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Compile Data Set for Download or QSAR

Found 4481 hits Enz. Inhib. hit(s) with Target = 'Angiotensin II receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213779
PNG
(CHEMBL313598)
Show SMILES CCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1cccs1
Show InChI InChI=1S/C34H34N4O5S4/c1-3-10-31-36-33(44-2)32(29(39)23-46(41)27-12-5-4-6-13-27)38(31)22-24-16-18-25(19-17-24)28-14-7-8-15-30(28)47(42,43)37-34(40)35-21-26-11-9-20-45-26/h4-9,11-20H,3,10,21-23H2,1-2H3,(H2,35,37,40)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213687
PNG
(CHEMBL87244)
Show SMILES CCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccc(C)cc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C37H38N4O5S3/c1-4-10-34-39-36(47-3)35(32(42)25-48(44)30-21-15-26(2)16-22-30)41(34)24-28-17-19-29(20-18-28)31-13-8-9-14-33(31)49(45,46)40-37(43)38-23-27-11-6-5-7-12-27/h5-9,11-22H,4,10,23-25H2,1-3H3,(H2,38,40,43)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213551
PNG
(CHEMBL90618)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCc1cccs1
Show InChI InChI=1S/C28H27F2N3O5S3/c1-2-6-23-31-26(40-28(29)30)25(27(35)36)33(23)17-18-10-12-19(13-11-18)21-8-3-4-9-22(21)41(37,38)32-24(34)15-14-20-7-5-16-39-20/h3-5,7-13,16,28H,2,6,14-15,17H2,1H3,(H,32,34)(H,35,36)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213592
PNG
(CHEMBL315236)
Show SMILES CCCCc1nc(SC)c(C(=O)CS(=O)(=O)c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C37H38N4O6S3/c1-3-4-19-34-39-36(48-2)35(32(42)26-49(44,45)30-15-9-6-10-16-30)41(34)25-28-20-22-29(23-21-28)31-17-11-12-18-33(31)50(46,47)40-37(43)38-24-27-13-7-5-8-14-27/h5-18,20-23H,3-4,19,24-26H2,1-2H3,(H2,38,40,43)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213695
PNG
(CHEMBL89032)
Show SMILES CCCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C37H38N4O5S3/c1-3-4-19-34-39-36(47-2)35(32(42)26-48(44)30-15-9-6-10-16-30)41(34)25-28-20-22-29(23-21-28)31-17-11-12-18-33(31)49(45,46)40-37(43)38-24-27-13-7-5-8-14-27/h5-18,20-23H,3-4,19,24-26H2,1-2H3,(H2,38,40,43)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035458
PNG
(CHEMBL138690 | N-[3-(3-Butyl-4-{2'-[(3,4-dichloro-...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1occ(Cl)c1Cl
Show InChI InChI=1S/C33H30Cl3N5O6S/c1-3-5-10-28-38-41(26-17-22(15-16-24(26)34)37-29(42)4-2)33(44)40(28)18-20-11-13-21(14-12-20)23-8-6-7-9-27(23)48(45,46)39-32(43)31-30(36)25(35)19-47-31/h6-9,11-17,19H,3-5,10,18H2,1-2H3,(H,37,42)(H,39,43)
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TBA

Assay Description
Antagonist activity at AT1 receptor in rabbit aorta membranes


Citation and Details

Article DOI: 10.1007/s00044-013-0831-x
BindingDB Entry DOI: 10.7270/Q2C82BRJ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035458
PNG
(CHEMBL138690 | N-[3-(3-Butyl-4-{2'-[(3,4-dichloro-...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1occ(Cl)c1Cl
Show InChI InChI=1S/C33H30Cl3N5O6S/c1-3-5-10-28-38-41(26-17-22(15-16-24(26)34)37-29(42)4-2)33(44)40(28)18-20-11-13-21(14-12-20)23-8-6-7-9-27(23)48(45,46)39-32(43)31-30(36)25(35)19-47-31/h6-9,11-17,19H,3-5,10,18H2,1-2H3,(H,37,42)(H,39,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50049199
PNG
(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C37H34N4O3S/c1-4-33-39-35-25(2)23-26(3)38-36(35)41(33)24-27-19-21-28(22-20-27)31-17-11-12-18-32(31)45(43,44)40-37(42)34(29-13-7-5-8-14-29)30-15-9-6-10-16-30/h5-23,34H,4,24H2,1-3H3,(H,40,42)
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DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 1


J Med Chem 39: 625-56 (1996)


Article DOI: 10.1021/jm9504722
BindingDB Entry DOI: 10.7270/Q29P3299
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035434
PNG
(CHEMBL265797 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C34H31Cl2N5O5S/c1-3-4-13-32-38-41(30-20-25(37-22(2)42)18-19-29(30)36)34(44)40(32)21-23-14-16-24(17-15-23)26-9-6-8-12-31(26)47(45,46)39-33(43)27-10-5-7-11-28(27)35/h5-12,14-20H,3-4,13,21H2,1-2H3,(H,37,42)(H,39,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035434
PNG
(CHEMBL265797 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C34H31Cl2N5O5S/c1-3-4-13-32-38-41(30-20-25(37-22(2)42)18-19-29(30)36)34(44)40(32)21-23-14-16-24(17-15-23)26-9-6-8-12-31(26)47(45,46)39-33(43)27-10-5-7-11-28(27)35/h5-12,14-20H,3-4,13,21H2,1-2H3,(H,37,42)(H,39,43)
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TBA

Assay Description
Antagonist activity at AT1 receptor in rabbit aorta membranes


Citation and Details

Article DOI: 10.1007/s00044-013-0831-x
BindingDB Entry DOI: 10.7270/Q2C82BRJ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035434
PNG
(CHEMBL265797 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C34H31Cl2N5O5S/c1-3-4-13-32-38-41(30-20-25(37-22(2)42)18-19-29(30)36)34(44)40(32)21-23-14-16-24(17-15-23)26-9-6-8-12-31(26)47(45,46)39-33(43)27-10-5-7-11-28(27)35/h5-12,14-20H,3-4,13,21H2,1-2H3,(H,37,42)(H,39,43)
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TBA

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta


Bioorg Med Chem Lett 4: 2787-2792 (1994)


Article DOI: 10.1016/S0960-894X(01)80595-3
BindingDB Entry DOI: 10.7270/Q2WS8T68
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50030726
PNG
(3-[4-(2'-Benzoylsulfamoyl-3-fluoro-biphenyl-4-ylme...)
Show SMILES CCCNC(=O)c1ccc(c(c1)-n1nc(CCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)c1=O)C(F)(F)F
Show InChI InChI=1S/C36H33F4N5O5S/c1-3-10-32-42-45(30-21-25(33(46)41-19-4-2)17-18-28(30)36(38,39)40)35(48)44(32)22-26-16-15-24(20-29(26)37)27-13-8-9-14-31(27)51(49,50)43-34(47)23-11-6-5-7-12-23/h5-9,11-18,20-21H,3-4,10,19,22H2,1-2H3,(H,41,46)(H,43,47)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50044402
PNG
(2-Butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Show SMILES CCCCc1nc2cccc(C(O)=O)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C26H24N6O2/c1-2-3-11-23-27-22-10-6-9-21(26(33)34)24(22)32(23)16-17-12-14-18(15-13-17)19-7-4-5-8-20(19)25-28-30-31-29-25/h4-10,12-15H,2-3,11,16H2,1H3,(H,33,34)(H,28,29,30,31)
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The M. S. University of Baroda

Curated by ChEMBL


Assay Description
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response


Bioorg Med Chem 18: 8418-56 (2010)


Article DOI: 10.1016/j.bmc.2010.10.043
BindingDB Entry DOI: 10.7270/Q2H70G3T
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282708
PNG
(CHEMBL289472 | Thiophene-2-carboxylic acid benzyl-...)
Show SMILES CCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)c1cccs1
Show InChI InChI=1S/C36H29N7O2S/c1-2-33-37-31-19-18-27(42(22-24-9-4-3-5-10-24)36(45)32-13-8-20-46-32)21-30(31)35(44)43(33)23-25-14-16-26(17-15-25)28-11-6-7-12-29(28)34-38-40-41-39-34/h3-21H,2,22-23H2,1H3,(H,38,39,40,41)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane


Bioorg Med Chem Lett 4: 1479-1484 (1994)


Article DOI: 10.1016/S0960-894X(01)80517-5
BindingDB Entry DOI: 10.7270/Q2BC401G
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213685
PNG
(CHEMBL431853)
Show SMILES CCCCc1nc(SC)c(C(=O)CS(=O)(=O)c2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C37H37FN4O6S3/c1-3-4-14-34-40-36(49-2)35(32(43)25-50(45,46)30-21-19-29(38)20-22-30)42(34)24-27-15-17-28(18-16-27)31-12-8-9-13-33(31)51(47,48)41-37(44)39-23-26-10-6-5-7-11-26/h5-13,15-22H,3-4,14,23-25H2,1-2H3,(H2,39,41,44)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50032352
PNG
(CHEMBL98665 | butyloxy 2-[2-(4-{4-ethyl-5-[3-diphe...)
Show SMILES CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C43H47FN4O6S/c1-5-15-40-45-37(6-2)41(38(49)24-26-47(34-18-11-8-12-19-34)42(50)31-16-9-7-10-17-31)48(40)29-33-23-22-32(28-36(33)44)35-20-13-14-21-39(35)55(52,53)46-43(51)54-27-25-30(3)4/h7-14,16-23,28,30H,5-6,15,24-27,29H2,1-4H3,(H,46,51)
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DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.


J Med Chem 38: 2938-45 (1995)


Article DOI: 10.1021/jm00015a016
BindingDB Entry DOI: 10.7270/Q2639NRN
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213505
PNG
(CHEMBL314975)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CC1CCCCC1
Show InChI InChI=1S/C29H33F2N3O5S2/c1-2-8-24-32-27(40-29(30)31)26(28(36)37)34(24)18-20-13-15-21(16-14-20)22-11-6-7-12-23(22)41(38,39)33-25(35)17-19-9-4-3-5-10-19/h6-7,11-16,19,29H,2-5,8-10,17-18H2,1H3,(H,33,35)(H,36,37)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213561
PNG
(CHEMBL312937)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)Cc1cccs1
Show InChI InChI=1S/C27H25F2N3O5S3/c1-2-6-22-30-25(39-27(28)29)24(26(34)35)32(22)16-17-10-12-18(13-11-17)20-8-3-4-9-21(20)40(36,37)31-23(33)15-19-7-5-14-38-19/h3-5,7-14,27H,2,6,15-16H2,1H3,(H,31,33)(H,34,35)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50030685
PNG
(CHEMBL338888 | Pentanoic acid {4-chloro-3-[3-ethyl...)
Show SMILES CCCCC(=O)Nc1ccc(Cl)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C33H37ClFN5O6S/c1-6-8-13-30(41)36-23-16-17-25(34)27(19-23)40-32(43)39(29(7-2)37-40)20-22-15-14-21(18-26(22)35)24-11-9-10-12-28(24)47(44,45)38-31(42)46-33(3,4)5/h9-12,14-19H,6-8,13,20H2,1-5H3,(H,36,41)(H,38,42)
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n/an/a 0.0700n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213697
PNG
(CHEMBL84908)
Show SMILES CCc1nc(SC)c(C(=O)C[S+]([O-])c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C35H34N4O5S3/c1-3-32-37-34(45-2)33(30(40)24-46(42)28-14-8-5-9-15-28)39(32)23-26-18-20-27(21-19-26)29-16-10-11-17-31(29)47(43,44)38-35(41)36-22-25-12-6-4-7-13-25/h4-21H,3,22-24H2,1-2H3,(H2,36,38,41)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213687
PNG
(CHEMBL87244)
Show SMILES CCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccc(C)cc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C37H38N4O5S3/c1-4-10-34-39-36(47-3)35(32(42)25-48(44)30-21-15-26(2)16-22-30)41(34)24-28-17-19-29(20-18-28)31-13-8-9-14-33(31)49(45,46)40-37(43)38-23-27-11-6-5-7-12-27/h5-9,11-22H,4,10,23-25H2,1-3H3,(H2,38,40,43)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035444
PNG
(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Show SMILES CCCCC(=O)Nc1ccc(Cl)c(c1)-n1nc(CCCC)n(Cc2ccc(cc2)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C35H42ClN5O6S/c1-6-8-14-31-38-41(29-22-26(20-21-28(29)36)37-32(42)15-9-7-2)34(44)40(31)23-24-16-18-25(19-17-24)27-12-10-11-13-30(27)48(45,46)39-33(43)47-35(3,4)5/h10-13,16-22H,6-9,14-15,23H2,1-5H3,(H,37,42)(H,39,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50030692
PNG
(CHEMBL339672 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C35H32Cl2FN5O5S/c1-3-5-14-32-40-43(30-20-24(17-18-28(30)37)39-33(44)4-2)35(46)42(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-27(26)36/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030692
PNG
(CHEMBL339672 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C35H32Cl2FN5O5S/c1-3-5-14-32-40-43(30-20-24(17-18-28(30)37)39-33(44)4-2)35(46)42(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-27(26)36/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035444
PNG
(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Show SMILES CCCCC(=O)Nc1ccc(Cl)c(c1)-n1nc(CCCC)n(Cc2ccc(cc2)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C35H42ClN5O6S/c1-6-8-14-31-38-41(29-22-26(20-21-28(29)36)37-32(42)15-9-7-2)34(44)40(31)23-24-16-18-25(19-17-24)27-12-10-11-13-30(27)48(45,46)39-33(43)47-35(3,4)5/h10-13,16-22H,6-9,14-15,23H2,1-5H3,(H,37,42)(H,39,43)
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TBA

Assay Description
Antagonist activity at AT1 receptor in rabbit aorta membranes


Citation and Details

Article DOI: 10.1007/s00044-013-0831-x
BindingDB Entry DOI: 10.7270/Q2C82BRJ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035454
PNG
(CHEMBL343309 | Cyclopropanecarboxylic acid (3-{3-b...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C36H33Cl2N5O5S/c1-2-3-12-33-40-43(31-21-26(19-20-30(31)38)39-34(44)25-17-18-25)36(46)42(33)22-23-13-15-24(16-14-23)27-8-5-7-11-32(27)49(47,48)41-35(45)28-9-4-6-10-29(28)37/h4-11,13-16,19-21,25H,2-3,12,17-18,22H2,1H3,(H,39,44)(H,41,45)
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TBA

Assay Description
Antagonist activity at AT1 receptor in rabbit aorta membranes


Citation and Details

Article DOI: 10.1007/s00044-013-0831-x
BindingDB Entry DOI: 10.7270/Q2C82BRJ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035454
PNG
(CHEMBL343309 | Cyclopropanecarboxylic acid (3-{3-b...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C36H33Cl2N5O5S/c1-2-3-12-33-40-43(31-21-26(19-20-30(31)38)39-34(44)25-17-18-25)36(46)42(33)22-23-13-15-24(16-14-23)27-8-5-7-11-32(27)49(47,48)41-35(45)28-9-4-6-10-29(28)37/h4-11,13-16,19-21,25H,2-3,12,17-18,22H2,1H3,(H,39,44)(H,41,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213782
PNG
(CHEMBL264304)
Show SMILES CCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C36H36N4O5S3/c1-3-12-33-38-35(46-2)34(31(41)25-47(43)29-15-8-5-9-16-29)40(33)24-27-19-21-28(22-20-27)30-17-10-11-18-32(30)48(44,45)39-36(42)37-23-26-13-6-4-7-14-26/h4-11,13-22H,3,12,23-25H2,1-2H3,(H2,37,39,42)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213688
PNG
(CHEMBL86538)
Show SMILES CCCc1nc(SC)c(C(C)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C30H32N4O4S2/c1-4-10-27-32-29(39-3)28(21(2)35)34(27)20-23-15-17-24(18-16-23)25-13-8-9-14-26(25)40(37,38)33-30(36)31-19-22-11-6-5-7-12-22/h5-9,11-18H,4,10,19-20H2,1-3H3,(H2,31,33,36)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213593
PNG
(CHEMBL91046)
Show SMILES CCCCc1nc(SC)c(C(=O)CS(C)(=O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C32H36N4O6S3/c1-4-5-15-29-34-31(43-2)30(27(37)22-44(3,39)40)36(29)21-24-16-18-25(19-17-24)26-13-9-10-14-28(26)45(41,42)35-32(38)33-20-23-11-7-6-8-12-23/h6-14,16-19H,4-5,15,20-22H2,1-3H3,(H2,33,35,38)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213680
PNG
(CHEMBL87091)
Show SMILES CCCCc1nc(SC)c(C(=O)CC(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C34H38N4O6S2/c1-4-6-16-30-36-33(45-3)32(28(39)21-31(40)44-5-2)38(30)23-25-17-19-26(20-18-25)27-14-10-11-15-29(27)46(42,43)37-34(41)35-22-24-12-8-7-9-13-24/h7-15,17-20H,4-6,16,21-23H2,1-3H3,(H2,35,37,41)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213681
PNG
(CHEMBL433010)
Show SMILES CCCc1nc(SC)c(C(=O)CS(=O)(=O)c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C36H36N4O6S3/c1-3-12-33-38-35(47-2)34(31(41)25-48(43,44)29-15-8-5-9-16-29)40(33)24-27-19-21-28(22-20-27)30-17-10-11-18-32(30)49(45,46)39-36(42)37-23-26-13-6-4-7-14-26/h4-11,13-22H,3,12,23-25H2,1-2H3,(H2,37,39,42)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50030721
PNG
(4-Bromo-N-butyl-3-{4-[2'-(2,5-dichloro-benzoylsulf...)
Show SMILES CCCCNC(=O)c1ccc(Br)c(c1)-n1nc(CCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)c1=O
Show InChI InChI=1S/C36H33BrCl2FN5O5S/c1-3-5-17-41-34(46)23-13-15-28(37)31(19-23)45-36(48)44(33(42-45)8-4-2)21-24-12-11-22(18-30(24)40)26-9-6-7-10-32(26)51(49,50)43-35(47)27-20-25(38)14-16-29(27)39/h6-7,9-16,18-20H,3-5,8,17,21H2,1-2H3,(H,41,46)(H,43,47)
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n/an/a 0.0920n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213460
PNG
(CHEMBL85081)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C33H29F2N3O5S2/c1-2-7-28-36-31(44-33(34)35)30(32(40)41)38(28)20-21-12-16-24(17-13-21)26-10-5-6-11-27(26)45(42,43)37-29(39)19-22-14-15-23-8-3-4-9-25(23)18-22/h3-6,8-18,33H,2,7,19-20H2,1H3,(H,37,39)(H,40,41)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50041969
PNG
(3-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C31H34N8O2/c1-5-6-11-28-33-27-17-16-23(32-31(41)38(4)20(2)3)18-26(27)30(40)39(28)19-21-12-14-22(15-13-21)24-9-7-8-10-25(24)29-34-36-37-35-29/h7-10,12-18,20H,5-6,11,19H2,1-4H3,(H,32,41)(H,34,35,36,37)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta


Bioorg Med Chem Lett 3: 1299-1304 (1993)


Article DOI: 10.1016/S0960-894X(00)80335-2
BindingDB Entry DOI: 10.7270/Q29P31KG
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213458
PNG
(CHEMBL90672)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C29H26F3N3O5S2/c1-2-5-24-33-27(41-29(31)32)26(28(37)38)35(24)17-19-8-12-20(13-9-19)22-6-3-4-7-23(22)42(39,40)34-25(36)16-18-10-14-21(30)15-11-18/h3-4,6-15,29H,2,5,16-17H2,1H3,(H,34,36)(H,37,38)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213504
PNG
(CHEMBL89369)
Show SMILES CCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C28H28N4O5S2/c1-3-24-30-26(38-2)25(27(33)34)32(24)18-20-13-15-21(16-14-20)22-11-7-8-12-23(22)39(36,37)31-28(35)29-17-19-9-5-4-6-10-19/h4-16H,3,17-18H2,1-2H3,(H,33,34)(H2,29,31,35)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213457
PNG
(CHEMBL84686)
Show SMILES CCCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCC1CCCCC1
Show InChI InChI=1S/C30H38N4O5S2/c1-3-4-14-26-32-28(40-2)27(29(35)36)34(26)20-22-15-17-23(18-16-22)24-12-8-9-13-25(24)41(38,39)33-30(37)31-19-21-10-6-5-7-11-21/h8-9,12-13,15-18,21H,3-7,10-11,14,19-20H2,1-2H3,(H,35,36)(H2,31,33,37)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213500
PNG
(CHEMBL86337)
Show SMILES CCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1cccs1
Show InChI InChI=1S/C27H28N4O5S3/c1-3-7-23-29-25(37-2)24(26(32)33)31(23)17-18-11-13-19(14-12-18)21-9-4-5-10-22(21)39(35,36)30-27(34)28-16-20-8-6-15-38-20/h4-6,8-15H,3,7,16-17H2,1-2H3,(H,32,33)(H2,28,30,34)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213456
PNG
(CHEMBL315000)
Show SMILES CCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCC1CCCC1
Show InChI InChI=1S/C28H34N4O5S2/c1-3-8-24-30-26(38-2)25(27(33)34)32(24)18-20-13-15-21(16-14-20)22-11-6-7-12-23(22)39(36,37)31-28(35)29-17-19-9-4-5-10-19/h6-7,11-16,19H,3-5,8-10,17-18H2,1-2H3,(H,33,34)(H2,29,31,35)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213552
PNG
(CHEMBL328302)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCc1ccccc1
Show InChI InChI=1S/C30H29F2N3O5S2/c1-2-8-25-33-28(41-30(31)32)27(29(37)38)35(25)19-21-13-16-22(17-14-21)23-11-6-7-12-24(23)42(39,40)34-26(36)18-15-20-9-4-3-5-10-20/h3-7,9-14,16-17,30H,2,8,15,18-19H2,1H3,(H,34,36)(H,37,38)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213567
PNG
(CHEMBL315983)
Show SMILES CCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCC1CCCCC1
Show InChI InChI=1S/C29H36N4O5S2/c1-3-9-25-31-27(39-2)26(28(34)35)33(25)19-21-14-16-22(17-15-21)23-12-7-8-13-24(23)40(37,38)32-29(36)30-18-20-10-5-4-6-11-20/h7-8,12-17,20H,3-6,9-11,18-19H2,1-2H3,(H,34,35)(H2,30,32,36)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50041969
PNG
(3-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C31H34N8O2/c1-5-6-11-28-33-27-17-16-23(32-31(41)38(4)20(2)3)18-26(27)30(40)39(28)19-21-12-14-22(15-13-21)24-9-7-8-10-25(24)29-34-36-37-35-29/h7-10,12-18,20H,5-6,11,19H2,1-4H3,(H,32,41)(H,34,35,36,37)
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n/an/a 0.100n/an/an/an/an/an/a



Organon Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against angiotensin II receptor, type 1


J Med Chem 48: 6523-43 (2005)


Article DOI: 10.1021/jm058225d
BindingDB Entry DOI: 10.7270/Q2SF2WZ9
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50283765
PNG
(CHEMBL321313 | N-{3-[3-Butyl-4-(3-fluoro-2'-(ethyl...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1cc(CCC)ccc1S(=O)(=O)NC(=O)OCC
Show InChI InChI=1S/C33H37ClFN5O6S/c1-5-8-10-31-37-40(29-19-25(36-21(4)41)14-15-27(29)34)33(43)39(31)20-24-13-12-23(18-28(24)35)26-17-22(9-6-2)11-16-30(26)47(44,45)38-32(42)46-7-3/h11-19H,5-10,20H2,1-4H3,(H,36,41)(H,38,42)
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TBA

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain


Bioorg Med Chem Lett 4: 2787-2792 (1994)


Article DOI: 10.1016/S0960-894X(01)80595-3
BindingDB Entry DOI: 10.7270/Q2WS8T68
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282276
PNG
(CHEMBL304947 | Pentanoic acid {2-butyl-3-[2'-(3-cy...)
Show SMILES CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(cc3)-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)c2nc1C
Show InChI InChI=1S/C37H47N5O4S/c1-4-6-16-34-39-32-24-31(40-35(43)17-7-5-2)26(3)38-37(32)42(34)25-28-18-21-29(22-19-28)30-14-10-11-15-33(30)47(45,46)41-36(44)23-20-27-12-8-9-13-27/h10-11,14-15,18-19,21-22,24,27H,4-9,12-13,16-17,20,23,25H2,1-3H3,(H,40,43)(H,41,44)
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TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type ...


Bioorg Med Chem Lett 4: 17-22 (1994)


Article DOI: 10.1016/S0960-894X(01)81115-X
BindingDB Entry DOI: 10.7270/Q2G73DPF
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282274
PNG
(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCC1CCCC1
Show InChI InChI=1S/C31H36N4O3S/c1-4-28-33-30-21(2)19-22(3)32-31(30)35(28)20-24-13-16-25(17-14-24)26-11-7-8-12-27(26)39(37,38)34-29(36)18-15-23-9-5-6-10-23/h7-8,11-14,16-17,19,23H,4-6,9-10,15,18,20H2,1-3H3,(H,34,36)
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TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type ...


Bioorg Med Chem Lett 4: 17-22 (1994)


Article DOI: 10.1016/S0960-894X(01)81115-X
BindingDB Entry DOI: 10.7270/Q2G73DPF
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283194
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL69721)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H44FN3O7S/c1-5-13-34-39-32(6-2)35(36(42)47-22-12-21-46-29-14-8-7-9-15-29)41(34)25-28-19-18-27(24-31(28)38)30-16-10-11-17-33(30)49(44,45)40-37(43)48-23-20-26(3)4/h7-11,14-19,24,26H,5-6,12-13,20-23,25H2,1-4H3,(H,40,43)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)


Article DOI: 10.1016/S0960-894X(00)80077-3
BindingDB Entry DOI: 10.7270/Q2DZ088W
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283201
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL305238)
Show SMILES CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H43FN4O7S/c1-5-12-33-40-31(6-2)35(36(44)48-22-20-34(43)39-28-13-8-7-9-14-28)42(33)24-27-18-17-26(23-30(27)38)29-15-10-11-16-32(29)50(46,47)41-37(45)49-21-19-25(3)4/h7-11,13-18,23,25H,5-6,12,19-22,24H2,1-4H3,(H,39,43)(H,41,45)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)


Article DOI: 10.1016/S0960-894X(00)80077-3
BindingDB Entry DOI: 10.7270/Q2DZ088W
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283219
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70843)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C39H43FN4O8S/c1-5-12-34-41-32(6-2)35(38(47)51-21-11-20-43-36(45)29-14-7-8-15-30(29)37(43)46)44(34)24-27-18-17-26(23-31(27)40)28-13-9-10-16-33(28)53(49,50)42-39(48)52-22-19-25(3)4/h7-10,13-18,23,25H,5-6,11-12,19-22,24H2,1-4H3,(H,42,48)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)


Article DOI: 10.1016/S0960-894X(00)80077-3
BindingDB Entry DOI: 10.7270/Q2DZ088W
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283231
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70935)
Show SMILES CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H40FN3O7S/c1-5-12-33-38-30(6-2)34(35(42)47-23-31(41)25-13-8-7-9-14-25)40(33)22-27-18-17-26(21-29(27)37)28-15-10-11-16-32(28)48(44,45)39-36(43)46-20-19-24(3)4/h7-11,13-18,21,24H,5-6,12,19-20,22-23H2,1-4H3,(H,39,43)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)


Article DOI: 10.1016/S0960-894X(00)80077-3
BindingDB Entry DOI: 10.7270/Q2DZ088W
More data for this
Ligand-Target Pair
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