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Compile Data Set for Download or QSAR

Found 51 hits Enz. Inhib. hit(s) with Target = 'Arginase-2, mitochondrial'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439247
PNG
(CHEMBL2418831)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C20H29BCl2N2O4/c22-17-6-3-13(9-18(17)23)12-25-15-4-5-16(25)11-14(10-15)20(24,19(26)27)7-1-2-8-21(28)29/h3,6,9,14-16,28-29H,1-2,4-5,7-8,10-12,24H2,(H,26,27)
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n/an/a 23n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439246
PNG
(CHEMBL2418830)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C20H30BClN2O4/c22-16-5-3-14(4-6-16)13-24-17-7-8-18(24)12-15(11-17)20(23,19(25)26)9-1-2-10-21(27)28/h3-6,15,17-18,27-28H,1-2,7-13,23H2,(H,25,26)
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n/an/a 30n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439245
PNG
(CHEMBL2418991)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(F)c(F)c1)C(O)=O
Show InChI InChI=1S/C20H29BF2N2O4/c22-17-6-3-13(9-18(17)23)12-25-15-4-5-16(25)11-14(10-15)20(24,19(26)27)7-1-2-8-21(28)29/h3,6,9,14-16,28-29H,1-2,4-5,7-8,10-12,24H2,(H,26,27)
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n/an/a 33n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439244
PNG
(CHEMBL2418829)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31BN2O4/c22-20(19(24)25,10-4-5-11-21(26)27)16-12-17-8-9-18(13-16)23(17)14-15-6-2-1-3-7-15/h1-3,6-7,16-18,26-27H,4-5,8-14,22H2,(H,24,25)
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n/an/a 47n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439243
PNG
(CHEMBL2418998)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCCc2ccc(Cl)cc2Cl)CC1)C(O)=O
Show InChI InChI=1S/C20H31BCl2N2O4/c22-17-6-5-15(18(23)14-17)4-3-11-25-12-7-16(8-13-25)20(24,19(26)27)9-1-2-10-21(28)29/h5-6,14,16,28-29H,1-4,7-13,24H2,(H,26,27)
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n/an/a 50n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427899
PNG
(CHEMBL2326090)
Show SMILES CN[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C14H29BN2O4/c1-16-14(13(18)19,7-3-4-9-15(20)21)8-12-17-10-5-2-6-11-17/h16,20-21H,2-12H2,1H3,(H,18,19)/t14-/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439241
PNG
(CHEMBL2418999)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCCc2ccc(cc2)C(F)(F)F)CC1)C(O)=O
Show InChI InChI=1S/C21H32BF3N2O4/c23-21(24,25)18-7-5-16(6-8-18)4-3-13-27-14-9-17(10-15-27)20(26,19(28)29)11-1-2-12-22(30)31/h5-8,17,30-31H,1-4,9-15,26H2,(H,28,29)
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n/an/a 70n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439242
PNG
(CHEMBL2418828)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2)C(O)=O
Show InChI InChI=1S/C13H25BN2O4/c15-13(12(17)18,5-1-2-6-14(19)20)9-7-10-3-4-11(8-9)16-10/h9-11,16,19-20H,1-8,15H2,(H,17,18)
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n/an/a 85n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427903
PNG
(CHEMBL2326087)
Show SMILES CC(C)NCC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C11H25BN2O4/c1-9(2)14-8-6-11(13,10(15)16)5-3-4-7-12(17)18/h9,14,17-18H,3-8,13H2,1-2H3,(H,15,16)/t11-/m1/s1
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n/an/a 190n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439239
PNG
(CHEMBL2418994)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccccc2)CC1)C(O)=O
Show InChI InChI=1S/C18H29BN2O4/c20-18(17(22)23,10-4-5-11-19(24)25)16-8-12-21(13-9-16)14-15-6-2-1-3-7-15/h1-3,6-7,16,24-25H,4-5,8-14,20H2,(H,22,23)
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n/an/a 230n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439240
PNG
(CHEMBL2418993)
Show SMILES CC(C)CCN1CCC(CC1)C(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C16H33BN2O4/c1-13(2)5-10-19-11-6-14(7-12-19)16(18,15(20)21)8-3-4-9-17(22)23/h13-14,22-23H,3-12,18H2,1-2H3,(H,20,21)
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n/an/a 230n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439238
PNG
(CHEMBL2418995)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)cc2)CC1)C(O)=O
Show InChI InChI=1S/C18H28BClN2O4/c20-16-5-3-14(4-6-16)13-22-11-7-15(8-12-22)18(21,17(23)24)9-1-2-10-19(25)26/h3-6,15,25-26H,1-2,7-13,21H2,(H,23,24)
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n/an/a 240n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427905
PNG
(CHEMBL2326085)
Show SMILES CCN(CC)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O4/c1-3-15(4-2)10-8-12(14,11(16)17)7-5-6-9-13(18)19/h18-19H,3-10,14H2,1-2H3,(H,16,17)/t12-/m1/s1
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n/an/a 270n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439237
PNG
(CHEMBL2418996)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)C(O)=O
Show InChI InChI=1S/C18H27BCl2N2O4/c20-15-4-3-13(11-16(15)21)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25)
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n/an/a 290n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
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n/an/a 310n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427904
PNG
(CHEMBL2326086)
Show SMILES CCCN(C)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O4/c1-3-9-15(2)10-7-12(14,11(16)17)6-4-5-8-13(18)19/h18-19H,3-10,14H2,1-2H3,(H,16,17)/t12-/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439236
PNG
(CHEMBL2418997)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCc2ccc(Cl)cc2Cl)CC1)C(O)=O
Show InChI InChI=1S/C19H29BCl2N2O4/c21-16-4-3-14(17(22)13-16)5-10-24-11-6-15(7-12-24)19(23,18(25)26)8-1-2-9-20(27)28/h3-4,13,15,27-28H,1-2,5-12,23H2,(H,25,26)
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n/an/a 330n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427909
PNG
(CHEMBL2326097)
Show SMILES COC[C@@H]1CCCN1CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H29BN2O5/c1-22-11-12-5-4-9-17(12)10-7-14(16,13(18)19)6-2-3-8-15(20)21/h12,20-21H,2-11,16H2,1H3,(H,18,19)/t12-,14+/m0/s1
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Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427906
PNG
(CHEMBL2326084)
Show SMILES CCN(CCO)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O5/c1-2-15(9-10-16)8-6-12(14,11(17)18)5-3-4-7-13(19)20/h16,19-20H,2-10,14H2,1H3,(H,17,18)/t12-/m1/s1
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n/an/a 390n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427913
PNG
(CHEMBL2326093)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCC(O)CC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O5/c15-13(12(18)19,5-1-2-7-14(20)21)6-10-16-8-3-11(17)4-9-16/h11,17,20-21H,1-10,15H2,(H,18,19)/t13-/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427900
PNG
((R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]he...)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m1/s1
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n/an/a 509n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427907
PNG
(CHEMBL2326099)
Show SMILES N[C@](CCCCB(O)O)(CCN1Cc2ccccc2C1)C(O)=O
Show InChI InChI=1S/C16H25BN2O4/c18-16(15(20)21,7-3-4-9-17(22)23)8-10-19-11-13-5-1-2-6-14(13)12-19/h1-2,5-6,22-23H,3-4,7-12,18H2,(H,20,21)/t16-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427910
PNG
(CHEMBL2326096)
Show SMILES N[C@](CCCCB(O)O)(CCN1CC[C@@H](CO)C1)C(O)=O
Show InChI InChI=1S/C13H27BN2O5/c15-13(12(18)19,4-1-2-6-14(20)21)5-8-16-7-3-11(9-16)10-17/h11,17,20-21H,1-10,15H2,(H,18,19)/t11-,13-/m1/s1
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n/an/a 600n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
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n/an/a 620n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
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n/an/a 620n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439235
PNG
(CHEMBL2418992)
Show SMILES NC(CCCCB(O)O)(C1CCNCC1)C(O)=O
Show InChI InChI=1S/C11H23BN2O4/c13-11(10(15)16,5-1-2-6-12(17)18)9-3-7-14-8-4-9/h9,14,17-18H,1-8,13H2,(H,15,16)
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n/an/a 640n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427905
PNG
(CHEMBL2326085)
Show SMILES CCN(CC)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O4/c1-3-15(4-2)10-8-12(14,11(16)17)7-5-6-9-13(18)19/h18-19H,3-10,14H2,1-2H3,(H,16,17)/t12-/m1/s1
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n/an/a 934n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427913
PNG
(CHEMBL2326093)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCC(O)CC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O5/c15-13(12(18)19,5-1-2-7-14(20)21)6-10-16-8-3-11(17)4-9-16/h11,17,20-21H,1-10,15H2,(H,18,19)/t13-/m1/s1
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n/an/a 980n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427912
PNG
(CHEMBL2326094)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCc2ccccc2C1)C(O)=O
Show InChI InChI=1S/C17H27BN2O4/c19-17(16(21)22,8-3-4-10-18(23)24)9-12-20-11-7-14-5-1-2-6-15(14)13-20/h1-2,5-6,23-24H,3-4,7-13,19H2,(H,21,22)/t17-/m1/s1
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n/an/a 1.09E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439234
PNG
(CHEMBL2418826)
Show SMILES NC(CCCCB(O)O)(C1CCN(CC1)C(=O)Nc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C18H27BClN3O5/c20-14-3-5-15(6-4-14)22-17(26)23-11-7-13(8-12-23)18(21,16(24)25)9-1-2-10-19(27)28/h3-6,13,27-28H,1-2,7-12,21H2,(H,22,26)(H,24,25)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439233
PNG
(CHEMBL2418827)
Show SMILES NC(CCCCB(O)O)(C1CCN(CC1)C(=S)NCc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C19H29BClN3O4S/c21-16-5-3-14(4-6-16)13-23-18(29)24-11-7-15(8-12-24)19(22,17(25)26)9-1-2-10-20(27)28/h3-6,15,27-28H,1-2,7-13,22H2,(H,23,29)(H,25,26)
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n/an/a 1.12E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431953
PNG
(CHEMBL2348490)
Show SMILES NCC(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C7H17BN2O4/c9-5-7(10,6(11)12)3-1-2-4-8(13)14/h13-14H,1-5,9-10H2,(H,11,12)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427908
PNG
(CHEMBL2326098)
Show SMILES COC[C@H]1CCCN1CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H29BN2O5/c1-22-11-12-5-4-9-17(12)10-7-14(16,13(18)19)6-2-3-8-15(20)21/h12,20-21H,2-11,16H2,1H3,(H,18,19)/t12-,14-/m1/s1
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n/an/a 1.71E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427901
PNG
(CHEMBL2326088)
Show SMILES N[C@H](CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m1/s1
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n/an/a 1.92E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/a 1.92E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/a 2.15E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427914
PNG
(CHEMBL2326092)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCSCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4S/c14-12(11(16)17,3-1-2-5-13(18)19)4-6-15-7-9-20-10-8-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
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n/an/a 2.56E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431954
PNG
(CHEMBL2348492)
Show SMILES NC(CCCCB(O)O)(Cc1cnc[nH]1)C(O)=O
Show InChI InChI=1S/C10H18BN3O4/c12-10(9(15)16,3-1-2-4-11(17)18)5-8-6-13-7-14-8/h6-7,17-18H,1-5,12H2,(H,13,14)(H,15,16)
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n/an/a 3.72E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431951
PNG
(CHEMBL2348489)
Show SMILES NC(CCCCB(O)O)(CCN1CCOCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O5/c14-12(11(16)17,3-1-2-5-13(18)19)4-6-15-7-9-20-10-8-15/h18-19H,1-10,14H2,(H,16,17)
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n/an/a 4.02E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431958
PNG
(CHEMBL2348496)
Show SMILES NC(CO)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C7H16BNO5/c9-7(5-10,6(11)12)3-1-2-4-8(13)14/h10,13-14H,1-5,9H2,(H,11,12)
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n/an/a 4.28E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431956
PNG
(CHEMBL2348495)
Show SMILES NC(CCCO)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H20BNO5/c11-9(8(13)14,5-3-7-12)4-1-2-6-10(15)16/h12,15-16H,1-7,11H2,(H,13,14)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431961
PNG
(CHEMBL2348498)
Show SMILES CCC(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H18BNO4/c1-2-8(10,7(11)12)5-3-4-6-9(13)14/h13-14H,2-6,10H2,1H3,(H,11,12)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439248
PNG
(CHEMBL2419000)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC(CC1)C(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H29BN2O6S/c1-14-4-6-16(7-5-14)28(26,27)21-12-8-15(9-13-21)18(20,17(22)23)10-2-3-11-19(24)25/h4-7,15,24-25H,2-3,8-13,20H2,1H3,(H,22,23)
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n/an/a 4.65E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350309
PNG
(CHEMBL1812662)
Show SMILES CC([NH3+])(CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11)
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n/an/a 5.07E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431952
PNG
(CHEMBL2348491)
Show SMILES NC(CCCCB(O)O)(CNCc1ccccc1)C(O)=O
Show InChI InChI=1S/C14H23BN2O4/c16-14(13(18)19,8-4-5-9-15(20)21)11-17-10-12-6-2-1-3-7-12/h1-3,6-7,17,20-21H,4-5,8-11,16H2,(H,18,19)
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n/an/a 5.98E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431955
PNG
(CHEMBL2348493)
Show SMILES COCCCC(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C10H22BNO5/c1-17-8-4-6-10(12,9(13)14)5-2-3-7-11(15)16/h15-16H,2-8,12H2,1H3,(H,13,14)
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n/an/a 6.44E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431960
PNG
(CHEMBL2348499)
Show SMILES CC(C)C(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H20BNO4/c1-7(2)9(11,8(12)13)5-3-4-6-10(14)15/h7,14-15H,3-6,11H2,1-2H3,(H,12,13)
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n/an/a 1.55E+4n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431959
PNG
(CHEMBL2348497)
Show SMILES NC(CCCCB(O)O)(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C13H20BNO4/c15-13(12(16)17,8-4-5-9-14(18)19)10-11-6-2-1-3-7-11/h1-3,6-7,18-19H,4-5,8-10,15H2,(H,16,17)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431957
PNG
(CHEMBL2348494)
Show SMILES NC(CCO)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H18BNO5/c10-8(4-6-11,7(12)13)3-1-2-5-9(14)15/h11,14-15H,1-6,10H2,(H,12,13)
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n/an/a 5.70E+4n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427902
PNG
(CHEMBL2326091)
Show SMILES N[C@@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


Citation and Details
More data for this
Ligand-Target Pair
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