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Compile Data Set for Download or QSAR

Found 4142 hits Enz. Inhib. hit(s) with Target = 'Anandamide amidohydrolase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50447747
PNG
(CHEMBL3113272)
Show SMILES Fc1ccc(F)c(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-15(21)14(12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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n/an/a 0.0250n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50447748
PNG
(CHEMBL3113271)
Show SMILES Fc1cccc(c1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-1-3-13(17(14)21)15-6-8-22-18(24-15)27-9-11-28(12-10-27)19(29)25-16-5-2-7-23-26-16/h1-8H,9-12H2,(H,25,26,29)
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n/an/a 0.0720n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50447745
PNG
(CHEMBL3113274)
Show SMILES Fc1cc(F)cc(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-10-13(11-15(21)12-14)16-3-5-22-18(24-16)27-6-8-28(9-7-27)19(29)25-17-2-1-4-23-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
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n/an/a 0.0800n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50350535
PNG
(CHEMBL1812722)
Show SMILES Fc1cccc(COc2ccc(OC3CCN(CC3)C(=O)n3ccnc3)cc2)c1
Show InChI InChI=1S/C22H22FN3O3/c23-18-3-1-2-17(14-18)15-28-19-4-6-20(7-5-19)29-21-8-11-25(12-9-21)22(27)26-13-10-24-16-26/h1-7,10,13-14,16,21H,8-9,11-12,15H2
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n/an/a 0.0930n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FAAH


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50247048
PNG
(CHEMBL462609 | methyl icosylphosphonofluoridate)
Show SMILES CCCCCCCCCCCCCCCCCCCCP(F)(=O)OC
Show InChI InChI=1S/C21H44FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h3-21H2,1-2H3
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n/an/a 0.100n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]anadamide hydrolysis in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50132714
PNG
((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenesulfonyl f...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCS(F)(=O)=O
Show InChI InChI=1S/C20H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24(21,22)23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 0.100n/an/an/an/an/an/a



Universit£ Catholique de Louvain

Curated by ChEMBL


Assay Description
Irreversible inhibition of fatty acid amide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50132713
PNG
(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
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n/an/a 0.100n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory potency of Fatty-acid amide hydrolase with Mouse brain memebrane


Bioorg Med Chem Lett 13: 3301-3 (2003)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50161525
PNG
(1-(oxazolo[4,5-b]pyridin-2-yl)-9-phenylnonan-1-one...)
Show SMILES O=C(CCCCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C21H24N2O2/c24-18(21-23-20-19(25-21)15-10-16-22-20)14-9-4-2-1-3-6-11-17-12-7-5-8-13-17/h5,7-8,10,12-13,15-16H,1-4,6,9,11,14H2
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n/an/a 0.100n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligand


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50132714
PNG
((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenesulfonyl f...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCS(F)(=O)=O
Show InChI InChI=1S/C20H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24(21,22)23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 0.110n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory potency of Fatty-acid amide hydrolase with Mouse brain memebrane


Bioorg Med Chem Lett 13: 3301-3 (2003)

More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309725
PNG
(CHEMBL598764 | nicotinaldehyde O-4-(undecyloxy)phe...)
Show SMILES CCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C24H33N3O3/c1-2-3-4-5-6-7-8-9-10-18-29-23-15-13-22(14-16-23)27-24(28)30-26-20-21-12-11-17-25-19-21/h11-17,19-20H,2-10,18H2,1H3,(H,27,28)/b26-20+
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n/an/a 0.150n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50247052
PNG
(2-Nonylsulfanyl-4H-benzo[1,3,2]dioxaphosphinine 2-...)
Show SMILES CCCCCCCCCSP1(=O)OCc2ccccc2O1
Show InChI InChI=1S/C16H25O3PS/c1-2-3-4-5-6-7-10-13-21-20(17)18-14-15-11-8-9-12-16(15)19-20/h8-9,11-12H,2-7,10,13-14H2,1H3
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n/an/a 0.150n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]anadamide hydrolysis in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50447747
PNG
(CHEMBL3113272)
Show SMILES Fc1ccc(F)c(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-15(21)14(12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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n/an/a 0.170n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309712
PNG
(4-fluorobenzaldehyde O-4-(nonyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C23H29FN2O3/c1-2-3-4-5-6-7-8-17-28-22-15-13-21(14-16-22)26-23(27)29-25-18-19-9-11-20(24)12-10-19/h9-16,18H,2-8,17H2,1H3,(H,26,27)/b25-18+
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n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50295654
PNG
(CHEMBL559034 | Dodecylcarbamic acid 3-(1,2,3-thiad...)
Show SMILES CCCCCCCCCCCCNC(=O)Oc1cccc(c1)-c1csnn1
Show InChI InChI=1S/C21H31N3O2S/c1-2-3-4-5-6-7-8-9-10-11-15-22-21(25)26-19-14-12-13-18(16-19)20-17-27-24-23-20/h12-14,16-17H,2-11,15H2,1H3,(H,22,25)
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n/an/a 0.240n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309701
PNG
(CHEMBL597430 | benzaldehyde O-4-(nonyloxy)phenylca...)
Show SMILES CCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O3/c1-2-3-4-5-6-7-11-18-27-22-16-14-21(15-17-22)25-23(26)28-24-19-20-12-9-8-10-13-20/h8-10,12-17,19H,2-7,11,18H2,1H3,(H,25,26)/b24-19+
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n/an/a 0.25n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309713
PNG
(4-fluorobenzaldehyde O-4-(decyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C24H31FN2O3/c1-2-3-4-5-6-7-8-9-18-29-23-16-14-22(15-17-23)27-24(28)30-26-19-20-10-12-21(25)13-11-20/h10-17,19H,2-9,18H2,1H3,(H,27,28)/b26-19+
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n/an/a 0.25n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309711
PNG
(4-fluorobenzaldehyde O-4-(octyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H27FN2O3/c1-2-3-4-5-6-7-16-27-21-14-12-20(13-15-21)25-22(26)28-24-17-18-8-10-19(23)11-9-18/h8-15,17H,2-7,16H2,1H3,(H,25,26)/b24-17+
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n/an/a 0.270n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50447746
PNG
(CHEMBL3113273)
Show SMILES Fc1ccc(cc1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-3-13(12-15(14)21)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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n/an/a 0.280n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM23316
PNG
(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C19H20N2O2/c22-16(19-21-18-17(23-19)13-8-14-20-18)12-7-2-1-4-9-15-10-5-3-6-11-15/h3,5-6,8,10-11,13-14H,1-2,4,7,9,12H2
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n/an/a 0.300n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligand


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50161520
PNG
(1-(oxazolo[4,5-b]pyridin-2-yl)-8-phenyloctan-1-one...)
Show SMILES O=C(CCCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C20H22N2O2/c23-17(20-22-19-18(24-20)14-9-15-21-19)13-8-3-1-2-5-10-16-11-6-4-7-12-16/h4,6-7,9,11-12,14-15H,1-3,5,8,10,13H2
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n/an/a 0.300n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligand


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM23316
PNG
(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C19H20N2O2/c22-16(19-21-18-17(23-19)13-8-14-20-18)12-7-2-1-4-9-15-10-5-3-6-11-15/h3,5-6,8,10-11,13-14H,1-2,4,7,9,12H2
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n/an/a 0.300n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Fatty-acid amide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50434318
PNG
(CHEMBL2386566)
Show SMILES CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(cc1)-c1ncn(C)c1Sc1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN3OS/c1-25(2)21(27)19-12-18(19)14-4-6-15(7-5-14)20-22(26(3)13-24-20)28-17-10-8-16(23)9-11-17/h4-11,13,18-19H,12H2,1-3H3/t18-,19+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50437233
PNG
(CHEMBL2402911)
Show SMILES CC(=O)c1cccc(c1)-c1cc(OC(=O)NC2CCCCC2)ccc1O
Show InChI InChI=1S/C21H23NO4/c1-14(23)15-6-5-7-16(12-15)19-13-18(10-11-20(19)24)26-21(25)22-17-8-3-2-4-9-17/h5-7,10-13,17,24H,2-4,8-9H2,1H3,(H,22,25)
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n/an/a 0.300n/an/an/an/an/an/a



Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat brain FAAH using [3H]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition by liquid scintillat...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM23316
PNG
(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C19H20N2O2/c22-16(19-21-18-17(23-19)13-8-14-20-18)12-7-2-1-4-9-15-10-5-3-6-11-15/h3,5-6,8,10-11,13-14H,1-2,4,7,9,12H2
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n/an/a 0.316n/an/an/an/a9.037



FUNDP



Assay Description
The effect of the test compounds on the enzymatic hydrolysis of [3H]anandamide was evaluated by using rat brain homogenate preparations. [3H]Ethanola...


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50132713
PNG
(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
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n/an/a 0.330n/an/an/an/an/an/a



Louvain Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human FAAH


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50132713
PNG
(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
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n/an/a 0.331n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-maltose binding protein


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50419129
PNG
(CHEMBL1830441)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCCCCc2ccccc2)c1
Show InChI InChI=1S/C24H24N2O3/c25-23(27)21-13-6-11-19(16-21)20-12-7-14-22(17-20)29-24(28)26-15-5-4-10-18-8-2-1-3-9-18/h1-3,6-9,11-14,16-17H,4-5,10,15H2,(H2,25,27)(H,26,28)
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n/an/a 0.331n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50447745
PNG
(CHEMBL3113274)
Show SMILES Fc1cc(F)cc(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-10-13(11-15(21)12-14)16-3-5-22-18(24-16)27-6-8-28(9-7-27)19(29)25-17-2-1-4-23-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
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n/an/a 0.340n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309702
PNG
(CHEMBL597431 | benzaldehyde O-4-(decyloxy)phenylca...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C24H32N2O3/c1-2-3-4-5-6-7-8-12-19-28-23-17-15-22(16-18-23)26-24(27)29-25-20-21-13-10-9-11-14-21/h9-11,13-18,20H,2-8,12,19H2,1H3,(H,26,27)/b25-20+
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n/an/a 0.350n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309726
PNG
(CHEMBL597940 | nicotinaldehyde O-4-(dodecyloxy)phe...)
Show SMILES CCCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C25H35N3O3/c1-2-3-4-5-6-7-8-9-10-11-19-30-24-16-14-23(15-17-24)28-25(29)31-27-21-22-13-12-18-26-20-22/h12-18,20-21H,2-11,19H2,1H3,(H,28,29)/b27-21+
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n/an/a 0.350n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309724
PNG
(CHEMBL598558 | nicotinaldehyde O-4-(decyloxy)pheny...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H31N3O3/c1-2-3-4-5-6-7-8-9-17-28-22-14-12-21(13-15-22)26-23(27)29-25-19-20-11-10-16-24-18-20/h10-16,18-19H,2-9,17H2,1H3,(H,26,27)/b25-19+
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n/an/a 0.350n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50275260
PNG
(1-(oxazol-2-yl)-4-(1-(3-phenoxybenzyl)piperidin-4-...)
Show SMILES O=C(CCCC1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)c1ncco1
Show InChI InChI=1S/C25H28N2O3/c28-24(25-26-14-17-29-25)11-5-6-20-12-15-27(16-13-20)19-21-7-4-10-23(18-21)30-22-8-2-1-3-9-22/h1-4,7-10,14,17-18,20H,5-6,11-13,15-16,19H2
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n/an/a 0.400n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50434329
PNG
(CHEMBL2386554)
Show SMILES Cn1cc(Sc2ccc(Cl)cc2)c(n1)-c1ccc2ccc(nc2c1)C(N)=O
Show InChI InChI=1S/C20H15ClN4OS/c1-25-11-18(27-15-7-5-14(21)6-8-15)19(24-25)13-3-2-12-4-9-16(20(22)26)23-17(12)10-13/h2-11H,1H3,(H2,22,26)
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TBA

Assay Description
Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...


Citation and Details
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50324698
PNG
(CHEMBL1222256 | Ethyl octylfluorophosphonate)
Show SMILES CCCCCCCCP(F)(=O)OC(C)C
Show InChI InChI=1S/C11H24FO2P/c1-4-5-6-7-8-9-10-15(12,13)14-11(2)3/h11H,4-10H2,1-3H3
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n/an/a 0.400n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]anandamide from FAAH in Swiss Webster mouse brain after 5 mins


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309714
PNG
(4-fluorobenzaldehyde O-4-(undecyloxy)phenylcarbamo...)
Show SMILES CCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C25H33FN2O3/c1-2-3-4-5-6-7-8-9-10-19-30-24-17-15-23(16-18-24)28-25(29)31-27-20-21-11-13-22(26)14-12-21/h11-18,20H,2-10,19H2,1H3,(H,28,29)/b27-20+
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n/an/a 0.400n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50447749
PNG
(CHEMBL3113270)
Show SMILES Fc1ccc(c(F)c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-14(15(21)12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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n/an/a 0.430n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309700
PNG
(CHEMBL597229 | benzaldehyde O-4-(octyloxy)phenylca...)
Show SMILES CCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C22H28N2O3/c1-2-3-4-5-6-10-17-26-21-15-13-20(14-16-21)24-22(25)27-23-18-19-11-8-7-9-12-19/h7-9,11-16,18H,2-6,10,17H2,1H3,(H,24,25)/b23-18+
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n/an/a 0.430n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50426652
PNG
(CHEMBL2326178)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccc(F)cc2F)c1C
Show InChI InChI=1S/C19H19F2N5O2S/c1-11-12(2)28-24-17(11)23-18(27)25-5-7-26(8-6-25)19-22-16(10-29-19)14-4-3-13(20)9-15(14)21/h3-4,9-10H,5-8H2,1-2H3,(H,23,24,27)
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n/an/a 0.430n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50309703
PNG
(CHEMBL586217 | benzaldehyde O-4-(undecyloxy)phenyl...)
Show SMILES CCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C25H34N2O3/c1-2-3-4-5-6-7-8-9-13-20-29-24-18-16-23(17-19-24)27-25(28)30-26-21-22-14-11-10-12-15-22/h10-12,14-19,21H,2-9,13,20H2,1H3,(H,27,28)/b26-21+
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n/an/a 0.450n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in human H4 cells


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50426652
PNG
(CHEMBL2326178)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccc(F)cc2F)c1C
Show InChI InChI=1S/C19H19F2N5O2S/c1-11-12(2)28-24-17(11)23-18(27)25-5-7-26(8-6-25)19-22-16(10-29-19)14-4-3-13(20)9-15(14)21/h3-4,9-10H,5-8H2,1-2H3,(H,23,24,27)
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n/an/a 0.460n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50437231
PNG
(CHEMBL2402925)
Show SMILES NC(=O)c1cccc(c1)-c1cc(O)cc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O4/c21-19(24)14-6-4-5-13(9-14)15-10-17(23)12-18(11-15)26-20(25)22-16-7-2-1-3-8-16/h4-6,9-12,16,23H,1-3,7-8H2,(H2,21,24)(H,22,25)
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n/an/a 0.5n/an/an/an/an/an/a



Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat brain FAAH using [3H]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition by liquid scintillat...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50437232
PNG
(3‐(3‐carbamoylphenyl)‐4‐me...)
Show SMILES COc1ccc(OC(=O)NC2CCCCC2)cc1-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C21H24N2O4/c1-26-19-11-10-17(27-21(25)23-16-8-3-2-4-9-16)13-18(19)14-6-5-7-15(12-14)20(22)24/h5-7,10-13,16H,2-4,8-9H2,1H3,(H2,22,24)(H,23,25)
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Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat brain FAAH using [3H]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition by liquid scintillat...


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50434329
PNG
(CHEMBL2386554)
Show SMILES Cn1cc(Sc2ccc(Cl)cc2)c(n1)-c1ccc2ccc(nc2c1)C(N)=O
Show InChI InChI=1S/C20H15ClN4OS/c1-25-11-18(27-15-7-5-14(21)6-8-15)19(24-25)13-3-2-12-4-9-16(20(22)26)23-17(12)10-13/h2-11H,1H3,(H2,22,26)
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TBA

Assay Description
Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...


Citation and Details
More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50434316
PNG
(CHEMBL2386568)
Show SMILES CNC(=O)[C@H]1C[C@@H]1c1ccc(cc1)-c1ncn(C)c1Sc1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClN3OS/c1-23-20(26)18-11-17(18)13-3-5-14(6-4-13)19-21(25(2)12-24-19)27-16-9-7-15(22)8-10-16/h3-10,12,17-18H,11H2,1-2H3,(H,23,26)/t17-,18+/m1/s1
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TBA

Assay Description
Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...


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More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50402675
PNG
(CHEMBL2207348)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3noc4cnccc34)c2)cc1
Show InChI InChI=1S/C24H22ClN5O3/c25-18-4-6-19(7-5-18)32-20-3-1-2-17(14-20)16-29-10-12-30(13-11-29)24(31)27-23-21-8-9-26-15-22(21)33-28-23/h1-9,14-15H,10-13,16H2,(H,27,28,31)
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Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of human FAAH preincubated for 60 mins


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More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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Max-Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of rat intact neuron FAAH


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More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50424227
PNG
(CHEMBL2314112)
Show SMILES CCCCCCNC(=O)Oc1cccc(c1)C1=NCCO1
Show InChI InChI=1S/C16H22N2O3/c1-2-3-4-5-9-18-16(19)21-14-8-6-7-13(12-14)15-17-10-11-20-15/h6-8,12H,2-5,9-11H2,1H3,(H,18,19)
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n/an/a 0.550n/an/an/an/an/an/a



Centre for Addiction and Mental Health

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production incubated for 90 mins prior to ...


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More data for this
Ligand-Target Pair
Fatty Acid Amide Hydrolase


(Homo sapiens (human))
BDBM50161515
PNG
(8-phenyl-1-(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES O=C(CCCCCCCc1ccccc1)c1nnc(o1)-c1ccccn1
Show InChI InChI=1S/C21H23N3O2/c25-19(21-24-23-20(26-21)18-14-9-10-16-22-18)15-8-3-1-2-5-11-17-12-6-4-7-13-17/h4,6-7,9-10,12-14,16H,1-3,5,8,11,15H2
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligand


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid amide hydrolase (FAAH)


(Rattus norvegicus (rat))
BDBM50434318
PNG
(CHEMBL2386566)
Show SMILES CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(cc1)-c1ncn(C)c1Sc1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN3OS/c1-25(2)21(27)19-12-18(19)14-4-6-15(7-5-14)20-22(26(3)13-24-20)28-17-10-8-16(23)9-11-17/h4-11,13,18-19H,12H2,1-3H3/t18-,19+/m1/s1
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TBA

Assay Description
Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin p...


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More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM50395423
PNG
(CHEMBL2165084)
Show SMILES NC(=O)c1ccn(c1)-c1cccc(OC(=O)NCCCCCCc2ccccc2)c1
Show InChI InChI=1S/C24H27N3O3/c25-23(28)20-14-16-27(18-20)21-12-8-13-22(17-21)30-24(29)26-15-7-2-1-4-9-19-10-5-3-6-11-19/h3,5-6,8,10-14,16-18H,1-2,4,7,9,15H2,(H2,25,28)(H,26,29)
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Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of mouse FAAH isolated from brain homogenate using [3H-ethanolamine]AEA as substrate incubated for 20 mins prior to substrate addition mea...


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Ligand-Target Pair
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