BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 48 hits Enz. Inhib. hit(s) with Target = 'Amiloride-sensitive sodium channel subunit alpha'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112170
PNG
(CHEMBL3608425)
Show SMILES [O-]C(=O)C(F)(F)F.COc1ccc(CCC[N+]2(CCCc3ccccc3)CCCC(C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1/C29H37ClN6O2.C2HF3O2/c1-38-24-15-13-22(14-16-24)11-6-18-36(17-5-10-21-8-3-2-4-9-21)19-7-12-23(20-36)33-29(37)25-27(31)35-28(32)26(30)34-25;3-2(4,5)1(6)7/h2-4,8-9,13-16,23H,5-7,10-12,17-20H2,1H3,(H4-,31,32,33,35,37);(H,6,7)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112167
PNG
(CHEMBL3608428)
Show SMILES Cl.[Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCc3ccccn3)cc2)(CCCc2ccc(OCC(=O)NCCc3ccccn3)cc2)C1
Show InChI InChI=1/C46H55ClN10O5.2ClH/c47-43-45(49)56-44(48)42(55-43)46(60)54-37-12-7-29-57(30-37,27-5-8-33-13-17-38(18-14-33)61-31-40(58)52-25-21-35-10-1-3-23-50-35)28-6-9-34-15-19-39(20-16-34)62-32-41(59)53-26-22-36-11-2-4-24-51-36;;/h1-4,10-11,13-20,23-24,37H,5-9,12,21-22,25-32H2,(H6-,48,49,52,53,54,56,58,59,60);2*1H/t37-;;/s2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190466
PNG
(CHEMBL212431 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCCO)cc1
Show InChI InChI=1S/C19H26ClN7O3/c20-15-17(22)26-16(21)14(25-15)18(29)27-19(23)24-9-2-1-4-12-5-7-13(8-6-12)30-11-3-10-28/h5-8,28H,1-4,9-11H2,(H4,21,22,26)(H3,23,24,27,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190487
PNG
(CHEMBL212531 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@@H](O)CO)cc1
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)/t12-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190462
PNG
(CHEMBL212432 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCC(O)CO)cc1
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190486
PNG
(CHEMBL211161 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCO)cc1
Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-8-2-1-3-11-4-6-12(7-5-11)29-10-9-27/h4-7,27H,1-3,8-10H2,(H4,20,21,25)(H3,22,23,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112171
PNG
(CHEMBL3608426)
Show SMILES Cl.[Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCn3ccnc3)cc2)(CCCc2ccc(OCC(=O)NCCn3ccnc3)cc2)C1
Show InChI InChI=1/C42H53ClN12O5.2ClH/c43-39-41(45)52-40(44)38(51-39)42(58)50-33-6-3-25-55(26-33,23-1-4-31-7-11-34(12-8-31)59-27-36(56)48-17-21-53-19-15-46-29-53)24-2-5-32-9-13-35(14-10-32)60-28-37(57)49-18-22-54-20-16-47-30-54;;/h7-16,19-20,29-30,33H,1-6,17-18,21-28H2,(H6-,44,45,48,49,50,52,56,57,58);2*1H/t33-;;/s2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190494
PNG
(CHEMBL209303 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@H](O)CO)cc1
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)/t12-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112172
PNG
(CHEMBL3608427)
Show SMILES [Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCCO)cc2)(CCCc2ccc(OCC(=O)NCCCO)cc2)C1
Show InChI InChI=1/C38H53ClN8O7.ClH/c39-35-37(41)46-36(40)34(45-35)38(52)44-29-8-3-21-47(24-29,19-1-6-27-9-13-30(14-10-27)53-25-32(50)42-17-4-22-48)20-2-7-28-11-15-31(16-12-28)54-26-33(51)43-18-5-23-49;/h9-16,29,48-49H,1-8,17-26H2,(H6-,40,41,42,43,44,46,50,51,52);1H/t29-;/s2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190481
PNG
(CHEMBL214239 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(CO)cc1
Show InChI InChI=1S/C17H22ClN7O2/c18-13-15(20)24-14(19)12(23-13)16(27)25-17(21)22-8-2-1-3-10-4-6-11(9-26)7-5-10/h4-7,26H,1-3,8-9H2,(H4,19,20,24)(H3,21,22,25,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190459
PNG
(CHEMBL377986 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C17H22ClN7O2/c1-27-11-7-5-10(6-8-11)4-2-3-9-22-17(21)25-16(26)12-14(19)24-15(20)13(18)23-12/h5-8H,2-4,9H2,1H3,(H4,19,20,24)(H3,21,22,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190484
PNG
(CHEMBL210876 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(O)cc1
Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-8-2-1-3-9-4-6-10(25)7-5-9/h4-7,25H,1-3,8H2,(H4,18,19,23)(H3,20,21,24,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190468
PNG
(CHEMBL211600 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(OCCO)c1
Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-7-2-1-4-11-5-3-6-12(10-11)29-9-8-27/h3,5-6,10,27H,1-2,4,7-9H2,(H4,20,21,25)(H3,22,23,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190489
PNG
((4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCC(O)=O)cc1
Show InChI InChI=1S/C19H24ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-9-2-1-3-11-4-6-12(7-5-11)31-10-8-13(28)29/h4-7H,1-3,8-10H2,(H,28,29)(H4,21,22,26)(H3,23,24,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112169
PNG
(CHEMBL3608424)
Show SMILES [Cl-].COc1ccc(CCC[N+]2(CCCc3ccc(cc3)C(=O)NCCCN(C)C)CCCC(C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1/C35H49ClN8O3.ClH/c1-43(2)20-7-19-39-34(45)27-15-11-25(12-16-27)8-4-21-44(22-5-9-26-13-17-29(47-3)18-14-26)23-6-10-28(24-44)40-35(46)30-32(37)42-33(38)31(36)41-30;/h11-18,28H,4-10,19-24H2,1-3H3,(H5-,37,38,39,40,42,45,46);1H
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190475
PNG
(CHEMBL380011 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(O)c1
Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-7-2-1-4-9-5-3-6-10(25)8-9/h3,5-6,8,25H,1-2,4,7H2,(H4,18,19,23)(H3,20,21,24,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190465
PNG
(1-(4-(4-aminophenyl)butyl)-3-(3,5-diamino-2-chloro...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(N)cc1
Show InChI InChI=1S/C16H21ClN8O/c17-12-14(20)24-13(19)11(23-12)15(26)25-16(21)22-8-2-1-3-9-4-6-10(18)7-5-9/h4-7H,1-3,8,18H2,(H4,19,20,24)(H3,21,22,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190458
PNG
(CHEMBL386222 | sulfuric acid mono-(4-{4-[N-(3,5-di...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(cc1)S(O)(=O)=O
Show InChI InChI=1S/C16H20ClN7O4S/c17-12-14(19)23-13(18)11(22-12)15(25)24-16(20)21-8-2-1-3-9-4-6-10(7-5-9)29(26,27)28/h4-7H,1-3,8H2,(H4,18,19,23)(H,26,27,28)(H3,20,21,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190488
PNG
(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Show SMILES COC(=O)c1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C18H22ClN7O3/c1-29-17(28)11-7-5-10(6-8-11)4-2-3-9-23-18(22)26-16(27)12-14(20)25-15(21)13(19)24-12/h5-8H,2-4,9H2,1H3,(H4,20,21,25)(H3,22,23,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190480
PNG
(CHEMBL214220 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(OCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C16H20ClN7O3/c1-26-9-3-5-10(6-4-9)27-8-2-7-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h3-6H,2,7-8H2,1H3,(H4,18,19,23)(H3,20,21,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190490
PNG
(CHEMBL212534 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(OCC(O)CO)c1
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-7-2-1-4-11-5-3-6-13(8-11)31-10-12(29)9-28/h3,5-6,8,12,28-29H,1-2,4,7,9-10H2,(H4,21,22,26)(H3,23,24,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190493
PNG
(CHEMBL211658 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1OCC(O)CO
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-4-3-6-11-5-1-2-7-13(11)31-10-12(29)9-28/h1-2,5,7,12,28-29H,3-4,6,8-10H2,(H4,21,22,26)(H3,23,24,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190456
PNG
(CHEMBL209659 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1
Show InChI InChI=1S/C16H20ClN7O/c17-12-14(19)23-13(18)11(22-12)15(25)24-16(20)21-9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2,(H4,18,19,23)(H3,20,21,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190471
PNG
(CHEMBL379066 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1O
Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-8-4-3-6-9-5-1-2-7-10(9)25/h1-2,5,7,25H,3-4,6,8H2,(H4,18,19,23)(H3,20,21,24,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190455
PNG
(CHEMBL208889 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1OCCO
Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-8-4-3-6-11-5-1-2-7-12(11)29-10-9-27/h1-2,5,7,27H,3-4,6,8-10H2,(H4,20,21,25)(H3,22,23,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190478
PNG
(CHEMBL211946 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCOc1ccc(O)cc1
Show InChI InChI=1S/C15H18ClN7O3/c16-11-13(18)22-12(17)10(21-11)14(25)23-15(19)20-6-1-7-26-9-4-2-8(24)3-5-9/h2-5,24H,1,6-7H2,(H4,17,18,22)(H3,19,20,23,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190460
PNG
(CHEMBL211773 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(COCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C16H20ClN7O3/c1-26-10-4-2-9(3-5-10)8-27-7-6-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h2-5H,6-8H2,1H3,(H4,18,19,23)(H3,20,21,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190457
PNG
(CHEMBL211072 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C16H20ClN7O3/c17-12-14(19)23-13(18)11(22-12)15(27)24-16(20)21-6-2-1-3-8-4-5-9(25)10(26)7-8/h4-5,7,25-26H,1-3,6H2,(H4,18,19,23)(H3,20,21,24,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190483
PNG
((4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C18H22ClN7O4/c19-14-16(21)25-15(20)13(24-14)17(29)26-18(22)23-8-2-1-3-10-4-6-11(7-5-10)30-9-12(27)28/h4-7H,1-3,8-9H2,(H,27,28)(H4,20,21,25)(H3,22,23,26,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190479
PNG
(CHEMBL211664 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCc1ccccc1
Show InChI InChI=1S/C15H18ClN7O/c16-11-13(18)22-12(17)10(21-11)14(24)23-15(19)20-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H4,17,18,22)(H3,19,20,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190477
PNG
(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C17H20ClN7O3/c18-12-14(20)24-13(19)11(23-12)15(26)25-17(21)22-8-2-1-3-9-4-6-10(7-5-9)16(27)28/h4-7H,1-3,8H2,(H,27,28)(H4,19,20,24)(H3,21,22,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190461
PNG
(CHEMBL208620 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCCc1ccccc1
Show InChI InChI=1S/C18H24ClN7O/c19-14-16(21)25-15(20)13(24-14)17(27)26-18(22)23-11-7-2-1-4-8-12-9-5-3-6-10-12/h3,5-6,9-10H,1-2,4,7-8,11H2,(H4,20,21,25)(H3,22,23,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 58n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190463
PNG
(CHEMBL209977 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCc1ccc(O)cc1
Show InChI InChI=1S/C14H16ClN7O2/c15-10-12(17)21-11(16)9(20-10)13(24)22-14(18)19-6-5-7-1-3-8(23)4-2-7/h1-4,23H,5-6H2,(H4,16,17,21)(H3,18,19,22,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 62n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190464
PNG
(1-(3,5-diamino-2-chloropyrazine-6-carbonyl)-3-(5-(...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCc1ccc(O)cc1
Show InChI InChI=1S/C17H22ClN7O2/c18-13-15(20)24-14(19)12(23-13)16(27)25-17(21)22-9-3-1-2-4-10-5-7-11(26)8-6-10/h5-8,26H,1-4,9H2,(H4,19,20,24)(H3,21,22,25,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 64n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190485
PNG
(CHEMBL211611 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCc1ccccc1
Show InChI InChI=1S/C14H16ClN7O/c15-10-12(17)21-11(16)9(20-10)13(23)22-14(18)19-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H4,16,17,21)(H3,18,19,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 66n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM81819
PNG
(Benzamil | CAS_1937-37-7 | CHEMBL212579 | NSC_1081...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCc1ccccc1
Show InChI InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 66n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190470
PNG
(CHEMBL377239 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCc1ccccc1
Show InChI InChI=1S/C17H22ClN7O/c18-13-15(20)24-14(19)12(23-13)16(26)25-17(21)22-10-6-2-5-9-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2,(H4,19,20,24)(H3,21,22,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 68n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112168
PNG
(CHEMBL3608423)
Show SMILES [Cl-].COc1ccc(CCC[N@@+]2(C)CCC[C@@H](C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1/C21H29ClN6O2.ClH/c1-28(11-3-5-14-7-9-16(30-2)10-8-14)12-4-6-15(13-28)25-21(29)17-19(23)27-20(24)18(22)26-17;/h7-10,15H,3-6,11-13H2,1-2H3,(H4-,23,24,25,27,29);1H/t15-,28-;/s2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190474
PNG
(6-(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbon...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)cc1
Show InChI InChI=1S/C22H28ClN7O8/c23-16-18(25)29-17(24)11(28-16)19(34)30-22(26)27-8-2-1-3-9-4-6-10(7-5-9)37-21-14(33)12(31)13(32)15(38-21)20(35)36/h4-7,12-15,21,31-33H,1-3,8H2,(H,35,36)(H4,24,25,29)(H3,26,27,30,34)/t12-,13-,14+,15-,21?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 73n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190495
PNG
(CHEMBL209104 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(CCCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C18H24ClN7O2/c1-28-12-8-6-11(7-9-12)5-3-2-4-10-23-18(22)26-17(27)13-15(20)25-16(21)14(19)24-13/h6-9H,2-5,10H2,1H3,(H4,20,21,25)(H3,22,23,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 77n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190491
PNG
(CHEMBL210966 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES CCCCCCN=C(N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C12H20ClN7O/c1-2-3-4-5-6-17-12(16)20-11(21)7-9(14)19-10(15)8(13)18-7/h2-6H2,1H3,(H4,14,15,19)(H3,16,17,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190472
PNG
(CHEMBL211793 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCc1ccc(O)cc1
Show InChI InChI=1S/C15H18ClN7O2/c16-11-13(18)22-12(17)10(21-11)14(25)23-15(19)20-7-1-2-8-3-5-9(24)6-4-8/h3-6,24H,1-2,7H2,(H4,17,18,22)(H3,19,20,23,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 88n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190473
PNG
(CHEMBL377688 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCO
Show InChI InChI=1S/C8H12ClN7O2/c9-4-6(11)15-5(10)3(14-4)7(18)16-8(12)13-1-2-17/h17H,1-2H2,(H4,10,11,15)(H3,12,13,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 107n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190492
PNG
(CHEMBL210981 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES CCCCCCCCN=C(N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C14H24ClN7O/c1-2-3-4-5-6-7-8-19-14(18)22-13(23)9-11(16)21-12(17)10(15)20-9/h2-8H2,1H3,(H4,16,17,21)(H3,18,19,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 108n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190482
PNG
(CHEMBL210967 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(CCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C16H20ClN7O2/c1-26-10-6-4-9(5-7-10)3-2-8-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h4-7H,2-3,8H2,1H3,(H4,18,19,23)(H3,20,21,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 124n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM115076
PNG
(3,5-bis(azanyl)-N-[azanyl(phenylazanyl)methylidene...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=Nc1ccccc1
Show InChI InChI=1S/C12H12ClN7O/c13-8-10(15)19-9(14)7(18-8)11(21)20-12(16)17-6-4-2-1-3-5-6/h1-5H,(H4,14,15,19)(H3,16,17,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 401n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190469
PNG
(CHEMBL210866 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCCCCc1ccccc1
Show InChI InChI=1S/C20H28ClN7O/c21-16-18(23)27-17(22)15(26-16)19(29)28-20(24)25-13-9-4-2-1-3-6-10-14-11-7-5-8-12-14/h5,7-8,11-12H,1-4,6,9-10,13H2,(H4,22,23,27)(H3,24,25,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 477n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM16173
PNG
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 776n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair