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Found 4346 hits Enz. Inhib. hit(s) with Target = 'Anandamide amidohydrolase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166892
PNG
(CHEMBL3797772)
Show SMILES Clc1ccc(OC(=O)N2CCN(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
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n/an/a 0.0100n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166881
PNG
(CHEMBL3798535)
Show SMILES Oc1c2CC=CCc2c(O)n1-c1ccc(cc1)C(=O)OCC(=O)c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C27H26N2O5/c30-24(18-7-11-20(12-8-18)28-15-3-4-16-28)17-34-27(33)19-9-13-21(14-10-19)29-25(31)22-5-1-2-6-23(22)26(29)32/h1-2,7-14,31-32H,3-6,15-17H2
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n/an/a 0.0100n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166880
PNG
(CHEMBL3798487)
Show SMILES Cc1ccc(cc1C)C(=O)COC(=O)c1ccc(cc1)-n1c(O)c2CC=CCc2c1O
Show InChI InChI=1S/C25H23NO5/c1-15-7-8-18(13-16(15)2)22(27)14-31-25(30)17-9-11-19(12-10-17)26-23(28)20-5-3-4-6-21(20)24(26)29/h3-4,7-13,28-29H,5-6,14H2,1-2H3
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n/an/a 0.0200n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50447747
PNG
(CHEMBL3113272)
Show SMILES Fc1ccc(F)c(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-15(21)14(12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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n/an/a 0.0250n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166868
PNG
(CHEMBL3797635)
Show SMILES Oc1c2CC=CCc2c(O)n1-c1ccc(cc1)C(=O)OCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C25H21NO7/c27-20(16-7-10-21-22(13-16)32-12-11-31-21)14-33-25(30)15-5-8-17(9-6-15)26-23(28)18-3-1-2-4-19(18)24(26)29/h1-2,5-10,13,28-29H,3-4,11-12,14H2
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n/an/a 0.0300n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166873
PNG
(CHEMBL3800456)
Show SMILES Cc1ccc(cc1C)C(=O)COC(=O)c1ccc(cc1)-n1c(O)ccc1O
Show InChI InChI=1S/C21H19NO5/c1-13-3-4-16(11-14(13)2)18(23)12-27-21(26)15-5-7-17(8-6-15)22-19(24)9-10-20(22)25/h3-11,24-25H,12H2,1-2H3
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n/an/a 0.0400n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166871
PNG
(CHEMBL3797841)
Show SMILES Oc1c2CC=CCc2c(O)n1-c1ccc(cc1)C(=O)OCC(=O)c1ccc2CCCc2c1
Show InChI InChI=1S/C26H23NO5/c28-23(19-9-8-16-4-3-5-18(16)14-19)15-32-26(31)17-10-12-20(13-11-17)27-24(29)21-6-1-2-7-22(21)25(27)30/h1-2,8-14,29-30H,3-7,15H2
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n/an/a 0.0600n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166866
PNG
(CHEMBL3798156)
Show SMILES Cc1ccc(cc1C)C(=O)COC(=O)c1ccc(cc1)N1C(=O)CCCC1=O
Show InChI InChI=1S/C22H21NO5/c1-14-6-7-17(12-15(14)2)19(24)13-28-22(27)16-8-10-18(11-9-16)23-20(25)4-3-5-21(23)26/h6-12H,3-5,13H2,1-2H3
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n/an/a 0.0700n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50447748
PNG
(CHEMBL3113271)
Show SMILES Fc1cccc(c1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-1-3-13(17(14)21)15-6-8-22-18(24-15)27-9-11-28(12-10-27)19(29)25-16-5-2-7-23-26-16/h1-8H,9-12H2,(H,25,26,29)
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n/an/a 0.0720n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166869
PNG
(CHEMBL3799744)
Show SMILES COc1ccc(cc1OC)C(=O)COC(=O)c1ccc(cc1)-n1c(O)c2CC=CCc2c1O
Show InChI InChI=1S/C25H23NO7/c1-31-21-12-9-16(13-22(21)32-2)20(27)14-33-25(30)15-7-10-17(11-8-15)26-23(28)18-5-3-4-6-19(18)24(26)29/h3-4,7-13,28-29H,5-6,14H2,1-2H3
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n/an/a 0.0800n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50447745
PNG
(CHEMBL3113274)
Show SMILES Fc1cc(F)cc(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-10-13(11-15(21)12-14)16-3-5-22-18(24-16)27-6-8-28(9-7-27)19(29)25-17-2-1-4-23-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
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n/an/a 0.0800n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166890
PNG
(CHEMBL3797809)
Show SMILES O=C(Oc1ccc(cc1)C#N)N1CCN(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
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n/an/a 0.0900n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50350535
PNG
(CHEMBL1812722)
Show SMILES Fc1cccc(COc2ccc(OC3CCN(CC3)C(=O)n3ccnc3)cc2)c1
Show InChI InChI=1S/C22H22FN3O3/c23-18-3-1-2-17(14-18)15-28-19-4-6-20(7-5-19)29-21-8-11-25(12-9-21)22(27)26-13-10-24-16-26/h1-7,10,13-14,16,21H,8-9,11-12,15H2
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n/an/a 0.0930n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FAAH


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50247048
PNG
(CHEMBL462609 | methyl icosylphosphonofluoridate)
Show SMILES CCCCCCCCCCCCCCCCCCCCP(F)(=O)OC
Show InChI InChI=1S/C21H44FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h3-21H2,1-2H3
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n/an/a 0.100n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]anadamide hydrolysis in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50161525
PNG
(1-(oxazolo[4,5-b]pyridin-2-yl)-9-phenylnonan-1-one...)
Show SMILES O=C(CCCCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C21H24N2O2/c24-18(21-23-20-19(25-21)15-10-16-22-20)14-9-4-2-1-3-6-11-17-12-7-5-8-13-17/h5,7-8,10,12-13,15-16H,1-4,6,9,11,14H2
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n/an/a 0.100n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligand


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50132714
PNG
((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenesulfonyl f...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCS(F)(=O)=O
Show InChI InChI=1S/C20H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24(21,22)23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 0.100n/an/an/an/an/an/a



Universit£ Catholique de Louvain

Curated by ChEMBL


Assay Description
Irreversible inhibition of fatty acid amide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50132713
PNG
(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
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n/an/a 0.100n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory potency of Fatty-acid amide hydrolase with Mouse brain memebrane


Bioorg Med Chem Lett 13: 3301-3 (2003)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50132714
PNG
((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenesulfonyl f...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCS(F)(=O)=O
Show InChI InChI=1S/C20H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24(21,22)23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 0.110n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory potency of Fatty-acid amide hydrolase with Mouse brain memebrane


Bioorg Med Chem Lett 13: 3301-3 (2003)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166867
PNG
(CHEMBL3798476)
Show SMILES CC1=CCc2c(O)n(c(O)c2C1)-c1ccc(cc1)C(=O)OCC(=O)c1ccc(C)c(C)c1
Show InChI InChI=1S/C26H25NO5/c1-15-4-11-21-22(12-15)25(30)27(24(21)29)20-9-7-18(8-10-20)26(31)32-14-23(28)19-6-5-16(2)17(3)13-19/h4-10,13,29-30H,11-12,14H2,1-3H3
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n/an/a 0.140n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50247052
PNG
(2-Nonylsulfanyl-4H-benzo[1,3,2]dioxaphosphinine 2-...)
Show SMILES CCCCCCCCCSP1(=O)OCc2ccccc2O1
Show InChI InChI=1S/C16H25O3PS/c1-2-3-4-5-6-7-10-13-21-20(17)18-14-15-11-8-9-12-16(15)19-20/h8-9,11-12H,2-7,10,13-14H2,1H3
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n/an/a 0.150n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]anadamide hydrolysis in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50309725
PNG
(CHEMBL598764 | nicotinaldehyde O-4-(undecyloxy)phe...)
Show SMILES CCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C24H33N3O3/c1-2-3-4-5-6-7-8-9-10-18-29-23-15-13-22(14-16-23)27-24(28)30-26-20-21-12-11-17-25-19-21/h11-17,19-20H,2-10,18H2,1H3,(H,27,28)/b26-20+
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n/an/a 0.150n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166910
PNG
(CHEMBL3798355)
Show SMILES FC(F)(F)c1ccc(OC(=O)N2CCN(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
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n/an/a 0.160n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50447747
PNG
(CHEMBL3113272)
Show SMILES Fc1ccc(F)c(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-15(21)14(12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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n/an/a 0.170n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166891
PNG
(CHEMBL3799008)
Show SMILES O=C(Oc1cccc(c1)C#N)N1CCN(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
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n/an/a 0.200n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166878
PNG
(CHEMBL3800599)
Show SMILES Oc1c2CC=CCc2c(O)n1-c1ccc(cc1)C(=O)OCC(=O)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C27H26N2O6/c30-24(18-5-9-20(10-6-18)28-13-15-34-16-14-28)17-35-27(33)19-7-11-21(12-8-19)29-25(31)22-3-1-2-4-23(22)26(29)32/h1-2,5-12,31-32H,3-4,13-17H2
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n/an/a 0.200n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50309712
PNG
(4-fluorobenzaldehyde O-4-(nonyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C23H29FN2O3/c1-2-3-4-5-6-7-8-17-28-22-15-13-21(14-16-22)26-23(27)29-25-18-19-9-11-20(24)12-10-19/h9-16,18H,2-8,17H2,1H3,(H,26,27)/b25-18+
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n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166911
PNG
(CHEMBL3799516)
Show SMILES [O-][N+](=O)c1ccc(OC(=O)N2CCN(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
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n/an/a 0.200n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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n/an/a 0.240n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50295654
PNG
(CHEMBL559034 | Dodecylcarbamic acid 3-(1,2,3-thiad...)
Show SMILES CCCCCCCCCCCCNC(=O)Oc1cccc(c1)-c1csnn1
Show InChI InChI=1S/C21H31N3O2S/c1-2-3-4-5-6-7-8-9-10-11-15-22-21(25)26-19-14-12-13-18(16-19)20-17-27-24-23-20/h12-14,16-17H,2-11,15H2,1H3,(H,22,25)
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n/an/a 0.240n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50309701
PNG
(CHEMBL597430 | benzaldehyde O-4-(nonyloxy)phenylca...)
Show SMILES CCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O3/c1-2-3-4-5-6-7-11-18-27-22-16-14-21(15-17-22)25-23(26)28-24-19-20-12-9-8-10-13-20/h8-10,12-17,19H,2-7,11,18H2,1H3,(H,25,26)/b24-19+
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n/an/a 0.25n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50309713
PNG
(4-fluorobenzaldehyde O-4-(decyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C24H31FN2O3/c1-2-3-4-5-6-7-8-9-18-29-23-16-14-22(15-17-23)27-24(28)30-26-19-20-10-12-21(25)13-11-20/h10-17,19H,2-9,18H2,1H3,(H,27,28)/b26-19+
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n/an/a 0.25n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50309711
PNG
(4-fluorobenzaldehyde O-4-(octyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H27FN2O3/c1-2-3-4-5-6-7-16-27-21-14-12-20(13-15-21)25-22(26)28-24-17-18-8-10-19(23)11-9-18/h8-15,17H,2-7,16H2,1H3,(H,25,26)/b24-17+
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n/an/a 0.270n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50447746
PNG
(CHEMBL3113273)
Show SMILES Fc1ccc(cc1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-3-13(12-15(14)21)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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n/an/a 0.280n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM23316
PNG
(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C19H20N2O2/c22-16(19-21-18-17(23-19)13-8-14-20-18)12-7-2-1-4-9-15-10-5-3-6-11-15/h3,5-6,8,10-11,13-14H,1-2,4,7,9,12H2
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n/an/a 0.300n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Fatty-acid amide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50161520
PNG
(1-(oxazolo[4,5-b]pyridin-2-yl)-8-phenyloctan-1-one...)
Show SMILES O=C(CCCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C20H22N2O2/c23-17(20-22-19-18(24-20)14-9-15-21-19)13-8-3-1-2-5-10-16-11-6-4-7-12-16/h4,6-7,9,11-12,14-15H,1-3,5,8,10,13H2
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n/an/a 0.300n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligand


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM23316
PNG
(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C19H20N2O2/c22-16(19-21-18-17(23-19)13-8-14-20-18)12-7-2-1-4-9-15-10-5-3-6-11-15/h3,5-6,8,10-11,13-14H,1-2,4,7,9,12H2
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n/an/a 0.300n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligand


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50434318
PNG
(CHEMBL2386566)
Show SMILES CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(cc1)-c1ncn(C)c1Sc1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN3OS/c1-25(2)21(27)19-12-18(19)14-4-6-15(7-5-14)20-22(26(3)13-24-20)28-17-10-8-16(23)9-11-17/h4-11,13,18-19H,12H2,1-3H3/t18-,19+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50437233
PNG
(CHEMBL2402911)
Show SMILES CC(=O)c1cccc(c1)-c1cc(OC(=O)NC2CCCCC2)ccc1O
Show InChI InChI=1S/C21H23NO4/c1-14(23)15-6-5-7-16(12-15)19-13-18(10-11-20(19)24)26-21(25)22-17-8-3-2-4-9-17/h5-7,10-13,17,24H,2-4,8-9H2,1H3,(H,22,25)
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n/an/a 0.300n/an/an/an/an/an/a



Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat brain FAAH using [3H]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition by liquid scintillat...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM23316
PNG
(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C19H20N2O2/c22-16(19-21-18-17(23-19)13-8-14-20-18)12-7-2-1-4-9-15-10-5-3-6-11-15/h3,5-6,8,10-11,13-14H,1-2,4,7,9,12H2
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n/an/a 0.316n/an/an/an/a9.037



FUNDP



Assay Description
The effect of the test compounds on the enzymatic hydrolysis of [3H]anandamide was evaluated by using rat brain homogenate preparations. [3H]Ethanola...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50132713
PNG
(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
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n/an/a 0.330n/an/an/an/an/an/a



Louvain Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human FAAH


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50132713
PNG
(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
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n/an/a 0.331n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-maltose binding protein


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50419129
PNG
(CHEMBL1830441)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCCCCc2ccccc2)c1
Show InChI InChI=1S/C24H24N2O3/c25-23(27)21-13-6-11-19(16-21)20-12-7-14-22(17-20)29-24(28)26-15-5-4-10-18-8-2-1-3-9-18/h1-3,6-9,11-14,16-17H,4-5,10,15H2,(H2,25,27)(H,26,28)
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n/an/a 0.331n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50447745
PNG
(CHEMBL3113274)
Show SMILES Fc1cc(F)cc(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-10-13(11-15(21)12-14)16-3-5-22-18(24-16)27-6-8-28(9-7-27)19(29)25-17-2-1-4-23-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
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n/an/a 0.340n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50309726
PNG
(CHEMBL597940 | nicotinaldehyde O-4-(dodecyloxy)phe...)
Show SMILES CCCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C25H35N3O3/c1-2-3-4-5-6-7-8-9-10-11-19-30-24-16-14-23(15-17-24)28-25(29)31-27-21-22-13-12-18-26-20-22/h12-18,20-21H,2-11,19H2,1H3,(H,28,29)/b27-21+
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n/an/a 0.350n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50309702
PNG
(CHEMBL597431 | benzaldehyde O-4-(decyloxy)phenylca...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C24H32N2O3/c1-2-3-4-5-6-7-8-12-19-28-23-17-15-22(16-18-23)26-24(27)29-25-20-21-13-10-9-11-14-21/h9-11,13-18,20H,2-8,12,19H2,1H3,(H,26,27)/b25-20+
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n/an/a 0.350n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50309724
PNG
(CHEMBL598558 | nicotinaldehyde O-4-(decyloxy)pheny...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H31N3O3/c1-2-3-4-5-6-7-8-9-17-28-22-14-12-21(13-15-22)26-23(27)29-25-19-20-11-10-16-24-18-20/h10-16,18-19H,2-9,17H2,1H3,(H,26,27)/b25-19+
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n/an/a 0.350n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM50166870
PNG
(CHEMBL3797226)
Show SMILES Oc1c2CC=CCc2c(O)n1-c1ccc(cc1)C(=O)OCC(=O)c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C29H29NO5/c31-26(21-12-10-20(11-13-21)19-6-2-1-3-7-19)18-35-29(34)22-14-16-23(17-15-22)30-27(32)24-8-4-5-9-25(24)28(30)33/h4-5,10-17,19,32-33H,1-3,6-9,18H2
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n/an/a 0.360n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50434329
PNG
(CHEMBL2386554)
Show SMILES Cn1cc(Sc2ccc(Cl)cc2)c(n1)-c1ccc2ccc(nc2c1)C(N)=O
Show InChI InChI=1S/C20H15ClN4OS/c1-25-11-18(27-15-7-5-14(21)6-8-15)19(24-25)13-3-2-12-4-9-16(20(22)26)23-17(12)10-13/h2-11H,1H3,(H2,22,26)
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n/an/a 0.400n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50324698
PNG
(CHEMBL1222256 | Ethyl octylfluorophosphonate)
Show SMILES CCCCCCCCP(F)(=O)OC(C)C
Show InChI InChI=1S/C11H24FO2P/c1-4-5-6-7-8-9-10-15(12,13)14-11(2)3/h11H,4-10H2,1-3H3
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n/an/a 0.400n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]anandamide from FAAH in Swiss Webster mouse brain after 5 mins


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Homo sapiens (human))
BDBM23120
PNG
(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
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n/an/a 0.400n/an/an/an/an/an/a



E.I. Du Pont de Nemours and Company

Curated by ChEMBL


Assay Description
Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...


Citation and Details
More data for this
Ligand-Target Pair
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