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Compile Data Set for Download or QSAR

Found 37 hits Enz. Inhib. hit(s) with Target = 'Bifunctional protein GlmU'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365095
PNG
(CHEMBL1951184)
Show SMILES COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1N1CCC(COC(=O)CCC(O)=O)CC1
Show InChI InChI=1S/C29H37N3O11S/c1-41-23-16-24(42-2)25(15-21(23)31-26(33)7-8-27(34)35)44(39,40)30-17-20-5-3-4-6-22(20)32-13-11-19(12-14-32)18-43-29(38)10-9-28(36)37/h3-6,15-16,19,30H,7-14,17-18H2,1-2H3,(H,31,33)(H,34,35)(H,36,37)
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n/an/a 500n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365097
PNG
(CHEMBL1951186)
Show SMILES COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1N1CCC(CC1)C(O)=O
Show InChI InChI=1S/C25H31N3O9S/c1-36-20-14-21(37-2)22(13-18(20)27-23(29)7-8-24(30)31)38(34,35)26-15-17-5-3-4-6-19(17)28-11-9-16(10-12-28)25(32)33/h3-6,13-14,16,26H,7-12,15H2,1-2H3,(H,27,29)(H,30,31)(H,32,33)
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n/an/a 2.00E+3n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365098
PNG
(CHEMBL1951187)
Show SMILES COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1N1CCC(CC(O)=O)CC1
Show InChI InChI=1S/C26H33N3O9S/c1-37-21-15-22(38-2)23(14-19(21)28-24(30)7-8-25(31)32)39(35,36)27-16-18-5-3-4-6-20(18)29-11-9-17(10-12-29)13-26(33)34/h3-6,14-15,17,27H,7-13,16H2,1-2H3,(H,28,30)(H,31,32)(H,33,34)
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n/an/a 2.00E+3n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365094
PNG
(CHEMBL1951183)
Show SMILES COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1N1CCC(CO)CC1
Show InChI InChI=1S/C25H33N3O8S/c1-35-21-14-22(36-2)23(13-19(21)27-24(30)7-8-25(31)32)37(33,34)26-15-18-5-3-4-6-20(18)28-11-9-17(16-29)10-12-28/h3-6,13-14,17,26,29H,7-12,15-16H2,1-2H3,(H,27,30)(H,31,32)
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n/an/a 5.00E+3n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365067
PNG
(CHEMBL1951078)
Show SMILES COc1cc(OC)c(cc1NC(=O)\C=C\C(O)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C22H24N2O7S/c1-14-8-9-15-6-4-5-7-17(15)24(14)32(28,29)20-12-16(18(30-2)13-19(20)31-3)23-21(25)10-11-22(26)27/h4-7,10-14H,8-9H2,1-3H3,(H,23,25)(H,26,27)/b11-10+
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n/an/a 1.00E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365093
PNG
(CHEMBL1951182)
Show SMILES COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1N1CCCCC1
Show InChI InChI=1S/C24H31N3O7S/c1-33-20-15-21(34-2)22(14-18(20)26-23(28)10-11-24(29)30)35(31,32)25-16-17-8-4-5-9-19(17)27-12-6-3-7-13-27/h4-5,8-9,14-15,25H,3,6-7,10-13,16H2,1-2H3,(H,26,28)(H,29,30)
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n/an/a 1.20E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365096
PNG
(CHEMBL1951185)
Show SMILES COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H26N2O9S/c1-36-21-14-22(37-2)23(13-20(21)28-24(29)11-12-25(30)31)38(34,35)27-15-18-5-3-4-6-19(18)16-7-9-17(10-8-16)26(32)33/h3-10,13-14,27H,11-12,15H2,1-2H3,(H,28,29)(H,30,31)(H,32,33)
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n/an/a 1.50E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365065
PNG
(CHEMBL1951075)
Show SMILES COc1cc(OC)c(cc1NC(=O)NCC(O)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C21H25N3O7S/c1-13-8-9-14-6-4-5-7-16(14)24(13)32(28,29)19-10-15(17(30-2)11-18(19)31-3)23-21(27)22-12-20(25)26/h4-7,10-11,13H,8-9,12H2,1-3H3,(H,25,26)(H2,22,23,27)
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n/an/a 2.00E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365068
PNG
(CHEMBL1951079)
Show SMILES COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C22H26N2O7S/c1-14-8-9-15-6-4-5-7-17(15)24(14)32(28,29)20-12-16(18(30-2)13-19(20)31-3)23-21(25)10-11-22(26)27/h4-7,12-14H,8-11H2,1-3H3,(H,23,25)(H,26,27)
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n/an/a 2.00E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365064
PNG
(CHEMBL1951074)
Show SMILES COc1cc(OC)c(cc1NC(=S)NCC(O)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C21H25N3O6S2/c1-13-8-9-14-6-4-5-7-16(14)24(13)32(27,28)19-10-15(17(29-2)11-18(19)30-3)23-21(31)22-12-20(25)26/h4-7,10-11,13H,8-9,12H2,1-3H3,(H,25,26)(H2,22,23,31)
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n/an/a 3.00E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365063
PNG
(CHEMBL1951073)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C20H24N2O5S/c1-13-9-10-15-7-5-6-8-17(15)22(13)28(24,25)20-11-16(21-14(2)23)18(26-3)12-19(20)27-4/h5-8,11-13H,9-10H2,1-4H3,(H,21,23)
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n/an/a 5.50E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365092
PNG
(CHEMBL1951181)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)NCc1ccccc1N1CCC(CO)CC1
Show InChI InChI=1S/C23H31N3O6S/c1-16(28)25-19-12-23(22(32-3)13-21(19)31-2)33(29,30)24-14-18-6-4-5-7-20(18)26-10-8-17(15-27)9-11-26/h4-7,12-13,17,24,27H,8-11,14-15H2,1-3H3,(H,25,28)
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n/an/a 7.00E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365066
PNG
(CHEMBL1951076)
Show SMILES COc1cc(OC)c(cc1NC(=O)COC(C)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C22H26N2O7S/c1-14-9-10-16-7-5-6-8-18(16)24(14)32(27,28)21-11-17(19(29-3)12-20(21)30-4)23-22(26)13-31-15(2)25/h5-8,11-12,14H,9-10,13H2,1-4H3,(H,23,26)
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n/an/a 9.00E+4n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365091
PNG
(CHEMBL1951180)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)NCc1ccccc1N1CCCCC1
Show InChI InChI=1S/C22H29N3O5S/c1-16(26)24-18-13-22(21(30-3)14-20(18)29-2)31(27,28)23-15-17-9-5-6-10-19(17)25-11-7-4-8-12-25/h5-6,9-10,13-14,23H,4,7-8,11-12,15H2,1-3H3,(H,24,26)
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n/an/a 1.10E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365076
PNG
(CHEMBL1951165)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N(C(C)C)c1ccccc1
Show InChI InChI=1S/C19H24N2O5S/c1-13(2)21(15-9-7-6-8-10-15)27(23,24)19-11-16(20-14(3)22)17(25-4)12-18(19)26-5/h6-13H,1-5H3,(H,20,22)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365077
PNG
(CHEMBL1951166)
Show SMILES CCN(c1ccccc1C)S(=O)(=O)c1cc(NC(C)=O)c(OC)cc1OC
Show InChI InChI=1S/C19H24N2O5S/c1-6-21(16-10-8-7-9-13(16)2)27(23,24)19-11-15(20-14(3)22)17(25-4)12-18(19)26-5/h7-12H,6H2,1-5H3,(H,20,22)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365078
PNG
(CHEMBL1951167)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N1CCCCC1C
Show InChI InChI=1S/C16H24N2O5S/c1-11-7-5-6-8-18(11)24(20,21)16-9-13(17-12(2)19)14(22-3)10-15(16)23-4/h9-11H,5-8H2,1-4H3,(H,17,19)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365079
PNG
(CHEMBL1951168)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N1CCCC1C
Show InChI InChI=1S/C15H22N2O5S/c1-10-6-5-7-17(10)23(19,20)15-8-12(16-11(2)18)13(21-3)9-14(15)22-4/h8-10H,5-7H2,1-4H3,(H,16,18)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365080
PNG
(CHEMBL1951169)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C15H22N2O5S/c1-11(18)16-12-9-15(14(22-3)10-13(12)21-2)23(19,20)17-7-5-4-6-8-17/h9-10H,4-8H2,1-3H3,(H,16,18)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365081
PNG
(CHEMBL1951170)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N(C)C
Show InChI InChI=1S/C12H18N2O5S/c1-8(15)13-9-6-12(20(16,17)14(2)3)11(19-5)7-10(9)18-4/h6-7H,1-5H3,(H,13,15)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365082
PNG
(CHEMBL1951171)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C16H17FN2O5S/c1-10(20)18-13-8-16(15(24-3)9-14(13)23-2)25(21,22)19-12-6-4-11(17)5-7-12/h4-9,19H,1-3H3,(H,18,20)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365083
PNG
(CHEMBL1951172)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C16H17FN2O5S/c1-10(20)18-13-8-16(15(24-3)9-14(13)23-2)25(21,22)19-12-6-4-5-11(17)7-12/h4-9,19H,1-3H3,(H,18,20)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365084
PNG
(CHEMBL1951173)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)Nc1ccccc1F
Show InChI InChI=1S/C16H17FN2O5S/c1-10(20)18-13-8-16(15(24-3)9-14(13)23-2)25(21,22)19-12-7-5-4-6-11(12)17/h4-9,19H,1-3H3,(H,18,20)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365085
PNG
(CHEMBL1951174)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C17H20N2O5S/c1-11-6-5-7-13(8-11)19-25(21,22)17-9-14(18-12(2)20)15(23-3)10-16(17)24-4/h5-10,19H,1-4H3,(H,18,20)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365086
PNG
(CHEMBL1951175)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)Nc1ccc(C)cc1
Show InChI InChI=1S/C17H20N2O5S/c1-11-5-7-13(8-6-11)19-25(21,22)17-9-14(18-12(2)20)15(23-3)10-16(17)24-4/h5-10,19H,1-4H3,(H,18,20)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365087
PNG
(CHEMBL1951176)
Show SMILES COc1ccccc1CNS(=O)(=O)c1cc(NC(C)=O)c(OC)cc1OC
Show InChI InChI=1S/C18H22N2O6S/c1-12(21)20-14-9-18(17(26-4)10-16(14)25-3)27(22,23)19-11-13-7-5-6-8-15(13)24-2/h5-10,19H,11H2,1-4H3,(H,20,21)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365088
PNG
(CHEMBL1951177)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)NCc1ccc2OCOc2c1
Show InChI InChI=1S/C18H20N2O7S/c1-11(21)20-13-7-18(17(25-3)8-15(13)24-2)28(22,23)19-9-12-4-5-14-16(6-12)27-10-26-14/h4-8,19H,9-10H2,1-3H3,(H,20,21)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365089
PNG
(CHEMBL1951178)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)NCc1ccccc1Br
Show InChI InChI=1S/C17H19BrN2O5S/c1-11(21)20-14-8-17(16(25-3)9-15(14)24-2)26(22,23)19-10-12-6-4-5-7-13(12)18/h4-9,19H,10H2,1-3H3,(H,20,21)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365090
PNG
(CHEMBL1951179)
Show SMILES COC(=O)c1ccccc1CNS(=O)(=O)c1cc(NC(C)=O)c(OC)cc1OC
Show InChI InChI=1S/C19H22N2O7S/c1-12(22)21-15-9-18(17(27-3)10-16(15)26-2)29(24,25)20-11-13-7-5-6-8-14(13)19(23)28-4/h5-10,20H,11H2,1-4H3,(H,21,22)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365071
PNG
(CHEMBL1951160)
Show SMILES COc1cc(OC)c(cc1NC(=O)COc1ccc(cc1)C(C)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C28H30N2O7S/c1-18-9-10-21-7-5-6-8-24(21)30(18)38(33,34)27-15-23(25(35-3)16-26(27)36-4)29-28(32)17-37-22-13-11-20(12-14-22)19(2)31/h5-8,11-16,18H,9-10,17H2,1-4H3,(H,29,32)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365070
PNG
(CHEMBL1951081)
Show SMILES COc1cc(OC)c(cc1NC(=O)CSc1ccncc1)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C25H27N3O5S2/c1-17-8-9-18-6-4-5-7-21(18)28(17)35(30,31)24-14-20(22(32-2)15-23(24)33-3)27-25(29)16-34-19-10-12-26-13-11-19/h4-7,10-15,17H,8-9,16H2,1-3H3,(H,27,29)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365069
PNG
(CHEMBL1951080)
Show SMILES COc1cc(OC)c(cc1NC(=O)CSCC(O)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C22H26N2O7S2/c1-14-8-9-15-6-4-5-7-17(15)24(14)33(28,29)20-10-16(18(30-2)11-19(20)31-3)23-21(25)12-32-13-22(26)27/h4-7,10-11,14H,8-9,12-13H2,1-3H3,(H,23,25)(H,26,27)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365062
PNG
(CHEMBL1951072 | Sulfonamide, 1)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N1C(C)Cc2ccccc12
Show InChI InChI=1S/C19H22N2O5S/c1-12-9-14-7-5-6-8-16(14)21(12)27(23,24)19-10-15(20-13(2)22)17(25-3)11-18(19)26-4/h5-8,10-12H,9H2,1-4H3,(H,20,22)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365075
PNG
(CHEMBL1951164 | Sulfonamide, 2)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N(C)c1ccccc1
Show InChI InChI=1S/C17H20N2O5S/c1-12(20)18-14-10-17(16(24-4)11-15(14)23-3)25(21,22)19(2)13-8-6-5-7-9-13/h5-11H,1-4H3,(H,18,20)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365072
PNG
(CHEMBL1951161)
Show SMILES COc1cc(OC)c(cc1NS(C)(=O)=O)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C19H24N2O6S2/c1-13-9-10-14-7-5-6-8-16(14)21(13)29(24,25)19-11-15(20-28(4,22)23)17(26-2)12-18(19)27-3/h5-8,11-13,20H,9-10H2,1-4H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365073
PNG
(CHEMBL1951162)
Show SMILES COc1cc(OC)c(cc1NC(=O)c1ccccc1)S(=O)(=O)N1C(C)CCc2ccccc12
Show InChI InChI=1S/C25H26N2O5S/c1-17-13-14-18-9-7-8-12-21(18)27(17)33(29,30)24-15-20(22(31-2)16-23(24)32-3)26-25(28)19-10-5-4-6-11-19/h4-12,15-17H,13-14H2,1-3H3,(H,26,28)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365074
PNG
(CHEMBL1951163)
Show SMILES COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C16H18N2O5S/c1-11(19)17-13-9-16(15(23-3)10-14(13)22-2)24(20,21)18-12-7-5-4-6-8-12/h4-10,18H,1-3H3,(H,17,19)
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n/an/a>2.00E+5n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Citation and Details
More data for this
Ligand-Target Pair