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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'C-terminal-binding protein 2 (CtBP2)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-terminal-binding protein 2 (CtBP2)


(Homo sapiens (Human))
BDBM154570
PNG
(2-Hydroxyimino-3-phenylpropanoic acid (HIPP))
Show SMILES ON=C(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C9H9NO3/c11-9(12)8(10-13)6-7-4-2-1-3-5-7/h1-5,13H,6H2,(H,11,12)/b10-8-
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
AffyNet 
PDB
Article
PubMed
n/an/a 745n/an/an/an/an/an/a



University of Massachusetts Medical School



Assay Description
Purified CtBP2 in 50% glycerol was added to 150 μM NADH and variable amounts of MTOB and HIPP in buffer containing 25 mM HEPES, pH 7.1, 25 mM p...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
C-terminal-binding protein 2 (CtBP2)


(Homo sapiens (Human))
BDBM154572
PNG
(Phenylpyruvate (PPy))
Show SMILES CC(=O)C(=O)Oc1ccccc1
Show InChI InChI=1S/C9H8O3/c1-7(10)9(11)12-8-5-3-2-4-6-8/h2-6H,1H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.35E+5n/an/an/an/an/an/a



University of Massachusetts Medical School



Assay Description
Purified CtBP2 in 50% glycerol was added to 150 μM NADH and variable amounts of MTOB and HIPP in buffer containing 25 mM HEPES, pH 7.1, 25 mM p...


Citation and Details
More data for this
Ligand-Target Pair
C-terminal-binding protein 2 (CtBP2)


(Homo sapiens (Human))
BDBM154570
PNG
(2-Hydroxyimino-3-phenylpropanoic acid (HIPP))
Show SMILES ON=C(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C9H9NO3/c11-9(12)8(10-13)6-7-4-2-1-3-5-7/h1-5,13H,6H2,(H,11,12)/b10-8-
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
AffyNet 
PDB
Article
PubMed
n/an/an/a 1.30E+3n/an/an/a8.5n/a



University of Massachusetts Medical School



Assay Description
Purified CtBP2 was dialyzed overnight against 500 mL of 50 mM glycylglycine at pH 8.5, 300 mM NaCl, 1 mM EDTA, and 2 mM TCEP, with or without 1.5 mM ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
C-terminal-binding protein 2 (CtBP2)


(Homo sapiens (Human))
BDBM154571
PNG
(4-Methylthio 2-oxobutyric acid (MTOB))
Show SMILES CSCCC(=O)C(O)=O
Show InChI InChI=1S/C5H8O3S/c1-9-3-2-4(6)5(7)8/h2-3H2,1H3,(H,7,8)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
AffyNet 
PDB
Article
PubMed
n/an/an/a 2.96E+6n/an/an/a8.5n/a



University of Massachusetts Medical School



Assay Description
Purified CtBP2 was dialyzed overnight against 500 mL of 50 mM glycylglycine at pH 8.5, 300 mM NaCl, 1 mM EDTA, and 2 mM TCEP, with or without 1.5 mM ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)