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Found 24 hits Enz. Inhib. hit(s) with Target = 'ATP-dependent RNA helicase DDX3X'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379302
PNG
(CHEMBL2011807)
Show SMILES Cc1ccccc1NC(=O)Nc1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H13N3O3/c1-10-5-2-3-8-13(10)16-14(18)15-11-6-4-7-12(9-11)17(19)20/h2-9H,1H3,(H2,15,16,18)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379305
PNG
(CHEMBL2011808)
Show SMILES Cc1ccccc1NC(=O)Nc1cccc(N)c1
Show InChI InChI=1S/C14H15N3O/c1-10-5-2-3-8-13(10)17-14(18)16-12-7-4-6-11(15)9-12/h2-9H,15H2,1H3,(H2,16,17,18)
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274024
PNG
(3-(5-(3-bromobenzylidene)-4-oxo-2-thioxothiazolidi...)
Show SMILES Oc1ccccc1NC(=O)CCN1C(=S)S\C(=C/c2cccc(Br)c2)C1=O
Show InChI InChI=1S/C19H15BrN2O3S2/c20-13-5-3-4-12(10-13)11-16-18(25)22(19(26)27-16)9-8-17(24)21-14-6-1-2-7-15(14)23/h1-7,10-11,23H,8-9H2,(H,21,24)/b16-11-
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n/an/a 5.40E+3n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379306
PNG
(CHEMBL2011806)
Show SMILES Cc1[nH]c2ccccc2c1C1=CC(=NN=C(C1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H21N3/c1-18-26(22-14-8-9-15-23(22)27-18)21-16-24(19-10-4-2-5-11-19)28-29-25(17-21)20-12-6-3-7-13-20/h2-16,27H,17H2,1H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379303
PNG
(CHEMBL2011804)
Show SMILES Cc1ccccc1NC(=O)Nc1cccc(NC(=O)Nc2ccccc2C)c1
Show InChI InChI=1S/C22H22N4O2/c1-15-8-3-5-12-19(15)25-21(27)23-17-10-7-11-18(14-17)24-22(28)26-20-13-6-4-9-16(20)2/h3-14H,1-2H3,(H2,23,25,27)(H2,24,26,28)
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n/an/a 1.70E+4n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometr...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379302
PNG
(CHEMBL2011807)
Show SMILES Cc1ccccc1NC(=O)Nc1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H13N3O3/c1-10-5-2-3-8-13(10)16-14(18)15-11-6-4-7-12(9-11)17(19)20/h2-9H,1H3,(H2,15,16,18)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometr...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379301
PNG
(CHEMBL2011809)
Show SMILES Nc1cccc(NC(=O)Nc2cccc(N)c2)c1
Show InChI InChI=1S/C13H14N4O/c14-9-3-1-5-11(7-9)16-13(18)17-12-6-2-4-10(15)8-12/h1-8H,14-15H2,(H2,16,17,18)
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274221
PNG
(5-amino-3-(1-cyano-2-(5-(3-nitrophenyl)furan-2-yl)...)
Show SMILES Nc1[nH]nc(C(=Cc2ccc(o2)-c2cccc(c2)[N+]([O-])=O)C#N)c1C#N
Show InChI InChI=1S/C17H10N6O3/c18-8-11(16-14(9-19)17(20)22-21-16)7-13-4-5-15(26-13)10-2-1-3-12(6-10)23(24)25/h1-7H,(H3,20,21,22)
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n/an/a 3.80E+4n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379305
PNG
(CHEMBL2011808)
Show SMILES Cc1ccccc1NC(=O)Nc1cccc(N)c1
Show InChI InChI=1S/C14H15N3O/c1-10-5-2-3-8-13(10)17-14(18)16-12-7-4-6-11(15)9-12/h2-9H,15H2,1H3,(H2,16,17,18)
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometr...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379304
PNG
(CHEMBL2011805)
Show SMILES O=C(Nc1ccc(cc1)-c1nc2ccccc2[nH]1)c1cc2ccccc2o1
Show InChI InChI=1S/C22H15N3O2/c26-22(20-13-15-5-1-4-8-19(15)27-20)23-16-11-9-14(10-12-16)21-24-17-6-2-3-7-18(17)25-21/h1-13H,(H,23,26)(H,24,25)
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n/an/a 4.20E+4n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM82820
PNG
(1,3-bis(3-nitrophenyl)urea | MLS000719904 | N,N...)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)Nc2cccc(c2)[N+]([O-])=O)c1
Show InChI InChI=1S/C13H10N4O5/c18-13(14-9-3-1-5-11(7-9)16(19)20)15-10-4-2-6-12(8-10)17(21)22/h1-8H,(H2,14,15,18)
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n/an/a 5.20E+4n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379303
PNG
(CHEMBL2011804)
Show SMILES Cc1ccccc1NC(=O)Nc1cccc(NC(=O)Nc2ccccc2C)c1
Show InChI InChI=1S/C22H22N4O2/c1-15-8-3-5-12-19(15)25-21(27)23-17-10-7-11-18(14-17)24-22(28)26-20-13-6-4-9-16(20)2/h3-14H,1-2H3,(H2,23,25,27)(H2,24,26,28)
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n/an/a 6.50E+4n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274022
PNG
(3-(5-(3-bromobenzylidene)-4-oxo-2-thioxothiazolidi...)
Show SMILES Oc1cccc(NC(=O)CCN2C(=S)S\C(=C/c3cccc(Br)c3)C2=O)c1
Show InChI InChI=1S/C19H15BrN2O3S2/c20-13-4-1-3-12(9-13)10-16-18(25)22(19(26)27-16)8-7-17(24)21-14-5-2-6-15(23)11-14/h1-6,9-11,23H,7-8H2,(H,21,24)/b16-10-
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n/an/a 9.00E+4n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274025
PNG
(4-(5-(3-bromobenzylidene)-4-oxo-2-thioxothiazolidi...)
Show SMILES Oc1cccc(NC(=O)CCCN2C(=S)S\C(=C/c3cccc(Br)c3)C2=O)c1
Show InChI InChI=1S/C20H17BrN2O3S2/c21-14-5-1-4-13(10-14)11-17-19(26)23(20(27)28-17)9-3-8-18(25)22-15-6-2-7-16(24)12-15/h1-2,4-7,10-12,24H,3,8-9H2,(H,22,25)/b17-11-
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n/an/a 1.50E+5n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274781
PNG
(3-(5-(2-methoxybenzylidene)-4-oxo-2-thioxothiazoli...)
Show SMILES COc1ccccc1\C=C1/SC(=S)N(CCC(=O)Nc2cccc(O)c2)C1=O
Show InChI InChI=1S/C20H18N2O4S2/c1-26-16-8-3-2-5-13(16)11-17-19(25)22(20(27)28-17)10-9-18(24)21-14-6-4-7-15(23)12-14/h2-8,11-12,23H,9-10H2,1H3,(H,21,24)/b17-11-
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n/an/a 2.00E+5n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274184
PNG
(2-(3-(5-(3-bromobenzylidene)-4-oxo-2-thioxothiazol...)
Show SMILES OC(=O)c1ccccc1NC(=O)CCN1C(=S)S\C(=C/c2cccc(Br)c2)C1=O
Show InChI InChI=1S/C20H15BrN2O4S2/c21-13-5-3-4-12(10-13)11-16-18(25)23(20(28)29-16)9-8-17(24)22-15-7-2-1-6-14(15)19(26)27/h1-7,10-11H,8-9H2,(H,22,24)(H,26,27)/b16-11-
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n/an/a 2.00E+5n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274220
PNG
(5-amino-3-(1-cyano-2-(5-(2-nitrophenyl)furan-2-yl)...)
Show SMILES Nc1c(C#N)c(nn1-c1ccccc1)C(=C\c1ccc(o1)-c1ccccc1[N+]([O-])=O)\C#N
Show InChI InChI=1S/C23H14N6O3/c24-13-15(22-19(14-25)23(26)28(27-22)16-6-2-1-3-7-16)12-17-10-11-21(32-17)18-8-4-5-9-20(18)29(30)31/h1-12H,26H2/b15-12+
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n/an/a 3.00E+5n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274023
PNG
(3-(5-(3-bromobenzylidene)-4-oxo-2-thioxothiazolidi...)
Show SMILES Oc1ccc(NC(=O)CCN2C(=S)S\C(=C/c3cccc(Br)c3)C2=O)cc1
Show InChI InChI=1S/C19H15BrN2O3S2/c20-13-3-1-2-12(10-13)11-16-18(25)22(19(26)27-16)9-8-17(24)21-14-4-6-15(23)7-5-14/h1-7,10-11,23H,8-9H2,(H,21,24)/b16-11-
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n/an/a 3.00E+5n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274222
PNG
(5-amino-3-(2-(5-(3-chlorophenyl)furan-2-yl)-1-cyan...)
Show SMILES Nc1c(C#N)c(nn1-c1ccccc1)C(=C\c1ccc(o1)-c1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C23H14ClN5O/c24-17-6-4-5-15(11-17)21-10-9-19(30-21)12-16(13-25)22-20(14-26)23(27)29(28-22)18-7-2-1-3-8-18/h1-12H,27H2/b16-12+
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n/an/a 5.00E+5n/an/an/an/an/an/a



Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50274780
PNG
(4-(5-(3-bromobenzylidene)-4-oxo-2-thioxothiazolidi...)
Show SMILES Oc1ccccc1NC(=O)CCCN1C(=S)S\C(=C/c2cccc(Br)c2)C1=O
Show InChI InChI=1S/C20H17BrN2O3S2/c21-14-6-3-5-13(11-14)12-17-19(26)23(20(27)28-17)10-4-9-18(25)22-15-7-1-2-8-16(15)24/h1-3,5-8,11-12,24H,4,9-10H2,(H,22,25)/b17-12-
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Istituto di Genetica Molecolare

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity in human recombinant DDX3 expressed in Escherichia coli by luciferase-based luminescence assay in presence of ATP


J Med Chem 51: 6635-8 (2008)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379304
PNG
(CHEMBL2011805)
Show SMILES O=C(Nc1ccc(cc1)-c1nc2ccccc2[nH]1)c1cc2ccccc2o1
Show InChI InChI=1S/C22H15N3O2/c26-22(20-13-15-5-1-4-8-19(15)27-20)23-16-11-9-14(10-12-16)21-24-17-6-2-3-7-18(17)25-21/h1-13H,(H,23,26)(H,24,25)
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometr...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379301
PNG
(CHEMBL2011809)
Show SMILES Nc1cccc(NC(=O)Nc2cccc(N)c2)c1
Show InChI InChI=1S/C13H14N4O/c14-9-3-1-5-11(7-9)16-13(18)17-12-6-2-4-10(15)8-12/h1-8H,14-15H2,(H2,16,17,18)
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometr...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM50379306
PNG
(CHEMBL2011806)
Show SMILES Cc1[nH]c2ccccc2c1C1=CC(=NN=C(C1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H21N3/c1-18-26(22-14-8-9-15-23(22)27-18)21-16-24(19-10-4-2-5-11-19)28-29-25(17-21)20-12-6-3-7-13-20/h2-16,27H,17H2,1H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometr...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DDX3X


(Homo sapiens)
BDBM82820
PNG
(1,3-bis(3-nitrophenyl)urea | MLS000719904 | N,N...)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)Nc2cccc(c2)[N+]([O-])=O)c1
Show InChI InChI=1S/C13H10N4O5/c18-13(14-9-3-1-5-11(7-9)16(19)20)15-10-4-2-6-12(8-10)17(21)22/h1-8H,(H2,14,15,18)
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Siena

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometr...


Bioorg Med Chem Lett 22: 2094-8 (2012)

More data for this
Ligand-Target Pair