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Compile Data Set for Download or QSAR

Found 84 hits Enz. Inhib. hit(s) with Target = 'Alpha-mannosidase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-mannosidase


(Canavalia ensiformis)
BDBM50124579
PNG
(CHEMBL3621532)
Show SMILES OC[C@]12CCC(=O)N1C[C@H](O)[C@@H](O)[C@@H]2O
Show InChI InChI=1/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7+,8-,9-/s2
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n/an/a 56n/an/an/an/an/an/a



Savitribai Phule Pune University (formerly University of Pune)

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate


J Med Chem 58: 7820-32 (2015)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Canavalia ensiformis)
BDBM50124578
PNG
(CHEMBL3621533)
Show SMILES OC[C@@]12CCC(=O)N1C[C@H](O)[C@@H](O)[C@@H]2O
Show InChI InChI=1/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7+,8-,9+/s2
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n/an/a 75n/an/an/an/an/an/a



Savitribai Phule Pune University (formerly University of Pune)

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate


J Med Chem 58: 7820-32 (2015)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168995
PNG
((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O
Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
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n/an/a 400n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168988
PNG
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1
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n/an/a 700n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Canavalia ensiformis)
BDBM50124580
PNG
(CHEMBL3621530)
Show SMILES OC[C@@]12CCC(=O)N1C[C@@H](O)[C@@H](O)[C@@H]2O
Show InChI InChI=1/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7-,8+,9-/s2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Savitribai Phule Pune University (formerly University of Pune)

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate


J Med Chem 58: 7820-32 (2015)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168991
PNG
((2R,3S,4R,5R)-2-Hydroxymethyl-5-[((R)-2-hydroxy-1-...)
Show SMILES OCC(NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C14H22N2O4/c17-7-11(9-4-2-1-3-5-9)15-6-10-13(19)14(20)12(8-18)16-10/h1-5,10-20H,6-8H2/t10-,11?,12-,13-,14+/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168991
PNG
((2R,3S,4R,5R)-2-Hydroxymethyl-5-[((R)-2-hydroxy-1-...)
Show SMILES OCC(NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C14H22N2O4/c17-7-11(9-4-2-1-3-5-9)15-6-10-13(19)14(20)12(8-18)16-10/h1-5,10-20H,6-8H2/t10-,11?,12-,13-,14+/m1/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168999
PNG
((2R,3R,4R,5R)-5-(Benzylamino-methyl)-pyrrolidine-2...)
Show SMILES O[C@H]1N[C@H](CNCc2ccccc2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C12H18N2O3/c15-10-9(14-12(17)11(10)16)7-13-6-8-4-2-1-3-5-8/h1-5,9-17H,6-7H2/t9-,10-,11-,12-/m1/s1
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n/an/a 6.20E+3n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168996
PNG
((2R,3R,4S)-2-{[(R)-2-(3-Fluoro-benzyloxy)-1-phenyl...)
Show SMILES O[C@H]1CN[C@H](CNC(COCc2cccc(F)c2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H25FN2O3/c21-16-8-4-5-14(9-16)12-26-13-18(15-6-2-1-3-7-15)22-10-17-20(25)19(24)11-23-17/h1-9,17-20,22-25H,10-13H2/t17-,18?,19+,20-/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168998
PNG
((2R,3R,4S)-2-((R)-Indan-1-ylaminomethyl)-pyrrolidi...)
Show SMILES O[C@H]1CN[C@H](CNC2CCc3ccccc23)[C@H]1O
Show InChI InChI=1S/C14H20N2O2/c17-13-8-16-12(14(13)18)7-15-11-6-5-9-3-1-2-4-10(9)11/h1-4,11-18H,5-8H2/t11?,12-,13+,14-/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50163438
PNG
((2S,3S,4R,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...)
Show SMILES OC[C@@H]1NC[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6+/m0/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against alpha-mannosidase of jack bean


J Med Chem 48: 2036-44 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168996
PNG
((2R,3R,4S)-2-{[(R)-2-(3-Fluoro-benzyloxy)-1-phenyl...)
Show SMILES O[C@H]1CN[C@H](CNC(COCc2cccc(F)c2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H25FN2O3/c21-16-8-4-5-14(9-16)12-26-13-18(15-6-2-1-3-7-15)22-10-17-20(25)19(24)11-23-17/h1-9,17-20,22-25H,10-13H2/t17-,18?,19+,20-/m1/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168988
PNG
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1
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n/an/a 4.60E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Inhibition of alpha-Mannosidase isolated from almond


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168989
PNG
(4-Bromo-benzoic acid 2-[((2R,3R,4S)-3,4-dihydroxy-...)
Show SMILES O[C@H]1CN[C@H](CNC(COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H23BrN2O4/c21-15-8-6-14(7-9-15)20(26)27-12-17(13-4-2-1-3-5-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17?,18+,19-/m1/s1
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n/an/a 5.50E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50169000
PNG
((2R,3R,4S)-2-[((R)-2-Benzyloxy-1-phenyl-ethylamino...)
Show SMILES O[C@H]1CN[C@H](CNC(COCc2ccccc2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H26N2O3/c23-19-12-22-17(20(19)24)11-21-18(16-9-5-2-6-10-16)14-25-13-15-7-3-1-4-8-15/h1-10,17-24H,11-14H2/t17-,18?,19+,20-/m1/s1
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n/an/a 5.80E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Inhibition of alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168993
PNG
((2R,3R,4S)-2-(Benzylamino-methyl)-pyrrolidine-3,4-...)
Show SMILES O[C@H]1CN[C@H](CNCc2ccccc2)[C@H]1O
Show InChI InChI=1S/C12H18N2O2/c15-11-8-14-10(12(11)16)7-13-6-9-4-2-1-3-5-9/h1-5,10-16H,6-8H2/t10-,11+,12-/m1/s1
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n/an/a 6.00E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168997
PNG
(4-Fluoro-benzoic acid 2-[((2R,3R,4S)-3,4-dihydroxy...)
Show SMILES O[C@H]1CN[C@H](CNC(COC(=O)c2ccc(F)cc2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H23FN2O4/c21-15-8-6-14(7-9-15)20(26)27-12-17(13-4-2-1-3-5-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17?,18+,19-/m1/s1
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n/an/a 6.00E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104307
PNG
(2-(Benzylamino-methyl)-pyrrolidine-3,4-diol | CHEM...)
Show SMILES OC1CNC(CNCc2ccccc2)C1O
Show InChI InChI=1S/C12H18N2O2/c15-11-8-14-10(12(11)16)7-13-6-9-4-2-1-3-5-9/h1-5,10-16H,6-8H2
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n/an/a 6.00E+4n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168994
PNG
(2-Fluoro-benzoic acid 2-[((2R,3R,4S)-3,4-dihydroxy...)
Show SMILES O[C@H]1CN[C@H](CNC(COC(=O)c2ccccc2F)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H23FN2O4/c21-15-9-5-4-8-14(15)20(26)27-12-17(13-6-2-1-3-7-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17?,18+,19-/m1/s1
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n/an/a 6.30E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104298
PNG
(2-{[(Thiophen-2-ylmethyl)-amino]-methyl}-pyrrolidi...)
Show SMILES OC1CNC(CNCc2cccs2)C1O
Show InChI InChI=1S/C10H16N2O2S/c13-9-6-12-8(10(9)14)5-11-4-7-2-1-3-15-7/h1-3,8-14H,4-6H2
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n/an/a 8.50E+4n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168992
PNG
(3-Bromo-N-{2-[((2R,3R,4S)-3,4-dihydroxy-pyrrolidin...)
Show SMILES O[C@H]1CN[C@H](CNC(CNC(=O)c2cccc(Br)c2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H24BrN3O3/c21-15-8-4-7-14(9-15)20(27)24-10-16(13-5-2-1-3-6-13)22-11-17-19(26)18(25)12-23-17/h1-9,16-19,22-23,25-26H,10-12H2,(H,24,27)/t16?,17-,18+,19-/m1/s1
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n/an/a 8.90E+4n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50169001
PNG
((2R,3R,4S)-2-({[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11-,12+,13-/m1/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50169002
PNG
((2R,3R,4S)-2-[((S)-Phenyl-1-(R)-2-hydroxy-2-phenyl...)
Show SMILES O[C@H]([C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H24N2O3/c22-16-12-20-15(19(16)24)11-21-17(13-7-3-1-4-8-13)18(23)14-9-5-2-6-10-14/h1-10,15-24H,11-12H2/t15-,16+,17-,18+,19-/m1/s1
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n/an/a 1.10E+5n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168990
PNG
((2R,3R,4S)-2-[((R)-Phenyl-1-(S)-2-hydroxy-2-phenyl...)
Show SMILES O[C@@H]([C@@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H24N2O3/c22-16-12-20-15(19(16)24)11-21-17(13-7-3-1-4-8-13)18(23)14-9-5-2-6-10-14/h1-10,15-24H,11-12H2/t15-,16+,17+,18-,19-/m1/s1
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n/an/a 1.28E+5n/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104306
PNG
(2-Aminomethyl-pyrrolidine-3,4-diol | CHEMBL79727)
Show SMILES NCC1NCC(O)C1O
Show InChI InChI=1S/C5H12N2O2/c6-1-3-5(9)4(8)2-7-3/h3-5,7-9H,1-2,6H2
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n/an/a 1.70E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104296
PNG
(2-(2,2-Dihydroxy-ethyl)-pyrrolidine-3,4-diol | CHE...)
Show SMILES OC(O)CC1NCC(O)C1O
Show InChI InChI=1S/C6H13NO4/c8-4-2-7-3(6(4)11)1-5(9)10/h3-11H,1-2H2
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n/an/a 1.80E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104307
PNG
(2-(Benzylamino-methyl)-pyrrolidine-3,4-diol | CHEM...)
Show SMILES OC1CNC(CNCc2ccccc2)C1O
Show InChI InChI=1S/C12H18N2O2/c15-11-8-14-10(12(11)16)7-13-6-9-4-2-1-3-5-9/h1-5,10-16H,6-8H2
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n/an/a 2.30E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Almond


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104301
PNG
(2-[((R)-1-Hydroxy-ethylamino)-methyl]-pyrrolidine-...)
Show SMILES C[C@@H](O)NCC1NCC(O)C1O
Show InChI InChI=1S/C7H16N2O3/c1-4(10)8-2-5-7(12)6(11)3-9-5/h4-12H,2-3H2,1H3/t4-,5?,6?,7?/m1/s1
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n/an/a 3.00E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104298
PNG
(2-{[(Thiophen-2-ylmethyl)-amino]-methyl}-pyrrolidi...)
Show SMILES OC1CNC(CNCc2cccs2)C1O
Show InChI InChI=1S/C10H16N2O2S/c13-9-6-12-8(10(9)14)5-11-4-7-2-1-3-15-7/h1-3,8-14H,4-6H2
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n/an/a 3.50E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Almond


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50182798
PNG
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)
Show SMILES O[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+
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n/an/a 3.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104295
PNG
(2-[(2-Hydroxy-1-methyl-2,2-diphenyl-ethylamino)-me...)
Show SMILES CC(NCC1NCC(O)C1O)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H26N2O3/c1-14(21-12-17-19(24)18(23)13-22-17)20(25,15-8-4-2-5-9-15)16-10-6-3-7-11-16/h2-11,14,17-19,21-25H,12-13H2,1H3
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n/an/a 4.40E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104309
PNG
(2-[((R)-1-Phenyl-ethylamino)-methyl]-pyrrolidine-3...)
Show SMILES C[C@@H](NCC1NCC(O)C1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O2/c1-9(10-5-3-2-4-6-10)14-7-11-13(17)12(16)8-15-11/h2-6,9,11-17H,7-8H2,1H3/t9-,11?,12?,13?/m1/s1
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n/an/a 4.40E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104304
PNG
(2-[((S)-1-Hydroxy-ethylamino)-methyl]-pyrrolidine-...)
Show SMILES C[C@H](O)NCC1NCC(O)C1O
Show InChI InChI=1S/C7H16N2O3/c1-4(10)8-2-5-7(12)6(11)3-9-5/h4-12H,2-3H2,1H3/t4-,5?,6?,7?/m0/s1
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n/an/a 4.90E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104300
PNG
(2-Cyclopentylaminomethyl-pyrrolidine-3,4-diol | CH...)
Show SMILES OC1CNC(CNC2CCCC2)C1O
Show InChI InChI=1S/C10H20N2O2/c13-9-6-12-8(10(9)14)5-11-7-3-1-2-4-7/h7-14H,1-6H2
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n/an/a 5.60E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104305
PNG
(2-{[(Imidazol-1-ylmethyl)-amino]-methyl}-pyrrolidi...)
Show SMILES OC1CNC(CNCn2ccnc2)C1O
Show InChI InChI=1S/C9H16N4O2/c14-8-4-12-7(9(8)15)3-11-6-13-2-1-10-5-13/h1-2,5,7-9,11-12,14-15H,3-4,6H2
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n/an/a 5.70E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Almond


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104302
PNG
(2-{[(1-Benzyl-piperidin-4-ylmethyl)-amino]-methyl}...)
Show SMILES OC1CNC(CNCC2CCN(Cc3ccccc3)CC2)C1O
Show InChI InChI=1S/C18H29N3O2/c22-17-12-20-16(18(17)23)11-19-10-14-6-8-21(9-7-14)13-15-4-2-1-3-5-15/h1-5,14,16-20,22-23H,6-13H2
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n/an/a 5.70E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Almond


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104305
PNG
(2-{[(Imidazol-1-ylmethyl)-amino]-methyl}-pyrrolidi...)
Show SMILES OC1CNC(CNCn2ccnc2)C1O
Show InChI InChI=1S/C9H16N4O2/c14-8-4-12-7(9(8)15)3-11-6-13-2-1-10-5-13/h1-2,5,7-9,11-12,14-15H,3-4,6H2
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n/an/a 5.70E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Almond


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104302
PNG
(2-{[(1-Benzyl-piperidin-4-ylmethyl)-amino]-methyl}...)
Show SMILES OC1CNC(CNCC2CCN(Cc3ccccc3)CC2)C1O
Show InChI InChI=1S/C18H29N3O2/c22-17-12-20-16(18(17)23)11-19-10-14-6-8-21(9-7-14)13-15-4-2-1-3-5-15/h1-5,14,16-20,22-23H,6-13H2
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n/an/a 7.00E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50403869
PNG
(CHEMBL2115197)
Show SMILES CC[C@H]1NC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5+,6-/m1/s1
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n/an/a 8.00E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50402977
PNG
(CHEMBL2207397)
Show SMILES OCC(O)[C@H]1NC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-4(10)5-6(11)3(9)1-7-5/h3-11H,1-2H2/t3-,4?,5+,6-/m0/s1
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n/an/a 8.00E+5n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50065259
PNG
((2R,3R,4R,5R)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
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n/an/a 8.40E+5n/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against alpha-mannosidase of jack bean


J Med Chem 48: 2036-44 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50288854
PNG
(5-Methylene-piperidine-3,4-diol | CHEMBL150938)
Show SMILES OC1CNCC(=C)C1O
Show InChI InChI=1S/C6H11NO2/c1-4-2-7-3-5(8)6(4)9/h5-9H,1-3H2
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50288855
PNG
(1-Butyl-piperidine-3,4,5-triol | CHEMBL152232)
Show SMILES CCCCN1CC(O)C(O)C(O)C1
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-10-5-7(11)9(13)8(12)6-10/h7-9,11-13H,2-6H2,1H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50288853
PNG
(1-Butyl-5-methyl-piperidine-3,4-diol | CHEMBL35602...)
Show SMILES CCCCN1CC(C)C(O)C(O)C1
Show InChI InChI=1S/C10H21NO2/c1-3-4-5-11-6-8(2)10(13)9(12)7-11/h8-10,12-13H,3-7H2,1-2H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50288852
PNG
(5-Methoxy-piperidine-3,4-diol | CHEMBL414447)
Show SMILES COC1CNCC(O)C1O
Show InChI InChI=1S/C6H13NO3/c1-10-5-3-7-2-4(8)6(5)9/h4-9H,2-3H2,1H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104412
PNG
((S)-5-Methyl-piperidine-3,4-diol | CHEMBL86305)
Show SMILES CC1CNC[C@H](O)C1O
Show InChI InChI=1S/C6H13NO2/c1-4-2-7-3-5(8)6(4)9/h4-9H,2-3H2,1H3/t4?,5-,6?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase


Bioorg Med Chem Lett 6: 553-558 (1996)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50104306
PNG
(2-Aminomethyl-pyrrolidine-3,4-diol | CHEMBL79727)
Show SMILES NCC1NCC(O)C1O
Show InChI InChI=1S/C5H12N2O2/c6-1-3-5(9)4(8)2-7-3/h3-5,7-9H,1-2,6H2
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n/an/a 1.00E+6n/an/an/an/an/an/a



Section de Chimie de l'Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Almond


Bioorg Med Chem Lett 11: 2489-93 (2001)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168997
PNG
(4-Fluoro-benzoic acid 2-[((2R,3R,4S)-3,4-dihydroxy...)
Show SMILES O[C@H]1CN[C@H](CNC(COC(=O)c2ccc(F)cc2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H23FN2O4/c21-15-8-6-14(7-9-15)20(26)27-12-17(13-4-2-1-3-5-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17?,18+,19-/m1/s1
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19n/an/an/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Binding affinity against alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Canavalia ensiformis)
BDBM50124579
PNG
(CHEMBL3621532)
Show SMILES OC[C@]12CCC(=O)N1C[C@H](O)[C@@H](O)[C@@H]2O
Show InChI InChI=1/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7+,8-,9-/s2
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35n/an/an/an/an/an/an/an/a



Savitribai Phule Pune University (formerly University of Pune)

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate


J Med Chem 58: 7820-32 (2015)

More data for this
Ligand-Target Pair
Alpha-mannosidase


(Canavalia ensiformis)
BDBM50124578
PNG
(CHEMBL3621533)
Show SMILES OC[C@@]12CCC(=O)N1C[C@H](O)[C@@H](O)[C@@H]2O
Show InChI InChI=1/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7+,8-,9+/s2
UniProtKB/SwissProt

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43n/an/an/an/an/an/an/an/a



Savitribai Phule Pune University (formerly University of Pune)

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate


J Med Chem 58: 7820-32 (2015)

More data for this
Ligand-Target Pair
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