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Compile Data Set for Download or QSAR

Found 38 hits Enz. Inhib. hit(s) with Target = 'ATP-binding cassette sub-family C member 8'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sulfonylurea receptor 1


(Homo sapiens)
BDBM50153520
PNG
((S)-2-ethoxy-4-(2-(3-methyl-1-(2-(piperidin-1-yl)p...)
Show SMILES CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O
Show InChI InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
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n/an/a 106n/an/an/an/an/an/a



University of Mainz

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)


Bioorg Med Chem Lett 14: 5205-9 (2004)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 1


(Homo sapiens)
BDBM50153521
PNG
(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)
Show SMILES COc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O
Show InChI InChI=1S/C26H34N2O4/c1-18(2)15-22(20-9-5-6-10-23(20)28-13-7-4-8-14-28)27-25(29)17-19-11-12-21(26(30)31)24(16-19)32-3/h5-6,9-12,16,18,22H,4,7-8,13-15,17H2,1-3H3,(H,27,29)(H,30,31)/t22-/m0/s1
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n/an/a 163n/an/an/an/an/an/a



University of Mainz

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)


Bioorg Med Chem Lett 14: 5205-9 (2004)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363009
PNG
(CHEMBL1946412)
Show SMILES CC(C)NC1=Nc2cc(Br)ccc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12BrN3O2S/c1-6(2)12-10-13-8-5-7(11)3-4-9(8)17(15,16)14-10/h3-6H,1-2H3,(H2,12,13,14)
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n/an/a 200n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363013
PNG
(CHEMBL191539)
Show SMILES COc1cc2c(cc1Cl)N=C(NC(C)C)NS2(=O)=O
Show InChI InChI=1S/C11H14ClN3O3S/c1-6(2)13-11-14-8-4-7(12)9(18-3)5-10(8)19(16,17)15-11/h4-6H,1-3H3,(H2,13,14,15)
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n/an/a 240n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363006
PNG
(CHEMBL363989)
Show SMILES CC(C)NC1=Nc2cc(Cl)c(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H11Cl2N3O2S/c1-5(2)13-10-14-8-3-6(11)7(12)4-9(8)18(16,17)15-10/h3-5H,1-2H3,(H2,13,14,15)
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n/an/a 280n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 1


(Homo sapiens)
BDBM50153522
PNG
(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)
Show SMILES CC(C)C[C@H](NC(=O)Cc1ccc(C(O)=O)c(OCCF)c1)c1ccccc1N1CCCCC1
Show InChI InChI=1S/C27H35FN2O4/c1-19(2)16-23(21-8-4-5-9-24(21)30-13-6-3-7-14-30)29-26(31)18-20-10-11-22(27(32)33)25(17-20)34-15-12-28/h4-5,8-11,17,19,23H,3,6-7,12-16,18H2,1-2H3,(H,29,31)(H,32,33)/t23-/m0/s1
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n/an/a 281n/an/an/an/an/an/a



University of Mainz

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)


Bioorg Med Chem Lett 14: 5205-9 (2004)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363004
PNG
(CHEMBL1946140)
Show SMILES C[C@H](CO)NC1=Nc2cc(Cl)c(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H11Cl2N3O3S/c1-5(4-16)13-10-14-8-2-6(11)7(12)3-9(8)19(17,18)15-10/h2-3,5,16H,4H2,1H3,(H2,13,14,15)/t5-/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50130735
PNG
((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Show SMILES CC(C)NC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O2S/c1-6(2)12-10-13-8-4-3-7(11)5-9(8)17(15,16)14-10/h3-6H,1-2H3,(H2,12,13,14)
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n/an/a 480n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363007
PNG
(CHEMBL1946272)
Show SMILES C[C@H](CO)NC1=Nc2cc(Cl)ccc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O3S/c1-6(5-15)12-10-13-8-4-7(11)2-3-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m1/s1
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n/an/a 520n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362998
PNG
(CHEMBL1945810)
Show SMILES C[C@H](CO)NC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O3S/c1-6(5-15)12-10-13-8-3-2-7(11)4-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m1/s1
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n/an/a 620n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363002
PNG
(CHEMBL115565)
Show SMILES CC(C)NC1=Nc2ccc(F)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12FN3O2S/c1-6(2)12-10-13-8-4-3-7(11)5-9(8)17(15,16)14-10/h3-6H,1-2H3,(H2,12,13,14)
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n/an/a 760n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363003
PNG
(CHEMBL1946139)
Show SMILES CC(CO)NC1=Nc2cc(Cl)c(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H11Cl2N3O3S/c1-5(4-16)13-10-14-8-2-6(11)7(12)3-9(8)19(17,18)15-10/h2-3,5,16H,4H2,1H3,(H2,13,14,15)
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n/an/a 1.41E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363008
PNG
(CHEMBL1946410)
Show SMILES C[C@H](CO)NC1=Nc2cc(Br)ccc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12BrN3O3S/c1-6(5-15)12-10-13-8-4-7(11)2-3-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m1/s1
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n/an/a 1.67E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362992
PNG
(CHEMBL1946411)
Show SMILES C[C@@H](CO)NC1=Nc2cc(Br)ccc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12BrN3O3S/c1-6(5-15)12-10-13-8-4-7(11)2-3-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m0/s1
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n/an/a 1.73E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363011
PNG
(CHEMBL189093)
Show SMILES COc1ccc2N=C(NC(C)C)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H15N3O3S/c1-7(2)12-11-13-9-5-4-8(17-3)6-10(9)18(15,16)14-11/h4-7H,1-3H3,(H2,12,13,14)
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n/an/a 1.75E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362991
PNG
(CHEMBL1946273)
Show SMILES C[C@@H](CO)NC1=Nc2cc(Cl)ccc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O3S/c1-6(5-15)12-10-13-8-4-7(11)2-3-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m0/s1
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n/an/a 1.81E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363001
PNG
(CHEMBL1946137)
Show SMILES C[C@H](CO)NC1=Nc2ccc(F)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12FN3O3S/c1-6(5-15)12-10-13-8-3-2-7(11)4-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m1/s1
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n/an/a 2.05E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363012
PNG
(CHEMBL1946759)
Show SMILES COc1cc2c(cc1Cl)N=C(N[C@H](C)CO)NS2(=O)=O
Show InChI InChI=1S/C11H14ClN3O4S/c1-6(5-16)13-11-14-8-3-7(12)9(19-2)4-10(8)20(17,18)15-11/h3-4,6,16H,5H2,1-2H3,(H2,13,14,15)/t6-/m1/s1
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n/an/a 2.98E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362995
PNG
(CHEMBL1945807)
Show SMILES CC(CO)NC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O3S/c1-6(5-15)12-10-13-8-3-2-7(11)4-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)
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n/an/a 3.03E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362997
PNG
(CHEMBL1945809)
Show SMILES CC(COC(C)=O)NC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C12H14ClN3O4S/c1-7(6-20-8(2)17)14-12-15-10-4-3-9(13)5-11(10)21(18,19)16-12/h3-5,7H,6H2,1-2H3,(H2,14,15,16)
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n/an/a 3.58E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362990
PNG
(CHEMBL1946138)
Show SMILES C[C@@H](CO)NC1=Nc2ccc(F)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12FN3O3S/c1-6(5-15)12-10-13-8-3-2-7(11)4-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m0/s1
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n/an/a 3.78E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363010
PNG
(CHEMBL1946414)
Show SMILES COc1ccc2N=C(N[C@H](C)CO)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H15N3O4S/c1-7(6-15)12-11-13-9-4-3-8(18-2)5-10(9)19(16,17)14-11/h3-5,7,15H,6H2,1-2H3,(H2,12,13,14)/t7-/m1/s1
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n/an/a 4.93E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362993
PNG
(CHEMBL1944656)
Show SMILES COc1ccc2N=C(N[C@@H](C)CO)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H15N3O4S/c1-7(6-15)12-11-13-9-4-3-8(18-2)5-10(9)19(16,17)14-11/h3-5,7,15H,6H2,1-2H3,(H2,12,13,14)/t7-/m0/s1
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n/an/a 6.31E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363005
PNG
(CHEMBL1946270)
Show SMILES C[C@@H](CO)NC1=Nc2cc(Cl)c(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H11Cl2N3O3S/c1-5(4-16)13-10-14-8-2-6(11)7(12)3-9(8)19(17,18)15-10/h2-3,5,16H,4H2,1H3,(H2,13,14,15)/t5-/m0/s1
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n/an/a 8.67E+3n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362994
PNG
(CHEMBL1946760)
Show SMILES COc1cc2c(cc1Cl)N=C(N[C@@H](C)CO)NS2(=O)=O
Show InChI InChI=1S/C11H14ClN3O4S/c1-6(5-16)13-11-14-8-3-7(12)9(19-2)4-10(8)20(17,18)15-11/h3-4,6,16H,5H2,1-2H3,(H2,13,14,15)/t6-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362993
PNG
(CHEMBL1944656)
Show SMILES COc1ccc2N=C(N[C@@H](C)CO)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H15N3O4S/c1-7(6-15)12-11-13-9-4-3-8(18-2)5-10(9)19(16,17)14-11/h3-5,7,15H,6H2,1-2H3,(H2,12,13,14)/t7-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362992
PNG
(CHEMBL1946411)
Show SMILES C[C@@H](CO)NC1=Nc2cc(Br)ccc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12BrN3O3S/c1-6(5-15)12-10-13-8-4-7(11)2-3-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362991
PNG
(CHEMBL1946273)
Show SMILES C[C@@H](CO)NC1=Nc2cc(Cl)ccc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O3S/c1-6(5-15)12-10-13-8-4-7(11)2-3-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362990
PNG
(CHEMBL1946138)
Show SMILES C[C@@H](CO)NC1=Nc2ccc(F)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12FN3O3S/c1-6(5-15)12-10-13-8-3-2-7(11)4-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50363000
PNG
(CHEMBL1946136)
Show SMILES COCC(C)NC1=Nc2ccc(F)cc2S(=O)(=O)N1
Show InChI InChI=1S/C11H14FN3O3S/c1-7(6-18-2)13-11-14-9-4-3-8(12)5-10(9)19(16,17)15-11/h3-5,7H,6H2,1-2H3,(H2,13,14,15)
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n/an/a 2.65E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362999
PNG
(CHEMBL1946134)
Show SMILES C[C@@H](CO)NC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O3S/c1-6(5-15)12-10-13-8-3-2-7(11)4-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)/t6-/m0/s1
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n/an/a 3.75E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362996
PNG
(CHEMBL1945808)
Show SMILES COCC(C)NC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C11H14ClN3O3S/c1-7(6-18-2)13-11-14-9-4-3-8(12)5-10(9)19(16,17)15-11/h3-5,7H,6H2,1-2H3,(H2,13,14,15)
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n/an/a 3.89E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
ATP-binding cassette sub-family C member 8


(Rattus norvegicus)
BDBM50362989
PNG
(CHEMBL1945806)
Show SMILES CC(O)CNC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O3S/c1-6(15)5-12-10-13-8-3-2-7(11)4-9(8)18(16,17)14-10/h2-4,6,15H,5H2,1H3,(H2,12,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Universit£ de Li£ge

Curated by ChEMBL


Assay Description
Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretion


J Med Chem 54: 8353-61 (2011)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 1


(Homo sapiens)
BDBM50025834
PNG
(CHEMBL3330880)
Show SMILES COc1cc(NC(C)=O)c(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Show InChI InChI=1S/C25H31ClN4O6S/c1-16(31)28-22-15-23(36-2)20(14-21(22)26)24(32)27-13-12-17-8-10-19(11-9-17)37(34,35)30-25(33)29-18-6-4-3-5-7-18/h8-11,14-15,18H,3-7,12-13H2,1-2H3,(H,27,32)(H,28,31)(H2,29,30,33)
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n/an/an/a 0.380n/an/an/an/an/a



Universidade Federal de Santa Catarina

Curated by ChEMBL


Assay Description
Binding affinity to SUR1 (unknown origin)


Eur J Med Chem 86: 491-501 (2014)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 1


(Homo sapiens)
BDBM50153521
PNG
(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)
Show SMILES COc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O
Show InChI InChI=1S/C26H34N2O4/c1-18(2)15-22(20-9-5-6-10-23(20)28-13-7-4-8-14-28)27-25(29)17-19-11-12-21(26(30)31)24(16-19)32-3/h5-6,9-12,16,18,22H,4,7-8,13-15,17H2,1-3H3,(H,27,29)(H,30,31)/t22-/m0/s1
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n/an/an/a 83n/an/an/an/an/a



University of Mainz

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)


Bioorg Med Chem Lett 14: 5205-9 (2004)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 1


(Homo sapiens)
BDBM50153520
PNG
((S)-2-ethoxy-4-(2-(3-methyl-1-(2-(piperidin-1-yl)p...)
Show SMILES CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O
Show InChI InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
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n/an/an/a 50n/an/an/an/an/a



University of Mainz

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)


Bioorg Med Chem Lett 14: 5205-9 (2004)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 1


(Homo sapiens)
BDBM50153522
PNG
(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)
Show SMILES CC(C)C[C@H](NC(=O)Cc1ccc(C(O)=O)c(OCCF)c1)c1ccccc1N1CCCCC1
Show InChI InChI=1S/C27H35FN2O4/c1-19(2)16-23(21-8-4-5-9-24(21)30-13-6-3-7-14-30)29-26(31)18-20-10-11-22(27(32)33)25(17-20)34-15-12-28/h4-5,8-11,17,19,23H,3,6-7,12-16,18H2,1-2H3,(H,29,31)(H,32,33)/t23-/m0/s1
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n/an/an/a 134n/an/an/an/an/a



University of Mainz

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)


Bioorg Med Chem Lett 14: 5205-9 (2004)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 1


(Homo sapiens)
BDBM50025847
PNG
(CHEMBL3330879)
Show SMILES COc1cc(NC(=O)CO[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Show InChI InChI=1/C31H41ClN4O12S/c1-46-23-14-22(35-25(38)16-47-30-28(41)27(40)26(39)24(15-37)48-30)21(32)13-20(23)29(42)33-12-11-17-7-9-19(10-8-17)49(44,45)36-31(43)34-18-5-3-2-4-6-18/h7-10,13-14,18,24,26-28,30,37,39-41H,2-6,11-12,15-16H2,1H3,(H,33,42)(H,35,38)(H2,34,36,43)/t24-,26-,27+,28-,30+/s2
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n/an/an/a 2.10n/an/an/an/an/a



Universidade Federal de Santa Catarina

Curated by ChEMBL


Assay Description
Binding affinity to SUR1 (unknown origin)


Eur J Med Chem 86: 491-501 (2014)

More data for this
Ligand-Target Pair