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Found 13 hits Enz. Inhib. hit(s) with Target = 'Aurora B/Incenp'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Aurora-A


(Homo sapiens (Human))
BDBM47224
PNG
(US9073917, 2-inventive)
Show SMILES CCc1[nH]cc2[C@@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)/t23-/s2
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US Patent
n/an/a 1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167515
PNG
(US9073917, 12- comparative)
Show SMILES CCOC(=O)c1[nH]cc2[C@@H](c3ccc(Sc4nc5ccccc5[nH]4)o3)C3=C(CCCC3=O)Nc12
Show InChI InChI=1/C25H22N4O4S/c1-2-32-24(31)23-22-13(12-26-23)20(21-16(27-22)8-5-9-17(21)30)18-10-11-19(33-18)34-25-28-14-6-3-4-7-15(14)29-25/h3-4,6-7,10-12,20,26-27H,2,5,8-9H2,1H3,(H,28,29)/t20-/s2
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US Patent
n/an/a 3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167510
PNG
(US9073917, 7- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CC(C)(C)CC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C28H28N4O2/c1-4-19-26-18(15-29-19)24(25-22(30-26)13-28(2,3)14-23(25)33)16-8-7-9-17(12-16)34-27-31-20-10-5-6-11-21(20)32-27/h5-12,15,24,29-30H,4,13-14H2,1-3H3,(H,31,32)
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US Patent
n/an/a 4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167506
PNG
(US9073917, 1-inventive)
Show SMILES CCc1[nH]cc2C(C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)
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US Patent
n/an/a 4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167507
PNG
(US9073917, 4- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CCCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C26H24N4OS/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)
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US Patent
n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167508
PNG
(US9073917, 5- comparative)
Show SMILES O=C1CCCC2=C1C(c1c[nH]nc1N2)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C23H19N5O2/c29-19-10-4-9-18-21(19)20(15-12-24-28-22(15)25-18)13-5-3-6-14(11-13)30-23-26-16-7-1-2-8-17(16)27-23/h1-3,5-8,11-12,20H,4,9-10H2,(H,26,27)(H2,24,25,28)
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US Patent
n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167512
PNG
(US9073917, 11- comparative | US9073917, 9- compara...)
Show SMILES CCc1[nH]cc2C(C3=C(CNCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C25H23N5OS/c1-2-17-24-16(11-27-17)22(23-20(28-24)12-26-13-21(23)31)14-6-5-7-15(10-14)32-25-29-18-8-3-4-9-19(18)30-25/h3-11,22,26-28H,2,12-13H2,1H3,(H,29,30)
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US Patent
n/an/a 8n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167513
PNG
(US9073917, 10- comparative)
Show SMILES CC1(C)CC(=O)C2=C(C1)Nc1n[nH]cc1C2c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C25H23N5O2/c1-25(2)11-19-22(20(31)12-25)21(16-13-26-30-23(16)27-19)14-6-5-7-15(10-14)32-24-28-17-8-3-4-9-18(17)29-24/h3-10,13,21H,11-12H2,1-2H3,(H,28,29)(H2,26,27,30)
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US Patent
n/an/a 9n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167516
PNG
(US9073917, 13- comparative)
Show SMILES CCOC(=O)c1[nH]cc2C(c3ccc(Sc4nc5cccc(OC)c5[nH]4)o3)C3=C(CCCC3=O)Nc12
Show InChI InChI=1/C26H24N4O5S/c1-3-34-25(32)24-22-13(12-27-24)20(21-14(28-22)6-4-8-16(21)31)17-10-11-19(35-17)36-26-29-15-7-5-9-18(33-2)23(15)30-26/h5,7,9-12,20,27-28H,3-4,6,8H2,1-2H3,(H,29,30)
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US Patent
n/an/a 10n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167509
PNG
(US9073917, 6- comparative)
Show SMILES O=C1CNCC2=C1C(c1c[nH]nc1N2)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C22H18N6O2/c29-18-11-23-10-17-20(18)19(14-9-24-28-21(14)25-17)12-4-3-5-13(8-12)30-22-26-15-6-1-2-7-16(15)27-22/h1-9,19,23H,10-11H2,(H,26,27)(H2,24,25,28)
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US Patent
n/an/a 13n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167511
PNG
(US9073917, 8- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CC(C)(C)CC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C28H28N4OS/c1-4-19-26-18(15-29-19)24(25-22(30-26)13-28(2,3)14-23(25)33)16-8-7-9-17(12-16)34-27-31-20-10-5-6-11-21(20)32-27/h5-12,15,24,29-30H,4,13-14H2,1-3H3,(H,31,32)
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US Patent
n/an/a 21n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167512
PNG
(US9073917, 11- comparative | US9073917, 9- compara...)
Show SMILES CCc1[nH]cc2C(C3=C(CNCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C25H23N5OS/c1-2-17-24-16(11-27-17)22(23-20(28-24)12-26-13-21(23)31)14-6-5-7-15(10-14)32-25-29-18-8-3-4-9-19(18)30-25/h3-11,22,26-28H,2,12-13H2,1H3,(H,29,30)
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US Patent
n/an/a 107n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Aurora-A


(Homo sapiens (Human))
BDBM60452
PNG
(US9073917, 3-comparative)
Show SMILES CCc1[nH]cc2[C@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)/t23-/s2
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US Patent
n/an/a 3.80E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair