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Compile Data Set for Download or QSAR

Found 3404 hits Enz. Inhib. hit(s) with Target = 'Aminopeptidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36597
PNG
(FOS-69)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)CCCCl
Show InChI InChI=1S/C20H31ClO6/c1-13(2)7-8-15-18(3,27-15)20(23)17(24-4)14(9-10-19(20)12-25-19)26-16(22)6-5-11-21/h7,14-15,17,23H,5-6,8-12H2,1-4H3/t14-,15?,17-,18-,19+,20+/m1/s1
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n/an/a 0.100n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137405
PNG
(CHEMBL176975 | Carbamic acid (3R,4S,5S,6R)-5-metho...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(N)=O
Show InChI InChI=1S/C17H27NO5/c1-10(2)5-6-12-16(3,23-12)14-13(20-4)11(22-15(18)19)7-8-17(14)9-21-17/h5,11-14H,6-9H2,1-4H3,(H2,18,19)/t11-,12-,13-,14-,16+,17+/m1/s1
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n/an/a 0.390n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36589
PNG
(Ovalicin)
Show SMILES CO[C@@H]1C(=O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,12-13,18H,6-9H2,1-4H3/t12?,13-,14-,15+,16+/m1/s1
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n/an/a 0.400n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50295172
PNG
(4-Hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methy...)
Show SMILES CO[C@@H]1C(=O)CC[C@]2(CO2)[C@@]1(O)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,12-13,18H,6-9H2,1-4H3/t12-,13-,14+,15+,16+/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



University of California Santa Cruz

Curated by ChEMBL


Assay Description
Inhibition of methionine aminopeptidase 2


J Nat Prod 72: 588-603 (2010)


Article DOI: 10.1021/np800817y
BindingDB Entry DOI: 10.7270/Q2765G84
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137403
PNG
(Acetyl-carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(R...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(Cl)=O
Show InChI InChI=1S/C18H26ClNO6/c1-10(2)5-6-12-17(3,26-12)14-13(23-4)11(7-8-18(14)9-24-18)25-16(22)20-15(19)21/h5,11-14H,6-9H2,1-4H3,(H,20,21,22)/t11-,12-,13-,14-,17+,18+/m1/s1
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n/an/a 0.430n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137404
PNG
(Acetic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(C)=O
Show InChI InChI=1S/C18H28O5/c1-11(2)6-7-14-17(4,23-14)16-15(20-5)13(22-12(3)19)8-9-18(16)10-21-18/h6,13-16H,7-10H2,1-5H3/t13-,14-,15-,16-,17+,18+/m1/s1
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n/an/a 0.510n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50113436
PNG
(CHEMBL32838 | fumagillin)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
Show InChI InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1
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n/an/a 0.630n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137402
PNG
(4-Ethyl-piperazine-1-carboxylic acid (3R,4S,5S,6R)...)
Show SMILES CCN1CCN(CC1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)C(\C)=N\OCC1CCCCC1
Show InChI InChI=1S/C24H41N3O5/c1-4-26-12-14-27(15-13-26)23(28)32-20-10-11-24(17-30-24)21(22(20)29-3)18(2)25-31-16-19-8-6-5-7-9-19/h19-22H,4-17H2,1-3H3/b25-18+/t20-,21+,22-,24+/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



University of California Santa Cruz

Curated by ChEMBL


Assay Description
Inhibition of methionine aminopeptidase 2


J Nat Prod 72: 588-603 (2010)


Article DOI: 10.1021/np800817y
BindingDB Entry DOI: 10.7270/Q2765G84
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002035
PNG
((2-Hydroxycarbamoyl-3-phenyl-propionylamino)-aceti...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C12H14N2O5/c15-10(16)7-13-11(17)9(12(18)14-19)6-8-4-2-1-3-5-8/h1-5,9,19H,6-7H2,(H,13,17)(H,14,18)(H,15,16)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)


Article DOI: 10.1021/jm00147a007
BindingDB Entry DOI: 10.7270/Q20C4WB5
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50131562
PNG
(CHEMBL117603 | Deca-2,4,6,8-tetraenedioic acid mon...)
Show SMILES CO[C@@H]1[C@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@H]1CC=C(C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
Show InChI InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23+,24+,25-,26-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against purified recombinant human Methionine Aminopeptidase 2 (MetAP2)


J Med Chem 46: 3452-4 (2003)


Article DOI: 10.1021/jm0341103
BindingDB Entry DOI: 10.7270/Q2NG4Q0J
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



The Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2


J Med Chem 49: 5645-8 (2006)


Article DOI: 10.1021/jm060559v
BindingDB Entry DOI: 10.7270/Q2PN959W
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36588
PNG
(AGM-1470)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,16?,18-,19+/m1/s1
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n/an/a 1n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137408
PNG
(CHEMBL172883 | Carbamic acid (3R,4S,5S,6R)-4-{1-[(...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1\C(C)=N\OCc1ccccc1)OC(N)=O
Show InChI InChI=1S/C18H24N2O5/c1-12(20-24-10-13-6-4-3-5-7-13)15-16(22-2)14(25-17(19)21)8-9-18(15)11-23-18/h3-7,14-16H,8-11H2,1-2H3,(H2,19,21)/b20-12+/t14-,15+,16-,18+/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137406
PNG
(Acetic acid (3R,4S,5S,6R)-4-{1-[(E)-benzyloxyimino...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1\C(C)=N\OCc1ccccc1)OC(C)=O
Show InChI InChI=1S/C19H25NO5/c1-13(20-24-11-15-7-5-4-6-8-15)17-18(22-3)16(25-14(2)21)9-10-19(17)12-23-19/h4-8,16-18H,9-12H2,1-3H3/b20-13+/t16-,17+,18-,19+/m1/s1
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Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188704
PNG
(US9169246, 246)
Show SMILES OC1CCN(C1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H18F3N5O2/c22-21(23,24)11-29-17-8-12(3-4-15(17)18-16(20(29)31)9-26-27-18)14-2-1-6-25-19(14)28-7-5-13(30)10-28/h1-4,6,8-9,13,30H,5,7,10-11H2,(H,26,27)
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n/an/a 1.46n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137409
PNG
(CHEMBL369152 | Carbamic acid (3R,4S,5S,6R)-4-((E)-...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1\C(C)=C\CC=C(C)C)OC(N)=O
Show InChI InChI=1S/C17H27NO4/c1-11(2)6-5-7-12(3)14-15(20-4)13(22-16(18)19)8-9-17(14)10-21-17/h6-7,13-15H,5,8-10H2,1-4H3,(H2,18,19)/b12-7+/t13-,14+,15-,17+/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002022
PNG
((2-Benzyl-3-hydroxycarbamoyl-propionylamino)-aceti...)
Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C13H16N2O5/c16-11(15-20)7-10(13(19)14-8-12(17)18)6-9-4-2-1-3-5-9/h1-5,10,20H,6-8H2,(H,14,19)(H,15,16)(H,17,18)
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)


Article DOI: 10.1021/jm00147a007
BindingDB Entry DOI: 10.7270/Q20C4WB5
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36595
PNG
(FOS-68)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO7/c1-11(2)5-6-13-17(3,28-13)19(24)15(25-4)12(7-8-18(19)10-26-18)27-16(23)21-14(22)9-20/h5,12-13,15,24H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,17-,18+,19+/m1/s1
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n/an/a 2n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188545
PNG
(US9169246, 30)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C22H20F3N5O/c23-22(24,25)13-30-19-11-15(3-6-17(19)20-18(21(30)31)12-27-28-20)14-1-4-16(5-2-14)29-9-7-26-8-10-29/h1-6,11-12,26H,7-10,13H2,(H,27,28)
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n/an/a 2.13n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50025913
PNG
(CHEMBL16457 | [2-(Formyl-hydroxy-amino)-3-phenyl-p...)
Show SMILES ON(C=O)C(Cc1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C12H14N2O5/c15-8-14(19)10(12(18)13-7-11(16)17)6-9-4-2-1-3-5-9/h1-5,8,10,19H,6-7H2,(H,13,18)(H,16,17)
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n/an/a 2.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)


Article DOI: 10.1021/jm00147a007
BindingDB Entry DOI: 10.7270/Q20C4WB5
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188567
PNG
(US9169246, 66)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C21H19F3N6O/c22-21(23,24)12-30-17-9-13(1-3-15(17)19-16(20(30)31)11-27-28-19)14-2-4-18(26-10-14)29-7-5-25-6-8-29/h1-4,9-11,25H,5-8,12H2,(H,27,28)
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n/an/a 3.06n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188731
PNG
(US9169246, 273)
Show SMILES FC1CCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H19F4N5O/c23-14-5-8-30(9-6-14)20-15(2-1-7-27-20)13-3-4-16-18(10-13)31(12-22(24,25)26)21(32)17-11-28-29-19(16)17/h1-4,7,10-11,14H,5-6,8-9,12H2,(H,28,29)
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n/an/a 3.45n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36592
PNG
(FOS-70)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C)OC(=O)CCCCl
Show InChI InChI=1S/C20H31ClO5/c1-13(2)7-8-15-19(3,26-15)18-17(23-4)14(9-10-20(18)12-24-20)25-16(22)6-5-11-21/h7,14-15,17-18H,5-6,8-12H2,1-4H3/t14-,15?,17-,18?,19-,20+/m1/s1
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n/an/a 3.5n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188706
PNG
(US9169246, 248)
Show SMILES CN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H16F3N5O/c1-26(2)17-12(4-3-7-23-17)11-5-6-13-15(8-11)27(10-19(20,21)22)18(28)14-9-24-25-16(13)14/h3-9H,10H2,1-2H3,(H,24,25)
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n/an/a 3.87n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188541
PNG
(US9169246, 19)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C23H22F3N5O/c1-29-8-10-30(11-9-29)17-5-2-15(3-6-17)16-4-7-18-20(12-16)31(14-23(24,25)26)22(32)19-13-27-28-21(18)19/h2-7,12-13H,8-11,14H2,1H3,(H,27,28)
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n/an/a 3.94n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36596
PNG
(FOS-34)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,11-13,17-18H,6-9H2,1-4H3/t11-,12?,13-,14-,15+,16+/m1/s1
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n/an/a 4n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188569
PNG
(US9169246, 68)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H21F3N6O/c1-29-6-8-30(9-7-29)19-11-15(4-5-26-19)14-2-3-16-18(10-14)31(13-22(23,24)25)21(32)17-12-27-28-20(16)17/h2-5,10-12H,6-9,13H2,1H3,(H,27,28)
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n/an/a 4.12n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188707
PNG
(US9169246, 249)
Show SMILES CCN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C20H18F3N5O/c1-3-27(2)18-13(5-4-8-24-18)12-6-7-14-16(9-12)28(11-20(21,22)23)19(29)15-10-25-26-17(14)15/h4-10H,3,11H2,1-2H3,(H,25,26)
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n/an/a 4.19n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188621
PNG
(US9169246, 121)
Show SMILES CCC(=O)Nc1ccc(C)cc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H19F3N4O2/c1-3-19(30)27-17-7-4-12(2)8-15(17)13-5-6-14-18(9-13)29(11-22(23,24)25)21(31)16-10-26-28-20(14)16/h4-10H,3,11H2,1-2H3,(H,26,28)(H,27,30)
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n/an/a 4.29n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50075321
PNG
(2-(2,6-Diisopropyl-phenyl)-4-hydroxy-isoindole-1,3...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2cccc(O)c2C1=O
Show InChI InChI=1S/C20H21NO3/c1-11(2)13-7-5-8-14(12(3)4)18(13)21-19(23)15-9-6-10-16(22)17(15)20(21)24/h5-12,22H,1-4H3
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n/an/a 4.30n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Bioorg Med Chem Lett 9: 559-62 (1999)


Article DOI: 10.1016/s0960-894x(99)00034-7
BindingDB Entry DOI: 10.7270/Q2ZW1MFX
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188708
PNG
(US9169246, 250)
Show SMILES CN(CCO)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C20H18F3N5O2/c1-27(7-8-29)18-13(3-2-6-24-18)12-4-5-14-16(9-12)28(11-20(21,22)23)19(30)15-10-25-26-17(14)15/h2-6,9-10,29H,7-8,11H2,1H3,(H,25,26)
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n/an/a 4.41n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188686
PNG
(US9169246, 226)
Show SMILES CC(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H14F3N5O2/c1-10(28)25-15-8-23-5-4-12(15)11-2-3-13-16(6-11)27(9-19(20,21)22)18(29)14-7-24-26-17(13)14/h2-8H,9H2,1H3,(H,24,26)(H,25,28)
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n/an/a 4.68n/an/an/an/an/an/a



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US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188659
PNG
(US9169246, 199)
Show SMILES FC(F)(F)Cn1c2cc(c(Cl)cc2c2[nH]ncc2c1=O)-c1cccnc1Cl
Show InChI InChI=1S/C17H9Cl2F3N4O/c18-12-4-10-13(5-9(12)8-2-1-3-23-15(8)19)26(7-17(20,21)22)16(27)11-6-24-25-14(10)11/h1-6H,7H2,(H,24,25)
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n/an/a 4.90n/an/an/an/an/an/a



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US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188693
PNG
(US9169246, 235)
Show SMILES CN(C)CCS(=O)(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H22F3N5O3S/c1-29(2)9-10-34(32,33)28-18-6-4-3-5-15(18)14-7-8-16-19(11-14)30(13-22(23,24)25)21(31)17-12-26-27-20(16)17/h3-8,11-12,28H,9-10,13H2,1-2H3,(H,26,27)
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n/an/a 4.99n/an/an/an/an/an/a



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US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)


Article DOI: 10.1021/jm00147a007
BindingDB Entry DOI: 10.7270/Q20C4WB5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188692
PNG
(US9169246, 234)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H15F3N4O3S/c1-30(28,29)25-15-5-3-2-4-12(15)11-6-7-13-16(8-11)26(10-19(20,21)22)18(27)14-9-23-24-17(13)14/h2-9,25H,10H2,1H3,(H,23,24)
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n/an/a 5.33n/an/an/an/an/an/a



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US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188709
PNG
(US9169246, 251)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCC1
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)12-29-17-10-13(5-6-15(17)18-16(20(29)30)11-26-27-18)14-4-3-7-25-19(14)28-8-1-2-9-28/h3-7,10-11H,1-2,8-9,12H2,(H,26,27)
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n/an/a 5.34n/an/an/an/an/an/a



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US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50075333
PNG
(5-Amino-2-(2,6-diisopropyl-phenyl)-isoindole-1,3-d...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccc(N)cc2C1=O
Show InChI InChI=1S/C20H22N2O2/c1-11(2)14-6-5-7-15(12(3)4)18(14)22-19(23)16-9-8-13(21)10-17(16)20(22)24/h5-12H,21H2,1-4H3
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PubMed
n/an/a 5.40n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Bioorg Med Chem Lett 9: 559-62 (1999)


Article DOI: 10.1016/s0960-894x(99)00034-7
BindingDB Entry DOI: 10.7270/Q2ZW1MFX
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188571
PNG
(US9169246, 70)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H19F3N6O/c22-21(23,24)12-30-17-9-13(1-2-15(17)19-16(20(30)31)11-27-28-19)14-3-4-26-18(10-14)29-7-5-25-6-8-29/h1-4,9-11,25H,5-8,12H2,(H,27,28)
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n/an/a 5.62n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188728
PNG
(US9169246, 270)
Show SMILES CN1CCCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C23H23F3N6O/c1-30-8-3-9-31(11-10-30)21-16(4-2-7-27-21)15-5-6-17-19(12-15)32(14-23(24,25)26)22(33)18-13-28-29-20(17)18/h2,4-7,12-13H,3,8-11,14H2,1H3,(H,28,29)
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n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36590
PNG
(FOS-72)
Show SMILES CO[C@H]1C([C@]2(C)OC2CC=C(C)C)[C@@]2(CO2)CCC1=O
Show InChI InChI=1S/C16H24O4/c1-10(2)5-6-12-15(3,20-12)14-13(18-4)11(17)7-8-16(14)9-19-16/h5,12-14H,6-9H2,1-4H3/t12?,13-,14?,15-,16+/m1/s1
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n/an/a 6n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188702
PNG
(US9169246, 244)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCNCC1
Show InChI InChI=1S/C22H21F3N6O/c23-22(24,25)13-31-18-11-14(4-5-16(18)19-17(21(31)32)12-28-29-19)15-3-1-7-27-20(15)30-9-2-6-26-8-10-30/h1,3-5,7,11-12,26H,2,6,8-10,13H2,(H,28,29)
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n/an/a 6.08n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188705
PNG
(US9169246, 247)
Show SMILES OC1CN(CC1O)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H18F3N5O3/c22-21(23,24)10-29-15-6-11(3-4-13(15)18-14(20(29)32)7-26-27-18)12-2-1-5-25-19(12)28-8-16(30)17(31)9-28/h1-7,16-17,30-31H,8-10H2,(H,26,27)
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n/an/a 6.41n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188531
PNG
(US9169246, 2)
Show SMILES Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C17H12F3N5O/c18-17(19,20)8-25-13-6-9(10-2-1-5-22-15(10)21)3-4-11(13)14-12(16(25)26)7-23-24-14/h1-7H,8H2,(H2,21,22)(H,23,24)
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n/an/a 7.06n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50020158
PNG
((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...)
Show SMILES CC(NC(=O)C(CC(=O)NO)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)
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n/an/a 7.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)


Article DOI: 10.1021/jm00147a007
BindingDB Entry DOI: 10.7270/Q20C4WB5
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188609
PNG
(US9169246, 109)
Show SMILES Fc1cc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2cc1-c1ccccn1
Show InChI InChI=1S/C17H10F4N4O/c18-12-5-10-14(6-9(12)13-3-1-2-4-22-13)25(8-17(19,20)21)16(26)11-7-23-24-15(10)11/h1-7H,8H2,(H,23,24)
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n/an/a 7.10n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188628
PNG
(US9169246, 166)
Show SMILES CN1CCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H21F3N6O/c1-29-7-9-30(10-8-29)20-15(3-2-6-26-20)14-4-5-16-18(11-14)31(13-22(23,24)25)21(32)17-12-27-28-19(16)17/h2-6,11-12H,7-10,13H2,1H3,(H,27,28)
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n/an/a 7.24n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188573
PNG
(US9169246, 72)
Show SMILES Cc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N4O/c1-10-12(3-2-6-22-10)11-4-5-13-15(7-11)25(9-18(19,20)21)17(26)14-8-23-24-16(13)14/h2-8H,9H2,1H3,(H,23,24)
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n/an/a 7.38n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM188611
PNG
(US9169246, 111)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1Cl
Show InChI InChI=1S/C17H10ClF3N4O/c18-15-10(2-1-5-22-15)9-3-4-11-13(6-9)25(8-17(19,20)21)16(26)12-7-23-24-14(11)12/h1-7H,8H2,(H,23,24)
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n/an/a 7.42n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
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