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Found 194 hits Enz. Inhib. hit(s) with Target = 'Beta-glucuronidase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193719
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(2-fluoro...)
Show SMILES Fc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C31H24FN5OS/c32-25-9-3-6-12-28(25)35-31(39)37-36-30(38)20-15-13-19(14-16-20)29(23-17-33-26-10-4-1-7-21(23)26)24-18-34-27-11-5-2-8-22(24)27/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 100n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193733
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(3,4-dich...)
Show SMILES Clc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1Cl
Show InChI InChI=1S/C31H23Cl2N5OS/c32-25-14-13-20(15-26(25)33)36-31(40)38-37-30(39)19-11-9-18(10-12-19)29(23-16-34-27-7-3-1-5-21(23)27)24-17-35-28-8-4-2-6-22(24)28/h1-17,29,34-35H,(H,37,39)(H2,36,38,40)
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n/an/a 120n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193734
PNG
(2-(4-(di(1H-indol-3-yl)methyl)benzoyl)-N-(4(triflu...)
Show SMILES FC(F)(F)c1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C32H24F3N5OS/c33-32(34,35)21-13-15-22(16-14-21)38-31(42)40-39-30(41)20-11-9-19(10-12-20)29(25-17-36-27-7-3-1-5-23(25)27)26-18-37-28-8-4-2-6-24(26)28/h1-18,29,36-37H,(H,39,41)(H2,38,40,42)
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n/an/a 200n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193720
PNG
(N-(2-Chlorophenyl)-2-(4-(di(1H-indol-3-yl)methyl)b...)
Show SMILES Clc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C31H24ClN5OS/c32-25-9-3-6-12-28(25)35-31(39)37-36-30(38)20-15-13-19(14-16-20)29(23-17-33-26-10-4-1-7-21(23)26)24-18-34-27-11-5-2-8-22(24)27/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 500n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019208
PNG
(CHEMBL137922)
Show SMILES COc1ccc(cc1OC)-c1nc(O)c2ccccc2n1
Show InChI InChI=1S/C16H14N2O3/c1-20-13-8-7-10(9-14(13)21-2)15-17-12-6-4-3-5-11(12)16(19)18-15/h3-9H,1-2H3,(H,17,18,19)
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n/an/a 600n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019283
PNG
(CHEMBL3289121)
Show SMILES CCOc1ccccc1-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O2/c1-2-20-14-10-6-4-8-12(14)15-17-13-9-5-3-7-11(13)16(19)18-15/h3-10H,2H2,1H3,(H,17,18,19)
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n/an/a 700n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50028013
PNG
(CHEMBL3360798)
Show SMILES CCOC(OCC)(OCC)\C=C\C(=O)c1sc2sc(C(=O)\C=C\C(OCC)(OCC)OCC)c(-c3ccccc3)c2c1C
Show InChI InChI=1S/C33H42O8S2/c1-8-36-32(37-9-2,38-10-3)21-19-25(34)29-23(7)27-28(24-17-15-14-16-18-24)30(43-31(27)42-29)26(35)20-22-33(39-11-4,40-12-5)41-13-6/h14-22H,8-13H2,1-7H3/b21-19+,22-20+
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n/an/a 900n/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide substrate incubated for 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019166
PNG
(CHEMBL336718)
Show SMILES COc1ccc(cc1)-c1nc(O)c2ccccc2n1
Show InChI InChI=1S/C15H12N2O2/c1-19-11-8-6-10(7-9-11)14-16-13-5-3-2-4-12(13)15(18)17-14/h2-9H,1H3,(H,16,17,18)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019203
PNG
(2-(3'-Ethoxy-4'-hydroxyphenyl)quinazolin-4...)
Show SMILES CCOc1cc(ccc1O)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O3/c1-2-21-14-9-10(7-8-13(14)19)15-17-12-6-4-3-5-11(12)16(20)18-15/h3-9,19H,2H2,1H3,(H,17,18,20)
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n/an/a 1.17E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019212
PNG
(CHEMBL3289116)
Show SMILES [O-][N+](=O)c1ccccc1-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H9N3O3/c18-14-9-5-1-3-7-11(9)15-13(16-14)10-6-2-4-8-12(10)17(19)20/h1-8H,(H,15,16,18)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM50008884
PNG
(CHEMBL3237329)
Show SMILES Oc1ccc(C(c2c[nH]c3ccc(Br)cc23)c2c[nH]c3ccc(Br)cc23)c(O)c1
Show InChI InChI=1S/C23H16Br2N2O2/c24-12-1-5-20-16(7-12)18(10-26-20)23(15-4-3-14(28)9-22(15)29)19-11-27-21-6-2-13(25)8-17(19)21/h1-11,23,26-29H
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n/an/a 1.62E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019286
PNG
(CHEMBL3289123)
Show SMILES Clc1ccccc1-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H9ClN2O/c15-11-7-3-1-5-9(11)13-16-12-8-4-2-6-10(12)14(18)17-13/h1-8H,(H,16,17,18)
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019285
PNG
(CHEMBL3289122)
Show SMILES COc1ccc(O)c(c1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C15H12N2O3/c1-20-9-6-7-13(18)11(8-9)14-16-12-5-3-2-4-10(12)15(19)17-14/h2-8,18H,1H3,(H,16,17,19)
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM50008901
PNG
(CHEMBL2430239)
Show SMILES Oc1ccc(cc1)C(c1c[nH]c2ccc(Br)cc12)c1c[nH]c2ccc(Br)cc12
Show InChI InChI=1S/C23H16Br2N2O/c24-14-3-7-21-17(9-14)19(11-26-21)23(13-1-5-16(28)6-2-13)20-12-27-22-8-4-15(25)10-18(20)22/h1-12,23,26-28H
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n/an/a 1.86E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019242
PNG
(2-(3',4'-Dihydroxyphenyl)quinazolin-4(3H)-...)
Show SMILES Oc1ccc(cc1O)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H10N2O3/c17-11-6-5-8(7-12(11)18)13-15-10-4-2-1-3-9(10)14(19)16-13/h1-7,17-18H,(H,15,16,19)
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019288
PNG
(CHEMBL3289384)
Show SMILES CCOc1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O2/c1-2-20-12-9-7-11(8-10-12)15-17-14-6-4-3-5-13(14)16(19)18-15/h3-10H,2H2,1H3,(H,17,18,19)
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092444
PNG
(CHEMBL3586121)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccc1O
Show InChI InChI=1S/C23H18N4O2/c1-13-11-18-19(12-14(13)2)25-21(24-18)15-7-9-16(10-8-15)22-26-27-23(29-22)17-5-3-4-6-20(17)28/h3-12,28H,1-2H3,(H,24,25)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193670
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2,4,...)
Show SMILES Clc1cc(Cl)c(cc1Cl)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1cc(Cl)c(Cl)cc1Cl
Show InChI InChI=1S/C24H14Cl6N2O4S4/c25-13-9-17(29)23(11-15(13)27)39(33,34)31-19-5-1-3-7-21(19)37-38-22-8-4-2-6-20(22)32-40(35,36)24-12-16(28)14(26)10-18(24)30/h1-12,31-32H
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n/an/a 2.20E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 ÁL...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193729
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(3-fluoro...)
Show SMILES Fc1cccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C31H24FN5OS/c32-21-6-5-7-22(16-21)35-31(39)37-36-30(38)20-14-12-19(13-15-20)29(25-17-33-27-10-3-1-8-23(25)27)26-18-34-28-11-4-2-9-24(26)28/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM222210
PNG
(2,4,5-Trichloro-N'-(4-(5-(2-methoxyphenyl)-1,3...)
Show SMILES COc1ccccc1-c1nnc(o1)-c1ccc(cc1)C(=O)NNS(=O)(=O)c1cc(Cl)c(Cl)cc1Cl
Show InChI InChI=1S/C22H15Cl3N4O5S/c1-33-18-5-3-2-4-14(18)22-28-27-21(34-22)13-8-6-12(7-9-13)20(30)26-29-35(31,32)19-11-16(24)15(23)10-17(19)25/h2-11,29H,1H3,(H,26,30)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 &#...


Bioorg Chem 71: 86-96 (2017)

More data for this
Ligand-Target Pair
Beta-glucuronidase


(Rattus norvegicus)
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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n/an/a 2.80E+3n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CB


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019170
PNG
(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Show SMILES COc1ccc(cc1O)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C15H12N2O3/c1-20-13-7-6-9(8-12(13)18)14-16-11-5-3-2-4-10(11)15(19)17-14/h2-8,18H,1H3,(H,16,17,19)
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM50008904
PNG
(CHEMBL3237336)
Show SMILES COc1cccc(C(c2c[nH]c3ccc(cc23)C#N)c2c[nH]c3ccc(cc23)C#N)c1O
Show InChI InChI=1S/C26H18N4O2/c1-32-24-4-2-3-17(26(24)31)25(20-13-29-22-7-5-15(11-27)9-18(20)22)21-14-30-23-8-6-16(12-28)10-19(21)23/h2-10,13-14,25,29-31H,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193721
PNG
(N-(2-Bromophenyl)-2-(4-(di(1H-indol-3-yl)methyl)be...)
Show SMILES Brc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C31H24BrN5OS/c32-25-9-3-6-12-28(25)35-31(39)37-36-30(38)20-15-13-19(14-16-20)29(23-17-33-26-10-4-1-7-21(23)26)24-18-34-27-11-5-2-8-22(24)27/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193723
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(4-fluoro...)
Show SMILES Fc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C31H24FN5OS/c32-21-13-15-22(16-14-21)35-31(39)37-36-30(38)20-11-9-19(10-12-20)29(25-17-33-27-7-3-1-5-23(25)27)26-18-34-28-8-4-2-6-24(26)28/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM50008903
PNG
(CHEMBL3237335)
Show SMILES Oc1ccc(Cl)cc1C(c1c[nH]c2ccc(Br)cc12)c1c[nH]c2ccc(Br)cc12
Show InChI InChI=1S/C23H15Br2ClN2O/c24-12-1-4-20-15(7-12)18(10-27-20)23(17-9-14(26)3-6-22(17)29)19-11-28-21-5-2-13(25)8-16(19)21/h1-11,23,27-29H
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n/an/a 3.10E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM222109
PNG
((E)-4-(3-Nitrophenyl)-2-(2-(pyren-1-ylmethylene)hy...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1csc(N\N=C\c2ccc3ccc4cccc5ccc2c3c45)n1
Show InChI InChI=1S/C26H16N4O2S/c31-30(32)21-6-2-5-19(13-21)23-15-33-26(28-23)29-27-14-20-10-9-18-8-7-16-3-1-4-17-11-12-22(20)25(18)24(16)17/h1-15H,(H,28,29)/b27-14+
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n/an/a 3.10E+3n/an/an/an/an/an/a



University of Karachi



Assay Description
β-Glucuronidase inhibitory activity was measured by quantifying the absorbance of para-nitrophenol which was formed from the substrate by the sp...


Bioorg Chem 70: 199-209 (2017)

More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092351
PNG
(CHEMBL3586128)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(O)cc1
Show InChI InChI=1S/C26H25Cl2N3O/c1-32-26-13-12-19-22(20(26)11-7-3-6-10-18-8-4-2-5-9-18)15-30-31-25(19)14-21-23(27)16-29-17-24(21)28/h2,4-5,8-9,12-13,15-17H,3,6-7,10-11,14H2,1H3
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n/an/a 3.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019277
PNG
(2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-...)
Show SMILES Oc1ccc(O)c(c1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H10N2O3/c17-8-5-6-12(18)10(7-8)13-15-11-4-2-1-3-9(11)14(19)16-13/h1-7,17-18H,(H,15,16,19)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM222114
PNG
((E)-2-(2-(2-(Pyren-1-ylmethylene)hydrazinyl)thiazo...)
Show SMILES Oc1ccccc1-c1csc(N\N=C\c2ccc3ccc4cccc5ccc2c3c45)n1
Show InChI InChI=1S/C26H17N3OS/c30-23-7-2-1-6-21(23)22-15-31-26(28-22)29-27-14-19-11-10-18-9-8-16-4-3-5-17-12-13-20(19)25(18)24(16)17/h1-15,30H,(H,28,29)/b27-14+
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Karachi



Assay Description
β-Glucuronidase inhibitory activity was measured by quantifying the absorbance of para-nitrophenol which was formed from the substrate by the sp...


Bioorg Chem 70: 199-209 (2017)

More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193667
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2,4-...)
Show SMILES [O-][N+](=O)c1ccc(c(c1)[N+]([O-])=O)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C24H16N6O12S4/c31-27(32)15-9-11-23(19(13-15)29(35)36)45(39,40)25-17-5-1-3-7-21(17)43-44-22-8-4-2-6-18(22)26-46(41,42)24-12-10-16(28(33)34)14-20(24)30(37)38/h1-14,25-26H
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n/an/a 3.34E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 ÁL...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM222116
PNG
((E)-2-(2-(Pyren-1-ylmethylene)hydrazinyl)thiazol-4...)
Show SMILES O=C1CSC(N\N=C\c2ccc3ccc4cccc5ccc2c3c45)=N1
Show InChI InChI=1S/C20H13N3OS/c24-17-11-25-20(22-17)23-21-10-15-7-6-14-5-4-12-2-1-3-13-8-9-16(15)19(14)18(12)13/h1-10H,11H2,(H,22,23,24)/b21-10+
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Karachi



Assay Description
β-Glucuronidase inhibitory activity was measured by quantifying the absorbance of para-nitrophenol which was formed from the substrate by the sp...


Bioorg Chem 70: 199-209 (2017)

More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092460
PNG
(CHEMBL3586119)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccn1
Show InChI InChI=1S/C22H17N5O/c1-13-11-18-19(12-14(13)2)25-20(24-18)15-6-8-16(9-7-15)21-26-27-22(28-21)17-5-3-4-10-23-17/h3-12H,1-2H3,(H,24,25)
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n/an/a 4.12E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM50008905
PNG
(CHEMBL3237340)
Show SMILES COc1cc(ccc1O)C(c1c[nH]c2ccc(cc12)C#N)c1c[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C26H18N4O2/c1-32-25-10-17(4-7-24(25)31)26(20-13-29-22-5-2-15(11-27)8-18(20)22)21-14-30-23-6-3-16(12-28)9-19(21)23/h2-10,13-14,26,29-31H,1H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM152561
PNG
(2-(4,6-dichloro-1H-benzo[d]imidazol-2-yl)phenol (1...)
Show SMILES Oc1ccccc1-c1nc2c(Cl)cc(Cl)cc2[nH]1
Show InChI InChI=1S/C13H8Cl2N2O/c14-7-5-9(15)12-10(6-7)16-13(17-12)8-3-1-2-4-11(8)18/h1-6,18H,(H,16,17)
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n/an/a 4.48E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019186
PNG
(CHEMBL1333995)
Show SMILES CN(C)c1ccc(cc1)-c1nc(O)c2ccccc2n1
Show InChI InChI=1S/C16H15N3O/c1-19(2)12-9-7-11(8-10-12)15-17-14-6-4-3-5-13(14)16(20)18-15/h3-10H,1-2H3,(H,17,18,20)
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM222103
PNG
((E)-2-(Pyren-1-ylmethylene)hydrazine-1-carbothioam...)
Show SMILES NC(=S)N\N=C\c1ccc2ccc3cccc4ccc1c2c34
Show InChI InChI=1S/C18H13N3S/c19-18(22)21-20-10-14-7-6-13-5-4-11-2-1-3-12-8-9-15(14)17(13)16(11)12/h1-10H,(H3,19,21,22)/b20-10+
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Karachi



Assay Description
β-Glucuronidase inhibitory activity was measured by quantifying the absorbance of para-nitrophenol which was formed from the substrate by the sp...


Bioorg Chem 70: 199-209 (2017)

More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193731
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(3-nitrop...)
Show SMILES [O-][N+](=O)c1cccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C31H24N6O3S/c38-30(35-36-31(41)34-21-6-5-7-22(16-21)37(39)40)20-14-12-19(13-15-20)29(25-17-32-27-10-3-1-8-23(25)27)26-18-33-28-11-4-2-9-24(26)28/h1-18,29,32-33H,(H,35,38)(H2,34,36,41)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase


(Rattus norvegicus)
BDBM50142192
PNG
(3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-o...)
Show SMILES Oc1ccc(c(O)c1)-c1coc2cc(O)cc(O)c2c1=O
Show InChI InChI=1S/C15H10O6/c16-7-1-2-9(11(18)3-7)10-6-21-13-5-8(17)4-12(19)14(13)15(10)20/h1-6,16-19H
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n/an/a 5.90E+3n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CB


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM222112
PNG
((E)-4-(3,4-Dichlorophenyl)-2-(2-(pyren-1-ylmethyle...)
Show SMILES Clc1ccc(cc1Cl)-c1csc(N\N=C\c2ccc3ccc4cccc5ccc2c3c45)n1
Show InChI InChI=1S/C26H15Cl2N3S/c27-21-11-9-18(12-22(21)28)23-14-32-26(30-23)31-29-13-19-7-6-17-5-4-15-2-1-3-16-8-10-20(19)25(17)24(15)16/h1-14H,(H,30,31)/b29-13+
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n/an/a 6.20E+3n/an/an/an/an/an/a



University of Karachi



Assay Description
β-Glucuronidase inhibitory activity was measured by quantifying the absorbance of para-nitrophenol which was formed from the substrate by the sp...


Bioorg Chem 70: 199-209 (2017)

More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193657
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2-fl...)
Show SMILES Fc1ccccc1S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C24H18F2N2O4S4/c25-17-9-1-7-15-23(17)35(29,30)27-19-11-3-5-13-21(19)33-34-22-14-6-4-12-20(22)28-36(31,32)24-16-8-2-10-18(24)26/h1-16,27-28H
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n/an/a 6.23E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 ÁL...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM222207
PNG
(N'-(4-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-y...)
Show SMILES COc1ccccc1-c1nnc(o1)-c1ccc(cc1)C(=O)NNS(=O)(=O)c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C22H16N6O9S/c1-36-18-5-3-2-4-16(18)22-25-24-21(37-22)14-8-6-13(7-9-14)20(29)23-26-38(34,35)19-11-10-15(27(30)31)12-17(19)28(32)33/h2-12,26H,1H3,(H,23,29)
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n/an/a 6.34E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 &#...


Bioorg Chem 71: 86-96 (2017)

More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193718
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(o-tolyl)...)
Show SMILES Cc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C32H27N5OS/c1-20-8-2-5-11-27(20)35-32(39)37-36-31(38)22-16-14-21(15-17-22)30(25-18-33-28-12-6-3-9-23(25)28)26-19-34-29-13-7-4-10-24(26)29/h2-19,30,33-34H,1H3,(H,36,38)(H2,35,37,39)
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n/an/a 7.12E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM50129852
PNG
(CHEMBL3628915)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccc(cc2)-c2nnc(o2)-c2ccccc2O)cc1O
Show InChI InChI=1S/C23H18N4O5/c1-31-20-11-6-14(12-19(20)29)13-24-25-21(30)15-7-9-16(10-8-15)22-26-27-23(32-22)17-4-2-3-5-18(17)28/h2-13,28-29H,1H3,(H,25,30)/b24-13+
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n/an/a 7.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate assessed as p-nitrophenol formation after 30 mins b...


Bioorg Med Chem 23: 7394-404 (2015)

More data for this
Ligand-Target Pair
Beta-glucuronidase


(Rattus norvegicus)
BDBM79181
PNG
(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Show SMILES CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChI InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
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n/an/a 7.80E+3n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CB


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More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092465
PNG
(CHEMBL3586113)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(O)c1
Show InChI InChI=1S/C23H18N4O2/c1-13-10-19-20(11-14(13)2)25-21(24-19)15-6-8-16(9-7-15)22-26-27-23(29-22)17-4-3-5-18(28)12-17/h3-12,28H,1-2H3,(H,24,25)
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n/an/a 8.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


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More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193654
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2-ch...)
Show SMILES Clc1ccccc1S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C24H18Cl2N2O4S4/c25-17-9-1-7-15-23(17)35(29,30)27-19-11-3-5-13-21(19)33-34-22-14-6-4-12-20(22)28-36(31,32)24-16-8-2-10-18(24)26/h1-16,27-28H
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n/an/a 8.18E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 ÁL...


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More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193725
PNG
(N-(4-Chlorophenyl)-2-(4-(di(1H-indol-3-yl)methyl)b...)
Show SMILES Clc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C31H24ClN5OS/c32-21-13-15-22(16-14-21)35-31(39)37-36-30(38)20-11-9-19(10-12-20)29(25-17-33-27-7-3-1-5-23(25)27)26-18-34-28-8-4-2-6-24(26)28/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 8.50E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM222115
PNG
((E)-3-(2-(2-(Pyren-1-ylmethylene)hydrazinyl)thiazo...)
Show SMILES Oc1cccc(c1)-c1csc(N\N=C\c2ccc3ccc4cccc5ccc2c3c45)n1
Show InChI InChI=1S/C26H17N3OS/c30-21-6-2-5-19(13-21)23-15-31-26(28-23)29-27-14-20-10-9-18-8-7-16-3-1-4-17-11-12-22(20)25(18)24(16)17/h1-15,30H,(H,28,29)/b27-14+
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n/an/a 8.50E+3n/an/an/an/an/an/a



University of Karachi



Assay Description
β-Glucuronidase inhibitory activity was measured by quantifying the absorbance of para-nitrophenol which was formed from the substrate by the sp...


Bioorg Chem 70: 199-209 (2017)

More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193735
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(2-methox...)
Show SMILES COc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C32H27N5O2S/c1-39-29-13-7-6-12-28(29)35-32(40)37-36-31(38)21-16-14-20(15-17-21)30(24-18-33-26-10-4-2-8-22(24)26)25-19-34-27-11-5-3-9-23(25)27/h2-19,30,33-34H,1H3,(H,36,38)(H2,35,37,40)
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n/an/a 9.40E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


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More data for this
Ligand-Target Pair
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