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Found 1444 hits Enz. Inhib. hit(s) with Target = 'Alkaline phosphatase, tissue-nonspecific isozyme'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253982
PNG
(CHEMBL461194 | N-(2-hydroxyethyl)-3-(2,3,4-trichlo...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)c(Cl)c1Cl
Show InChI InChI=1S/C12H10Cl3N3O2/c13-7-2-1-6(10(14)11(7)15)8-5-9(18-17-8)12(20)16-3-4-19/h1-2,5,19H,3-4H2,(H,16,20)(H,17,18)
KEGG

UniProtKB/SwissProt

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n/an/a 4.22n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253982
PNG
(CHEMBL461194 | N-(2-hydroxyethyl)-3-(2,3,4-trichlo...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)c(Cl)c1Cl
Show InChI InChI=1S/C12H10Cl3N3O2/c13-7-2-1-6(10(14)11(7)15)8-5-9(18-17-8)12(20)16-3-4-19/h1-2,5,19H,3-4H2,(H,16,20)(H,17,18)
KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253982
PNG
(CHEMBL461194 | N-(2-hydroxyethyl)-3-(2,3,4-trichlo...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)c(Cl)c1Cl
Show InChI InChI=1S/C12H10Cl3N3O2/c13-7-2-1-6(10(14)11(7)15)8-5-9(18-17-8)12(20)16-3-4-19/h1-2,5,19H,3-4H2,(H,16,20)(H,17,18)
KEGG

UniProtKB/SwissProt

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PCBioAssay
n/an/a 7.44n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254415
PNG
(3-(2,4-dichlorophenyl)-N-(3-hydroxypropyl)-1H-pyra...)
Show SMILES OCCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O2/c14-8-2-3-9(10(15)6-8)11-7-12(18-17-11)13(20)16-4-1-5-19/h2-3,6-7,19H,1,4-5H2,(H,16,20)(H,17,18)
KEGG

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Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254415
PNG
(3-(2,4-dichlorophenyl)-N-(3-hydroxypropyl)-1H-pyra...)
Show SMILES OCCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O2/c14-8-2-3-9(10(15)6-8)11-7-12(18-17-11)13(20)16-4-1-5-19/h2-3,6-7,19H,1,4-5H2,(H,16,20)(H,17,18)
KEGG

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n/an/a 31.3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254416
PNG
(3-(2,4-dichlorophenyl)-N-(4-hydroxybutyl)-1H-pyraz...)
Show SMILES OCCCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O2/c15-9-3-4-10(11(16)7-9)12-8-13(19-18-12)14(21)17-5-1-2-6-20/h3-4,7-8,20H,1-2,5-6H2,(H,17,21)(H,18,19)
KEGG

UniProtKB/SwissProt

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UniChem

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PCBioAssay
n/an/a 34.5n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254026
PNG
(3-(2,4-difluorophenyl)-N-(2-hydroxyethyl)-1H-pyraz...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1ccc(F)cc1F
Show InChI InChI=1S/C12H11F2N3O2/c13-7-1-2-8(9(14)5-7)10-6-11(17-16-10)12(19)15-3-4-18/h1-2,5-6,18H,3-4H2,(H,15,19)(H,16,17)
KEGG

UniProtKB/SwissProt

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UniChem

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n/an/a 35n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254026
PNG
(3-(2,4-difluorophenyl)-N-(2-hydroxyethyl)-1H-pyraz...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1ccc(F)cc1F
Show InChI InChI=1S/C12H11F2N3O2/c13-7-1-2-8(9(14)5-7)10-6-11(17-16-10)12(19)15-3-4-18/h1-2,5-6,18H,3-4H2,(H,15,19)(H,16,17)
KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254416
PNG
(3-(2,4-dichlorophenyl)-N-(4-hydroxybutyl)-1H-pyraz...)
Show SMILES OCCCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O2/c15-9-3-4-10(11(16)7-9)12-8-13(19-18-12)14(21)17-5-1-2-6-20/h3-4,7-8,20H,1-2,5-6H2,(H,17,21)(H,18,19)
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254414
PNG
(3-(2,4-dichlorophenyl)-1H-pyrazole-5-carbohydrazid...)
Show SMILES NNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C10H8Cl2N4O/c11-5-1-2-6(7(12)3-5)8-4-9(16-15-8)10(17)14-13/h1-4H,13H2,(H,14,17)(H,15,16)
KEGG

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Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254319
PNG
(3-(2,4-dichlorophenyl)-N-(2-hydroxyethyl)-1H-pyraz...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C12H11Cl2N3O2/c13-7-1-2-8(9(14)5-7)10-6-11(17-16-10)12(19)15-3-4-18/h1-2,5-6,18H,3-4H2,(H,15,19)(H,16,17)
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254319
PNG
(3-(2,4-dichlorophenyl)-N-(2-hydroxyethyl)-1H-pyraz...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C12H11Cl2N3O2/c13-7-1-2-8(9(14)5-7)10-6-11(17-16-10)12(19)15-3-4-18/h1-2,5-6,18H,3-4H2,(H,15,19)(H,16,17)
KEGG

UniProtKB/SwissProt

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PCBioAssay
n/an/a 44.4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254417
PNG
(3-(2,4-dichlorophenyl)-N-(2-methoxyethyl)-1H-pyraz...)
Show SMILES COCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O2/c1-20-5-4-16-13(19)12-7-11(17-18-12)9-3-2-8(14)6-10(9)15/h2-3,6-7H,4-5H2,1H3,(H,16,19)(H,17,18)
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254417
PNG
(3-(2,4-dichlorophenyl)-N-(2-methoxyethyl)-1H-pyraz...)
Show SMILES COCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O2/c1-20-5-4-16-13(19)12-7-11(17-18-12)9-3-2-8(14)6-10(9)15/h2-3,6-7H,4-5H2,1H3,(H,16,19)(H,17,18)
KEGG

UniProtKB/SwissProt

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PCBioAssay
n/an/a 46.4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253955
PNG
(3-(2,4-dichlorophenyl)-N,N-bis(2-hydroxyethyl)-1H-...)
Show SMILES OCCN(CCO)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O3/c15-9-1-2-10(11(16)7-9)12-8-13(18-17-12)14(22)19(3-5-20)4-6-21/h1-2,7-8,20-21H,3-6H2,(H,17,18)
KEGG

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n/an/a 46.8n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253955
PNG
(3-(2,4-dichlorophenyl)-N,N-bis(2-hydroxyethyl)-1H-...)
Show SMILES OCCN(CCO)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O3/c15-9-1-2-10(11(16)7-9)12-8-13(18-17-12)14(22)19(3-5-20)4-6-21/h1-2,7-8,20-21H,3-6H2,(H,17,18)
KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254320
PNG
(3-(2,4-dichlorophenyl)-N-isopropyl-1H-pyrazole-5-c...)
Show SMILES CC(C)NC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O/c1-7(2)16-13(19)12-6-11(17-18-12)9-4-3-8(14)5-10(9)15/h3-7H,1-2H3,(H,16,19)(H,17,18)
KEGG

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Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254320
PNG
(3-(2,4-dichlorophenyl)-N-isopropyl-1H-pyrazole-5-c...)
Show SMILES CC(C)NC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O/c1-7(2)16-13(19)12-6-11(17-18-12)9-4-3-8(14)5-10(9)15/h3-7H,1-2H3,(H,16,19)(H,17,18)
KEGG

UniProtKB/SwissProt

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n/an/a 51.1n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253959
PNG
(3-(2,4-dichloro-5-fluorophenyl)-N-(3-hydroxypropyl...)
Show SMILES OCCCNC(=O)c1cc(n[nH]1)-c1cc(F)c(Cl)cc1Cl
Show InChI InChI=1S/C13H12Cl2FN3O2/c14-8-5-9(15)10(16)4-7(8)11-6-12(19-18-11)13(21)17-2-1-3-20/h4-6,20H,1-3H2,(H,17,21)(H,18,19)
KEGG

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n/an/a 55.8n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253959
PNG
(3-(2,4-dichloro-5-fluorophenyl)-N-(3-hydroxypropyl...)
Show SMILES OCCCNC(=O)c1cc(n[nH]1)-c1cc(F)c(Cl)cc1Cl
Show InChI InChI=1S/C13H12Cl2FN3O2/c14-8-5-9(15)10(16)4-7(8)11-6-12(19-18-11)13(21)17-2-1-3-20/h4-6,20H,1-3H2,(H,17,21)(H,18,19)
KEGG

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UniChem

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Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254414
PNG
(3-(2,4-dichlorophenyl)-1H-pyrazole-5-carbohydrazid...)
Show SMILES NNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C10H8Cl2N4O/c11-5-1-2-6(7(12)3-5)8-4-9(16-15-8)10(17)14-13/h1-4H,13H2,(H,14,17)(H,15,16)
KEGG

UniProtKB/SwissProt

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Purchase

CHEMBL
PC cid
PC sid
UniChem

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AffyNet 
PCBioAssay
n/an/a 68.4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253956
PNG
(3-(2,4-dichlorophenyl)-N-isobutyl-1H-pyrazole-5-ca...)
Show SMILES CC(C)CNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c1-8(2)7-17-14(20)13-6-12(18-19-13)10-4-3-9(15)5-11(10)16/h3-6,8H,7H2,1-2H3,(H,17,20)(H,18,19)
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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AffyNet 
PCBioAssay
n/an/a 81.5n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253956
PNG
(3-(2,4-dichlorophenyl)-N-isobutyl-1H-pyrazole-5-ca...)
Show SMILES CC(C)CNC(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c1-8(2)7-17-14(20)13-6-12(18-19-13)10-4-3-9(15)5-11(10)16/h3-6,8H,7H2,1-2H3,(H,17,20)(H,18,19)
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n/an/a 82n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299534
PNG
(5-Bromo-2-methoxy-N-(quinolin-3-yl)benzenesulfonam...)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C16H13BrN2O3S/c1-22-15-7-6-12(17)9-16(15)23(20,21)19-13-8-11-4-2-3-5-14(11)18-10-13/h2-10,19H,1H3
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n/an/a 91n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254411
PNG
(3-(2,4-dichloro-5-fluorophenyl)-N-(2-hydroxyethyl)...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1cc(F)c(Cl)cc1Cl
Show InChI InChI=1S/C12H10Cl2FN3O2/c13-7-4-8(14)9(15)3-6(7)10-5-11(18-17-10)12(20)16-1-2-19/h3-5,19H,1-2H2,(H,16,20)(H,17,18)
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n/an/a 100n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254411
PNG
(3-(2,4-dichloro-5-fluorophenyl)-N-(2-hydroxyethyl)...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1cc(F)c(Cl)cc1Cl
Show InChI InChI=1S/C12H10Cl2FN3O2/c13-7-4-8(14)9(15)3-6(7)10-5-11(18-17-10)12(20)16-1-2-19/h3-5,19H,1-2H2,(H,16,20)(H,17,18)
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n/an/a 100n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222186
PNG
(6-(Dimethylamino)-3-(4'-nitrophenyl)-2,3-dihyd...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1/C19H17N3O4S/c1-21(2)16-11-10-15-18-14(16)4-3-5-17(18)27(25,26)20-19(15)12-6-8-13(9-7-12)22(23)24/h3-11,19-20H,1-2H3
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n/an/a 110n/an/an/an/an/an/a



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)

More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50068225
PNG
(CHEMBL3403324)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N2O4S2/c1-11-2-6-14(7-3-11)22(19,20)16-10-12-4-8-13(9-5-12)21(15,17)18/h2-9,16H,10H2,1H3,(H2,15,17,18)
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n/an/a 115n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254321
PNG
(3-(2,4-dichlorophenyl)-N,N-dimethyl-1H-pyrazole-5-...)
Show SMILES CN(C)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C12H11Cl2N3O/c1-17(2)12(18)11-6-10(15-16-11)8-4-3-7(13)5-9(8)14/h3-6H,1-2H3,(H,15,16)
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n/an/a 119n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254321
PNG
(3-(2,4-dichlorophenyl)-N,N-dimethyl-1H-pyrazole-5-...)
Show SMILES CN(C)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C12H11Cl2N3O/c1-17(2)12(18)11-6-10(15-16-11)8-4-3-7(13)5-9(8)14/h3-6H,1-2H3,(H,15,16)
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n/an/a 119n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299534
PNG
(5-Bromo-2-methoxy-N-(quinolin-3-yl)benzenesulfonam...)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C16H13BrN2O3S/c1-22-15-7-6-12(17)9-16(15)23(20,21)19-13-8-11-4-2-3-5-14(11)18-10-13/h2-10,19H,1H3
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n/an/a 120n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM45998
PNG
(3-(2,4-difluorophenyl)-1H-pyrazole-5-carbohydrazid...)
Show SMILES NNC(=O)c1cc(n[nH]1)-c1ccc(F)cc1F
Show InChI InChI=1S/C10H8F2N4O/c11-5-1-2-6(7(12)3-5)8-4-9(16-15-8)10(17)14-13/h1-4H,13H2,(H,14,17)(H,15,16)
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n/an/a 120n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299523
PNG
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
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n/an/a 125n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM39626
PNG
(2-(3-benzyl-1H-1,2,4-triazol-5-yl)-3a,4,7,7a-tetra...)
Show SMILES Oc1c2CC=CCc2c(O)n1-c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1S/C17H16N4O2/c22-15-12-8-4-5-9-13(12)16(23)21(15)17-18-14(19-20-17)10-11-6-2-1-3-7-11/h1-7,22-23H,8-10H2,(H,18,19,20)
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n/an/a 126n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253960
PNG
(3-(2,4-dichloro-5-fluorophenyl)-N,N-bis(2-hydroxye...)
Show SMILES OCCN(CCO)C(=O)c1cc(n[nH]1)-c1cc(F)c(Cl)cc1Cl
Show InChI InChI=1S/C14H14Cl2FN3O3/c15-9-6-10(16)11(17)5-8(9)12-7-13(19-18-12)14(23)20(1-3-21)2-4-22/h5-7,21-22H,1-4H2,(H,18,19)
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n/an/a 127n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50253960
PNG
(3-(2,4-dichloro-5-fluorophenyl)-N,N-bis(2-hydroxye...)
Show SMILES OCCN(CCO)C(=O)c1cc(n[nH]1)-c1cc(F)c(Cl)cc1Cl
Show InChI InChI=1S/C14H14Cl2FN3O3/c15-9-6-10(16)11(17)5-8(9)12-7-13(19-18-12)14(23)20(1-3-21)2-4-22/h5-7,21-22H,1-4H2,(H,18,19)
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n/an/a 127n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254025
PNG
(CHEMBL461425 | N-(2-hydroxyethyl)-3-(2,4,5-trifluo...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1cc(F)c(F)cc1F
Show InChI InChI=1S/C12H10F3N3O2/c13-7-4-9(15)8(14)3-6(7)10-5-11(18-17-10)12(20)16-1-2-19/h3-5,19H,1-2H2,(H,16,20)(H,17,18)
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n/an/a 134n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50254025
PNG
(CHEMBL461425 | N-(2-hydroxyethyl)-3-(2,4,5-trifluo...)
Show SMILES OCCNC(=O)c1cc(n[nH]1)-c1cc(F)c(F)cc1F
Show InChI InChI=1S/C12H10F3N3O2/c13-7-4-9(15)8(14)3-6(7)10-5-11(18-17-10)12(20)16-1-2-19/h3-5,19H,1-2H2,(H,16,20)(H,17,18)
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n/an/a 134n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299534
PNG
(5-Bromo-2-methoxy-N-(quinolin-3-yl)benzenesulfonam...)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C16H13BrN2O3S/c1-22-15-7-6-12(17)9-16(15)23(20,21)19-13-8-11-4-2-3-5-14(11)18-10-13/h2-10,19H,1H3
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n/an/a 141n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299523
PNG
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
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n/an/a 143n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299523
PNG
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
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n/an/a 150n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50068229
PNG
(CHEMBL3403327)
Show SMILES NS(=O)(=O)c1cccc(NS(=O)(=O)c2ccc(F)cc2)c1
Show InChI InChI=1S/C12H11FN2O4S2/c13-9-4-6-11(7-5-9)21(18,19)15-10-2-1-3-12(8-10)20(14,16)17/h1-8,15H,(H2,14,16,17)
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n/an/a 150n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM39626
PNG
(2-(3-benzyl-1H-1,2,4-triazol-5-yl)-3a,4,7,7a-tetra...)
Show SMILES Oc1c2CC=CCc2c(O)n1-c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1S/C17H16N4O2/c22-15-12-8-4-5-9-13(12)16(23)21(15)17-18-14(19-20-17)10-11-6-2-1-3-7-11/h1-7,22-23H,8-10H2,(H,18,19,20)
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n/an/a 169n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM39626
PNG
(2-(3-benzyl-1H-1,2,4-triazol-5-yl)-3a,4,7,7a-tetra...)
Show SMILES Oc1c2CC=CCc2c(O)n1-c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1S/C17H16N4O2/c22-15-12-8-4-5-9-13(12)16(23)21(15)17-18-14(19-20-17)10-11-6-2-1-3-7-11/h1-7,22-23H,8-10H2,(H,18,19,20)
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n/an/a 172n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50428400
PNG
(CHEMBL182659 | [(4-Methylphenyl)Sulfonyl]Phenylami...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C13H13NO2S/c1-11-7-9-13(10-8-11)17(15,16)14-12-5-3-2-4-6-12/h2-10,14H,1H3
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n/an/a 180n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Citation and Details
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222179
PNG
(6-(Dimethylamino)-3-phenyl-2,3-dihydronaphtho[1,8-...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccccc1
Show InChI InChI=1/C19H18N2O2S/c1-21(2)16-12-11-15-18-14(16)9-6-10-17(18)24(22,23)20-19(15)13-7-4-3-5-8-13/h3-12,19-20H,1-2H3
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n/an/a 190n/an/an/an/an/an/a



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299523
PNG
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
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n/an/a 190n/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM45995
PNG
(3-(2,4-difluorophenyl)-1H-pyrazole-5-carboxylic ac...)
Show SMILES COC(=O)c1cc(n[nH]1)-c1ccc(F)cc1F
Show InChI InChI=1S/C11H8F2N2O2/c1-17-11(16)10-5-9(14-15-10)7-3-2-6(12)4-8(7)13/h2-5H,1H3,(H,14,15)
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n/an/a 192n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299523
PNG
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
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n/an/a 194n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222188
PNG
(6-(Dimethylamino)-3-(4'-hydroxy-3'-methoxy...)
Show SMILES COc1cc(ccc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1/C20H20N2O4S/c1-22(2)15-9-8-14-19-13(15)5-4-6-18(19)27(24,25)21-20(14)12-7-10-16(23)17(11-12)26-3/h4-11,20-21,23H,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
AffyNet 
PubMed
n/an/a 200n/an/an/an/an/an/a



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)

More data for this
Ligand-Target Pair
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