O)N(CCCN3CCCCC3)C(=O)c3cccc(n1)c23
Show InChI InChI=1S/C19H20ClN3O2/c20-16-12-14-17-13(6-4-7-15(17)21-16)18(24)23(19(14)25)11-5-10-22-8-2-1-3-9-22/h4,6-7,12H,1-3,5,8-11H2
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n/an/a 453n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Antagonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as inhibition of serotonin-induced receptor/Gbeta1 coupling ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50403897
PNG
(CHEMBL334923)
Show SMILES CN(C)CCO\N=C1\c2cccn2-c2c(C)csc12
Show InChI InChI=1S/C14H17N3OS/c1-10-9-19-14-12(15-18-8-7-16(2)3)11-5-4-6-17(11)13(10)14/h4-6,9H,7-8H2,1-3H3/b15-12-
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n/an/a 871n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Compound was tested for agonistic activity against 5-hydroxytryptamine 4 receptor on guinea colon at a concentration 0.1 uM


Bioorg Med Chem Lett 11: 453-7 (2001)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50019522
PNG
(CHEMBL3291077)
Show SMILES COc1cc2C(=O)N(CCCN3CCCCC3)Cc3cccc(n1)c23
Show InChI InChI=1S/C20H25N3O2/c1-25-18-13-16-19-15(7-5-8-17(19)21-18)14-23(20(16)24)12-6-11-22-9-3-2-4-10-22/h5,7-8,13H,2-4,6,9-12,14H2,1H3
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n/an/a 916n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Antagonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as inhibition of serotonin-induced receptor/Gbeta1 coupling ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards 5-hydroxytryptamine 4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50252711
PNG
(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Show SMILES CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1
Show InChI InChI=1S/C19H27Cl2FN2O/c1-19(2,3)5-7-24-6-4-13(17(22)12-24)11-23-18(25)14-8-15(20)10-16(21)9-14/h8-10,13,17H,4-7,11-12H2,1-3H3,(H,23,25)/t13-,17-/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301929
PNG
(4-amino-5-chloro-N-((3S,4R)-1-(((1S,2S)-2-hydroxy-...)
Show SMILES CO[C@H]1CN(C[C@@H]2CCCC[C@@]2(O)c2cccc(OC)c2)CC[C@H]1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C28H38ClN3O5/c1-35-20-9-6-8-18(13-20)28(34)11-5-4-7-19(28)16-32-12-10-24(26(17-32)37-3)31-27(33)21-14-22(29)23(30)15-25(21)36-2/h6,8-9,13-15,19,24,26,34H,4-5,7,10-12,16-17,30H2,1-3H3,(H,31,33)/t19-,24+,26-,28+/m0/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301925
PNG
(4-amino-5-chloro-N-((3R,4S)-1-(((1S,2S)-2-hydroxy-...)
Show SMILES CO[C@@H]1CN(C[C@@H]2CCCC[C@@]2(O)c2cccc(OC)c2)CC[C@@H]1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C28H38ClN3O5/c1-35-20-9-6-8-18(13-20)28(34)11-5-4-7-19(28)16-32-12-10-24(26(17-32)37-3)31-27(33)21-14-22(29)23(30)15-25(21)36-2/h6,8-9,13-15,19,24,26,34H,4-5,7,10-12,16-17,30H2,1-3H3,(H,31,33)/t19-,24-,26+,28+/m0/s1
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n/an/a 4.60E+3n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301926
PNG
(4-amino-5-chloro-N-(2-((((1R,2R)-2-hydroxy-2-(3-me...)
Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)CCNC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C25H34ClN3O4/c1-29(12-11-28-24(30)20-14-21(26)22(27)15-23(20)33-3)16-18-7-4-5-10-25(18,31)17-8-6-9-19(13-17)32-2/h6,8-9,13-15,18,31H,4-5,7,10-12,16,27H2,1-3H3,(H,28,30)/t18-,25+/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301923
PNG
(4-amino-5-chloro-N-((3R,4S)-1-(((1R,2R)-2-hydroxy-...)
Show SMILES CO[C@@H]1CN(C[C@H]2CCCC[C@]2(O)c2cccc(OC)c2)CC[C@@H]1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C28H38ClN3O5/c1-35-20-9-6-8-18(13-20)28(34)11-5-4-7-19(28)16-32-12-10-24(26(17-32)37-3)31-27(33)21-14-22(29)23(30)15-25(21)36-2/h6,8-9,13-15,19,24,26,34H,4-5,7,10-12,16-17,30H2,1-3H3,(H,31,33)/t19-,24+,26-,28+/m1/s1
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n/an/a 6.10E+3n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301928
PNG
(4-amino-5-chloro-N-((3R,4S)-1-(((1S,2S)-2-hydroxy-...)
Show SMILES CO[C@@H]1CN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)CC[C@@H]1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C27H36ClN3O5/c1-35-24-14-22(29)21(28)13-20(24)26(33)30-23-9-11-31(16-25(23)36-2)15-18-6-3-4-10-27(18,34)17-7-5-8-19(32)12-17/h5,7-8,12-14,18,23,25,32,34H,3-4,6,9-11,15-16,29H2,1-2H3,(H,30,33)/t18-,23-,25+,27+/m0/s1
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n/an/a 9.90E+3n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50345777
PNG
(1-(2-Bromo benzenesulfonyl)-5-(4-ethylpiperazin-1-...)
Show SMILES CCN1CCN(Cc2ccc3n(ccc3c2)S(=O)(=O)c2ccccc2Br)CC1
Show InChI InChI=1S/C21H24BrN3O2S/c1-2-23-11-13-24(14-12-23)16-17-7-8-20-18(15-17)9-10-25(20)28(26,27)21-6-4-3-5-19(21)22/h3-10,15H,2,11-14,16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human 5HT4 receptor expressed in CHO cells after 5 hrs by luciferase reporter assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301930
PNG
(4-amino-5-chloro-N-((3S,4R)-1-(((1S,2S)-2-hydroxy-...)
Show SMILES CO[C@H]1CN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)CC[C@H]1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C27H36ClN3O5/c1-35-24-14-22(29)21(28)13-20(24)26(33)30-23-9-11-31(16-25(23)36-2)15-18-6-3-4-10-27(18,34)17-7-5-8-19(32)12-17/h5,7-8,12-14,18,23,25,32,34H,3-4,6,9-11,15-16,29H2,1-2H3,(H,30,33)/t18-,23+,25-,27+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301924
PNG
(4-amino-5-chloro-N-((3R,4S)-1-(((1R,2R)-2-hydroxy-...)
Show SMILES CO[C@@H]1CN(C[C@H]2CCCC[C@]2(O)c2cccc(O)c2)CC[C@@H]1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C27H36ClN3O5/c1-35-24-14-22(29)21(28)13-20(24)26(33)30-23-9-11-31(16-25(23)36-2)15-18-6-3-4-10-27(18,34)17-7-5-8-19(32)12-17/h5,7-8,12-14,18,23,25,32,34H,3-4,6,9-11,15-16,29H2,1-2H3,(H,30,33)/t18-,23+,25-,27+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301922
PNG
(4-amino-5-chloro-N-((3S,4R)-1-(((1R,2R)-2-hydroxy-...)
Show SMILES CO[C@H]1CN(C[C@H]2CCCC[C@]2(O)c2cccc(O)c2)CC[C@H]1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C27H36ClN3O5/c1-35-24-14-22(29)21(28)13-20(24)26(33)30-23-9-11-31(16-25(23)36-2)15-18-6-3-4-10-27(18,34)17-7-5-8-19(32)12-17/h5,7-8,12-14,18,23,25,32,34H,3-4,6,9-11,15-16,29H2,1-2H3,(H,30,33)/t18-,23-,25+,27+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301921
PNG
(4-amino-5-chloro-N-((3S,4R)-1-(((1R,2R)-2-hydroxy-...)
Show SMILES CO[C@H]1CN(C[C@H]2CCCC[C@]2(O)c2cccc(OC)c2)CC[C@H]1NC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C28H38ClN3O5/c1-35-20-9-6-8-18(13-20)28(34)11-5-4-7-19(28)16-32-12-10-24(26(17-32)37-3)31-27(33)21-14-22(29)23(30)15-25(21)36-2/h6,8-9,13-15,19,24,26,34H,4-5,7,10-12,16-17,30H2,1-3H3,(H,31,33)/t19-,24-,26+,28+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301920
PNG
(4-amino-5-chloro-N-(2-((((1S,2S)-2-hydroxy-2-(3-hy...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCCN(C)C[C@@H]1CCCC[C@@]1(O)c1cccc(O)c1
Show InChI InChI=1S/C24H32ClN3O4/c1-28(11-10-27-23(30)19-13-20(25)21(26)14-22(19)32-2)15-17-6-3-4-9-24(17,31)16-7-5-8-18(29)12-16/h5,7-8,12-14,17,29,31H,3-4,6,9-11,15,26H2,1-2H3,(H,27,30)/t17-,24+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301919
PNG
(4-amino-5-chloro-N-(2-((((1R,2R)-2-hydroxy-2-(3-hy...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCCN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1
Show InChI InChI=1S/C24H32ClN3O4/c1-28(11-10-27-23(30)19-13-20(25)21(26)14-22(19)32-2)15-17-6-3-4-9-24(17,31)16-7-5-8-18(29)12-16/h5,7-8,12-14,17,29,31H,3-4,6,9-11,15,26H2,1-2H3,(H,27,30)/t17-,24+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301918
PNG
(4-amino-5-chloro-N-(2-((((1S,2S)-2-hydroxy-2-(3-me...)
Show SMILES COc1cccc(c1)[C@]1(O)CCCC[C@H]1CN(C)CCNC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C25H34ClN3O4/c1-29(12-11-28-24(30)20-14-21(26)22(27)15-23(20)33-3)16-18-7-4-5-10-25(18,31)17-8-6-9-19(13-17)32-2/h6,8-9,13-15,18,31H,4-5,7,10-12,16,27H2,1-3H3,(H,28,30)/t18-,25+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50301919
PNG
(4-amino-5-chloro-N-(2-((((1R,2R)-2-hydroxy-2-(3-hy...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCCN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1
Show InChI InChI=1S/C24H32ClN3O4/c1-28(11-10-27-23(30)19-13-20(25)21(26)14-22(19)32-2)15-17-6-3-4-9-24(17,31)16-7-5-8-18(29)12-16/h5,7-8,12-14,17,29,31H,3-4,6,9-11,15,26H2,1-2H3,(H,27,30)/t17-,24+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50033447
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards 5-hydroxy tryptamine 4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50345754
PNG
(3-chloro-1-(4-fluoro benzenesulfonyl)-5-(4-methylp...)
Show SMILES CN1CCN(Cc2ccc3n(cc(Cl)c3c2)S(=O)(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C20H21ClFN3O2S/c1-23-8-10-24(11-9-23)13-15-2-7-20-18(12-15)19(21)14-25(20)28(26,27)17-5-3-16(22)4-6-17/h2-7,12,14H,8-11,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human 5HT4 receptor expressed in CHO cells after 5 hrs by luciferase reporter assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50213737
PNG
(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Show SMILES Oc1cc(cc2c1N=C(Nc1ccccc1Oc1ccccc1)NS2(=O)=O)[N+]([O-])=O
Show InChI InChI=1S/C19H14N4O6S/c24-15-10-12(23(25)26)11-17-18(15)21-19(22-30(17,27)28)20-14-8-4-5-9-16(14)29-13-6-2-1-3-7-13/h1-11,24H,(H2,20,21,22)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 5HT4A receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50330813
PNG
(3-[(1S,3R)-3-Dimethylaminocyclopentyl]-1H-indole-5...)
Show SMILES CN(C)[C@@H]1CC[C@@H](C1)c1c[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C16H19N3/c1-19(2)13-5-4-12(8-13)15-10-18-16-6-3-11(9-17)7-14(15)16/h3,6-7,10,12-13,18H,4-5,8H2,1-2H3/t12-,13+/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb

Curated by ChEMBL


Assay Description
Binding affinity to 5HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50330814
PNG
(CHEMBL1275791 | [(1R,3S)-3-(5-Fluoro-1H-indol-3-yl...)
Show SMILES CN(C)[C@H]1CC[C@H](C1)c1c[nH]c2ccc(F)cc12
Show InChI InChI=1S/C15H19FN2/c1-18(2)12-5-3-10(7-12)14-9-17-15-6-4-11(16)8-13(14)15/h4,6,8-10,12,17H,3,5,7H2,1-2H3/t10-,12+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb

Curated by ChEMBL


Assay Description
Binding affinity to 5HT4 receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50399614
PNG
(CHEMBL2181170)
Show SMILES CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1
Show InChI InChI=1S/C21H24FN3O/c1-2-11-25-12-8-15(9-13-25)14-26-21-17-6-4-10-23-19(17)16-5-3-7-18(22)20(16)24-21/h3-7,10,15H,2,8-9,11-14H2,1H3
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0.0398n/an/an/an/an/an/an/an/a



Universit£ de Caen Basse-Normandie

Curated by ChEMBL


Assay Description
Displacement of radioligand from human 5HT4R by Cerep protocol based assay


Citation and Details
More data for this
Ligand-Target Pair
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