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Found 63 hits Enz. Inhib. hit(s) with Target = 'Amiloride-sensitive cation channel 3'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348097
PNG
(CHEMBL1800440)
Show SMILES CN(C)C1CCc2c1cccc2C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C22H21ClN2S/c1-25(2)19-11-10-16-15(4-3-5-17(16)19)8-6-14-7-9-18-20(12-14)26-21(13-24)22(18)23/h3-5,7,9,12,19H,10-11,13,24H2,1-2H3
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n/an/a 190n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348098
PNG
(CHEMBL1800430)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCNCc2c1
Show InChI InChI=1S/C20H17ClN2S/c21-20-17-6-4-14(10-18(17)24-19(20)11-22)2-1-13-3-5-15-7-8-23-12-16(15)9-13/h3-6,9-10,23H,7-8,11-12,22H2
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n/an/a 220n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348111
PNG
(CHEMBL1800436)
Show SMILES CN(C)C1CCCc2c(cccc12)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C23H23ClN2S/c1-26(2)20-8-4-6-17-16(5-3-7-18(17)20)11-9-15-10-12-19-21(13-15)27-22(14-25)23(19)24/h3,5,7,10,12-13,20H,4,6,8,14,25H2,1-2H3
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348107
PNG
(CHEMBL1800432)
Show SMILES CCN1CCc2ccc(cc2C1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C22H21ClN2S/c1-2-25-10-9-17-7-5-15(11-18(17)14-25)3-4-16-6-8-19-20(12-16)26-21(13-24)22(19)23/h5-8,11-12H,2,9-10,13-14,24H2,1H3
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348104
PNG
(CHEMBL1800428)
Show SMILES CC1N(C)CCc2ccc(cc12)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C22H21ClN2S/c1-14-19-11-15(5-7-17(19)9-10-25(14)2)3-4-16-6-8-18-20(12-16)26-21(13-24)22(18)23/h5-8,11-12,14H,9-10,13,24H2,1-2H3
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n/an/a 270n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348113
PNG
(CHEMBL1800433)
Show SMILES CC(C)N1CCc2ccc(cc2C1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C23H23ClN2S/c1-15(2)26-10-9-18-7-5-16(11-19(18)14-26)3-4-17-6-8-20-21(12-17)27-22(13-25)23(20)24/h5-8,11-12,15H,9-10,13-14,25H2,1-2H3
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n/an/a 310n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348099
PNG
(CHEMBL1800331)
Show SMILES CC(C)C1N(C)CCc2ccc(cc12)C#Cc1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C26H27N3/c1-17(2)25-24-15-19(6-8-20(24)12-13-29(25)3)5-4-18-7-9-22-16-23(26(27)28)11-10-21(22)14-18/h6-11,14-17,25H,12-13H2,1-3H3,(H3,27,28)
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n/an/a 460n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50259583
PNG
(3-amino-5-(biphenyl-3-yl)-N-(diaminomethylene)pyra...)
Show SMILES NC(=N)NC(=O)c1ncc(nc1N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N6O/c19-16-15(17(25)24-18(20)21)22-10-14(23-16)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,19,23)(H4,20,21,24,25)
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n/an/a 490n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348095
PNG
(CHEMBL1800437)
Show SMILES CCN(CC)N1CCCc2c(cccc12)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C24H26ClN3S/c1-3-27(4-2)28-14-6-8-19-18(7-5-9-21(19)28)12-10-17-11-13-20-22(15-17)29-23(16-26)24(20)25/h5,7,9,11,13,15H,3-4,6,8,14,16,26H2,1-2H3
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n/an/a 510n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50259353
PNG
(3-amino-6-chloro-N-(diaminomethylene)-5-(naphthale...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(Nc2ccc3ccccc3c2)nc1N
Show InChI InChI=1S/C16H14ClN7O/c17-12-14(23-13(18)11(22-12)15(25)24-16(19)20)21-10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,18,21,23)(H4,19,20,24,25)
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n/an/a 510n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50259584
PNG
(3-amino-N-(diaminomethylene)-5-(3-(thiophen-3-yl)p...)
Show SMILES NC(=N)NC(=O)c1ncc(nc1N)-c1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C16H14N6OS/c17-14-13(15(23)22-16(18)19)20-7-12(21-14)10-3-1-2-9(6-10)11-4-5-24-8-11/h1-8H,(H2,17,21)(H4,18,19,22,23)
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n/an/a 640n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348106
PNG
(CHEMBL1800431)
Show SMILES CN1CCc2ccc(cc2C1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C21H19ClN2S/c1-24-9-8-16-6-4-14(10-17(16)13-24)2-3-15-5-7-18-19(11-15)25-20(12-23)21(18)22/h4-7,10-11H,8-9,12-13,23H2,1H3
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n/an/a 680n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Rattus norvegicus)
BDBM50259583
PNG
(3-amino-5-(biphenyl-3-yl)-N-(diaminomethylene)pyra...)
Show SMILES NC(=N)NC(=O)c1ncc(nc1N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N6O/c19-16-15(17(25)24-18(20)21)22-10-14(23-16)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,19,23)(H4,20,21,24,25)
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n/an/a 950n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC3 assessed as inhibition of peak current by patch clamp electrophisiology


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342661
PNG
(2-(3-(phenylethynyl)phenyl)pyridin-4-amine | CHEMB...)
Show SMILES Nc1ccnc(c1)-c1cccc(c1)C#Cc1ccccc1
Show InChI InChI=1S/C19H14N2/c20-18-11-12-21-19(14-18)17-8-4-7-16(13-17)10-9-15-5-2-1-3-6-15/h1-8,11-14H,(H2,20,21)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342642
PNG
(6-(6-(2-methylpiperidin-1-yl)pyridin-2-yl)-1,2,3,4...)
Show SMILES CC1CCCCN1c1cccc(n1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C20H25N3/c1-15-5-2-3-12-23(15)20-7-4-6-19(22-20)17-8-9-18-14-21-11-10-16(18)13-17/h4,6-9,13,15,21H,2-3,5,10-12,14H2,1H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348112
PNG
(CHEMBL1800438)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1cccc2C(CCCc12)N1CCCC1
Show InChI InChI=1S/C25H25ClN2S/c26-25-21-12-10-17(15-23(21)29-24(25)16-27)9-11-18-5-3-7-20-19(18)6-4-8-22(20)28-13-1-2-14-28/h3,5,7,10,12,15,22H,1-2,4,6,8,13-14,16,27H2
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n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342660
PNG
(4-(3-(4-aminopyridin-2-yl)phenyl)but-3-yn-1-ol | C...)
Show SMILES Nc1ccnc(c1)-c1cccc(c1)C#CCCO
Show InChI InChI=1S/C15H14N2O/c16-14-7-8-17-15(11-14)13-6-3-5-12(10-13)4-1-2-9-18/h3,5-8,10-11,18H,2,9H2,(H2,16,17)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348103
PNG
(CHEMBL1800427)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C17H12ClNS/c18-17-14-9-8-13(10-15(14)20-16(17)11-19)7-6-12-4-2-1-3-5-12/h1-5,8-10H,11,19H2
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n/an/a 2.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342647
PNG
(6-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...)
Show SMILES CN1CCN(CC1)c1ccc(cc1C(F)(F)F)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C21H24F3N3/c1-26-8-10-27(11-9-26)20-5-4-16(13-19(20)21(22,23)24)15-2-3-18-14-25-7-6-17(18)12-15/h2-5,12-13,25H,6-11,14H2,1H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342641
PNG
(6-(3,5-dichlorophenyl)-1,2,3,4-tetrahydroisoquinol...)
Show SMILES Clc1cc(Cl)cc(c1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C15H13Cl2N/c16-14-6-13(7-15(17)8-14)10-1-2-12-9-18-4-3-11(12)5-10/h1-2,5-8,18H,3-4,9H2
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n/an/a 3.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348102
PNG
(CHEMBL1800334)
Show SMILES NC(=N)c1sc2cc(ccc2c1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C17H11ClN2S/c18-15-13-9-8-12(7-6-11-4-2-1-3-5-11)10-14(13)21-16(15)17(19)20/h1-5,8-10H,(H3,19,20)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342649
PNG
(6-methyl-N-(4-(6-(piperazin-1-yl)pyridin-3-yl)phen...)
Show SMILES Cc1cccc(Nc2ccc(cc2)-c2ccc(nc2)N2CCNCC2)n1
Show InChI InChI=1S/C21H23N5/c1-16-3-2-4-20(24-16)25-19-8-5-17(6-9-19)18-7-10-21(23-15-18)26-13-11-22-12-14-26/h2-10,15,22H,11-14H2,1H3,(H,24,25)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348096
PNG
(CHEMBL1800439)
Show SMILES CC(N(C)C)c1cccc(c1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C21H21ClN2S/c1-14(24(2)3)17-6-4-5-15(11-17)7-8-16-9-10-18-19(12-16)25-20(13-23)21(18)22/h4-6,9-12,14H,13,23H2,1-3H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM16173
PNG
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348101
PNG
(CHEMBL1800333)
Show SMILES NCc1ccc2cc(ccc2c1)C#Cc1ccccc1
Show InChI InChI=1S/C19H15N/c20-14-17-9-11-18-12-16(8-10-19(18)13-17)7-6-15-4-2-1-3-5-15/h1-5,8-13H,14,20H2
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n/an/a 4.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342662
PNG
(2-phenyl-6-(pyridin-2-ylmethyl)pyridin-4-amine | C...)
Show SMILES Nc1cc(Cc2ccccn2)nc(c1)-c1ccccc1
Show InChI InChI=1S/C17H15N3/c18-14-10-16(12-15-8-4-5-9-19-15)20-17(11-14)13-6-2-1-3-7-13/h1-11H,12H2,(H2,18,20)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348100
PNG
(CHEMBL1800332)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C#Cc1ccccc1
Show InChI InChI=1S/C19H14N2/c20-19(21)18-11-10-16-12-15(8-9-17(16)13-18)7-6-14-4-2-1-3-5-14/h1-5,8-13H,(H3,20,21)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342659
PNG
(2-phenylpyridin-4-amine | CHEMBL1770738)
Show SMILES Nc1ccnc(c1)-c1ccccc1
Show InChI InChI=1S/C11H10N2/c12-10-6-7-13-11(8-10)9-4-2-1-3-5-9/h1-8H,(H2,12,13)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342643
PNG
(6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydrois...)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C16H14F3N/c17-16(18,19)15-3-1-2-11(9-15)12-4-5-14-10-20-7-6-13(14)8-12/h1-5,8-9,20H,6-7,10H2
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n/an/a 7.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342651
PNG
(CHEMBL1770730 | N-(6-methylpyridin-2-yl)furo[2,3-c...)
Show SMILES Cc1cccc(Nc2nccc3ccoc23)n1
Show InChI InChI=1S/C13H11N3O/c1-9-3-2-4-11(15-9)16-13-12-10(5-7-14-13)6-8-17-12/h2-8H,1H3,(H,14,15,16)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Rattus norvegicus)
BDBM50157090
PNG
(6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...)
Show SMILES CC(C)C1N(C)CCc2ccc(cc12)C1CC1c1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C27H31N3/c1-16(2)26-25-14-21(7-4-17(25)10-11-30(26)3)24-15-23(24)20-8-5-19-13-22(27(28)29)9-6-18(19)12-20/h4-9,12-14,16,23-24,26H,10-11,15H2,1-3H3,(H3,28,29)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 in rat DRG neurons


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342650
PNG
(4-amino-N-(4-chlorophenethyl)-2-propylquinoline-6-...)
Show SMILES CCCc1cc(N)c2cc(ccc2n1)C(=O)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN3O/c1-2-3-17-13-19(23)18-12-15(6-9-20(18)25-17)21(26)24-11-10-14-4-7-16(22)8-5-14/h4-9,12-13H,2-3,10-11H2,1H3,(H2,23,25)(H,24,26)
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n/an/a 9.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348108
PNG
(CHEMBL1800434)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCN(CC(F)F)Cc2c1
Show InChI InChI=1S/C22H19ClF2N2S/c23-22-18-6-4-15(10-19(18)28-20(22)11-26)2-1-14-3-5-16-7-8-27(13-21(24)25)12-17(16)9-14/h3-6,9-10,21H,7-8,11-13,26H2
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n/an/a 1.02E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342640
PNG
(6-bromo-2-((5-methoxy-1H-indol-3-yl)methyl)-1,2,3,...)
Show SMILES COc1ccc2[nH]cc(CN3CCc4cc(Br)ccc4C3)c2c1
Show InChI InChI=1S/C19H19BrN2O/c1-23-17-4-5-19-18(9-17)15(10-21-19)12-22-7-6-13-8-16(20)3-2-14(13)11-22/h2-5,8-10,21H,6-7,11-12H2,1H3
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n/an/a 1.09E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342646
PNG
(6-(4-(4-methylpiperazin-1-yl)phenyl)-1,2,3,4-tetra...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C20H25N3/c1-22-10-12-23(13-11-22)20-6-4-16(5-7-20)17-2-3-19-15-21-9-8-18(19)14-17/h2-7,14,21H,8-13,15H2,1H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342648
PNG
(2-methyl-4-(4-(6-methylpyridin-2-ylamino)phenyl)bu...)
Show SMILES Cc1cccc(Nc2ccc(cc2)C#CC(C)(C)O)n1
Show InChI InChI=1S/C17H18N2O/c1-13-5-4-6-16(18-13)19-15-9-7-14(8-10-15)11-12-17(2,3)20/h4-10,20H,1-3H3,(H,18,19)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348110
PNG
(CHEMBL1800079)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCN(Cc3ccccc3)Cc2c1
Show InChI InChI=1S/C27H23ClN2S/c28-27-24-11-9-20(15-25(24)31-26(27)16-29)7-6-19-8-10-22-12-13-30(18-23(22)14-19)17-21-4-2-1-3-5-21/h1-5,8-11,14-15H,12-13,16-18,29H2
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n/an/a 1.71E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342645
PNG
(6-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,...)
Show SMILES C1Cc2cc(cnc2N1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C16H17N3/c1-2-14-9-17-5-3-12(14)7-11(1)15-8-13-4-6-18-16(13)19-10-15/h1-2,7-8,10,17H,3-6,9H2,(H,18,19)
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n/an/a 1.94E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342663
PNG
(4-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-meth...)
Show SMILES Cc1cc(N2CCc3cc(Br)ccc3C2)c2ccccc2n1
Show InChI InChI=1S/C19H17BrN2/c1-13-10-19(17-4-2-3-5-18(17)21-13)22-9-8-14-11-16(20)7-6-15(14)12-22/h2-7,10-11H,8-9,12H2,1H3
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n/an/a 2.76E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348109
PNG
(CHEMBL1800435)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCN(CC(F)(F)F)Cc2c1
Show InChI InChI=1S/C22H18ClF3N2S/c23-21-18-6-4-15(10-19(18)29-20(21)11-27)2-1-14-3-5-16-7-8-28(12-17(16)9-14)13-22(24,25)26/h3-6,9-10H,7-8,11-13,27H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348105
PNG
(CHEMBL1800429)
Show SMILES CC(C)(C)OC(=O)N1CCc2ccc(cc2C1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C25H25ClN2O2S/c1-25(2,3)30-24(29)28-11-10-18-8-6-16(12-19(18)15-28)4-5-17-7-9-20-21(13-17)31-22(14-27)23(20)26/h6-9,12-13H,10-11,14-15,27H2,1-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296576
PNG
(2-(3-chloro-5-methylphenyl)-1H-indole-5-carboximid...)
Show SMILES Cc1cc(Cl)cc(c1)-c1cc2cc(ccc2[nH]1)C(N)=N
Show InChI InChI=1S/C16H14ClN3/c1-9-4-11(7-13(17)5-9)15-8-12-6-10(16(18)19)2-3-14(12)20-15/h2-8,20H,1H3,(H3,18,19)
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n/an/a 5.10E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296570
PNG
(2-(3-bromo-5-fluorophenyl)-1H-indole-5-carboximida...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(F)cc(Br)c1
Show InChI InChI=1S/C15H11BrFN3/c16-11-4-10(5-12(17)7-11)14-6-9-3-8(15(18)19)1-2-13(9)20-14/h1-7,20H,(H3,18,19)
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n/an/a 5.90E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296571
PNG
(2-(3,5-dibromophenyl)-1H-indole-5-carboximidamide ...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(Br)cc(Br)c1
Show InChI InChI=1S/C15H11Br2N3/c16-11-4-10(5-12(17)7-11)14-6-9-3-8(15(18)19)1-2-13(9)20-14/h1-7,20H,(H3,18,19)
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n/an/a 5.90E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296575
PNG
(2-(3-(benzylamino)-5-chlorophenyl)-1H-indole-5-car...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(NCc2ccccc2)c1
Show InChI InChI=1S/C22H19ClN4/c23-18-9-17(10-19(12-18)26-13-14-4-2-1-3-5-14)21-11-16-8-15(22(24)25)6-7-20(16)27-21/h1-12,26-27H,13H2,(H3,24,25)
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n/an/a 7.70E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296573
PNG
(2-(3-amino-5-chlorophenyl)-1H-indole-5-carboximida...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(N)cc(Cl)c1
Show InChI InChI=1S/C15H13ClN4/c16-11-4-10(5-12(17)7-11)14-6-9-3-8(15(18)19)1-2-13(9)20-14/h1-7,20H,17H2,(H3,18,19)
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n/an/a 9.50E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342656
PNG
(CHEMBL1770735 | benzo[b]thiophen-2-ylmethanamine)
Show SMILES NCc1cc2ccccc2s1
Show InChI InChI=1S/C9H9NS/c10-6-8-5-7-3-1-2-4-9(7)11-8/h1-5H,6,10H2
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n/an/a 9.70E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


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More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342644
PNG
(2-((5-methoxy-1H-indol-3-yl)methyl)-6-(3-(trifluor...)
Show SMILES COc1ccc2[nH]cc(CN3CCc4cc(ccc4C3)-c3cccc(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C26H23F3N2O/c1-32-23-7-8-25-24(13-23)21(14-30-25)16-31-10-9-19-11-18(5-6-20(19)15-31)17-3-2-4-22(12-17)26(27,28)29/h2-8,11-14,30H,9-10,15-16H2,1H3
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n/an/a 1.03E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296574
PNG
(2-(3-chloro-5-((phenylamino)methyl)phenyl)-1H-indo...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(CNc2ccccc2)c1
Show InChI InChI=1S/C22H19ClN4/c23-18-9-14(13-26-19-4-2-1-3-5-19)8-16(11-18)21-12-17-10-15(22(24)25)6-7-20(17)27-21/h1-12,26-27H,13H2,(H3,24,25)
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n/an/a 1.14E+5n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342654
PNG
(6-phenylpyrimidin-4-amine | CHEMBL1770733)
Show SMILES Nc1cc(ncn1)-c1ccccc1
Show InChI InChI=1S/C10H9N3/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H,(H2,11,12,13)
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n/an/a 1.30E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Citation and Details
More data for this
Ligand-Target Pair
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