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Compile Data Set for Download or QSAR

Found 6364 hits Enz. Inhib. hit(s) with Target = 'Angiotensin II receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213779
PNG
(CHEMBL313598)
Show SMILES CCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1cccs1
Show InChI InChI=1/C34H34N4O5S4/c1-3-10-31-36-33(44-2)32(29(39)23-46(41)27-12-5-4-6-13-27)38(31)22-24-16-18-25(19-17-24)28-14-7-8-15-30(28)47(42,43)37-34(40)35-21-26-11-9-20-45-26/h4-9,11-20H,3,10,21-23H2,1-2H3,(H2,35,37,40)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213687
PNG
(CHEMBL87244)
Show SMILES CCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccc(C)cc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1/C37H38N4O5S3/c1-4-10-34-39-36(47-3)35(32(42)25-48(44)30-21-15-26(2)16-22-30)41(34)24-28-17-19-29(20-18-28)31-13-8-9-14-33(31)49(45,46)40-37(43)38-23-27-11-6-5-7-12-27/h5-9,11-22H,4,10,23-25H2,1-3H3,(H2,38,40,43)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213551
PNG
(CHEMBL90618)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCc1cccs1
Show InChI InChI=1S/C28H27F2N3O5S3/c1-2-6-23-31-26(40-28(29)30)25(27(35)36)33(23)17-18-10-12-19(13-11-18)21-8-3-4-9-22(21)41(37,38)32-24(34)15-14-20-7-5-16-39-20/h3-5,7-13,16,28H,2,6,14-15,17H2,1H3,(H,32,34)(H,35,36)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213592
PNG
(CHEMBL315236)
Show SMILES CCCCc1nc(SC)c(C(=O)CS(=O)(=O)c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C37H38N4O6S3/c1-3-4-19-34-39-36(48-2)35(32(42)26-49(44,45)30-15-9-6-10-16-30)41(34)25-28-20-22-29(23-21-28)31-17-11-12-18-33(31)50(46,47)40-37(43)38-24-27-13-7-5-8-14-27/h5-18,20-23H,3-4,19,24-26H2,1-2H3,(H2,38,40,43)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213695
PNG
(CHEMBL89032)
Show SMILES CCCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1/C37H38N4O5S3/c1-3-4-19-34-39-36(47-2)35(32(42)26-48(44)30-15-9-6-10-16-30)41(34)25-28-20-22-29(23-21-28)31-17-11-12-18-33(31)49(45,46)40-37(43)38-24-27-13-7-5-8-14-27/h5-18,20-23H,3-4,19,24-26H2,1-2H3,(H2,38,40,43)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035458
PNG
(CHEMBL138690 | N-[3-(3-Butyl-4-{2'-[(3,4-dichloro-...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1occ(Cl)c1Cl
Show InChI InChI=1S/C33H30Cl3N5O6S/c1-3-5-10-28-38-41(26-17-22(15-16-24(26)34)37-29(42)4-2)33(44)40(28)18-20-11-13-21(14-12-20)23-8-6-7-9-27(23)48(45,46)39-32(43)31-30(36)25(35)19-47-31/h6-9,11-17,19H,3-5,10,18H2,1-2H3,(H,37,42)(H,39,43)
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TBA

Assay Description
Antagonist activity at AT1 receptor in rabbit aorta membranes


Citation and Details

Article DOI: 10.1007/s00044-013-0831-x
BindingDB Entry DOI: 10.7270/Q2C82BRJ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035458
PNG
(CHEMBL138690 | N-[3-(3-Butyl-4-{2'-[(3,4-dichloro-...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1occ(Cl)c1Cl
Show InChI InChI=1S/C33H30Cl3N5O6S/c1-3-5-10-28-38-41(26-17-22(15-16-24(26)34)37-29(42)4-2)33(44)40(28)18-20-11-13-21(14-12-20)23-8-6-7-9-27(23)48(45,46)39-32(43)31-30(36)25(35)19-47-31/h6-9,11-17,19H,3-5,10,18H2,1-2H3,(H,37,42)(H,39,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50049199
PNG
(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C37H34N4O3S/c1-4-33-39-35-25(2)23-26(3)38-36(35)41(33)24-27-19-21-28(22-20-27)31-17-11-12-18-32(31)45(43,44)40-37(42)34(29-13-7-5-8-14-29)30-15-9-6-10-16-30/h5-23,34H,4,24H2,1-3H3,(H,40,42)
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DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 1


J Med Chem 39: 625-56 (1996)


Article DOI: 10.1021/jm9504722
BindingDB Entry DOI: 10.7270/Q29P3299
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035434
PNG
(CHEMBL265797 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C34H31Cl2N5O5S/c1-3-4-13-32-38-41(30-20-25(37-22(2)42)18-19-29(30)36)34(44)40(32)21-23-14-16-24(17-15-23)26-9-6-8-12-31(26)47(45,46)39-33(43)27-10-5-7-11-28(27)35/h5-12,14-20H,3-4,13,21H2,1-2H3,(H,37,42)(H,39,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035434
PNG
(CHEMBL265797 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C34H31Cl2N5O5S/c1-3-4-13-32-38-41(30-20-25(37-22(2)42)18-19-29(30)36)34(44)40(32)21-23-14-16-24(17-15-23)26-9-6-8-12-31(26)47(45,46)39-33(43)27-10-5-7-11-28(27)35/h5-12,14-20H,3-4,13,21H2,1-2H3,(H,37,42)(H,39,43)
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TBA

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta


Bioorg Med Chem Lett 4: 2787-2792 (1994)


Article DOI: 10.1016/S0960-894X(01)80595-3
BindingDB Entry DOI: 10.7270/Q2WS8T68
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035434
PNG
(CHEMBL265797 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C34H31Cl2N5O5S/c1-3-4-13-32-38-41(30-20-25(37-22(2)42)18-19-29(30)36)34(44)40(32)21-23-14-16-24(17-15-23)26-9-6-8-12-31(26)47(45,46)39-33(43)27-10-5-7-11-28(27)35/h5-12,14-20H,3-4,13,21H2,1-2H3,(H,37,42)(H,39,43)
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TBA

Assay Description
Antagonist activity at AT1 receptor in rabbit aorta membranes


Citation and Details

Article DOI: 10.1007/s00044-013-0831-x
BindingDB Entry DOI: 10.7270/Q2C82BRJ
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50030726
PNG
(3-[4-(2'-Benzoylsulfamoyl-3-fluoro-biphenyl-4-ylme...)
Show SMILES CCCNC(=O)c1ccc(c(c1)-n1nc(CCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)c1=O)C(F)(F)F
Show InChI InChI=1S/C36H33F4N5O5S/c1-3-10-32-42-45(30-21-25(33(46)41-19-4-2)17-18-28(30)36(38,39)40)35(48)44(32)22-26-16-15-24(20-29(26)37)27-13-8-9-14-31(27)51(49,50)43-34(47)23-11-6-5-7-12-23/h5-9,11-18,20-21H,3-4,10,19,22H2,1-2H3,(H,41,46)(H,43,47)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50044402
PNG
(2-Butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Show SMILES CCCCc1nc2cccc(C(O)=O)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C26H24N6O2/c1-2-3-11-23-27-22-10-6-9-21(26(33)34)24(22)32(23)16-17-12-14-18(15-13-17)19-7-4-5-8-20(19)25-28-30-31-29-25/h4-10,12-15H,2-3,11,16H2,1H3,(H,33,34)(H,28,29,30,31)
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The M. S. University of Baroda

Curated by ChEMBL


Assay Description
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response


Bioorg Med Chem 18: 8418-56 (2010)


Article DOI: 10.1016/j.bmc.2010.10.043
BindingDB Entry DOI: 10.7270/Q2H70G3T
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282708
PNG
(CHEMBL289472 | Thiophene-2-carboxylic acid benzyl-...)
Show SMILES CCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)c1cccs1
Show InChI InChI=1S/C36H29N7O2S/c1-2-33-37-31-19-18-27(42(22-24-9-4-3-5-10-24)36(45)32-13-8-20-46-32)21-30(31)35(44)43(33)23-25-14-16-26(17-15-25)28-11-6-7-12-29(28)34-38-40-41-39-34/h3-21H,2,22-23H2,1H3,(H,38,39,40,41)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane


Bioorg Med Chem Lett 4: 1479-1484 (1994)


Article DOI: 10.1016/S0960-894X(01)80517-5
BindingDB Entry DOI: 10.7270/Q2BC401G
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213685
PNG
(CHEMBL431853)
Show SMILES CCCCc1nc(SC)c(C(=O)CS(=O)(=O)c2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C37H37FN4O6S3/c1-3-4-14-34-40-36(49-2)35(32(43)25-50(45,46)30-21-19-29(38)20-22-30)42(34)24-27-15-17-28(18-16-27)31-12-8-9-13-33(31)51(47,48)41-37(44)39-23-26-10-6-5-7-11-26/h5-13,15-22H,3-4,14,23-25H2,1-2H3,(H2,39,41,44)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50032352
PNG
(CHEMBL98665 | butyloxy 2-[2-(4-{4-ethyl-5-[3-diphe...)
Show SMILES CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C43H47FN4O6S/c1-5-15-40-45-37(6-2)41(38(49)24-26-47(34-18-11-8-12-19-34)42(50)31-16-9-7-10-17-31)48(40)29-33-23-22-32(28-36(33)44)35-20-13-14-21-39(35)55(52,53)46-43(51)54-27-25-30(3)4/h7-14,16-23,28,30H,5-6,15,24-27,29H2,1-4H3,(H,46,51)
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DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.


J Med Chem 38: 2938-45 (1995)


Article DOI: 10.1021/jm00015a016
BindingDB Entry DOI: 10.7270/Q2639NRN
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50229504
PNG
(SARALASIN | Saralasin)
Show SMILES CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/s2
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Berlex Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity as antagonist of AII on guinea pig ileum


J Med Chem 34: 2402-10 (1991)


Article DOI: 10.1021/jm00112a014
BindingDB Entry DOI: 10.7270/Q2VD71PJ
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213505
PNG
(CHEMBL314975)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CC1CCCCC1
Show InChI InChI=1S/C29H33F2N3O5S2/c1-2-8-24-32-27(40-29(30)31)26(28(36)37)34(24)18-20-13-15-21(16-14-20)22-11-6-7-12-23(22)41(38,39)33-25(35)17-19-9-4-3-5-10-19/h6-7,11-16,19,29H,2-5,8-10,17-18H2,1H3,(H,33,35)(H,36,37)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213561
PNG
(CHEMBL312937)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)Cc1cccs1
Show InChI InChI=1S/C27H25F2N3O5S3/c1-2-6-22-30-25(39-27(28)29)24(26(34)35)32(22)16-17-10-12-18(13-11-17)20-8-3-4-9-21(20)40(36,37)31-23(33)15-19-7-5-14-38-19/h3-5,7-14,27H,2,6,15-16H2,1H3,(H,31,33)(H,34,35)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50030685
PNG
(CHEMBL338888 | Pentanoic acid {4-chloro-3-[3-ethyl...)
Show SMILES CCCCC(=O)Nc1ccc(Cl)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C33H37ClFN5O6S/c1-6-8-13-30(41)36-23-16-17-25(34)27(19-23)40-32(43)39(29(7-2)37-40)20-22-15-14-21(18-26(22)35)24-11-9-10-12-28(24)47(44,45)38-31(42)46-33(3,4)5/h9-12,14-19H,6-8,13,20H2,1-5H3,(H,36,41)(H,38,42)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213687
PNG
(CHEMBL87244)
Show SMILES CCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccc(C)cc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1/C37H38N4O5S3/c1-4-10-34-39-36(47-3)35(32(42)25-48(44)30-21-15-26(2)16-22-30)41(34)24-28-17-19-29(20-18-28)31-13-8-9-14-33(31)49(45,46)40-37(43)38-23-27-11-6-5-7-12-27/h5-9,11-22H,4,10,23-25H2,1-3H3,(H2,38,40,43)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213697
PNG
(CHEMBL84908)
Show SMILES CCc1nc(SC)c(C(=O)C[S+]([O-])c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1/C35H34N4O5S3/c1-3-32-37-34(45-2)33(30(40)24-46(42)28-14-8-5-9-15-28)39(32)23-26-18-20-27(21-19-26)29-16-10-11-17-31(29)47(43,44)38-35(41)36-22-25-12-6-4-7-13-25/h4-21H,3,22-24H2,1-2H3,(H2,36,38,41)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50030692
PNG
(CHEMBL339672 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C35H32Cl2FN5O5S/c1-3-5-14-32-40-43(30-20-24(17-18-28(30)37)39-33(44)4-2)35(46)42(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-27(26)36/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035444
PNG
(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Show SMILES CCCCC(=O)Nc1ccc(Cl)c(c1)-n1nc(CCCC)n(Cc2ccc(cc2)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C35H42ClN5O6S/c1-6-8-14-31-38-41(29-22-26(20-21-28(29)36)37-32(42)15-9-7-2)34(44)40(31)23-24-16-18-25(19-17-24)27-12-10-11-13-30(27)48(45,46)39-33(43)47-35(3,4)5/h10-13,16-22H,6-9,14-15,23H2,1-5H3,(H,37,42)(H,39,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035444
PNG
(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Show SMILES CCCCC(=O)Nc1ccc(Cl)c(c1)-n1nc(CCCC)n(Cc2ccc(cc2)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C35H42ClN5O6S/c1-6-8-14-31-38-41(29-22-26(20-21-28(29)36)37-32(42)15-9-7-2)34(44)40(31)23-24-16-18-25(19-17-24)27-12-10-11-13-30(27)48(45,46)39-33(43)47-35(3,4)5/h10-13,16-22H,6-9,14-15,23H2,1-5H3,(H,37,42)(H,39,43)
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TBA

Assay Description
Antagonist activity at AT1 receptor in rabbit aorta membranes


Citation and Details

Article DOI: 10.1007/s00044-013-0831-x
BindingDB Entry DOI: 10.7270/Q2C82BRJ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50030692
PNG
(CHEMBL339672 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C35H32Cl2FN5O5S/c1-3-5-14-32-40-43(30-20-24(17-18-28(30)37)39-33(44)4-2)35(46)42(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-27(26)36/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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TBA

Assay Description
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030692
PNG
(CHEMBL339672 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C35H32Cl2FN5O5S/c1-3-5-14-32-40-43(30-20-24(17-18-28(30)37)39-33(44)4-2)35(46)42(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-27(26)36/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50030692
PNG
(CHEMBL339672 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C35H32Cl2FN5O5S/c1-3-5-14-32-40-43(30-20-24(17-18-28(30)37)39-33(44)4-2)35(46)42(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-27(26)36/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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TBA

Assay Description
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50470233
PNG
(CHEMBL80177)
Show SMILES CCCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C30H31N3O5S2/c1-3-4-14-26-31-29(39-2)28(30(35)36)33(26)20-22-15-17-23(18-16-22)24-12-8-9-13-25(24)40(37,38)32-27(34)19-21-10-6-5-7-11-21/h5-13,15-18H,3-4,14,19-20H2,1-2H3,(H,32,34)(H,35,36)
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Hoechst Roussel PGU Cardiovascular Agents

Curated by ChEMBL


Assay Description
Specific binding inhibition of [125I]AII to Angiotensin II receptor, type 1 in rat liver membrane


J Med Chem 38: 2357-77 (1995)

More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035454
PNG
(CHEMBL343309 | Cyclopropanecarboxylic acid (3-{3-b...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C36H33Cl2N5O5S/c1-2-3-12-33-40-43(31-21-26(19-20-30(31)38)39-34(44)25-17-18-25)36(46)42(33)22-23-13-15-24(16-14-23)27-8-5-7-11-32(27)49(47,48)41-35(45)28-9-4-6-10-29(28)37/h4-11,13-16,19-21,25H,2-3,12,17-18,22H2,1H3,(H,39,44)(H,41,45)
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TBA

Assay Description
Antagonist activity at AT1 receptor in rabbit aorta membranes


Citation and Details

Article DOI: 10.1007/s00044-013-0831-x
BindingDB Entry DOI: 10.7270/Q2C82BRJ
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213782
PNG
(CHEMBL264304)
Show SMILES CCCc1nc(SC)c(C(=O)C[S+]([O-])c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1/C36H36N4O5S3/c1-3-12-33-38-35(46-2)34(31(41)25-47(43)29-15-8-5-9-16-29)40(33)24-27-19-21-28(22-20-27)30-17-10-11-18-32(30)48(44,45)39-36(42)37-23-26-13-6-4-7-14-26/h4-11,13-22H,3,12,23-25H2,1-2H3,(H2,37,39,42)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213593
PNG
(CHEMBL91046)
Show SMILES CCCCc1nc(SC)c(C(=O)CS(C)(=O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C32H36N4O6S3/c1-4-5-15-29-34-31(43-2)30(27(37)22-44(3,39)40)36(29)21-24-16-18-25(19-17-24)26-13-9-10-14-28(26)45(41,42)35-32(38)33-20-23-11-7-6-8-12-23/h6-14,16-19H,4-5,15,20-22H2,1-3H3,(H2,33,35,38)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213688
PNG
(CHEMBL86538)
Show SMILES CCCc1nc(SC)c(C(C)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C30H32N4O4S2/c1-4-10-27-32-29(39-3)28(21(2)35)34(27)20-23-15-17-24(18-16-23)25-13-8-9-14-26(25)40(37,38)33-30(36)31-19-22-11-6-5-7-12-22/h5-9,11-18H,4,10,19-20H2,1-3H3,(H2,31,33,36)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035454
PNG
(CHEMBL343309 | Cyclopropanecarboxylic acid (3-{3-b...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C36H33Cl2N5O5S/c1-2-3-12-33-40-43(31-21-26(19-20-30(31)38)39-34(44)25-17-18-25)36(46)42(33)22-23-13-15-24(16-14-23)27-8-5-7-11-32(27)49(47,48)41-35(45)28-9-4-6-10-29(28)37/h4-11,13-16,19-21,25H,2-3,12,17-18,22H2,1H3,(H,39,44)(H,41,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50470229
PNG
(CHEMBL76870)
Show SMILES CCCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H29N3O5S2/c1-3-4-14-25-30-28(38-2)26(29(34)35)32(25)19-20-15-17-21(18-16-20)23-12-8-9-13-24(23)39(36,37)31-27(33)22-10-6-5-7-11-22/h5-13,15-18H,3-4,14,19H2,1-2H3,(H,31,33)(H,34,35)
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Hoechst Roussel PGU Cardiovascular Agents

Curated by ChEMBL


Assay Description
Specific binding inhibition of [125I]AII to Angiotensin II receptor, type 1 in rat liver membrane


J Med Chem 38: 2357-77 (1995)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213681
PNG
(CHEMBL433010)
Show SMILES CCCc1nc(SC)c(C(=O)CS(=O)(=O)c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C36H36N4O6S3/c1-3-12-33-38-35(47-2)34(31(41)25-48(43,44)29-15-8-5-9-16-29)40(33)24-27-19-21-28(22-20-27)30-17-10-11-18-32(30)49(45,46)39-36(42)37-23-26-13-6-4-7-14-26/h4-11,13-22H,3,12,23-25H2,1-2H3,(H2,37,39,42)
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TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213680
PNG
(CHEMBL87091)
Show SMILES CCCCc1nc(SC)c(C(=O)CC(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C34H38N4O6S2/c1-4-6-16-30-36-33(45-3)32(28(39)21-31(40)44-5-2)38(30)23-25-17-19-26(20-18-25)27-14-10-11-15-29(27)46(42,43)37-34(41)35-22-24-12-8-7-9-13-24/h7-15,17-20H,4-6,16,21-23H2,1-3H3,(H2,35,37,41)
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n/an/a 0.0900n/an/an/an/an/an/a


TBA

Assay Description
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC63CR
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50030721
PNG
(4-Bromo-N-butyl-3-{4-[2'-(2,5-dichloro-benzoylsulf...)
Show SMILES CCCCNC(=O)c1ccc(Br)c(c1)-n1nc(CCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)c1=O
Show InChI InChI=1S/C36H33BrCl2FN5O5S/c1-3-5-17-41-34(46)23-13-15-28(37)31(19-23)45-36(48)44(33(42-45)8-4-2)21-24-12-11-22(18-30(24)40)26-9-6-7-10-32(26)51(49,50)43-35(47)27-20-25(38)14-16-29(27)39/h6-7,9-16,18-20H,3-5,8,17,21H2,1-2H3,(H,41,46)(H,43,47)
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n/an/a 0.0920n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.


J Med Chem 38: 3741-58 (1995)


Article DOI: 10.1021/jm00019a004
BindingDB Entry DOI: 10.7270/Q2Q81C35
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50493576
PNG
(CHEMBL2435828)
Show SMILES CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C34H33N3O3/c1-3-9-31-36-33-23(2)20-27(35-32(38)19-16-24-10-5-4-6-11-24)21-30(33)37(31)22-25-14-17-26(18-15-25)28-12-7-8-13-29(28)34(39)40/h4-8,10-15,17-18,20-21H,3,9,16,19,22H2,1-2H3,(H,35,38)(H,39,40)
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n/an/a 0.100n/an/an/an/an/an/a



Beijing Institute of Technology

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis


Eur J Med Chem 69: 44-54 (2013)

More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50041969
PNG
(3-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C31H34N8O2/c1-5-6-11-28-33-27-17-16-23(32-31(41)38(4)20(2)3)18-26(27)30(40)39(28)19-21-12-14-22(15-13-21)24-9-7-8-10-25(24)29-34-36-37-35-29/h7-10,12-18,20H,5-6,11,19H2,1-4H3,(H,32,41)(H,34,35,36,37)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta


Bioorg Med Chem Lett 3: 1299-1304 (1993)


Article DOI: 10.1016/S0960-894X(00)80335-2
BindingDB Entry DOI: 10.7270/Q29P31KG
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50470239
PNG
(CHEMBL311312)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc(SC)c2C(O)=O)cc1
Show InChI InChI=1S/C27H33N3O6S2/c1-4-6-12-23-28-25(37-3)24(26(31)32)30(23)18-19-13-15-20(16-14-19)21-10-8-9-11-22(21)38(34,35)29-27(33)36-17-7-5-2/h8-11,13-16H,4-7,12,17-18H2,1-3H3,(H,29,33)(H,31,32)
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Hoechst Roussel PGU Cardiovascular Agents

Curated by ChEMBL


Assay Description
Specific binding inhibition of [125I]AII to Angiotensin II receptor, type 1 in rat liver membrane


J Med Chem 38: 2357-77 (1995)

More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50030684
PNG
(CHEMBL339722 | N-{3-[3-Butyl-4-(3-fluoro-2-(N-t-bu...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H39ClFN5O7S/c1-6-8-13-30-38-41(28-19-24(16-17-26(28)35)37-31(42)21-47-7-2)33(44)40(30)20-23-15-14-22(18-27(23)36)25-11-9-10-12-29(25)49(45,46)39-32(43)48-34(3,4)5/h9-12,14-19H,6-8,13,20-21H2,1-5H3,(H,37,42)(H,39,43)
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TBA

Assay Description
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50030684
PNG
(CHEMBL339722 | N-{3-[3-Butyl-4-(3-fluoro-2-(N-t-bu...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H39ClFN5O7S/c1-6-8-13-30-38-41(28-19-24(16-17-26(28)35)37-31(42)21-47-7-2)33(44)40(30)20-23-15-14-22(18-27(23)36)25-11-9-10-12-29(25)49(45,46)39-32(43)48-34(3,4)5/h9-12,14-19H,6-8,13,20-21H2,1-5H3,(H,37,42)(H,39,43)
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TBA

Assay Description
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213504
PNG
(CHEMBL89369)
Show SMILES CCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C28H28N4O5S2/c1-3-24-30-26(38-2)25(27(33)34)32(24)18-20-13-15-21(16-14-20)22-11-7-8-12-23(22)39(36,37)31-28(35)29-17-19-9-5-4-6-10-19/h4-16H,3,17-18H2,1-2H3,(H,33,34)(H2,29,31,35)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213457
PNG
(CHEMBL84686)
Show SMILES CCCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCC1CCCCC1
Show InChI InChI=1S/C30H38N4O5S2/c1-3-4-14-26-32-28(40-2)27(29(35)36)34(26)20-22-15-17-23(18-16-22)24-12-8-9-13-25(24)41(38,39)33-30(37)31-19-21-10-6-5-7-11-21/h8-9,12-13,15-18,21H,3-7,10-11,14,19-20H2,1-2H3,(H,35,36)(H2,31,33,37)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213500
PNG
(CHEMBL86337)
Show SMILES CCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1cccs1
Show InChI InChI=1S/C27H28N4O5S3/c1-3-7-23-29-25(37-2)24(26(32)33)31(23)17-18-11-13-19(14-12-18)21-9-4-5-10-22(21)39(35,36)30-27(34)28-16-20-8-6-15-38-20/h4-6,8-15H,3,7,16-17H2,1-2H3,(H,32,33)(H2,28,30,34)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213456
PNG
(CHEMBL315000)
Show SMILES CCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCC1CCCC1
Show InChI InChI=1S/C28H34N4O5S2/c1-3-8-24-30-26(38-2)25(27(33)34)32(24)18-20-13-15-21(16-14-20)22-11-6-7-12-23(22)39(36,37)31-28(35)29-17-19-9-4-5-10-19/h6-7,11-16,19H,3-5,8-10,17-18H2,1-2H3,(H,33,34)(H2,29,31,35)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213552
PNG
(CHEMBL328302)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCc1ccccc1
Show InChI InChI=1S/C30H29F2N3O5S2/c1-2-8-25-33-28(41-30(31)32)27(29(37)38)35(25)19-21-13-16-22(17-14-21)23-11-6-7-12-24(23)42(39,40)34-26(36)18-15-20-9-4-3-5-10-20/h3-7,9-14,16-17,30H,2,8,15,18-19H2,1H3,(H,34,36)(H,37,38)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213567
PNG
(CHEMBL315983)
Show SMILES CCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCC1CCCCC1
Show InChI InChI=1S/C29H36N4O5S2/c1-3-9-25-31-27(39-2)26(28(34)35)33(25)19-21-14-16-22(17-15-21)23-12-7-8-13-24(23)40(37,38)32-29(36)30-18-20-10-5-4-6-11-20/h7-8,12-17,20H,3-6,9-11,18-19H2,1-2H3,(H,34,35)(H2,30,32,36)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50213460
PNG
(CHEMBL85081)
Show SMILES CCCc1nc(SC(F)F)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C33H29F2N3O5S2/c1-2-7-28-36-31(44-33(34)35)30(32(40)41)38(28)20-21-12-16-24(17-13-21)26-10-5-6-11-27(26)45(42,43)37-29(39)19-22-14-15-23-8-3-4-9-25(23)18-22/h3-6,8-18,33H,2,7,19-20H2,1H3,(H,37,39)(H,40,41)
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TBA

Assay Description
In vitro displacement of [125I]angiotensin II from rat liver (Angiotensin 1 receptor) membrane preparation


Citation and Details

BindingDB Entry DOI: 10.7270/Q2S184PR
More data for this
Ligand-Target Pair
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