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Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with Target = 'Apolipoprotein B-100 '   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apolipoprotein B-100


(Homo sapiens)
BDBM50107813
PNG
((S)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)
Show SMILES COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C26H23F3N2O3/c1-15-4-3-5-22(23(15)16-6-9-19(10-7-16)26(27,28)29)24(32)30-20-11-8-17-12-21(14-18(17)13-20)31-25(33)34-2/h3-11,13,21H,12,14H2,1-2H3,(H,30,32)(H,31,33)/t21-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107808
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3C[C@H](Cc3c2)NS(=O)(=O)c2cccs2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H23F3N2O3S2/c1-17-4-2-5-24(26(17)18-7-10-21(11-8-18)28(29,30)31)27(34)32-22-12-9-19-14-23(16-20(19)15-22)33-38(35,36)25-6-3-13-37-25/h2-13,15,23,33H,14,16H2,1H3,(H,32,34)/t23-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107774
PNG
(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carboxy...)
Show SMILES Cc1cc(C)c(-c2ccc(cc2)C(F)(F)F)c(c1)C(=O)Nc1ccc2C[C@H](Cc2c1)NS(=O)(=O)c1cccs1
Show InChI InChI=1S/C29H25F3N2O3S2/c1-17-12-18(2)27(19-5-8-22(9-6-19)29(30,31)32)25(13-17)28(35)33-23-10-7-20-14-24(16-21(20)15-23)34-39(36,37)26-4-3-11-38-26/h3-13,15,24,34H,14,16H2,1-2H3,(H,33,35)/t24-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107809
PNG
(CHEMBL143284 | {5-[(4,6-Dimethyl-4'-trifluoromethy...)
Show SMILES COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cc(C)cc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C27H25F3N2O3/c1-15-10-16(2)24(17-4-7-20(8-5-17)27(28,29)30)23(11-15)25(33)31-21-9-6-18-12-22(14-19(18)13-21)32-26(34)35-3/h4-11,13,22H,12,14H2,1-3H3,(H,31,33)(H,32,34)/t22-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107797
PNG
(4'-Fluoro-6-methyl-biphenyl-2-carboxylic acid (2-b...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(=O)(=O)c2ccccc2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN2O3S/c1-19-6-5-9-27(28(19)20-10-13-23(30)14-11-20)29(33)31-24-15-12-21-16-25(18-22(21)17-24)32-36(34,35)26-7-3-2-4-8-26/h2-15,17,25,32H,16,18H2,1H3,(H,31,33)
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n/an/a 1.20n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107790
PNG
(4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-b...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2CC(Cc2c1)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C29H23F3N2O3S/c30-29(31,32)22-13-10-19(11-14-22)26-8-4-5-9-27(26)28(35)33-23-15-12-20-16-24(18-21(20)17-23)34-38(36,37)25-6-2-1-3-7-25/h1-15,17,24,34H,16,18H2,(H,33,35)
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n/an/a 1.30n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107772
PNG
(4'-Fluoro-6-methyl-biphenyl-2-carboxylic acid [2-(...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(=O)(=O)c2cccs2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C27H23FN2O3S2/c1-17-4-2-5-24(26(17)18-7-10-21(28)11-8-18)27(31)29-22-12-9-19-14-23(16-20(19)15-22)30-35(32,33)25-6-3-13-34-25/h2-13,15,23,30H,14,16H2,1H3,(H,29,31)
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n/an/a 1.40n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107804
PNG
(CHEMBL142975 | {2-[(6-Methyl-4'-trifluoromethyl-bi...)
Show SMILES COC(=O)NC1CCc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2CC1
Show InChI InChI=1S/C28H27F3N2O3/c1-17-4-3-5-24(25(17)19-6-11-21(12-7-19)28(29,30)31)26(34)32-23-15-9-18-8-13-22(33-27(35)36-2)14-10-20(18)16-23/h3-7,9,11-12,15-16,22H,8,10,13-14H2,1-2H3,(H,32,34)(H,33,35)
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n/an/a 1.60n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107803
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CCC(CCc3c2)NS(=O)(=O)c2cccs2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C30H27F3N2O3S2/c1-19-4-2-5-26(28(19)21-7-12-23(13-8-21)30(31,32)33)29(36)34-25-16-10-20-9-14-24(15-11-22(20)18-25)35-40(37,38)27-6-3-17-39-27/h2-8,10,12-13,16-18,24,35H,9,11,14-15H2,1H3,(H,34,36)
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n/an/a 1.60n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107787
PNG
((S)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3C[C@@H](Cc3c2)NCc2ccccn2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C30H26F3N3O/c1-19-5-4-7-27(28(19)20-8-11-23(12-9-20)30(31,32)33)29(37)36-24-13-10-21-15-26(17-22(21)16-24)35-18-25-6-2-3-14-34-25/h2-14,16,26,35H,15,17-18H2,1H3,(H,36,37)/t26-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107810
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3C[C@H](Cc3c2)NS(C)(=O)=O)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H23F3N2O3S/c1-15-4-3-5-22(23(15)16-6-9-19(10-7-16)25(26,27)28)24(31)29-20-11-8-17-12-21(14-18(17)13-20)30-34(2,32)33/h3-11,13,21,30H,12,14H2,1-2H3,(H,29,31)/t21-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107812
PNG
(CHEMBL142928 | {5-[(6,4'-Bis-trifluoromethyl-biphe...)
Show SMILES COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cccc(c3-c3ccc(cc3)C(F)(F)F)C(F)(F)F)cc2C1
Show InChI InChI=1S/C26H20F6N2O3/c1-37-24(36)34-19-11-15-7-10-18(12-16(15)13-19)33-23(35)20-3-2-4-21(26(30,31)32)22(20)14-5-8-17(9-6-14)25(27,28)29/h2-10,12,19H,11,13H2,1H3,(H,33,35)(H,34,36)/t19-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107775
PNG
(4-{5-[(6-Methyl-4'-trifluoromethyl-biphenyl-2-carb...)
Show SMILES COC(=O)N1CCN(CC1)[C@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C30H30F3N3O3/c1-19-4-3-5-26(27(19)20-6-9-23(10-7-20)30(31,32)33)28(37)34-24-11-8-21-17-25(18-22(21)16-24)35-12-14-36(15-13-35)29(38)39-2/h3-11,16,25H,12-15,17-18H2,1-2H3,(H,34,37)/t25-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107798
PNG
(CHEMBL139992 | {5-[(4'-Trifluoromethyl-biphenyl-2-...)
Show SMILES COC(=O)N[C@H]1Cc2ccc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C25H21F3N2O3/c1-33-24(32)30-20-12-16-8-11-19(13-17(16)14-20)29-23(31)22-5-3-2-4-21(22)15-6-9-18(10-7-15)25(26,27)28/h2-11,13,20H,12,14H2,1H3,(H,29,31)(H,30,32)/t20-/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107815
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(CNS(=O)(=O)c4cccs4)Cc3c2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H25F3N2O3S2/c1-18-4-2-5-25(27(18)20-7-10-23(11-8-20)29(30,31)32)28(35)34-24-12-9-21-14-19(15-22(21)16-24)17-33-39(36,37)26-6-3-13-38-26/h2-13,16,19,33H,14-15,17H2,1H3,(H,34,35)
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n/an/a 1.90n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107802
PNG
(4'-Chloro-6-methoxy-biphenyl-2-carboxylic acid (2-...)
Show SMILES COc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(=O)(=O)c2ccccc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25ClN2O4S/c1-36-27-9-5-8-26(28(27)19-10-13-22(30)14-11-19)29(33)31-23-15-12-20-16-24(18-21(20)17-23)32-37(34,35)25-6-3-2-4-7-25/h2-15,17,24,32H,16,18H2,1H3,(H,31,33)
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n/an/a 2n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107800
PNG
(CHEMBL356126 | {2-[(4'-Chloro-6-methyl-biphenyl-2-...)
Show SMILES COC(=O)NC1CCc2ccc(NC(=O)c3cccc(C)c3-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C27H27ClN2O3/c1-17-4-3-5-24(25(17)19-6-11-21(28)12-7-19)26(31)29-23-15-9-18-8-13-22(30-27(32)33-2)14-10-20(18)16-23/h3-7,9,11-12,15-16,22H,8,10,13-14H2,1-2H3,(H,29,31)(H,30,32)
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n/an/a 2n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107811
PNG
(CHEMBL142733 | {5-[(4,6-Dimethyl-4'-trifluoromethy...)
Show SMILES COC(=O)NCC1Cc2ccc(NC(=O)c3cc(C)cc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C28H27F3N2O3/c1-16-10-17(2)25(19-4-7-22(8-5-19)28(29,30)31)24(11-16)26(34)33-23-9-6-20-12-18(13-21(20)14-23)15-32-27(35)36-3/h4-11,14,18H,12-13,15H2,1-3H3,(H,32,35)(H,33,34)
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n/an/a 2.20n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107788
PNG
(CHEMBL143514 | {5-[(4-Methyl-4'-trifluoromethyl-bi...)
Show SMILES COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cc(C)ccc3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C26H23F3N2O3/c1-15-3-10-22(16-4-7-19(8-5-16)26(27,28)29)23(11-15)24(32)30-20-9-6-17-12-21(14-18(17)13-20)31-25(33)34-2/h3-11,13,21H,12,14H2,1-2H3,(H,30,32)(H,31,33)/t21-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107805
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CCC(CCc3c2)NS(C)(=O)=O)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N2O3S/c1-17-4-3-5-24(25(17)19-6-11-21(12-7-19)27(28,29)30)26(33)31-23-15-9-18-8-13-22(32-36(2,34)35)14-10-20(18)16-23/h3-7,9,11-12,15-16,22,32H,8,10,13-14H2,1-2H3,(H,31,33)
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n/an/a 2.30n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107792
PNG
(4'-Chloro-6-methyl-biphenyl-2-carboxylic acid (2-b...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(=O)(=O)c2ccccc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25ClN2O3S/c1-19-6-5-9-27(28(19)20-10-13-23(30)14-11-20)29(33)31-24-15-12-21-16-25(18-22(21)17-24)32-36(34,35)26-7-3-2-4-8-26/h2-15,17,25,32H,16,18H2,1H3,(H,31,33)
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n/an/a 2.40n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107785
PNG
(CHEMBL341974 | {2-[(4,6-Dimethyl-4'-trifluoromethy...)
Show SMILES COC(=O)NC1CCc2ccc(NC(=O)c3cc(C)cc(C)c3-c3ccc(cc3)C(F)(F)F)cc2CC1
Show InChI InChI=1S/C29H29F3N2O3/c1-17-14-18(2)26(20-4-9-22(10-5-20)29(30,31)32)25(15-17)27(35)33-24-13-7-19-6-11-23(34-28(36)37-3)12-8-21(19)16-24/h4-5,7,9-10,13-16,23H,6,8,11-12H2,1-3H3,(H,33,35)(H,34,36)
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n/an/a 2.40n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107781
PNG
(6,4'-Dimethyl-biphenyl-2-carboxylic acid (2-benzen...)
Show SMILES Cc1ccc(cc1)-c1c(C)cccc1C(=O)Nc1ccc2CC(Cc2c1)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C30H28N2O3S/c1-20-11-13-22(14-12-20)29-21(2)7-6-10-28(29)30(33)31-25-16-15-23-17-26(19-24(23)18-25)32-36(34,35)27-8-4-3-5-9-27/h3-16,18,26,32H,17,19H2,1-2H3,(H,31,33)
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n/an/a 2.5n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107793
PNG
(CHEMBL358141 | {5-[(4,6-Dimethyl-4'-trifluoromethy...)
Show SMILES COC(=O)N[C@@H]1Cc2ccc(NC(=O)c3cc(C)cc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C27H25F3N2O3/c1-15-10-16(2)24(17-4-7-20(8-5-17)27(28,29)30)23(11-15)25(33)31-21-9-6-18-12-22(14-19(18)13-21)32-26(34)35-3/h4-11,13,22H,12,14H2,1-3H3,(H,31,33)(H,32,34)/t22-/m1/s1
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n/an/a 2.5n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107777
PNG
(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carboxy...)
Show SMILES Cc1cc(C)c(-c2ccc(cc2)C(F)(F)F)c(c1)C(=O)Nc1ccc2C[C@@H](Cc2c1)NS(=O)(=O)c1cccs1
Show InChI InChI=1S/C29H25F3N2O3S2/c1-17-12-18(2)27(19-5-8-22(9-6-19)29(30,31)32)25(13-17)28(35)33-23-10-7-20-14-24(16-21(20)15-23)34-39(36,37)26-4-3-11-38-26/h3-13,15,24,34H,14,16H2,1-2H3,(H,33,35)/t24-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107770
PNG
(4'-Chloro-6-methyl-biphenyl-2-carboxylic acid [2-(...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(=O)(=O)c2cccs2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H23ClN2O3S2/c1-17-4-2-5-24(26(17)18-7-10-21(28)11-8-18)27(31)29-22-12-9-19-14-23(16-20(19)15-22)30-35(32,33)25-6-3-13-34-25/h2-13,15,23,30H,14,16H2,1H3,(H,29,31)
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n/an/a 3n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107783
PNG
(CHEMBL343837 | {5-[(4'-Chloro-4,6-dimethyl-bipheny...)
Show SMILES COC(=O)NC1Cc2ccc(NC(=O)c3cc(C)cc(C)c3-c3ccc(Cl)cc3)cc2C1
Show InChI InChI=1S/C26H25ClN2O3/c1-15-10-16(2)24(17-4-7-20(27)8-5-17)23(11-15)25(30)28-21-9-6-18-12-22(14-19(18)13-21)29-26(31)32-3/h4-11,13,22H,12,14H2,1-3H3,(H,28,30)(H,29,31)
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n/an/a 3.40n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107799
PNG
(CHEMBL142332 | {5-[(6-Methyl-4'-trifluoromethyl-bi...)
Show SMILES COC(=O)NCC1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C27H25F3N2O3/c1-16-4-3-5-23(24(16)18-6-9-21(10-7-18)27(28,29)30)25(33)32-22-11-8-19-12-17(13-20(19)14-22)15-31-26(34)35-2/h3-11,14,17H,12-13,15H2,1-2H3,(H,31,34)(H,32,33)
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n/an/a 4.10n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107773
PNG
(4'-Chloro-6-methyl-biphenyl-2-carboxylic acid (7-m...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CCC(CCc3c2)NS(C)(=O)=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN2O3S/c1-17-4-3-5-24(25(17)19-6-11-21(27)12-7-19)26(30)28-23-15-9-18-8-13-22(29-33(2,31)32)14-10-20(18)16-23/h3-7,9,11-12,15-16,22,29H,8,10,13-14H2,1-2H3,(H,28,30)
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n/an/a 5n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107814
PNG
(CHEMBL142731 | {5-[(4'-Trifluoromethyl-biphenyl-2-...)
Show SMILES COC(=O)N[C@@H]1Cc2ccc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C25H21F3N2O3/c1-33-24(32)30-20-12-16-8-11-19(13-17(16)14-20)29-23(31)22-5-3-2-4-21(22)15-6-9-18(10-7-15)25(26,27)28/h2-11,13,20H,12,14H2,1H3,(H,29,31)(H,30,32)/t20-/m1/s1
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n/an/a 5.20n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107771
PNG
(4'-Cyano-6-methyl-biphenyl-2-carboxylic acid (2-be...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(=O)(=O)c2ccccc2)c1-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H25N3O3S/c1-20-6-5-9-28(29(20)22-12-10-21(19-31)11-13-22)30(34)32-25-15-14-23-16-26(18-24(23)17-25)33-37(35,36)27-7-3-2-4-8-27/h2-15,17,26,33H,16,18H2,1H3,(H,32,34)
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n/an/a 5.5n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107789
PNG
((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)
Show SMILES COC(=O)N[C@@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C26H23F3N2O3/c1-15-4-3-5-22(23(15)16-6-9-19(10-7-16)26(27,28)29)24(32)30-20-11-8-17-12-21(14-18(17)13-20)31-25(33)34-2/h3-11,13,21H,12,14H2,1-2H3,(H,30,32)(H,31,33)/t21-/m1/s1
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n/an/a 6.40n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107779
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(CNS(C)(=O)=O)Cc3c2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H25F3N2O3S/c1-16-4-3-5-23(24(16)18-6-9-21(10-7-18)26(27,28)29)25(32)31-22-11-8-19-12-17(13-20(19)14-22)15-30-35(2,33)34/h3-11,14,17,30H,12-13,15H2,1-2H3,(H,31,32)
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n/an/a 6.5n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107782
PNG
(4'-Chloro-6-methyl-biphenyl-2-carboxylic acid (2-m...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(C)(=O)=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN2O3S/c1-15-4-3-5-22(23(15)16-6-9-19(25)10-7-16)24(28)26-20-11-8-17-12-21(14-18(17)13-20)27-31(2,29)30/h3-11,13,21,27H,12,14H2,1-2H3,(H,26,28)
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n/an/a 6.60n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107794
PNG
(CHEMBL356937 | {5-[(4,4'-Bis-trifluoromethyl-biphe...)
Show SMILES COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cc(ccc3-c3ccc(cc3)C(F)(F)F)C(F)(F)F)cc2C1
Show InChI InChI=1S/C26H20F6N2O3/c1-37-24(36)34-20-10-15-4-8-19(11-16(15)12-20)33-23(35)22-13-18(26(30,31)32)7-9-21(22)14-2-5-17(6-3-14)25(27,28)29/h2-9,11,13,20H,10,12H2,1H3,(H,33,35)(H,34,36)/t20-/m0/s1
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n/an/a 7.5n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107784
PNG
(4'-Fluoro-6-methyl-biphenyl-2-carboxylic acid (2-m...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(C)(=O)=O)c1-c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O3S/c1-15-4-3-5-22(23(15)16-6-9-19(25)10-7-16)24(28)26-20-11-8-17-12-21(14-18(17)13-20)27-31(2,29)30/h3-11,13,21,27H,12,14H2,1-2H3,(H,26,28)
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n/an/a 8.30n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107767
PNG
(CHEMBL358538 | {5-[(4'-Chloro-6-methyl-biphenyl-2-...)
Show SMILES COC(=O)NCC1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(Cl)cc3)cc2C1
Show InChI InChI=1S/C26H25ClN2O3/c1-16-4-3-5-23(24(16)18-6-9-21(27)10-7-18)25(30)29-22-11-8-19-12-17(13-20(19)14-22)15-28-26(31)32-2/h3-11,14,17H,12-13,15H2,1-2H3,(H,28,31)(H,29,30)
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n/an/a 8.70n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107780
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3C[C@@H](Cc3c2)NS(C)(=O)=O)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H23F3N2O3S/c1-15-4-3-5-22(23(15)16-6-9-19(10-7-16)25(26,27)28)24(31)29-20-11-8-17-12-21(14-18(17)13-20)30-34(2,32)33/h3-11,13,21,30H,12,14H2,1-2H3,(H,29,31)/t21-/m0/s1
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n/an/a 8.80n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107766
PNG
((2-{5-[(6-Methyl-4'-trifluoromethyl-biphenyl-2-car...)
Show SMILES COC(=O)NCCC1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C28H27F3N2O3/c1-17-4-3-5-24(25(17)19-6-9-22(10-7-19)28(29,30)31)26(34)33-23-11-8-20-14-18(15-21(20)16-23)12-13-32-27(35)36-2/h3-11,16,18H,12-15H2,1-2H3,(H,32,35)(H,33,34)
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n/an/a 10n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107778
PNG
(Biphenyl-2-carboxylic acid (2-benzenesulfonylamino...)
Show SMILES O=C(Nc1ccc2CC(Cc2c1)NS(=O)(=O)c1ccccc1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H24N2O3S/c31-28(27-14-8-7-13-26(27)20-9-3-1-4-10-20)29-23-16-15-21-17-24(19-22(21)18-23)30-34(32,33)25-11-5-2-6-12-25/h1-16,18,24,30H,17,19H2,(H,29,31)
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n/an/a 12n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107791
PNG
(4'-Chloro-6-methoxy-biphenyl-2-carboxylic acid (2-...)
Show SMILES COc1cccc(C(=O)Nc2ccc3CC(Cc3c2)NS(C)(=O)=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN2O4S/c1-31-22-5-3-4-21(23(22)15-6-9-18(25)10-7-15)24(28)26-19-11-8-16-12-20(14-17(16)13-19)27-32(2,29)30/h3-11,13,20,27H,12,14H2,1-2H3,(H,26,28)
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n/an/a 15n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107768
PNG
(4'-Chloro-6-methyl-biphenyl-2-carboxylic acid [2-(...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CC(CNS(C)(=O)=O)Cc3c2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H25ClN2O3S/c1-16-4-3-5-23(24(16)18-6-9-21(26)10-7-18)25(29)28-22-11-8-19-12-17(13-20(19)14-22)15-27-32(2,30)31/h3-11,14,17,27H,12-13,15H2,1-2H3,(H,28,29)
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n/an/a 16n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107806
PNG
(4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-b...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2C[C@@H](Cc2c1)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C29H23F3N2O3S/c30-29(31,32)22-13-10-19(11-14-22)26-8-4-5-9-27(26)28(35)33-23-15-12-20-16-24(18-21(20)17-23)34-38(36,37)25-6-2-1-3-7-25/h1-15,17,24,34H,16,18H2,(H,33,35)/t24-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107807
PNG
(4-{5-[(6-Methyl-4'-trifluoromethyl-biphenyl-2-carb...)
Show SMILES COC(=O)N1CCN(CC1)[C@@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C30H30F3N3O3/c1-19-4-3-5-26(27(19)20-6-9-23(10-7-20)30(31,32)33)28(37)34-24-11-8-21-17-25(18-22(21)16-24)35-12-14-36(15-13-35)29(38)39-2/h3-11,16,25H,12-15,17-18H2,1-2H3,(H,34,37)/t25-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107769
PNG
(4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-m...)
Show SMILES CS(=O)(=O)NC1Cc2ccc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C24H21F3N2O3S/c1-33(31,32)29-20-12-16-8-11-19(13-17(16)14-20)28-23(30)22-5-3-2-4-21(22)15-6-9-18(10-7-15)24(25,26)27/h2-11,13,20,29H,12,14H2,1H3,(H,28,30)
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n/an/a 60n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107796
PNG
(4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-a...)
Show SMILES CC(=O)NC1Cc2ccc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C25H21F3N2O2/c1-15(31)29-21-12-17-8-11-20(13-18(17)14-21)30-24(32)23-5-3-2-4-22(23)16-6-9-19(10-7-16)25(26,27)28/h2-11,13,21H,12,14H2,1H3,(H,29,31)(H,30,32)
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n/an/a 120n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107795
PNG
(4'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(...)
Show SMILES CN(C)C(=O)NC1Cc2ccc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C26H24F3N3O2/c1-32(2)25(34)31-21-13-17-9-12-20(14-18(17)15-21)30-24(33)23-6-4-3-5-22(23)16-7-10-19(11-8-16)26(27,28)29/h3-12,14,21H,13,15H2,1-2H3,(H,30,33)(H,31,34)
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n/an/a 120n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107801
PNG
(4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-b...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2CC(Cc2c1)NC(=O)c1ccccc1
Show InChI InChI=1S/C30H23F3N2O2/c31-30(32,33)23-13-10-19(11-14-23)26-8-4-5-9-27(26)29(37)34-24-15-12-21-16-25(18-22(21)17-24)35-28(36)20-6-2-1-3-7-20/h1-15,17,25H,16,18H2,(H,34,37)(H,35,36)
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n/an/a 270n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens)
BDBM50107776
PNG
(4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-b...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2CC(Cc2c1)NCc1ccccc1
Show InChI InChI=1S/C30H25F3N2O/c31-30(32,33)24-13-10-21(11-14-24)27-8-4-5-9-28(27)29(36)35-25-15-12-22-16-26(18-23(22)17-25)34-19-20-6-2-1-3-7-20/h1-15,17,26,34H,16,18-19H2,(H,35,36)
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n/an/a 340n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)

More data for this
Ligand-Target Pair