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Compile Data Set for Download or QSAR

Found 46 hits Enz. Inhib. hit(s) with Target = 'AGTR1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Type-1A angiotensin II receptor


(Mus musculus)
BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 5.67E+3n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479157
PNG
(3-Methylbenzyl 2''-Nitrobenzoate | CHEMBL498499)
Show SMILES Cc1cccc(COC(=O)c2ccccc2[N+]([O-])=O)c1
Show InChI InChI=1S/C15H13NO4/c1-11-5-4-6-12(9-11)10-20-15(17)13-7-2-3-8-14(13)16(18)19/h2-9H,10H2,1H3
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n/an/a 4.05E+4n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479144
PNG
(3-Methylbenzyl Benzoate | CHEMBL453990)
Show SMILES Cc1cccc(COC(=O)c2ccccc2)c1
Show InChI InChI=1S/C15H14O2/c1-12-6-5-7-13(10-12)11-17-15(16)14-8-3-2-4-9-14/h2-10H,11H2,1H3
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n/an/a 4.86E+4n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479155
PNG
(3-Methylbenzyl 4''-Hydroxybenzoate | CHEMBL498340)
Show SMILES Cc1cccc(COC(=O)c2ccc(O)cc2)c1
Show InChI InChI=1S/C15H14O3/c1-11-3-2-4-12(9-11)10-18-15(17)13-5-7-14(16)8-6-13/h2-9,16H,10H2,1H3
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n/an/a 8.66E+4n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479172
PNG
(2-Methylbenzyl Benzoate | CHEMBL526378)
Show SMILES Cc1ccccc1COC(=O)c1ccccc1
Show InChI InChI=1S/C15H14O2/c1-12-7-5-6-10-14(12)11-17-15(16)13-8-3-2-4-9-13/h2-10H,11H2,1H3
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n/an/a 8.83E+4n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479180
PNG
(4-Methylbenzyl Benzoate | CHEMBL498646)
Show SMILES Cc1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H14O2/c1-12-7-9-13(10-8-12)11-17-15(16)14-5-3-2-4-6-14/h2-10H,11H2,1H3
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n/an/a 9.28E+4n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479167
PNG
(3-Methylbenzyl 2''-Methoxybenzoate | CHEMBL506779)
Show SMILES COc1ccccc1C(=O)OCc1cccc(C)c1
Show InChI InChI=1S/C16H16O3/c1-12-6-5-7-13(10-12)11-19-16(17)14-8-3-4-9-15(14)18-2/h3-10H,11H2,1-2H3
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n/an/a 9.75E+4n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479163
PNG
(3-Methylbenzyl 2''-Methylbenzoate | CHEMBL498661)
Show SMILES Cc1cccc(COC(=O)c2ccccc2C)c1
Show InChI InChI=1S/C16H16O2/c1-12-6-5-8-14(10-12)11-18-16(17)15-9-4-3-7-13(15)2/h3-10H,11H2,1-2H3
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n/an/a 9.98E+4n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479154
PNG
(3-Methylbenzyl 3'',4''-Dihydroxybenzoate | CHEMBL4...)
Show SMILES Cc1cccc(COC(=O)c2ccc(O)c(O)c2)c1
Show InChI InChI=1S/C15H14O4/c1-10-3-2-4-11(7-10)9-19-15(18)12-5-6-13(16)14(17)8-12/h2-8,16-17H,9H2,1H3
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n/an/a 1.00E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479182
PNG
(3-Methylbenzyl 3''-Hydroxybenzoate | CHEMBL500017)
Show SMILES Cc1cccc(COC(=O)c2cccc(O)c2)c1
Show InChI InChI=1S/C15H14O3/c1-11-4-2-5-12(8-11)10-18-15(17)13-6-3-7-14(16)9-13/h2-9,16H,10H2,1H3
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n/an/a 1.03E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479178
PNG
(3-Methylbenzyl 4''-Methylbenzoate | CHEMBL500113)
Show SMILES Cc1ccc(cc1)C(=O)OCc1cccc(C)c1
Show InChI InChI=1S/C16H16O2/c1-12-6-8-15(9-7-12)16(17)18-11-14-5-3-4-13(2)10-14/h3-10H,11H2,1-2H3
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n/an/a 1.08E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479162
PNG
(3-Methylbenzyl 3''-Methylbenzoate | CHEMBL443154)
Show SMILES Cc1cccc(COC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C16H16O2/c1-12-5-3-7-14(9-12)11-18-16(17)15-8-4-6-13(2)10-15/h3-10H,11H2,1-2H3
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n/an/a 1.33E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479160
PNG
(3-Methylbenzyl 4''-Methoxybenzoate | CHEMBL497482)
Show SMILES COc1ccc(cc1)C(=O)OCc1cccc(C)c1
Show InChI InChI=1S/C16H16O3/c1-12-4-3-5-13(10-12)11-19-16(17)14-6-8-15(18-2)9-7-14/h3-10H,11H2,1-2H3
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n/an/a 1.36E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479176
PNG
(3-Methylbenzyl 4''-Sulfonamoylbenzoate | CHEMBL507...)
Show SMILES Cc1cccc(COC(=O)c2ccc(cc2)S(N)(=O)=O)c1
Show InChI InChI=1S/C15H15NO4S/c1-11-3-2-4-12(9-11)10-20-15(17)13-5-7-14(8-6-13)21(16,18)19/h2-9H,10H2,1H3,(H2,16,18,19)
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n/an/a 1.40E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479147
PNG
(3-Iodobenzyl Benzoate | CHEMBL498500)
Show SMILES Ic1cccc(COC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11IO2/c15-13-8-4-5-11(9-13)10-17-14(16)12-6-2-1-3-7-12/h1-9H,10H2
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n/an/a 1.56E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479183
PNG
(3-Methoxybenzyl Benzoate | CHEMBL498648)
Show SMILES COc1cccc(COC(=O)c2ccccc2)c1
Show InChI InChI=1S/C15H14O3/c1-17-14-9-5-6-12(10-14)11-18-15(16)13-7-3-2-4-8-13/h2-10H,11H2,1H3
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n/an/a 1.60E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479151
PNG
(2-Chlorobenzyl Benzoate | CHEMBL502731)
Show SMILES Clc1ccccc1COC(=O)c1ccccc1
Show InChI InChI=1S/C14H11ClO2/c15-13-9-5-4-8-12(13)10-17-14(16)11-6-2-1-3-7-11/h1-9H,10H2
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n/an/a 1.66E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479166
PNG
(4-Methoxybenzyl Benzoate | CHEMBL450043)
Show SMILES COc1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H14O3/c1-17-14-9-7-12(8-10-14)11-18-15(16)13-5-3-2-4-6-13/h2-10H,11H2,1H3
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n/an/a 1.73E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479161
PNG
(3-Methylbenzyl 3''-Methoxybenzoate | CHEMBL493429)
Show SMILES COc1cccc(c1)C(=O)OCc1cccc(C)c1
Show InChI InChI=1S/C16H16O3/c1-12-5-3-6-13(9-12)11-19-16(17)14-7-4-8-15(10-14)18-2/h3-10H,11H2,1-2H3
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n/an/a 1.75E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479153
PNG
(CHEBI:71231 | CHEMBL490512)
Show SMILES O=C(CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H14O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-10H,11-12H2
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n/an/a 1.80E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479164
PNG
(3,4-Dimethoxybenzyl Benzoate | CHEMBL452671)
Show SMILES COc1ccc(COC(=O)c2ccccc2)cc1OC
Show InChI InChI=1S/C16H16O4/c1-18-14-9-8-12(10-15(14)19-2)11-20-16(17)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3
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n/an/a 1.83E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50149609
PNG
((E)-3-Phenyl-acrylic acid benzyl ester | CHEMBL361...)
Show SMILES O=C(OCc1ccccc1)\C=C\c1ccccc1
Show InChI InChI=1S/C16H14O2/c17-16(12-11-14-7-3-1-4-8-14)18-13-15-9-5-2-6-10-15/h1-12H,13H2/b12-11+
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n/an/a 1.97E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479159
PNG
(3-Methylbenzyl 2''-Chlorobenzoate | CHEMBL498670)
Show SMILES Cc1cccc(COC(=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C15H13ClO2/c1-11-5-4-6-12(9-11)10-18-15(17)13-7-2-3-8-14(13)16/h2-9H,10H2,1H3
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n/an/a 2.14E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479177
PNG
(3-Methylbenzyl 3''-Chlorobenzoate | CHEMBL498497)
Show SMILES Cc1cccc(COC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C15H13ClO2/c1-11-4-2-5-12(8-11)10-18-15(17)13-6-3-7-14(16)9-13/h2-9H,10H2,1H3
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n/an/a 2.14E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479150
PNG
(3-Chlorobenzyl Benzoate | CHEMBL497299)
Show SMILES Clc1cccc(COC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11ClO2/c15-13-8-4-5-11(9-13)10-17-14(16)12-6-2-1-3-7-12/h1-9H,10H2
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n/an/a 2.18E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479165
PNG
(2-Ethylbenzyl Benzoate | CHEMBL498649)
Show SMILES CCc1ccccc1COC(=O)c1ccccc1
Show InChI InChI=1S/C16H16O2/c1-2-13-8-6-7-11-15(13)12-18-16(17)14-9-4-3-5-10-14/h3-11H,2,12H2,1H3
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n/an/a 2.33E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479185
PNG
(4-Acetamidobenzyl Benzoate | CHEMBL449577)
Show SMILES CC(=O)Nc1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H15NO3/c1-12(18)17-15-9-7-13(8-10-15)11-20-16(19)14-5-3-2-4-6-14/h2-10H,11H2,1H3,(H,17,18)
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n/an/a 2.63E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479148
PNG
(4-Bromobenzyl Benzoate | CHEMBL449299)
Show SMILES Brc1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H11BrO2/c15-13-8-6-11(7-9-13)10-17-14(16)12-4-2-1-3-5-12/h1-9H,10H2
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n/an/a 2.98E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479175
PNG
(2-Fluorobenzyl Benzoate | CHEMBL498478)
Show SMILES Fc1ccccc1COC(=O)c1ccccc1
Show InChI InChI=1S/C14H11FO2/c15-13-9-5-4-8-12(13)10-17-14(16)11-6-2-1-3-7-11/h1-9H,10H2
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n/an/a 3.08E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479168
PNG
(4-Isopropylbenzyl Benzoate | CHEMBL525189)
Show SMILES CC(C)c1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C17H18O2/c1-13(2)15-10-8-14(9-11-15)12-19-17(18)16-6-4-3-5-7-16/h3-11,13H,12H2,1-2H3
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n/an/a 3.18E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479149
PNG
(3-Bromobenzyl Benzoate | CHEMBL485216)
Show SMILES Brc1cccc(COC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11BrO2/c15-13-8-4-5-11(9-13)10-17-14(16)12-6-2-1-3-7-12/h1-9H,10H2
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n/an/a 3.33E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479156
PNG
(3-Methylbenzyl 3''-Nitrobenzoate | CHEMBL526296)
Show SMILES Cc1cccc(COC(=O)c2cccc(c2)[N+]([O-])=O)c1
Show InChI InChI=1S/C15H13NO4/c1-11-4-2-5-12(8-11)10-20-15(17)13-6-3-7-14(9-13)16(18)19/h2-9H,10H2,1H3
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n/an/a 3.35E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479179
PNG
(4-Ethylbenzyl Benzoate | CHEMBL498484)
Show SMILES CCc1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H16O2/c1-2-13-8-10-14(11-9-13)12-18-16(17)15-6-4-3-5-7-15/h3-11H,2,12H2,1H3
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n/an/a 3.37E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479170
PNG
(3-Methylbenzyl 4''-Nitrobenzoate | CHEMBL498671)
Show SMILES Cc1cccc(COC(=O)c2ccc(cc2)[N+]([O-])=O)c1
Show InChI InChI=1S/C15H13NO4/c1-11-3-2-4-12(9-11)10-20-15(17)13-5-7-14(8-6-13)16(18)19/h2-9H,10H2,1H3
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n/an/a 3.42E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479174
PNG
(4-Chlorobenzyl Benzoate | CHEMBL497471)
Show SMILES Clc1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H11ClO2/c15-13-8-6-11(7-9-13)10-17-14(16)12-4-2-1-3-5-12/h1-9H,10H2
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n/an/a 3.60E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479169
PNG
(4-Fluorobenzyl Benzoate | CHEMBL497298)
Show SMILES Fc1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H11FO2/c15-13-8-6-11(7-9-13)10-17-14(16)12-4-2-1-3-5-12/h1-9H,10H2
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n/an/a 3.69E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479158
PNG
(3-Methylbenzyl 4''-Chlorobenzoate | CHEMBL498498)
Show SMILES Cc1cccc(COC(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C15H13ClO2/c1-11-3-2-4-12(9-11)10-18-15(17)13-5-7-14(16)8-6-13/h2-9H,10H2,1H3
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n/an/a>3.83E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479152
PNG
(3-Fluorobenzyl Benzoate | CHEMBL497297)
Show SMILES Fc1cccc(COC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11FO2/c15-13-8-4-5-11(9-13)10-17-14(16)12-6-2-1-3-7-12/h1-9H,10H2
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n/an/a 4.29E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479184
PNG
(3-Acetamidobenzyl Benzoate | CHEMBL521893)
Show SMILES CC(=O)Nc1cccc(COC(=O)c2ccccc2)c1
Show InChI InChI=1S/C16H15NO3/c1-12(18)17-15-9-5-6-13(10-15)11-20-16(19)14-7-3-2-4-8-14/h2-10H,11H2,1H3,(H,17,18)
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n/an/a 4.45E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479171
PNG
(2-Methoxybenzyl Benzoate | CHEMBL498647)
Show SMILES COc1ccccc1COC(=O)c1ccccc1
Show InChI InChI=1S/C15H14O3/c1-17-14-10-6-5-9-13(14)11-18-15(16)12-7-3-2-4-8-12/h2-10H,11H2,1H3
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n/an/a 4.82E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50134035
PNG
(BENZYL BENZOATE | CHEMBL1239)
Show SMILES O=C(OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H2
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n/an/a 5.04E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479146
PNG
(3-Nitrobenzyl Benzoate | CHEMBL450030)
Show SMILES [O-][N+](=O)c1cccc(COC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11NO4/c16-14(12-6-2-1-3-7-12)19-10-11-5-4-8-13(9-11)15(17)18/h1-9H,10H2
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n/an/a 5.28E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479173
PNG
(2-Nitrobenzyl Benzoate | CHEMBL498501)
Show SMILES [O-][N+](=O)c1ccccc1COC(=O)c1ccccc1
Show InChI InChI=1S/C14H11NO4/c16-14(11-6-2-1-3-7-11)19-10-12-8-4-5-9-13(12)15(17)18/h1-9H,10H2
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n/an/a 7.23E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479145
PNG
(2-Acetamidobenzyl Benzoate | CHEMBL508363)
Show SMILES CC(=O)Nc1ccccc1COC(=O)c1ccccc1
Show InChI InChI=1S/C16H15NO3/c1-12(18)17-15-10-6-5-9-14(15)11-20-16(19)13-7-3-2-4-8-13/h2-10H,11H2,1H3,(H,17,18)
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n/an/a 8.50E+5n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
Type-1A angiotensin II receptor


(Mus musculus)
BDBM50479181
PNG
(4-Nitrobenzyl Benzoate | Benzoic Acid 4-Nitro-Benz...)
Show SMILES [O-][N+](=O)c1ccc(COC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H11NO4/c16-14(12-4-2-1-3-5-12)19-10-11-6-8-13(9-7-11)15(17)18/h1-9H,10H2
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n/an/a 1.08E+6n/an/an/an/an/an/a



Nagoya University

Curated by ChEMBL


Assay Description
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracell...


Bioorg Med Chem 16: 7843-52 (2008)

More data for this
Ligand-Target Pair
AGTR1


(Xenopus tropicalis)
BDBM82273
PNG
(CAS_167710-87-4 | RS 39604)
Show SMILES COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1
Show InChI InChI=1S/C26H36ClN3O6S/c1-34-20-12-19(13-21(14-20)35-2)17-36-26-16-24(28)23(27)15-22(26)25(31)5-4-18-6-9-30(10-7-18)11-8-29-37(3,32)33/h12-16,18,29H,4-11,17,28H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Syntex Discovery Research

Curated by PDSP Ki Database




Br J Pharmacol 115: 1087-95 (1995)


Article DOI: 10.1111/j.1476-5381.1995.tb15922.x
BindingDB Entry DOI: 10.7270/Q2707ZX4
More data for this
Ligand-Target Pair