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Compile Data Set for Download or QSAR

Found 422 hits Enz. Inhib. hit(s) with Target = 'Bone morphogenetic protein 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111856
PNG
(CHEMBL21249 | {(R)-2-Amino-4-[benzo[1,3]dioxol-5-y...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@@H](C(=O)NO)C(=O)C(N)CNC(=O)OCC1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C35H34N4O10S/c1-46-22-11-13-23(14-12-22)50(44,45)39(18-21-10-15-30-31(16-21)49-20-48-30)32(34(41)38-43)33(40)29(36)17-37-35(42)47-19-28-26-8-4-2-6-24(26)25-7-3-5-9-27(25)28/h2-16,28-29,32,43H,17-20,36H2,1H3,(H,37,42)(H,38,41)/t29?,32-/m1/s1
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n/an/a 0.0240n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111848
PNG
((R)-2-[Benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](Cc1cccs1)C(=O)NO
Show InChI InChI=1S/C22H22N2O7S2/c1-29-16-5-7-18(8-6-16)33(27,28)24(13-15-4-9-20-21(11-15)31-14-30-20)19(22(25)23-26)12-17-3-2-10-32-17/h2-11,19,26H,12-14H2,1H3,(H,23,25)/t19-/m1/s1
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n/an/a 0.200n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111848
PNG
((R)-2-[Benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](Cc1cccs1)C(=O)NO
Show InChI InChI=1S/C22H22N2O7S2/c1-29-16-5-7-18(8-6-16)33(27,28)24(13-15-4-9-20-21(11-15)31-14-30-20)19(22(25)23-26)12-17-3-2-10-32-17/h2-11,19,26H,12-14H2,1H3,(H,23,25)/t19-/m1/s1
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n/an/a 0.200n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216807
PNG
((3R)-6-cyclohexyl-3-[3-({[(3,4-dimethoxyphenyl)sul...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)NC(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C23H32N4O8S/c1-33-18-12-11-17(14-19(18)34-2)36(31,32)27-22(29)21-24-23(35-26-21)16(13-20(28)25-30)10-6-9-15-7-4-3-5-8-15/h11-12,14-16,30H,3-10,13H2,1-2H3,(H,25,28)(H,27,29)/t16-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216831
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(4-pyridinyl)-1,2...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1ccncc1
Show InChI InChI=1S/C19H26N4O3/c24-17(22-25)13-16(8-4-7-14-5-2-1-3-6-14)19-21-18(23-26-19)15-9-11-20-12-10-15/h9-12,14,16,25H,1-8,13H2,(H,22,24)/t16-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216796
PNG
((3R)-3-(3-{[acetyl(methyl)amino]methyl}-1,2,4-oxad...)
Show SMILES CN(Cc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO)C(C)=O
Show InChI InChI=1S/C18H30N4O4/c1-13(23)22(2)12-16-19-18(26-21-16)15(11-17(24)20-25)10-6-9-14-7-4-3-5-8-14/h14-15,25H,3-12H2,1-2H3,(H,20,24)/t15-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216838
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-{3-[1-(methylsulfony...)
Show SMILES CS(=O)(=O)N1CCC(CC1)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C21H37N5O5S/c1-32(29,30)26-12-10-18(11-13-26)22-15-19-23-21(31-25-19)17(14-20(27)24-28)9-5-8-16-6-3-2-4-7-16/h16-18,22,28H,2-15H2,1H3,(H,24,27)/t17-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216824
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{4-[(methylsulfon...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C21H30N4O5S/c1-31(28,29)25-18-12-10-16(11-13-18)20-22-21(30-24-20)17(14-19(26)23-27)9-5-8-15-6-3-2-4-7-15/h10-13,15,17,25,27H,2-9,14H2,1H3,(H,23,26)/t17-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50102948
PNG
(CHEMBL279023 | {(R)-4-[Benzo[1,3]dioxol-5-ylmethyl...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCNC(=O)OCc1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C28H30ClN3O9S/c1-38-21-9-11-22(12-10-21)42(36,37)32(16-19-8-13-25-26(15-19)41-18-40-25)24(27(33)31-35)7-4-14-30-28(34)39-17-20-5-2-3-6-23(20)29/h2-3,5-6,8-13,15,24,35H,4,7,14,16-18H2,1H3,(H,30,34)(H,31,33)/t24-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50102948
PNG
(CHEMBL279023 | {(R)-4-[Benzo[1,3]dioxol-5-ylmethyl...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCNC(=O)OCc1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C28H30ClN3O9S/c1-38-21-9-11-22(12-10-21)42(36,37)32(16-19-8-13-25-26(15-19)41-18-40-25)24(27(33)31-35)7-4-14-30-28(34)39-17-20-5-2-3-6-23(20)29/h2-3,5-6,8-13,15,24,35H,4,7,14,16-18H2,1H3,(H,30,34)(H,31,33)/t24-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against procollagen C-Proteinase (PCP).


Bioorg Med Chem Lett 11: 2085-8 (2001)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111808
PNG
(CHEMBL282484 | {(R)-2-Amino-4-[benzo[1,3]dioxol-5-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@@H](C(=O)NO)C(=O)C(N)CNC(=O)OCc1ccccc1Cl
Show InChI InChI=1S/C28H29ClN4O10S/c1-40-19-7-9-20(10-8-19)44(38,39)33(14-17-6-11-23-24(12-17)43-16-42-23)25(27(35)32-37)26(34)22(30)13-31-28(36)41-15-18-4-2-3-5-21(18)29/h2-12,22,25,37H,13-16,30H2,1H3,(H,31,36)(H,32,35)/t22?,25-/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216841
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(4-morpholinylmet...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CN2CCOCC2)no1
Show InChI InChI=1S/C19H32N4O4/c24-18(21-25)13-16(8-4-7-15-5-2-1-3-6-15)19-20-17(22-27-19)14-23-9-11-26-12-10-23/h15-16,25H,1-14H2,(H,21,24)/t16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216848
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(3-pyridinylmethy...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(Cc2cccnc2)no1
Show InChI InChI=1S/C20H28N4O3/c25-19(23-26)13-17(10-4-8-15-6-2-1-3-7-15)20-22-18(24-27-20)12-16-9-5-11-21-14-16/h5,9,11,14-15,17,26H,1-4,6-8,10,12-13H2,(H,23,25)/t17-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216823
PNG
(2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C20H26N4O5/c25-17(23-28)12-14(8-4-7-13-5-2-1-3-6-13)19-22-18(24-29-19)16-11-15(20(26)27)9-10-21-16/h9-11,13-14,28H,1-8,12H2,(H,23,25)(H,26,27)/t14-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216833
PNG
((3R)-6-cyclohexyl-3-{3-[(cyclopropylamino)methyl]-...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CNC2CC2)no1
Show InChI InChI=1S/C18H30N4O3/c23-17(21-24)11-14(8-4-7-13-5-2-1-3-6-13)18-20-16(22-25-18)12-19-15-9-10-15/h13-15,19,24H,1-12H2,(H,21,23)/t14-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111840
PNG
((R)-N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-(2-tr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1C(F)(F)F)[C@H](C)C(=O)NO
Show InChI InChI=1S/C18H19F3N2O5S/c1-12(17(24)22-25)23(11-13-5-3-4-6-16(13)18(19,20)21)29(26,27)15-9-7-14(28-2)8-10-15/h3-10,12,25H,11H2,1-2H3,(H,22,24)/t12-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216843
PNG
(3-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cccc(c1)C(O)=O
Show InChI InChI=1S/C21H27N3O5/c25-18(23-28)13-16(10-4-8-14-6-2-1-3-7-14)20-22-19(24-29-20)15-9-5-11-17(12-15)21(26)27/h5,9,11-12,14,16,28H,1-4,6-8,10,13H2,(H,23,25)(H,26,27)/t16-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216842
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(2-pyridinylmethy...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(Cc2ccccn2)no1
Show InChI InChI=1S/C20H28N4O3/c25-19(23-26)13-16(10-6-9-15-7-2-1-3-8-15)20-22-18(24-27-20)14-17-11-4-5-12-21-17/h4-5,11-12,15-16,26H,1-3,6-10,13-14H2,(H,23,25)/t16-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216830
PNG
((3R)-3-{3-[(cyclobutylamino)methyl]-1,2,4-oxadiazo...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CNC2CCC2)no1
Show InChI InChI=1S/C19H32N4O3/c24-18(22-25)12-15(9-4-8-14-6-2-1-3-7-14)19-21-17(23-26-19)13-20-16-10-5-11-16/h14-16,20,25H,1-13H2,(H,22,24)/t15-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216817
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H28N4O6S/c26-18(23-28)14-16(11-7-10-15-8-3-1-4-9-15)21-22-19(24-31-21)20(27)25-32(29,30)17-12-5-2-6-13-17/h2,5-6,12-13,15-16,28H,1,3-4,7-11,14H2,(H,23,26)(H,25,27)/t16-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216829
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(2-hydroxy-1,1-...)
Show SMILES CC(C)(CO)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C19H34N4O4/c1-19(2,13-24)20-12-16-21-18(27-23-16)15(11-17(25)22-26)10-6-9-14-7-4-3-5-8-14/h14-15,20,24,26H,3-13H2,1-2H3,(H,22,25)/t15-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216813
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-{3-[6-(4-methyl-1-pi...)
Show SMILES CN1CCNC(C1)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C19H33N5O3/c1-24-11-10-20-16(13-24)18-21-19(27-23-18)15(12-17(25)22-26)9-5-8-14-6-3-2-4-7-14/h14-16,20,26H,2-13H2,1H3,(H,22,25)/t15-,16?/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50102988
PNG
(CHEMBL21486 | {(R)-4-[Benzo[1,3]dioxol-5-ylmethyl-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCNC(=O)OCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C28H31N3O9S/c1-37-22-10-12-23(13-11-22)41(35,36)31(17-21-9-14-25-26(16-21)40-19-39-25)24(27(32)30-34)8-5-15-29-28(33)38-18-20-6-3-2-4-7-20/h2-4,6-7,9-14,16,24,34H,5,8,15,17-19H2,1H3,(H,29,33)(H,30,32)/t24-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against procollagen C-Proteinase (PCP).


Bioorg Med Chem Lett 11: 2085-8 (2001)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50102988
PNG
(CHEMBL21486 | {(R)-4-[Benzo[1,3]dioxol-5-ylmethyl-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCNC(=O)OCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C28H31N3O9S/c1-37-22-10-12-23(13-11-22)41(35,36)31(17-21-9-14-25-26(16-21)40-19-39-25)24(27(32)30-34)8-5-15-29-28(33)38-18-20-6-3-2-4-7-20/h2-4,6-7,9-14,16,24,34H,5,8,15,17-19H2,1H3,(H,29,33)(H,30,32)/t24-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50241177
PNG
((R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-...)
Show SMILES CN(C)C(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C17H28N4O4/c1-21(2)17(23)15-18-16(25-20-15)13(11-14(22)19-24)10-6-9-12-7-4-3-5-8-12/h12-13,24H,3-11H2,1-2H3,(H,19,22)/t13-/m1/s1
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n/an/a 9.30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase assessed as [3H]procollagen turnover by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50241177
PNG
((R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-...)
Show SMILES CN(C)C(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C17H28N4O4/c1-21(2)17(23)15-18-16(25-20-15)13(11-14(22)19-24)10-6-9-12-7-4-3-5-8-12/h12-13,24H,3-11H2,1-2H3,(H,19,22)/t13-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216855
PNG
((3R)-3-{3-[(tert-butylamino)methyl]-1,2,4-oxadiazo...)
Show SMILES CC(C)(C)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C19H34N4O3/c1-19(2,3)20-13-16-21-18(26-23-16)15(12-17(24)22-25)11-7-10-14-8-5-4-6-9-14/h14-15,20,25H,4-13H2,1-3H3,(H,22,24)/t15-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216790
PNG
((3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahyd...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1c[nH]c(=O)[nH]c1=O
Show InChI InChI=1S/C18H25N5O5/c24-14(22-27)9-12(8-4-7-11-5-2-1-3-6-11)17-20-15(23-28-17)13-10-19-18(26)21-16(13)25/h10-12,27H,1-9H2,(H,22,24)(H2,19,21,25,26)/t12-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50402510
PNG
(CHEMBL2204087)
Show SMILES COc1ccc(CCN(CCC(=O)NO)S(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1
Show InChI InChI=1S/C26H30N4O6S/c1-36-23-11-7-20(8-12-23)15-17-30(18-16-25(31)29-33)37(34,35)24-13-9-22(10-14-24)28-26(32)27-19-21-5-3-2-4-6-21/h2-14,33H,15-19H2,1H3,(H,29,31)(H2,27,28,32)
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n/an/a 10n/an/an/an/an/an/a



FibroGen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PCP after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111842
PNG
((R)-2-[Benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CC#C)C(O)=O
Show InChI InChI=1S/C20H19NO7S/c1-3-4-17(20(22)23)21(12-14-5-10-18-19(11-14)28-13-27-18)29(24,25)16-8-6-15(26-2)7-9-16/h1,5-11,17H,4,12-13H2,2H3,(H,22,23)/t17-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against procollagen C-proteinase (PCP).


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216802
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl...)
Show SMILES CS(=O)(=O)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C16H28N4O5S/c1-26(23,24)17-11-14-18-16(25-20-14)13(10-15(21)19-22)9-5-8-12-6-3-2-4-7-12/h12-13,17,22H,2-11H2,1H3,(H,19,21)/t13-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216836
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-{3-[(4-hydroxy-1-pip...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CN2CCC(O)CC2)no1
Show InChI InChI=1S/C20H34N4O4/c25-17-9-11-24(12-10-17)14-18-21-20(28-23-18)16(13-19(26)22-27)8-4-7-15-5-2-1-3-6-15/h15-17,25,27H,1-14H2,(H,22,26)/t16-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216801
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-{3-[6-(methylamino)-...)
Show SMILES CNc1ccc(cn1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C20H29N5O3/c1-21-17-11-10-16(13-22-17)19-23-20(28-25-19)15(12-18(26)24-27)9-5-8-14-6-3-2-4-7-14/h10-11,13-15,27H,2-9,12H2,1H3,(H,21,22)(H,24,26)/t15-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216812
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-[3-({[(4-methylpheny...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C22H30N4O6S/c1-15-10-12-18(13-11-15)33(30,31)26-21(28)20-23-22(32-25-20)17(14-19(27)24-29)9-5-8-16-6-3-2-4-7-16/h10-13,16-17,29H,2-9,14H2,1H3,(H,24,27)(H,26,28)/t17-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216808
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(2-pyrazinyl)-1,2...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cnccn1
Show InChI InChI=1S/C18H25N5O3/c24-16(22-25)11-14(8-4-7-13-5-2-1-3-6-13)18-21-17(23-26-18)15-12-19-9-10-20-15/h9-10,12-14,25H,1-8,11H2,(H,22,24)/t14-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111854
PNG
(CHEMBL21237 | {(R)-2-Amino-4-[benzo[1,3]dioxol-5-y...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@@H](C(=O)NO)C(=O)C(N)CNC(=O)OCc1ccccc1
Show InChI InChI=1S/C28H30N4O10S/c1-39-20-8-10-21(11-9-20)43(37,38)32(15-19-7-12-23-24(13-19)42-17-41-23)25(27(34)31-36)26(33)22(29)14-30-28(35)40-16-18-5-3-2-4-6-18/h2-13,22,25,36H,14-17,29H2,1H3,(H,30,35)(H,31,34)/t22?,25-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216809
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(5-pyrimidinyl)-1...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cncnc1
Show InChI InChI=1S/C18H25N5O3/c24-16(22-25)9-14(8-4-7-13-5-2-1-3-6-13)18-21-17(23-26-18)15-10-19-12-20-11-15/h10-14,25H,1-9H2,(H,22,24)/t14-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216805
PNG
((3R)-6-cyclohexyl-3-[3-(1,1-dioxido-2-isothiazolid...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CN2CCCS2(=O)=O)no1
Show InChI InChI=1S/C18H30N4O5S/c23-17(20-24)12-15(9-4-8-14-6-2-1-3-7-14)18-19-16(21-27-18)13-22-10-5-11-28(22,25)26/h14-15,24H,1-13H2,(H,20,23)/t15-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111861
PNG
(CHEMBL281582 | {(R)-5-[Benzo[1,3]dioxol-5-ylmethyl...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCCNC(=O)OCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H33N3O9S/c1-38-23-11-13-24(14-12-23)42(36,37)32(18-22-10-15-26-27(17-22)41-20-40-26)25(28(33)31-35)9-5-6-16-30-29(34)39-19-21-7-3-2-4-8-21/h2-4,7-8,10-15,17,25,35H,5-6,9,16,18-20H2,1H3,(H,30,34)(H,31,33)/t25-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50256367
PNG
((R)-2-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-...)
Show SMILES Cc1oc(nc1C(N)=O)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C17H27N3O4/c1-11-15(16(18)22)19-17(24-11)13(10-14(21)20-23)9-5-8-12-6-3-2-4-7-12/h12-13,23H,2-10H2,1H3,(H2,18,22)(H,20,21)/t13-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase assessed as [3H]procollagen turnover by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50256368
PNG
((R)-2-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-...)
Show SMILES CN(C)C(=O)c1nc(oc1C)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C19H31N3O4/c1-13-17(19(24)22(2)3)20-18(26-13)15(12-16(23)21-25)11-7-10-14-8-5-4-6-9-14/h14-15,25H,4-12H2,1-3H3,(H,21,23)/t15-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase assessed as [3H]procollagen turnover by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216834
PNG
(2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...)
Show SMILES NC(=O)c1ccnc(c1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C20H27N5O4/c21-18(27)14-9-10-22-16(11-14)19-23-20(29-25-19)15(12-17(26)24-28)8-4-7-13-5-2-1-3-6-13/h9-11,13,15,28H,1-8,12H2,(H2,21,27)(H,24,26)/t15-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216811
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-[3-({[(4-methoxyphen...)
Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C22H30N4O7S/c1-32-17-10-12-18(13-11-17)34(30,31)26-21(28)20-23-22(33-25-20)16(14-19(27)24-29)9-5-8-15-6-3-2-4-7-15/h10-13,15-16,29H,2-9,14H2,1H3,(H,24,27)(H,26,28)/t16-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216851
PNG
(5-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cncc(c1)C(O)=O
Show InChI InChI=1S/C20H26N4O5/c25-17(23-28)10-14(8-4-7-13-5-2-1-3-6-13)19-22-18(24-29-19)15-9-16(20(26)27)12-21-11-15/h9,11-14,28H,1-8,10H2,(H,23,25)(H,26,27)/t14-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216847
PNG
(2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...)
Show SMILES CN(C)C(=O)c1ccnc(c1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C22H31N5O4/c1-27(2)22(29)17-11-12-23-18(13-17)20-24-21(31-26-20)16(14-19(28)25-30)10-6-9-15-7-4-3-5-8-15/h11-13,15-16,30H,3-10,14H2,1-2H3,(H,25,28)/t16-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50111858
PNG
(CHEMBL276883 | {(R)-2-Amino-4-[benzo[1,3]dioxol-5-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@@H](C(=O)NO)C(=O)C(N)CNC(=O)OCc1ccccc1Br
Show InChI InChI=1S/C28H29BrN4O10S/c1-40-19-7-9-20(10-8-19)44(38,39)33(14-17-6-11-23-24(12-17)43-16-42-23)25(27(35)32-37)26(34)22(30)13-31-28(36)41-15-18-4-2-3-5-21(18)29/h2-12,22,25,37H,13-16,30H2,1H3,(H,31,36)(H,32,35)/t22?,25-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Roche Bioscience

Curated by ChEMBL


Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP)


Bioorg Med Chem Lett 12: 1233-5 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216828
PNG
((3R)-3-[3-(6-amino-3-pyridinyl)-1,2,4-oxadiazol-5-...)
Show SMILES Nc1ccc(cn1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C19H27N5O3/c20-16-10-9-15(12-21-16)18-22-19(27-24-18)14(11-17(25)23-26)8-4-7-13-5-2-1-3-6-13/h9-10,12-14,26H,1-8,11H2,(H2,20,21)(H,23,25)/t14-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216791
PNG
((3R)-3-{3-[(acetylamino)methyl]-1,2,4-oxadiazol-5-...)
Show SMILES CC(=O)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C17H28N4O4/c1-12(22)18-11-15-19-17(25-21-15)14(10-16(23)20-24)9-5-8-13-6-3-2-4-7-13/h13-14,24H,2-11H2,1H3,(H,18,22)(H,20,23)/t14-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50216827
PNG
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{2-[(methylsulfon...)
Show SMILES CS(=O)(=O)NCCNCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C18H33N5O5S/c1-29(26,27)20-11-10-19-13-16-21-18(28-23-16)15(12-17(24)22-25)9-5-8-14-6-3-2-4-7-14/h14-15,19-20,25H,2-13H2,1H3,(H,22,24)/t15-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 1


(Homo sapiens)
BDBM50256303
PNG
((R)-2-(5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan...)
Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)C(=O)NCC(O)=O
Show InChI InChI=1S/C17H26N4O6/c22-13(20-26)9-12(8-4-7-11-5-2-1-3-6-11)17-19-15(21-27-17)16(25)18-10-14(23)24/h11-12,26H,1-10H2,(H,18,25)(H,20,22)(H,23,24)/t12-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human procollagen C-proteinase assessed as [3H]procollagen turnover by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
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