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Compile Data Set for Download or QSAR

Found 13 hits Enz. Inhib. hit(s) with Target = 'ATP-dependent RNA helicase DHX29'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50235738
PNG
(HIPPURISTANOL | Hippuristanol)
Show SMILES C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C
Show InChI InChI=1/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


Bioorg Med Chem 25: 2200-2209 (2017)


Article DOI: 10.1016/j.bmc.2017.02.035
BindingDB Entry DOI: 10.7270/Q2902613
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50239861
PNG
(CHEMBL4092701)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1
Show InChI InChI=1S/C23H20N4O4S/c24-19-17(12-16-9-10-18(31-16)14-7-4-8-15(11-14)22(29)30)20(28)25-23-27(19)26-21(32-23)13-5-2-1-3-6-13/h4,7-13,24H,1-3,5-6H2,(H,29,30)/b17-12-,24-19?
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n/an/a 5.80E+4n/an/an/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


J Med Chem 60: 5759-5771 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00461
BindingDB Entry DOI: 10.7270/Q2MC925G
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50239866
PNG
(CHEMBL4065018)
Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C27H23N3O3/c31-26-15-25-22(17-29(26)16-20-8-3-1-4-9-20)18-30(27(32)28-25)23-12-7-13-24(14-23)33-19-21-10-5-2-6-11-21/h1-15,17H,16,18-19H2,(H,28,32)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


J Med Chem 60: 5759-5771 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00461
BindingDB Entry DOI: 10.7270/Q2MC925G
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50239869
PNG
(CHEMBL4084949)
Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1
Show InChI InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


J Med Chem 60: 5759-5771 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00461
BindingDB Entry DOI: 10.7270/Q2MC925G
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50283445
PNG
(CHEMBL4175313)
Show SMILES FC(F)(F)c1cccc(c1)-c1cc(cn(-c2ccccc2)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1
Show InChI InChI=1S/C35H25BrClF3N4O3/c36-26-11-14-30(41-19-26)34(47)43-16-15-42(21-31(43)22-9-12-27(37)13-10-22)32(45)24-18-29(23-5-4-6-25(17-23)35(38,39)40)33(46)44(20-24)28-7-2-1-3-8-28/h1-14,17-20,31H,15-16,21H2/t31-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal full length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


ACS Med Chem Lett 8: 1077-1082 (2017)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50265561
PNG
(CHEMBL4073833)
Show SMILES Cc1c(cnn1-c1cccc(c1)C#N)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C29H23BrClN5O2/c1-19-26(17-33-36(19)25-4-2-3-20(15-25)16-32)29(38)34-13-14-35(28(37)22-5-9-23(30)10-6-22)27(18-34)21-7-11-24(31)12-8-21/h2-12,15,17,27H,13-14,18H2,1H3/t27-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cells us...


J Med Chem 60: 3335-3351 (2017)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50260424
PNG
(CHEMBL4091579)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21
Show InChI InChI=1/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-FLAG-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


Bioorg Med Chem 25: 4753-4767 (2017)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50260390
PNG
(CHEMBL4070683)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21
Show InChI InChI=1/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-FLAG-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


Bioorg Med Chem 25: 4753-4767 (2017)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM65493
PNG
(eIF4A3 inhibitor, 2)
Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12
Show InChI InChI=1/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal full length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


ACS Med Chem Lett 8: 1077-1082 (2017)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50283443
PNG
(CHEMBL4170030)
Show SMILES Cn1cc(cc(-c2cccc(c2)C#N)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1
Show InChI InChI=1S/C30H23BrClN5O3/c1-35-17-22(14-25(29(35)39)21-4-2-3-19(13-21)15-33)28(38)36-11-12-37(30(40)26-10-7-23(31)16-34-26)27(18-36)20-5-8-24(32)9-6-20/h2-10,13-14,16-17,27H,11-12,18H2,1H3/t27-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal full length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


ACS Med Chem Lett 8: 1077-1082 (2017)

More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50235737
PNG
(CHEMBL4070102)
Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O
Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


Bioorg Med Chem 25: 2200-2209 (2017)


Article DOI: 10.1016/j.bmc.2017.02.035
BindingDB Entry DOI: 10.7270/Q2902613
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM65493
PNG
(eIF4A3 inhibitor, 2)
Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12
Show InChI InChI=1/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



BC Cancer Agency



Assay Description
Inhibitory activity was assessed under the following conditions: 350 uM ATP/1.5 ug mL−1 RNA indicated by black; 35 uM ATP/1.5 ug mL−1 RNA...


ACS Chem Biol 12: 1760-1768 (2017)


Article DOI: 10.1021/acschembio.7b00041
BindingDB Entry DOI: 10.7270/Q2T151TG
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))
BDBM50239863
PNG
(CHEMBL4087449)
Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F
Show InChI InChI=1/C29H25FN4O3/c1-18-12-20-9-10-25(28-22(30)8-5-11-31-28)37-26(20)14-24(18)34-17-21-16-33(15-19-6-3-2-4-7-19)27(35)13-23(21)32-29(34)36/h2-8,11-14,16,25H,9-10,15,17H2,1H3,(H,32,36)
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Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...


J Med Chem 60: 5759-5771 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00461
BindingDB Entry DOI: 10.7270/Q2MC925G
More data for this
Ligand-Target Pair