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Compile Data Set for Download or QSAR

Found 163 hits Enz. Inhib. hit(s) with Target = 'Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443648
PNG
(CHEMBL3093076)
Show SMILES Fc1ncccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1
Show InChI InChI=1S/C18H15FN6O/c19-15-12(4-2-7-20-15)14(10-5-6-10)23-18-25-24-17(26-18)13-9-22-16-11(13)3-1-8-21-16/h1-4,7-10,14H,5-6H2,(H,21,22)(H,23,25)/t14-/m1/s1
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n/an/a 0.690n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443649
PNG
(CHEMBL3093075)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1
Show InChI InChI=1S/C19H16FN5O/c20-15-6-2-1-4-13(15)16(11-7-8-11)23-19-25-24-18(26-19)14-10-22-17-12(14)5-3-9-21-17/h1-6,9-11,16H,7-8H2,(H,21,22)(H,23,25)/t16-/m1/s1
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n/an/a 0.850n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380229
PNG
(CHEMBL2016996)
Show SMILES O=C1NCC2(CCCCC2)c2sc(cc12)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C17H17N5OS/c23-16-10-6-11(12-13-15(21-8-19-12)22-9-20-13)24-14(10)17(7-18-16)4-2-1-3-5-17/h6,8-9H,1-5,7H2,(H,18,23)(H,19,20,21,22)
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TBA

Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443650
PNG
(CHEMBL3093074)
Show SMILES C1CC1[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C19H17N5O/c1-2-5-12(6-3-1)16(13-8-9-13)22-19-24-23-18(25-19)15-11-21-17-14(15)7-4-10-20-17/h1-7,10-11,13,16H,8-9H2,(H,20,21)(H,22,24)/t16-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380230
PNG
(CHEMBL2016862)
Show SMILES O=C1NCC2(CCCCC2)c2sc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C15H17N3OS/c19-14-11-6-12(10-7-17-18-8-10)20-13(11)15(9-16-14)4-2-1-3-5-15/h6-8H,1-5,9H2,(H,16,19)(H,17,18)
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TBA

Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380236
PNG
(CHEMBL2016856)
Show SMILES O=C1CCC2(CCCCC2)c2sc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C16H18N2OS/c19-13-4-7-16(5-2-1-3-6-16)15-12(13)8-14(20-15)11-9-17-18-10-11/h8-10H,1-7H2,(H,17,18)
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TBA

Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443644
PNG
(CHEMBL3093080)
Show SMILES Fc1cnc2[nH]cc(-c3nnc(N[C@H](C4CC4)c4cccnc4F)o3)c2c1
Show InChI InChI=1S/C18H14F2N6O/c19-10-6-12-13(8-23-16(12)22-7-10)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-5-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443646
PNG
(CHEMBL3093078)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncncc12)C1CC1
Show InChI InChI=1S/C18H15FN6O/c19-14-4-2-1-3-11(14)15(10-5-6-10)23-18-25-24-17(26-18)13-8-21-16-12(13)7-20-9-22-16/h1-4,7-10,15H,5-6H2,(H,23,25)(H,20,21,22)/t15-/m1/s1
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n/an/a 1.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443647
PNG
(CHEMBL3093077)
Show SMILES Fc1cnccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1
Show InChI InChI=1S/C18H15FN6O/c19-14-9-20-7-5-12(14)15(10-3-4-10)23-18-25-24-17(26-18)13-8-22-16-11(13)2-1-6-21-16/h1-2,5-10,15H,3-4H2,(H,21,22)(H,23,25)/t15-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443651
PNG
(CHEMBL3093073)
Show SMILES CC(C)[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C19H19N5O/c1-12(2)16(13-7-4-3-5-8-13)22-19-24-23-18(25-19)15-11-21-17-14(15)9-6-10-20-17/h3-12,16H,1-2H3,(H,20,21)(H,22,24)/t16-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 3.80n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443645
PNG
(CHEMBL3093079)
Show SMILES Fc1ccc2c(c[nH]c2n1)-c1nnc(N[C@H](C2CC2)c2cccnc2F)o1
Show InChI InChI=1S/C18H14F2N6O/c19-13-6-5-10-12(8-22-16(10)23-13)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-7-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443652
PNG
(CHEMBL3093072)
Show SMILES CC[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C18H17N5O/c1-2-15(12-7-4-3-5-8-12)21-18-23-22-17(24-18)14-11-20-16-13(14)9-6-10-19-16/h3-11,15H,2H2,1H3,(H,19,20)(H,21,23)/t15-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016165
PNG
(CHEMBL3261516)
Show SMILES Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5OS/c1-7-2-3-8(9(16)6-7)11-12(13(17)22)23-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 6n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 6.80n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380225
PNG
(CHEMBL2017000)
Show SMILES Nc1cc(ccn1)-c1cc2c(s1)C1(CCCCC1)CNC2=O
Show InChI InChI=1S/C17H19N3OS/c18-14-8-11(4-7-19-14)13-9-12-15(22-13)17(10-20-16(12)21)5-2-1-3-6-17/h4,7-9H,1-3,5-6,10H2,(H2,18,19)(H,20,21)
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n/an/a 8n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380234
PNG
(CHEMBL2016858)
Show SMILES O=C1CCC2(CCCCC2)c2sc(cc12)-c1ccncc1
Show InChI InChI=1S/C18H19NOS/c20-15-4-9-18(7-2-1-3-8-18)17-14(15)12-16(21-17)13-5-10-19-11-6-13/h5-6,10-12H,1-4,7-9H2
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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 1 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443642
PNG
(CHEMBL3093056)
Show SMILES Fc1cc2cc(ccc2cn1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C18H13FN4O/c19-16-9-15-8-13(6-7-14(15)11-20-16)17-22-23-18(24-17)21-10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,21,23)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443660
PNG
(CHEMBL3093064)
Show SMILES Fc1cccc(CNc2nnc(o2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C16H12FN5O/c17-11-4-1-3-10(7-11)8-20-16-22-21-15(23-16)13-9-19-14-12(13)5-2-6-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 2 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443665
PNG
(CHEMBL3093059)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C16H14N6O/c17-14-12-8-11(6-7-13(12)19-20-14)15-21-22-16(23-15)18-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,18,22)(H3,17,19,20)
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n/an/a 11n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 13n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 6 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016148
PNG
(CHEMBL3261500)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C15H9Cl2N3OS/c16-9-1-2-10(11(17)7-9)12-13(14(18)21)22-15(20-12)8-3-5-19-6-4-8/h1-7H,(H2,18,21)
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n/an/a 14n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 14n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.667 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443643
PNG
(CHEMBL3093055)
Show SMILES C(Nc1nnc(o1)-c1ccc2cnccc2c1)c1ccccc1
Show InChI InChI=1S/C18H14N4O/c1-2-4-13(5-3-1)11-20-18-22-21-17(23-18)15-6-7-16-12-19-9-8-14(16)10-15/h1-10,12H,11H2,(H,20,22)
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 17n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.012 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 18n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 9 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016160
PNG
(CHEMBL3261511)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C14H10FN5OS/c15-8-4-2-1-3-7(8)10-11(12(16)21)22-13(20-10)9-5-6-18-14(17)19-9/h1-6H,(H2,16,21)(H2,17,18,19)
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n/an/a 18n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016161
PNG
(CHEMBL3261512)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1C(F)(F)F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H10F3N5OS/c16-15(17,18)8-4-2-1-3-7(8)10-11(12(19)24)25-13(23-10)9-5-6-21-14(20)22-9/h1-6H,(H2,19,24)(H2,20,21,22)
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n/an/a 18n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443666
PNG
(CHEMBL3093058)
Show SMILES C(Nc1nnc(o1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C16H13N5O/c1-2-4-11(5-3-1)9-17-16-21-20-15(22-16)12-6-7-14-13(8-12)10-18-19-14/h1-8,10H,9H2,(H,17,21)(H,18,19)
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n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 20n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.333 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016167
PNG
(CHEMBL3261518)
Show SMILES CN(C)c1nc(sc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C10H12N6OS/c1-16(2)8-6(7(11)17)18-9(15-8)5-3-4-13-10(12)14-5/h3-4H,1-2H3,(H2,11,17)(H2,12,13,14)
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n/an/a 21n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 23n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 18 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443662
PNG
(CHEMBL3093062)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C16H13N5O/c1-2-5-11(6-3-1)9-19-16-21-20-15(22-16)13-10-18-14-12(13)7-4-8-17-14/h1-8,10H,9H2,(H,17,18)(H,19,21)
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443659
PNG
(CHEMBL3093065)
Show SMILES Fc1ccc(CNc2nnc(o2)-c2c[nH]c3ncccc23)cc1
Show InChI InChI=1S/C16H12FN5O/c17-11-5-3-10(4-6-11)8-20-16-22-21-15(23-16)13-9-19-14-12(13)2-1-7-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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n/an/a 25n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 29n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.111 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443654
PNG
(CHEMBL3093070)
Show SMILES C[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C17H15N5O/c1-11(12-6-3-2-4-7-12)20-17-22-21-16(23-17)14-10-19-15-13(14)8-5-9-18-15/h2-11H,1H3,(H,18,19)(H,20,22)/t11-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016162
PNG
(CHEMBL3261513)
Show SMILES NC(=O)c1sc(nc1-c1cc(F)ccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9F2N5OS/c15-6-1-2-8(16)7(5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 33n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380235
PNG
(CHEMBL2016857)
Show SMILES Nc1cc(ccn1)-c1cc2c(s1)C1(CCCCC1)CCC2=O
Show InChI InChI=1S/C18H20N2OS/c19-16-10-12(5-9-20-16)15-11-13-14(21)4-8-18(17(13)22-15)6-2-1-3-7-18/h5,9-11H,1-4,6-8H2,(H2,19,20)
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n/an/a 33n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380233
PNG
(CHEMBL2016859)
Show SMILES O=C1NCCc2sc(cc12)-c1ccncc1
Show InChI InChI=1S/C12H10N2OS/c15-12-9-7-11(8-1-4-13-5-2-8)16-10(9)3-6-14-12/h1-2,4-5,7H,3,6H2,(H,14,15)
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n/an/a 33n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 35n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.222 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443655
PNG
(CHEMBL3093069)
Show SMILES C[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C17H15N5O/c1-11(12-6-3-2-4-7-12)20-17-22-21-16(23-17)14-10-19-15-13(14)8-5-9-18-15/h2-11H,1H3,(H,18,19)(H,20,22)/t11-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50443661
PNG
(CHEMBL3093063)
Show SMILES Fc1ccccc1CNc1nnc(o1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H12FN5O/c17-13-6-2-1-4-10(13)8-20-16-22-21-15(23-16)12-9-19-14-11(12)5-3-7-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.025 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380226
PNG
(CHEMBL2016999)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cc2c(s1)C1(CCCCC1)CNC2=O
Show InChI InChI=1S/C19H21N3O2S/c1-12(23)22-16-9-13(5-8-20-16)15-10-14-17(25-15)19(11-21-18(14)24)6-3-2-4-7-19/h5,8-10H,2-4,6-7,11H2,1H3,(H,21,24)(H,20,22,23)
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n/an/a 41n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016153
PNG
(CHEMBL3261505)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccnc(N)n1
Show InChI InChI=1S/C10H10N4O3S/c1-2-17-9(16)6-7(15)14-8(18-6)5-3-4-12-10(11)13-5/h3-4,15H,2H2,1H3,(H2,11,12,13)
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n/an/a 42n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 44n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 27 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016164
PNG
(CHEMBL3261515)
Show SMILES NC(=O)c1sc(nc1-c1cc(Cl)cc(Cl)c1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-7-3-6(4-8(16)5-7)10-11(12(17)22)23-13(21-10)9-1-2-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 62n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Citation and Details
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 63n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.037 uM of ATP as substrate by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
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