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Compile Data Set for Download or QSAR

Found 1073 hits Enz. Inhib. hit(s) with Target = 'Aminopeptidase N (APN)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002035
PNG
((2-Hydroxycarbamoyl-3-phenyl-propionylamino)-aceti...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C12H14N2O5/c15-10(16)7-13-11(17)9(12(18)14-19)6-8-4-2-1-3-5-8/h1-5,9,19H,6-7H2,(H,13,17)(H,14,18)(H,15,16)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002022
PNG
((2-Benzyl-3-hydroxycarbamoyl-propionylamino)-aceti...)
Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C13H16N2O5/c16-11(15-20)7-10(13(19)14-8-12(17)18)6-9-4-2-1-3-5-9/h1-5,10,20H,6-8H2,(H,14,19)(H,15,16)(H,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50025913
PNG
(CHEMBL16457 | [2-(Formyl-hydroxy-amino)-3-phenyl-p...)
Show SMILES ON(C=O)C(Cc1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C12H14N2O5/c15-8-14(19)10(12(18)13-7-11(16)17)6-9-4-2-1-3-5-9/h1-5,8,10,19H,6-7H2,(H,13,18)(H,16,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50020158
PNG
((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...)
Show SMILES CC(NC(=O)C(CC(=O)NO)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)
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n/an/a 7.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50025915
PNG
(CHEMBL16622 | [2-Benzyl-3-(formyl-hydroxy-amino)-p...)
Show SMILES ON(CC(Cc1ccccc1)C(=O)NCC(O)=O)C=O
Show InChI InChI=1S/C13H16N2O5/c16-9-15(20)8-11(13(19)14-7-12(17)18)6-10-4-2-1-3-5-10/h1-5,9,11,20H,6-8H2,(H,14,19)(H,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


J Med Chem 28: 1158-69 (1985)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002031
PNG
(1-Mercaptomethyl-3-methylsulfanyl-propyl-ammonium)
Show SMILES CSCCC([NH3+])CS
Show InChI InChI=1S/C5H13NS2/c1-8-3-2-5(6)4-7/h5,7H,2-4,6H2,1H3/p+1
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002026
PNG
(2-Mercapto-1-methylsulfanylmethyl-ethyl-ammonium)
Show SMILES CSCC([NH3+])CS
Show InChI InChI=1S/C4H11NS2/c1-7-3-4(5)2-6/h4,6H,2-3,5H2,1H3/p+1
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144944
PNG
(CHEMBL3764919)
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n/an/a 20n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50368599
PNG
(CHEMBL1159809)
Show SMILES CS(=O)CCC(N)CS
Show InChI InChI=1S/C5H13NOS2/c1-9(7)3-2-5(6)4-8/h5,8H,2-4,6H2,1H3
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50368598
PNG
(CHEMBL1159810)
Show SMILES CS(=O)CC(N)CS
Show InChI InChI=1S/C4H11NOS2/c1-8(6)3-4(5)2-7/h4,7H,2-3,5H2,1H3
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002027
PNG
(1-Mercaptomethyl-3-methyl-butyl-ammonium)
Show SMILES CC(C)CC([NH3+])CS
Show InChI InChI=1S/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/p+1
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n/an/a 22n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50405949
PNG
(CHEMBL2114408)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C21H24N2O5/c24-19(23-28)13-17(11-15-7-3-1-4-8-15)21(27)22-18(14-20(25)26)12-16-9-5-2-6-10-16/h1-10,17-18,28H,11-14H2,(H,22,27)(H,23,24)(H,25,26)/t17-,18+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50001950
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m1/s1
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Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain aminopeptidase


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002034
PNG
(2-Mercapto-1-phenyl-ethyl-ammonium)
Show SMILES [NH3+]C(CS)c1ccccc1
Show InChI InChI=1S/C8H11NS/c9-8(6-10)7-4-2-1-3-5-7/h1-5,8,10H,6,9H2/p+1
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INSERM

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50036828
PNG
(1-Mercaptomethyl-2-phenyl-ethyl-ammonium | 2-Amino...)
Show SMILES NC(CS)Cc1ccccc1
Show InChI InChI=1S/C9H13NS/c10-9(7-11)6-8-4-2-1-3-5-8/h1-5,9,11H,6-7,10H2
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n/an/a 30n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144931
PNG
(CHEMBL3764432)
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n/an/a 30n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50405952
PNG
(CHEMBL2114407)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)c1ccccc1
Show InChI InChI=1S/C20H22N2O5/c23-18(22-27)12-16(11-14-7-3-1-4-8-14)20(26)21-17(13-19(24)25)15-9-5-2-6-10-15/h1-10,16-17,27H,11-13H2,(H,21,26)(H,22,23)(H,24,25)/t16-,17+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002019
PNG
(2-tert-Butylsulfanyl-1-mercaptomethyl-ethyl-ammoni...)
Show SMILES CC(C)(C)SCC([NH3+])CS
Show InChI InChI=1S/C7H17NS2/c1-7(2,3)10-5-6(8)4-9/h6,9H,4-5,8H2,1-3H3/p+1
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002037
PNG
(2-(4-Hydroxy-phenyl)-1-mercaptomethyl-ethyl-ammoni...)
Show SMILES [NH3+]C(CS)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H13NOS/c10-8(6-12)5-7-1-3-9(11)4-2-7/h1-4,8,11-12H,5-6,10H2/p+1
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INSERM

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002030
PNG
(2-Cyclohexyl-1-mercaptomethyl-ethyl-ammonium)
Show SMILES [NH3+]C(CS)CC1CCCCC1
Show InChI InChI=1S/C9H19NS/c10-9(7-11)6-8-4-2-1-3-5-8/h8-9,11H,1-7,10H2/p+1
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INSERM

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50400532
PNG
(CHEMBL2204959)
Show SMILES CC(C)C[C@H](NC(=O)NCc1cccc2ccccc12)C(=O)NO
Show InChI InChI=1S/C18H23N3O3/c1-12(2)10-16(17(22)21-24)20-18(23)19-11-14-8-5-7-13-6-3-4-9-15(13)14/h3-9,12,16,24H,10-11H2,1-2H3,(H,21,22)(H2,19,20,23)/t16-/m0/s1
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TBA

Assay Description
Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substra...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144929
PNG
(CHEMBL3764200)
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Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002028
PNG
(1-Benzyloxymethyl-2-mercapto-ethyl-ammonium)
Show SMILES [NH3+]C(CS)COCc1ccccc1
Show InChI InChI=1S/C10H15NOS/c11-10(8-13)7-12-6-9-4-2-1-3-5-9/h1-5,10,13H,6-8,11H2/p+1
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50430635
PNG
(CHEMBL2332525)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1Br)C(=O)NO
Show InChI InChI=1S/C13H18BrN3O3/c1-8(2)7-11(12(18)17-20)16-13(19)15-10-6-4-3-5-9(10)14/h3-6,8,11,20H,7H2,1-2H3,(H,17,18)(H2,15,16,19)/t11-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144946
PNG
(CHEMBL3763918)
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n/an/a 70n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50018216
PNG
(2-Benzyl-3-(2-benzyl-3-hydroxycarbamoyl-propionyla...)
Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NCC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H24N2O5/c24-19(23-28)13-17(11-15-7-3-1-4-8-15)20(25)22-14-18(21(26)27)12-16-9-5-2-6-10-16/h1-10,17-18,28H,11-14H2,(H,22,25)(H,23,24)(H,26,27)
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INSERM

Curated by ChEMBL


Assay Description
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433055
PNG
(CHEMBL2376113)
Show SMILES ONC(=O)CN1C(=O)C2(OCCCCO2)c2cc(Cl)ccc12
Show InChI InChI=1S/C14H15ClN2O5/c15-9-3-4-11-10(7-9)14(21-5-1-2-6-22-14)13(19)17(11)8-12(18)16-20/h3-4,7,20H,1-2,5-6,8H2,(H,16,18)
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n/an/a 74n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144923
PNG
(CHEMBL3764156)
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n/an/a 80n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50197498
PNG
(CHEMBL220311 | N-hydroxy-2-isobutyl-N'-(4-phenyl-b...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C17H26N2O3/c1-13(2)12-15(17(21)19-22)16(20)18-11-7-6-10-14-8-4-3-5-9-14/h3-5,8-9,13,15,22H,6-7,10-12H2,1-2H3,(H,18,20)(H,19,21)
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n/an/a 82n/an/an/an/an/an/a



University of Lille 2

Curated by ChEMBL


Assay Description
Inhibition of microsomal neural aminopeptidase in pig kidney


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433053
PNG
(CHEMBL2376115)
Show SMILES ONC(=O)CN1C(=O)C2(OCCCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C14H15BrN2O5/c15-9-3-4-11-10(7-9)14(21-5-1-2-6-22-14)13(19)17(11)8-12(18)16-20/h3-4,7,20H,1-2,5-6,8H2,(H,16,18)
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n/an/a 86n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002020
PNG
(2-Benzylsulfanyl-1-mercaptomethyl-ethyl-ammonium)
Show SMILES [NH3+]C(CS)CSCc1ccccc1
Show InChI InChI=1S/C10H15NS2/c11-10(6-12)8-13-7-9-4-2-1-3-5-9/h1-5,10,12H,6-8,11H2/p+1
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n/an/a 90n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144917
PNG
(CHEMBL3764826)
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n/an/a 90n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50430636
PNG
(CHEMBL2332524)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C13H18ClN3O3/c1-8(2)7-11(12(18)17-20)16-13(19)15-10-6-4-3-5-9(10)14/h3-6,8,11,20H,7H2,1-2H3,(H,17,18)(H2,15,16,19)/t11-/m0/s1
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n/an/a 93n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50400529
PNG
(CHEMBL2204943)
Show SMILES CC(C)C[C@H](NC(=O)Nc1cccc2ccccc12)C(=O)NO
Show InChI InChI=1S/C17H21N3O3/c1-11(2)10-15(16(21)20-23)19-17(22)18-14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11,15,23H,10H2,1-2H3,(H,20,21)(H2,18,19,22)/t15-/m0/s1
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n/an/a 99n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substra...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50018219
PNG
(2-[(2-Benzyl-3-hydroxycarbamoyl-propionyl)-methyl-...)
Show SMILES CN(C(Cc1ccccc1)C(O)=O)C(=O)C(CC(=O)NO)Cc1ccccc1
Show InChI InChI=1S/C21H24N2O5/c1-23(18(21(26)27)13-16-10-6-3-7-11-16)20(25)17(14-19(24)22-28)12-15-8-4-2-5-9-15/h2-11,17-18,28H,12-14H2,1H3,(H,22,24)(H,26,27)
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n/an/a 120n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50002017
PNG
(1-Mercaptomethyl-2-naphthalen-2-yl-ethyl-ammonium)
Show SMILES [NH3+]C(CS)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C13H15NS/c14-13(9-15)8-10-5-6-11-3-1-2-4-12(11)7-10/h1-7,13,15H,8-9,14H2/p+1
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n/an/a 130n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney


J Med Chem 35: 1259-66 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50430631
PNG
(CHEMBL2332519)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccccc1Br)C(=O)NO
Show InChI InChI=1S/C14H20BrN3O3/c1-9(2)7-12(13(19)18-21)17-14(20)16-8-10-5-3-4-6-11(10)15/h3-6,9,12,21H,7-8H2,1-2H3,(H,18,19)(H2,16,17,20)/t12-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50018218
PNG
((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...)
Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H22N2O5/c23-18(22-27)13-16(11-14-7-3-1-4-8-14)19(24)21-17(20(25)26)12-15-9-5-2-6-10-15/h1-10,16-17,27H,11-13H2,(H,21,24)(H,22,23)(H,25,26)
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n/an/a 130n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50430633
PNG
(CHEMBL2332527)
Show SMILES COc1ccccc1NC(=O)N[C@@H](CC(C)C)C(=O)NO
Show InChI InChI=1S/C14H21N3O4/c1-9(2)8-11(13(18)17-20)16-14(19)15-10-6-4-5-7-12(10)21-3/h4-7,9,11,20H,8H2,1-3H3,(H,17,18)(H2,15,16,19)/t11-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50430634
PNG
(CHEMBL2332526)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1C)C(=O)NO
Show InChI InChI=1S/C14H21N3O3/c1-9(2)8-12(13(18)17-20)16-14(19)15-11-7-5-4-6-10(11)3/h4-7,9,12,20H,8H2,1-3H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144922
PNG
(CHEMBL3765787)
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n/an/a 180n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50430632
PNG
(CHEMBL2332518)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C14H20ClN3O3/c1-9(2)7-12(13(19)18-21)17-14(20)16-8-10-5-3-4-6-11(10)15/h3-6,9,12,21H,7-8H2,1-2H3,(H,18,19)(H2,16,17,20)/t12-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144928
PNG
(CHEMBL3765179)
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n/an/a 230n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50430644
PNG
(CHEMBL2332513)
Show SMILES CC(C)C[C@H](NC(=O)Nc1cccc(C)c1)C(=O)NO
Show InChI InChI=1S/C14H21N3O3/c1-9(2)7-12(13(18)17-20)16-14(19)15-11-6-4-5-10(3)8-11/h4-6,8-9,12,20H,7H2,1-3H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50400541
PNG
(CHEMBL2204950)
Show SMILES COc1cccc(CNC(=O)N[C@@H](CC(C)C)C(=O)NO)c1
Show InChI InChI=1S/C15H23N3O4/c1-10(2)7-13(14(19)18-21)17-15(20)16-9-11-5-4-6-12(8-11)22-3/h4-6,8,10,13,21H,7,9H2,1-3H3,(H,18,19)(H2,16,17,20)/t13-/m0/s1
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TBA

Assay Description
Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substra...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433060
PNG
(CHEMBL2376104)
Show SMILES ONC(=O)CN1C(=O)C2(OCCO2)c2cc(Cl)ccc12
Show InChI InChI=1S/C12H11ClN2O5/c13-7-1-2-9-8(5-7)12(19-3-4-20-12)11(17)15(9)6-10(16)14-18/h1-2,5,18H,3-4,6H2,(H,14,16)
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n/an/a 310n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50001947
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)C(O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19-,22?/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain aminopeptidase


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50400544
PNG
(CHEMBL2204947)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)NO
Show InChI InChI=1S/C14H21N3O3/c1-9(2)8-12(13(18)17-20)16-14(19)15-11-6-4-10(3)5-7-11/h4-7,9,12,20H,8H2,1-3H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a 330n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substra...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50144914
PNG
(CHEMBL3764417)
PDB

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n/an/a 330n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
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