BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3334 hits Enz. Inhib. hit(s) with Target = 'B-Raf Protein Kinase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25619
PNG
((1Z)-5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]...)
Show SMILES Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O
Show InChI InChI=1S/C18H16N4O/c1-22-11-16(18(20-22)12-6-8-19-9-7-12)14-2-4-15-13(10-14)3-5-17(15)21-23/h2,4,6-11,17H,3,5H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.0200n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25636
PNG
((1Z)-5-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyr...)
Show SMILES O=NC1CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCNCC1
Show InChI InChI=1S/C22H23N5O/c28-26-21-4-2-16-13-17(1-3-19(16)21)20-14-27(18-7-11-24-12-8-18)25-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,21,24H,2,4,7-8,11-12H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.0300n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50006650
PNG
(CHEMBL526479)
Show SMILES O\N=C1/CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCNCC1
Show InChI InChI=1S/C22H23N5O/c28-26-21-4-2-16-13-17(1-3-19(16)21)20-14-27(18-7-11-24-12-8-18)25-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,24,28H,2,4,7-8,11-12H2/b26-21+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
Article
PubMed
n/an/a 0.0300n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of BRAF (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25625
PNG
((1S,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Show SMILES O[C@H]1CCC[C@H](C1)n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O
Show InChI InChI=1S/C23H24N4O2/c28-19-3-1-2-18(13-19)27-14-21(23(25-27)15-8-10-24-11-9-15)17-4-6-20-16(12-17)5-7-22(20)26-29/h4,6,8-12,14,18-19,22,28H,1-3,5,7,13H2/t18-,19+,22?/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.0400n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25629
PNG
(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Show SMILES OCCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O
Show InChI InChI=1S/C20H20N4O2/c25-11-1-10-24-13-18(20(22-24)14-6-8-21-9-7-14)16-2-4-17-15(12-16)3-5-19(17)23-26/h2,4,6-9,12-13,19,25H,1,3,5,10-11H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.0500n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103702
PNG
(US8563553, 127)
Show SMILES CS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(nc2-c2ccnc(NCCC#N)n2)C2CC2)c1F
Show InChI InChI=1S/C20H19ClFN7O2S/c1-32(30,31)29-15-10-12(21)9-13(16(15)22)17-18(28-19(27-17)11-3-4-11)14-5-8-25-20(26-14)24-7-2-6-23/h5,8-11,29H,2-4,7H2,1H3,(H,27,28)(H,24,25,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0800n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103683
PNG
(US8563553, 108)
Show SMILES CCCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(nc2-c2ccnc(N)n2)C(C)(C)C)c1F
Show InChI InChI=1S/C20H24ClFN6O2S/c1-5-8-31(29,30)28-14-10-11(21)9-12(15(14)22)16-17(13-6-7-24-19(23)25-13)27-18(26-16)20(2,3)4/h6-7,9-10,28H,5,8H2,1-4H3,(H,26,27)(H2,23,24,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0800n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25626
PNG
((1R,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Show SMILES O[C@@H]1CCC[C@H](C1)n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O
Show InChI InChI=1S/C23H24N4O2/c28-19-3-1-2-18(13-19)27-14-21(23(25-27)15-8-10-24-11-9-15)17-4-6-20-16(12-17)5-7-22(20)26-29/h4,6,8-12,14,18-19,22,28H,1-3,5,7,13H2/t18-,19-,22?/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.0900n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50139058
PNG
(CHEMBL3752213)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.100n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50026212
PNG
(CHEMBL1276185)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1ccc(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c2[nH]ncc12
Show InChI InChI=1/C30H24F2N8/c1-38-15-20-12-19(38)16-39(20)18-2-3-22(25(32)13-18)26-8-11-34-30-27(21-4-5-24(31)29-23(21)14-35-36-29)28(37-40(26)30)17-6-9-33-10-7-17/h2-11,13-14,19-20H,12,15-16H2,1H3,(H,35,36)/t19-,20-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a<0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of BRAF


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50026207
PNG
(CHEMBL1276170)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1ccc(c(Cl)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12
Show InChI InChI=1/C30H25ClN8/c1-37-16-21-13-20(37)17-38(21)19-5-6-23(25(31)14-19)27-9-12-33-30-28(22-3-2-4-26-24(22)15-34-35-26)29(36-39(27)30)18-7-10-32-11-8-18/h2-12,14-15,20-21H,13,16-17H2,1H3,(H,34,35)/t20-,21-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a<0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of BRAF


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103632
PNG
(US8563553, 57)
Show SMILES CCS(=O)(=O)Nc1cc(Cl)cc(c1)-c1[nH]c(nc1-c1ccnc(NC[C@H](C)NC(=O)OC)n1)C(C)(C)C
Show InChI InChI=1S/C24H32ClN7O4S/c1-7-37(34,35)32-17-11-15(10-16(25)12-17)19-20(31-21(30-19)24(3,4)5)18-8-9-26-22(29-18)27-13-14(2)28-23(33)36-6/h8-12,14,32H,7,13H2,1-6H3,(H,28,33)(H,30,31)(H,26,27,29)/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.100n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103684
PNG
(US8563553, 109)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(F)cc(NS(=O)(=O)c2c(F)cccc2F)c1Cl)C1CC1
Show InChI InChI=1S/C27H25ClF3N7O4S/c1-13(34-27(39)42-2)12-33-26-32-9-8-19(35-26)23-22(36-25(37-23)14-6-7-14)16-10-15(29)11-20(21(16)28)38-43(40,41)24-17(30)4-3-5-18(24)31/h3-5,8-11,13-14,38H,6-7,12H2,1-2H3,(H,34,39)(H,36,37)(H,32,33,35)/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.100n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103628
PNG
(US8563553, 53)
Show SMILES CCCS(=O)(=O)Nc1cc(Cl)cc(c1)-c1[nH]c(nc1-c1ccnc(NC[C@H](C)NC(=O)OC)n1)C(C)(C)C
Show InChI InChI=1S/C25H34ClN7O4S/c1-7-10-38(35,36)33-18-12-16(11-17(26)13-18)20-21(32-22(31-20)25(3,4)5)19-8-9-27-23(30-19)28-14-15(2)29-24(34)37-6/h8-9,11-13,15,33H,7,10,14H2,1-6H3,(H,29,34)(H,31,32)(H,27,28,30)/t15-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.100n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103629
PNG
(US8563553, 54)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(=O)(=O)C2CC2)c1)C(C)(C)C
Show InChI InChI=1S/C25H32ClN7O4S/c1-14(29-24(34)37-5)13-28-23-27-9-8-19(30-23)21-20(31-22(32-21)25(2,3)4)15-10-16(26)12-17(11-15)33-38(35,36)18-6-7-18/h8-12,14,18,33H,6-7,13H2,1-5H3,(H,29,34)(H,31,32)(H,27,28,30)/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.100n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103681
PNG
(US8563553, 106)
Show SMILES Nc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(=O)(=O)c2c(F)cccc2F)c1F)C1CC1
Show InChI InChI=1S/C22H16ClF3N6O2S/c23-11-8-12(17(26)16(9-11)32-35(33,34)20-13(24)2-1-3-14(20)25)18-19(15-6-7-28-22(27)29-15)31-21(30-18)10-4-5-10/h1-3,6-10,32H,4-5H2,(H,30,31)(H2,27,28,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.100n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50330925
PNG
(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c2[nH]ncc12
Show InChI InChI=1S/C30H23F3N8/c1-39-14-19-10-18(39)15-40(19)17-11-23(32)27(24(33)12-17)25-6-9-35-30-26(20-2-3-22(31)29-21(20)13-36-37-29)28(38-41(25)30)16-4-7-34-8-5-16/h2-9,11-13,18-19H,10,14-15H2,1H3,(H,36,37)/t18-,19-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.110n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of BRAF


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103699
PNG
(US8563553, 124)
Show SMILES CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(nc2-c2ccnc(NC)n2)C2CC2)c1Cl
Show InChI InChI=1S/C20H22ClFN6O2S/c1-3-8-31(29,30)28-15-10-12(22)9-13(16(15)21)17-18(27-19(26-17)11-4-5-11)14-6-7-24-20(23-2)25-14/h6-7,9-11,28H,3-5,8H2,1-2H3,(H,26,27)(H,23,24,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.110n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103677
PNG
(US8563553, 102)
Show SMILES CC1(CC1)c1nc(c([nH]1)-c1cc(Cl)cc(NS(C)(=O)=O)c1F)-c1ccnc(NCCC#N)n1
Show InChI InChI=1S/C21H21ClFN7O2S/c1-21(5-6-21)19-28-17(13-10-12(22)11-15(16(13)23)30-33(2,31)32)18(29-19)14-4-9-26-20(27-14)25-8-3-7-24/h4,9-11,30H,3,5-6,8H2,1-2H3,(H,28,29)(H,25,26,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.110n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103723
PNG
(US8563553, 148)
Show SMILES CCCS(=O)(=O)Nc1c(F)ccc(-c2[nH]c(nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C(C)(C)C)c1F
Show InChI InChI=1S/C25H33F2N7O4S/c1-7-12-39(36,37)34-20-16(26)9-8-15(18(20)27)19-21(33-22(32-19)25(3,4)5)17-10-11-28-23(31-17)29-13-14(2)30-24(35)38-6/h8-11,14,34H,7,12-13H2,1-6H3,(H,30,35)(H,32,33)(H,28,29,31)/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.120n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25628
PNG
(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Show SMILES OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O
Show InChI InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.130n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103721
PNG
(US8563553, 146)
Show SMILES CCCS(=O)(=O)Nc1cccc(-c2[nH]c(nc2-c2ccnc(NCCC#N)n2)C2CC2)c1F
Show InChI InChI=1S/C22H24FN7O2S/c1-2-13-33(31,32)30-16-6-3-5-15(18(16)23)19-20(29-21(28-19)14-7-8-14)17-9-12-26-22(27-17)25-11-4-10-24/h3,5-6,9,12,14,30H,2,4,7-8,11,13H2,1H3,(H,28,29)(H,25,26,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.130n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103715
PNG
(US8563553, 140)
Show SMILES CCCS(=O)(=O)Nc1cccc(-c2[nH]c(nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C2CC2)c1Cl
Show InChI InChI=1S/C24H30ClN7O4S/c1-4-12-37(34,35)32-17-7-5-6-16(19(17)25)20-21(31-22(30-20)15-8-9-15)18-10-11-26-23(29-18)27-13-14(2)28-24(33)36-3/h5-7,10-11,14-15,32H,4,8-9,12-13H2,1-3H3,(H,28,33)(H,30,31)(H,26,27,29)/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.130n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103680
PNG
(US8563553, 105)
Show SMILES CC(C)(C)c1nc(c([nH]1)-c1cc(Cl)cc(NS(=O)(=O)c2c(F)cccc2F)c1F)-c1ccnc(N)n1
Show InChI InChI=1S/C23H20ClF3N6O2S/c1-23(2,3)21-31-18(19(32-21)15-7-8-29-22(28)30-15)12-9-11(24)10-16(17(12)27)33-36(34,35)20-13(25)5-4-6-14(20)26/h4-10,33H,1-3H3,(H,31,32)(H2,28,29,30)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.130n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25618
PNG
((1Z)-5-[3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihy...)
Show SMILES O=NC1CCc2cc(ccc12)-c1c[nH]nc1-c1ccncc1
Show InChI InChI=1S/C17H14N4O/c22-21-16-4-2-12-9-13(1-3-14(12)16)15-10-19-20-17(15)11-5-7-18-8-6-11/h1,3,5-10,16H,2,4H2,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.150n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM202851
PNG
(US9242969, 204)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1nc(N2CCOCC2)c2sccc2n1
Show InChI InChI=1S/C25H21F3N4O2S/c1-15-5-6-18(29-24(33)16-3-2-4-17(13-16)25(26,27)28)14-19(15)22-30-20-7-12-35-21(20)23(31-22)32-8-10-34-11-9-32/h2-7,12-14H,8-11H2,1H3,(H,29,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.152n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...


US Patent US9242969 (2016)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103717
PNG
(US8563553, 142)
Show SMILES CCCS(=O)(=O)Nc1cccc(-c2[nH]c(nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C2CC2)c1F
Show InChI InChI=1S/C24H30FN7O4S/c1-4-12-37(34,35)32-17-7-5-6-16(19(17)25)20-21(31-22(30-20)15-8-9-15)18-10-11-26-23(29-18)27-13-14(2)28-24(33)36-3/h5-7,10-11,14-15,32H,4,8-9,12-13H2,1-3H3,(H,28,33)(H,30,31)(H,26,27,29)/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.160n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50330905
PNG
(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C30H24F2N8/c1-38-15-20-11-19(38)16-39(20)18-12-23(31)28(24(32)13-18)26-7-10-34-30-27(21-3-2-4-25-22(21)14-35-36-25)29(37-40(26)30)17-5-8-33-9-6-17/h2-10,12-14,19-20H,11,15-16H2,1H3,(H,35,36)/t19-,20-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.160n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of BRAF


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103648
PNG
(US8563553, 73)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(=O)(=O)C2CC2)c1F)C1CC1
Show InChI InChI=1S/C24H27ClFN7O4S/c1-12(29-24(34)37-2)11-28-23-27-8-7-17(30-23)21-20(31-22(32-21)13-3-4-13)16-9-14(25)10-18(19(16)26)33-38(35,36)15-5-6-15/h7-10,12-13,15,33H,3-6,11H2,1-2H3,(H,29,34)(H,31,32)(H,27,28,30)/t12-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.180n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103647
PNG
(US8563553, 72)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(C)(=O)=O)c1Cl)C1CC1
Show InChI InChI=1S/C22H25Cl2N7O4S/c1-11(27-22(32)35-2)10-26-21-25-7-6-15(28-21)19-18(29-20(30-19)12-4-5-12)14-8-13(23)9-16(17(14)24)31-36(3,33)34/h6-9,11-12,31H,4-5,10H2,1-3H3,(H,27,32)(H,29,30)(H,25,26,28)/t11-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.180n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103693
PNG
(US8563553, 118)
Show SMILES Nc1nccc(n1)-c1nc([nH]c1-c1cc(F)cc(NS(=O)(=O)c2c(F)cccc2F)c1Cl)C1CC1
Show InChI InChI=1S/C22H16ClF3N6O2S/c23-17-12(18-19(15-6-7-28-22(27)29-15)31-21(30-18)10-4-5-10)8-11(24)9-16(17)32-35(33,34)20-13(25)2-1-3-14(20)26/h1-3,6-10,32H,4-5H2,(H,30,31)(H2,27,28,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.190n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50118382
PNG
(CHEMBL3613198)
Show SMILES CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(Br)c23)c1
Show InChI InChI=1S/C15H17BrN6O2S/c1-17-25(23,24)9-4-5-12(22(2)3)11(6-9)21-15-13-10(16)7-18-14(13)19-8-20-15/h4-8,17H,1-3H3,(H2,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of His6-tagged full length BRAF V600E mutant (2 to 766 residues) (unknown origin) expressed in Baculovirus expression system by BRAMA meth...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM221684
PNG
(US9314464, 5)
Show SMILES CCCS(=O)(=O)Nc1cc(Cl)cc(c1)-c1nn(cc1-c1ccnc(NC[C@H](C)NC(=O)OC)n1)C(C)C
Show InChI InChI=1/C24H32ClN7O4S/c1-6-9-37(34,35)31-19-11-17(10-18(25)12-19)22-20(14-32(30-22)15(2)3)21-7-8-26-23(29-21)27-13-16(4)28-24(33)36-5/h7-8,10-12,14-16,31H,6,9,13H2,1-5H3,(H,28,33)(H,26,27,29)/t16-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
B-Raf (V600E; 4 μM) and biotinylated Mek (kinase dead; 10 nM) were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, ...


US Patent US9314464 (2016)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103645
PNG
(US8563553, 70)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(F)cc(NS(C)(=O)=O)c1F)C1CC1
Show InChI InChI=1S/C22H25F2N7O4S/c1-11(27-22(32)35-2)10-26-21-25-7-6-15(28-21)19-18(29-20(30-19)12-4-5-12)14-8-13(23)9-16(17(14)24)31-36(3,33)34/h6-9,11-12,31H,4-5,10H2,1-3H3,(H,27,32)(H,29,30)(H,25,26,28)/t11-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103624
PNG
(US8563553, 49)
Show SMILES Cl.COC(=O)N[C@@H](C)CNc1nccc(n1)-c1[nH]c(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C1CC1
Show InChI InChI=1S/C22H25ClFN7O4S.ClH/c1-11(27-22(32)35-2)10-26-21-25-7-6-15(28-21)19-18(29-20(30-19)12-4-5-12)14-8-13(23)9-16(17(14)24)31-36(3,33)34;/h6-9,11-12,31H,4-5,10H2,1-3H3,(H,27,32)(H,29,30)(H,25,26,28);1H/t11-;/m0./s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103625
PNG
(US8563553, 50)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(C)cc(NS(C)(=O)=O)c1F)C1CC1
Show InChI InChI=1S/C23H28FN7O4S/c1-12-9-15(18(24)17(10-12)31-36(4,33)34)19-20(30-21(29-19)14-5-6-14)16-7-8-25-22(28-16)26-11-13(2)27-23(32)35-3/h7-10,13-14,31H,5-6,11H2,1-4H3,(H,27,32)(H,29,30)(H,25,26,28)/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103694
PNG
(US8563553, 119)
Show SMILES CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(nc2-c2ccnc(N)n2)C2CC2)c1Cl
Show InChI InChI=1S/C19H20ClFN6O2S/c1-2-7-30(28,29)27-14-9-11(21)8-12(15(14)20)16-17(13-5-6-23-19(22)24-13)26-18(25-16)10-3-4-10/h5-6,8-10,27H,2-4,7H2,1H3,(H,25,26)(H2,22,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50006653
PNG
(CHEMBL497671)
Show SMILES O\N=C1/CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCOCC1
Show InChI InChI=1S/C22H22N4O2/c27-25-21-4-2-16-13-17(1-3-19(16)21)20-14-26(18-7-11-28-12-8-18)24-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,27H,2,4,7-8,11-12H2/b25-21+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.220n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of BRAF (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103686
PNG
(US8563553, 111)
Show SMILES CC(C)(C)c1nc(c([nH]1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C23H21ClF2N6O2S/c1-23(2,3)21-30-18(19(31-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)24)32-35(33,34)20-13(25)7-5-8-14(20)26/h4-11,32H,1-3H3,(H,30,31)(H2,27,28,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.220n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25638
PNG
((1Z)-5-[1-(oxan-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-...)
Show SMILES O=NC1CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCOCC1
Show InChI InChI=1S/C22H22N4O2/c27-25-21-4-2-16-13-17(1-3-19(16)21)20-14-26(18-7-11-28-12-8-18)24-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,21H,2,4,7-8,11-12H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.220n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50330924
PNG
(7-(2-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2...)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1ccc(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C30H25FN8/c1-37-16-21-13-20(37)17-38(21)19-5-6-23(25(31)14-19)27-9-12-33-30-28(22-3-2-4-26-24(22)15-34-35-26)29(36-39(27)30)18-7-10-32-11-8-18/h2-12,14-15,20-21H,13,16-17H2,1H3,(H,34,35)/t20-,21-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.230n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of BRAF


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103695
PNG
(US8563553, 120)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C1CCC1
Show InChI InChI=1S/C23H27ClFN7O4S/c1-12(28-23(33)36-2)11-27-22-26-8-7-16(29-22)20-19(30-21(31-20)13-5-4-6-13)15-9-14(24)10-17(18(15)25)32-37(3,34)35/h7-10,12-13,32H,4-6,11H2,1-3H3,(H,28,33)(H,30,31)(H,26,27,29)/t12-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.230n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103674
PNG
(US8563553, 99)
Show SMILES CC1(CC1)c1nc(c([nH]1)-c1cc(F)cc(NS(C)(=O)=O)c1Cl)-c1ccnc(NCCC#N)n1
Show InChI InChI=1S/C21H21ClFN7O2S/c1-21(5-6-21)19-28-17(13-10-12(23)11-15(16(13)22)30-33(2,31)32)18(29-19)14-4-9-26-20(27-14)25-8-3-7-24/h4,9-11,30H,3,5-6,8H2,1-2H3,(H,28,29)(H,25,26,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.230n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM25641
PNG
(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Show SMILES CNC1CCCC(C1)n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O
Show InChI InChI=1S/C24H27N5O/c1-25-19-3-2-4-20(14-19)29-15-22(24(27-29)16-9-11-26-12-10-16)18-5-7-21-17(13-18)6-8-23(21)28-30/h5,7,9-13,15,19-20,23,25H,2-4,6,8,14H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.230n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103649
PNG
(US8563553, 74)
Show SMILES CCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C2CC2)c1F
Show InChI InChI=1S/C23H27ClFN7O4S/c1-4-37(34,35)32-17-10-14(24)9-15(18(17)25)19-20(31-21(30-19)13-5-6-13)16-7-8-26-22(29-16)27-11-12(2)28-23(33)36-3/h7-10,12-13,32H,4-6,11H2,1-3H3,(H,28,33)(H,30,31)(H,26,27,29)/t12-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.240n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103690
PNG
(US8563553, 115)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(C)cc(NS(=O)(=O)CC(F)(F)F)c1F)C1CC1
Show InChI InChI=1S/C24H27F4N7O4S/c1-12-8-15(18(25)17(9-12)35-40(37,38)11-24(26,27)28)19-20(34-21(33-19)14-4-5-14)16-6-7-29-22(32-16)30-10-13(2)31-23(36)39-3/h6-9,13-14,35H,4-5,10-11H2,1-3H3,(H,31,36)(H,33,34)(H,29,30,32)/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.25n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103691
PNG
(US8563553, 116)
Show SMILES CC(C)(C)c1nc(c([nH]1)-c1cc(F)cc(NS(=O)(=O)c2c(F)cccc2F)c1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C23H20ClF3N6O2S/c1-23(2,3)21-31-18(19(32-21)15-7-8-29-22(28)30-15)12-9-11(25)10-16(17(12)24)33-36(34,35)20-13(26)5-4-6-14(20)27/h4-10,33H,1-3H3,(H,31,32)(H2,28,29,30)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.260n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103652
PNG
(US8563553, 77)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(=O)(=O)CC2CC2)c1F)C1CC1
Show InChI InChI=1S/C25H29ClFN7O4S/c1-13(30-25(35)38-2)11-29-24-28-8-7-18(31-24)22-21(32-23(33-22)15-5-6-15)17-9-16(26)10-19(20(17)27)34-39(36,37)12-14-3-4-14/h7-10,13-15,34H,3-6,11-12H2,1-2H3,(H,30,35)(H,32,33)(H,28,29,31)/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.260n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103703
PNG
(US8563553, 128)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NS(=O)(=O)C2CC2)c1F)C(C)(C)C
Show InChI InChI=1S/C25H32FN7O4S/c1-14(29-24(34)37-5)13-28-23-27-12-11-18(30-23)21-20(31-22(32-21)25(2,3)4)16-7-6-8-17(19(16)26)33-38(35,36)15-9-10-15/h6-8,11-12,14-15,33H,9-10,13H2,1-5H3,(H,29,34)(H,31,32)(H,27,28,30)/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.270n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM103658
PNG
(US8563553, 83)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)(C)C
Show InChI InChI=1S/C23H29ClFN7O4S/c1-12(28-22(33)36-5)11-27-21-26-8-7-15(29-21)19-18(30-20(31-19)23(2,3)4)14-9-13(24)10-16(17(14)25)32-37(6,34)35/h7-10,12,32H,11H2,1-6H3,(H,28,33)(H,30,31)(H,26,27,29)/t12-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.280n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 3334 total )  |  Next  |  Last  >>
Jump to: