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Compile Data Set for Download or QSAR

Found 60 hits Enz. Inhib. hit(s) with Target = 'CAM-RNase A'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CAM-RNase A


(Bison bison (American bison))
BDBM22984
PNG
((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Show SMILES COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
Show InChI InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Kumamoto University

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentration


J Nat Prod 64: 204-7 (2001)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50242374
PNG
(CHEMBL505529 | topostatin)
Show SMILES CCCCCCCC(C)CC=C(C)C=CC(=O)C(C)CCC1OC(=O)[C@H](CC(OS(O)(=O)=O)C(N)=O)NC(=O)[C@@H](C)CNC(=O)C(=C)NC(=O)C1C
Show InChI InChI=1S/C36H58N4O11S/c1-8-9-10-11-12-13-22(2)14-15-23(3)16-18-29(41)24(4)17-19-30-26(6)34(44)39-27(7)35(45)38-21-25(5)33(43)40-28(36(46)50-30)20-31(32(37)42)51-52(47,48)49/h15-16,18,22,24-26,28,30-31H,7-14,17,19-21H2,1-6H3,(H2,37,42)(H,38,45)(H,39,44)(H,40,43)(H,47,48,49)/t22?,24?,25-,26?,28-,30?,31?/m0/s1
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n/an/a>2.50E+5n/an/an/an/an/an/a



Kumamoto University

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentration


J Nat Prod 64: 204-7 (2001)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50008923
PNG
((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
Show InChI InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Kumamoto University

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentration


J Nat Prod 64: 204-7 (2001)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50164888
PNG
(6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...)
Show SMILES Oc1ccc(\C=C2\C(=O)Oc3cc(O)ccc23)cc1
Show InChI InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)7-13-12-6-5-11(17)8-14(12)19-15(13)18/h1-8,16-17H/b13-7+
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n/an/a>4.00E+5n/an/an/an/an/an/a



Kumamoto University

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentration


J Nat Prod 64: 204-7 (2001)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50342010
PNG
(5'-phospho-2'-deoxyuridine-3'-pyrophosphate(P'->5'...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](OP(O)(=O)OC[C@H]2O[C@H](C[C@@H]2OP(O)(=O)OP(O)(O)=O)n2ccc(=O)[nH]c2=O)[C@H]1O
Show InChI InChI=1S/C19H26N7O17P3/c20-16-13-17(22-6-21-16)26(7-23-13)18-14(29)15(9(4-27)40-18)42-45(34,35)38-5-10-8(41-46(36,37)43-44(31,32)33)3-12(39-10)25-2-1-11(28)24-19(25)30/h1-2,6-10,12,14-15,18,27,29H,3-5H2,(H,34,35)(H,36,37)(H2,20,21,22)(H,24,28,30)(H2,31,32,33)/t8-,9+,10+,12+,14+,15+,18+/m0/s1
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27n/an/an/an/an/an/an/an/a



Indian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A at pH 5.9 by spectrophotometric method


Bioorg Med Chem 19: 2478-84 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50292721
PNG
(CHEMBL504858 | [({[(2R,3S,4R,5R)-5-(6-amino-9H-pur...)
Show SMILES Cc1cn([C@H]2C[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3OP(O)(O)=O)n3cnc4c(N)ncnc34)[C@@H](COP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C20H29N7O20P4/c1-8-3-26(20(30)25-18(8)29)12-2-9(10(43-12)4-41-48(31,32)33)45-51(39,40)47-50(37,38)42-5-11-15(46-49(34,35)36)14(28)19(44-11)27-7-24-13-16(21)22-6-23-17(13)27/h3,6-7,9-12,14-15,19,28H,2,4-5H2,1H3,(H,37,38)(H,39,40)(H2,21,22,23)(H,25,29,30)(H2,31,32,33)(H2,34,35,36)/t9-,10+,11+,12+,14+,15+,19+/m0/s1
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41n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50402337
PNG
(CHEMBL2206660)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Cn2ccc(=O)[nH]c2=O)nn1
Show InChI InChI=1S/C12H15N5O6/c18-5-7-9(20)10(21)11(23-7)17-4-6(14-15-17)3-16-2-1-8(19)13-12(16)22/h1-2,4,7,9-11,18,20-21H,3,5H2,(H,13,19,22)/t7-,9-,10-,11-/m1/s1
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240n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A


Bioorg Med Chem 20: 7184-93 (2012)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50292724
PNG
(CHEMBL460901 | URACIL ARABINOSE-3'-PHOSPHATE | ara...)
Show SMILES OC[C@H]1O[C@H]([C@@H](O)[C@@H]1OP(O)(O)=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6+,7-,8-/m1/s1
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6.00E+3n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM50298711
PNG
((2R,3R,4R,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-...)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(20-21(16,17)18)6(14)4(3-13)19-8/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric assay


Bioorg Med Chem 17: 4921-7 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM50292723
PNG
((2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(...)
Show SMILES OC[C@H]1O[C@H]([C@H](OP(O)(O)=O)[C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-6(14)7(20-21(16,17)18)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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7.10E+3n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM50292723
PNG
((2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(...)
Show SMILES OC[C@H]1O[C@H]([C@H](OP(O)(O)=O)[C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-6(14)7(20-21(16,17)18)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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1.16E+4n/an/an/an/an/an/an/an/a



National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6


Eur J Med Chem 44: 4496-508 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM50233301
PNG
(CHEMBL258728 | cytidine-3'-monophosphate)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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2.01E+4n/an/an/an/an/an/an/an/a



National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6


Eur J Med Chem 44: 4496-508 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM50438455
PNG
(CHEMBL2414522)
Show SMILES Cc1cn([C@H]2C[C@@H]([C@@H](CS(=O)(=O)CC(O)=O)O2)S(=O)(=O)CC(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H18N2O11S2/c1-7-3-16(14(22)15-13(7)21)10-2-9(29(25,26)6-12(19)20)8(27-10)4-28(23,24)5-11(17)18/h3,8-10H,2,4-6H2,1H3,(H,17,18)(H,19,20)(H,15,21,22)/t8-,9+,10-/m1/s1
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2.50E+4n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50331790
PNG
(3-Amino-N-[2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3...)
Show SMILES Cc1cn([C@H]2C[C@H](NC(=O)C(N)CC(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H20N4O7/c1-6-4-18(14(24)17-12(6)22)10-3-8(9(5-19)25-10)16-13(23)7(15)2-11(20)21/h4,7-10,19H,2-3,5,15H2,1H3,(H,16,23)(H,20,21)(H,17,22,24)/t7?,8-,9+,10+/m0/s1
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3.70E+4n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine pancreatic RNase A ribonucleolytic activity of by Dixon plot analysis


Bioorg Med Chem 18: 8257-63 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50438453
PNG
(CHEMBL2414524)
Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CS(=O)(=O)CC(O)=O)O2)S(=O)(=O)CC(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H18N2O11S2/c1-7-3-16(14(22)15-13(7)21)10-2-9(29(25,26)6-12(19)20)8(27-10)4-28(23,24)5-11(17)18/h3,8-10H,2,4-6H2,1H3,(H,17,18)(H,19,20)(H,15,21,22)/t8-,9-,10-/m1/s1
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3.90E+4n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM173610
PNG
(9-[3'-[4-[(Uracil-1-yl)methyl]-1,2,3-triazol-1...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1n1cc(Cn2ccc(=O)[nH]c2=O)nn1)n1cnc2c(NC(=O)c3ccccc3)ncnc12
Show InChI InChI=1/C24H22N10O6/c35-10-15-18(34-9-14(30-31-34)8-32-7-6-16(36)28-24(32)39)19(37)23(40-15)33-12-27-17-20(25-11-26-21(17)33)29-22(38)13-4-2-1-3-5-13/h1-7,9,11-12,15,18-19,23,35,37H,8,10H2,(H,28,36,39)(H,25,26,29,38)/t15-,18+,19?,23-/s2
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5.55E+4n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...


Bioorg Chem 63: 152-65 (2015)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50342006
PNG
(5'-Deoxy-5'-N-(4-carboxypiperidinyl)uridine | CHEM...)
Show SMILES O[C@@H]1[C@@H](CN2CCC(CC2)C(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H21N3O7/c19-10-3-6-18(15(24)16-10)13-12(21)11(20)9(25-13)7-17-4-1-8(2-5-17)14(22)23/h3,6,8-9,11-13,20-21H,1-2,4-5,7H2,(H,22,23)(H,16,19,24)/t9-,11-,12-,13-/m1/s1
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6.10E+4n/an/an/an/an/an/an/an/a



Indian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Dixon plot analysis


Bioorg Med Chem 19: 2478-84 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50331791
PNG
((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(O)=O
Show InChI InChI=1S/C10H11N5O5/c11-7-3-8(13-1-12-7)15(2-14-3)9-5(17)4(16)6(20-9)10(18)19/h1-2,4-6,9,16-17H,(H,18,19)(H2,11,12,13)/t4-,5+,6-,9+/m0/s1
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6.70E+4n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine pancreatic RNase A ribonucleolytic activity of by Dixon plot analysis


Bioorg Med Chem 18: 8257-63 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM173614
PNG
(9-[3'-[4-[(Thymine-1-yl)methyl]-1,2,3-triazol-...)
Show SMILES Cc1cn(Cc2cn(nn2)[C@H]2[C@@H](CO)O[C@H](C2O)N2C=NC3C2N=CN=C3N)c(=O)[nH]c1=O
Show InChI InChI=1/C18H22N10O5/c1-8-2-26(18(32)23-16(8)31)3-9-4-28(25-24-9)12-10(5-29)33-17(13(12)30)27-7-22-11-14(19)20-6-21-15(11)27/h2,4,6-7,10-13,15,17,29-30H,3,5H2,1H3,(H2,19,20,21)(H,23,31,32)/t10-,11?,12+,13?,15?,17-/s2
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6.88E+4n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...


Bioorg Chem 63: 152-65 (2015)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50342006
PNG
(5'-Deoxy-5'-N-(4-carboxypiperidinyl)uridine | CHEM...)
Show SMILES O[C@@H]1[C@@H](CN2CCC(CC2)C(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H21N3O7/c19-10-3-6-18(15(24)16-10)13-12(21)11(20)9(25-13)7-17-4-1-8(2-5-17)14(22)23/h3,6,8-9,11-13,20-21H,1-2,4-5,7H2,(H,22,23)(H,16,19,24)/t9-,11-,12-,13-/m1/s1
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7.50E+4n/an/an/an/an/an/an/an/a



Indian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Lineweaver-Burk analysis


Bioorg Med Chem 19: 2478-84 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50292715
PNG
(5'-deoxy-5'-N-(ethyl isonipecotatyl)uridine | CHEM...)
Show SMILES CCOC(=O)C1CCN(C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)CC1
Show InChI InChI=1S/C17H25N3O7/c1-2-26-16(24)10-3-6-19(7-4-10)9-11-13(22)14(23)15(27-11)20-8-5-12(21)18-17(20)25/h5,8,10-11,13-15,22-23H,2-4,6-7,9H2,1H3,(H,18,21,25)/t11-,13-,14-,15-/m1/s1
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7.70E+4n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50292722
PNG
(3'-UMP | 3'-uridylic acid | CHEMBL460741)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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7.85E+4n/an/an/an/an/an/an/an/a



National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6


Eur J Med Chem 44: 4496-508 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM50298713
PNG
(2',3'-Dideoxy-3'-L-serinylamino thymidine | CHEMBL...)
Show SMILES Cc1cn(C[C@H]2C[C@H](NC(=O)C(N)CO)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H22N4O6/c1-7-3-18(14(23)17-12(7)21)4-8-2-10(11(6-20)24-8)16-13(22)9(15)5-19/h3,8-11,19-20H,2,4-6,15H2,1H3,(H,16,22)(H,17,21,23)/t8-,9?,10+,11-/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric assay


Bioorg Med Chem 17: 4921-7 (2009)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50292722
PNG
(3'-UMP | 3'-uridylic acid | CHEMBL460741)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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8.20E+4n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM50438456
PNG
(CHEMBL2414521)
Show SMILES Cc1cn([C@H]2C[C@@H]([C@@H](CO)O2)S(=O)(=O)CC(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H16N2O8S/c1-6-3-14(12(19)13-11(6)18)9-2-8(7(4-15)22-9)23(20,21)5-10(16)17/h3,7-9,15H,2,4-5H2,1H3,(H,16,17)(H,13,18,19)/t7-,8+,9-/m1/s1
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8.80E+4n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50438454
PNG
(CHEMBL2414523)
Show SMILES Cc1cn([C@H]2C[C@H](SCC(O)=O)[C@@H](CSCC(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H18N2O7S2/c1-7-3-16(14(22)15-13(7)21)10-2-9(25-6-12(19)20)8(23-10)4-24-5-11(17)18/h3,8-10H,2,4-6H2,1H3,(H,17,18)(H,19,20)(H,15,21,22)/t8-,9+,10-/m1/s1
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9.30E+4n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50438451
PNG
(CHEMBL2414510)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CS(=O)(=O)CC(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H16N2O8S/c1-6-3-14(12(19)13-11(6)18)9-2-7(15)8(22-9)4-23(20,21)5-10(16)17/h3,7-9,15H,2,4-5H2,1H3,(H,16,17)(H,13,18,19)/t7-,8+,9+/m0/s1
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9.50E+4n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM173612
PNG
(9-[3'-[4-[(Cytosine-1-yl)methyl]-1,2,3-triazol...)
Show SMILES NC1=NC=NC2C1N=CN2[C@@H]1O[C@H](CO)[C@@H](C1O)n1cc(Cn2ccc(N)nc2=O)nn1
Show InChI InChI=1/C17H21N11O4/c18-10-1-2-26(17(31)23-10)3-8-4-28(25-24-8)12-9(5-29)32-16(13(12)30)27-7-22-11-14(19)20-6-21-15(11)27/h1-2,4,6-7,9,11-13,15-16,29-30H,3,5H2,(H2,18,23,31)(H2,19,20,21)/t9-,11?,12+,13?,15?,16-/s2
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9.85E+4n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...


Bioorg Chem 63: 152-65 (2015)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50292714
PNG
(3'-N-piperidine-4-carboxyl-3'-deoxyara-uridine | C...)
Show SMILES OC[C@]1(O[C@H]([C@@H](O)[C@@H]1N1CCCCC1)n1ccc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C15H21N3O7/c19-8-15(13(22)23)11(17-5-2-1-3-6-17)10(21)12(25-15)18-7-4-9(20)16-14(18)24/h4,7,10-12,19,21H,1-3,5-6,8H2,(H,22,23)(H,16,20,24)/t10-,11-,12+,15+/m0/s1
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1.03E+5n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50233301
PNG
(CHEMBL258728 | cytidine-3'-monophosphate)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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1.03E+5n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric assay


Bioorg Med Chem 17: 4921-7 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM50233301
PNG
(CHEMBL258728 | cytidine-3'-monophosphate)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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1.03E+5n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CAM-RNase A


(Bison bison (American bison))
BDBM173613
PNG
(9-[3'-[4-[(Uracil-1-yl)methyl]-1,2,3-triazol-1...)
Show SMILES NC1=NC=NC2C1N=CN2[C@@H]1O[C@H](CO)[C@@H](C1O)n1cc(Cn2ccc(=O)[nH]c2=O)nn1
Show InChI InChI=1/C17H20N10O5/c18-14-11-15(20-6-19-14)26(7-21-11)16-13(30)12(9(5-28)32-16)27-4-8(23-24-27)3-25-2-1-10(29)22-17(25)31/h1-2,4,6-7,9,11-13,15-16,28,30H,3,5H2,(H2,18,19,20)(H,22,29,31)/t9-,11?,12+,13?,15?,16-/s2
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1.06E+5n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...


Bioorg Chem 63: 152-65 (2015)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50438452
PNG
(CHEMBL2414509)
Show SMILES Cc1cn([C@H]2C[C@@H](SCC(O)=O)[C@@H](CSCC(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H18N2O7S2/c1-7-3-16(14(22)15-13(7)21)10-2-9(25-6-12(19)20)8(23-10)4-24-5-11(17)18/h3,8-10H,2,4-6H2,1H3,(H,17,18)(H,19,20)(H,15,21,22)/t8-,9-,10-/m1/s1
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1.08E+5n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50342007
PNG
(5'-Deoxy-5'-N-(4-carboxypiperidinyl)thymidine | CH...)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CN3CCC(CC3)C(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H23N3O6/c1-9-7-19(16(24)17-14(9)21)13-6-11(20)12(25-13)8-18-4-2-10(3-5-18)15(22)23/h7,10-13,20H,2-6,8H2,1H3,(H,22,23)(H,17,21,24)/t11-,12+,13+/m0/s1
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1.21E+5n/an/an/an/an/an/an/an/a



Indian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Dixon plot analysis


Bioorg Med Chem 19: 2478-84 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50438448
PNG
(CHEMBL2414513)
Show SMILES COC(=O)CS(=O)(=O)[C@H]1C[C@@H](O[C@@H]1CO)n1cc(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C13H18N2O8S/c1-7-4-15(13(19)14-12(7)18)10-3-9(8(5-16)23-10)24(20,21)6-11(17)22-2/h4,8-10,16H,3,5-6H2,1-2H3,(H,14,18,19)/t8-,9+,10-/m1/s1
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1.40E+5n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM173611
PNG
(9-[3'-[4-[(Thymine-1-yl)methyl]-1,2,3-triazol-...)
Show SMILES Cc1cn(Cc2cn(nn2)[C@H]2[C@@H](CO)O[C@H](C2O)n2cnc3c(NC(=O)c4ccccc4)ncnc23)c(=O)[nH]c1=O
Show InChI InChI=1/C25H24N10O6/c1-13-7-33(25(40)30-22(13)38)8-15-9-35(32-31-15)18-16(10-36)41-24(19(18)37)34-12-28-17-20(26-11-27-21(17)34)29-23(39)14-5-3-2-4-6-14/h2-7,9,11-12,16,18-19,24,36-37H,8,10H2,1H3,(H,30,38,40)(H,26,27,29,39)/t16-,18+,19?,24-/s2
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1.50E+5n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...


Bioorg Chem 63: 152-65 (2015)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM173608
PNG
(1-[3'-[4-[(Adenine-9-yl)methyl]-1,2,3-triazol-...)
Show SMILES Nc1ncnc2n(Cc3cn(nn3)[C@H]3[C@@H](CO)O[C@H](C3O)n3ccc(=O)[nH]c3=O)cnc12
Show InChI InChI=1/C17H18N10O5/c18-14-11-15(20-6-19-14)25(7-21-11)3-8-4-27(24-23-8)12-9(5-28)32-16(13(12)30)26-2-1-10(29)22-17(26)31/h1-2,4,6-7,9,12-13,16,28,30H,3,5H2,(H2,18,19,20)(H,22,29,31)/t9-,12+,13?,16-/s2
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1.59E+5n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...


Bioorg Chem 63: 152-65 (2015)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50342007
PNG
(5'-Deoxy-5'-N-(4-carboxypiperidinyl)thymidine | CH...)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CN3CCC(CC3)C(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H23N3O6/c1-9-7-19(16(24)17-14(9)21)13-6-11(20)12(25-13)8-18-4-2-10(3-5-18)15(22)23/h7,10-13,20H,2-6,8H2,1H3,(H,22,23)(H,17,21,24)/t11-,12+,13+/m0/s1
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1.62E+5n/an/an/an/an/an/an/an/a



Indian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Lineweaver-Burk analysis


Bioorg Med Chem 19: 2478-84 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50438457
PNG
(CHEMBL2414520)
Show SMILES Cc1cn([C@H]2C[C@H](SCC(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H16N2O6S/c1-6-3-14(12(19)13-11(6)18)9-2-8(7(4-15)20-9)21-5-10(16)17/h3,7-9,15H,2,4-5H2,1H3,(H,16,17)(H,13,18,19)/t7-,8+,9-/m1/s1
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1.69E+5n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50292719
PNG
(5'-deoxy-5'-N-piperidinouridine | CHEMBL444258)
Show SMILES O[C@@H]1[C@@H](CN2CCCCC2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C14H21N3O5/c18-10-4-7-17(14(21)15-10)13-12(20)11(19)9(22-13)8-16-5-2-1-3-6-16/h4,7,9,11-13,19-20H,1-3,5-6,8H2,(H,15,18,21)/t9-,11-,12-,13-/m1/s1
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1.72E+5n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50292720
PNG
(5'-deoxy-5'-N-morpholinouridine | CHEMBL460902)
Show SMILES O[C@@H]1[C@@H](CN2CCOCC2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C13H19N3O6/c17-9-1-2-16(13(20)14-9)12-11(19)10(18)8(22-12)7-15-3-5-21-6-4-15/h1-2,8,10-12,18-19H,3-7H2,(H,14,17,20)/t8-,10-,11-,12-/m1/s1
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1.79E+5n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50342008
PNG
(1-[2,5-Dideoxy-5-(4-carboxypiperidinyl)-beta-D-thr...)
Show SMILES Cc1cn([C@H]2C[C@@H](O)[C@@H](CN3CCC(CC3)C(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H23N3O6/c1-9-7-19(16(24)17-14(9)21)13-6-11(20)12(25-13)8-18-4-2-10(3-5-18)15(22)23/h7,10-13,20H,2-6,8H2,1H3,(H,22,23)(H,17,21,24)/t11-,12-,13-/m1/s1
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1.83E+5n/an/an/an/an/an/an/an/a



Indian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Dixon plot analysis


Bioorg Med Chem 19: 2478-84 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50438458
PNG
(CHEMBL2414519)
Show SMILES Cc1cn([C@H]2C[C@H](NCC(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H17N3O6/c1-6-4-15(12(20)14-11(6)19)9-2-7(8(5-16)21-9)13-3-10(17)18/h4,7-9,13,16H,2-3,5H2,1H3,(H,17,18)(H,14,19,20)/t7-,8+,9+/m0/s1
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1.86E+5n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50331792
PNG
(5'-Carboxy thymidine | CHEMBL1288589)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@H](O2)C(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H12N2O6/c1-4-3-12(10(17)11-8(4)14)6-2-5(13)7(18-6)9(15)16/h3,5-7,13H,2H2,1H3,(H,15,16)(H,11,14,17)/t5-,6+,7-/m0/s1
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1.93E+5n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine pancreatic RNase A ribonucleolytic activity of by Dixon plot analysis


Bioorg Med Chem 18: 8257-63 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50438445
PNG
(CHEMBL2414517)
Show SMILES COC(=O)CS(=O)(=O)C[C@H]1O[C@H](C[C@@H]1O)n1cc(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C13H18N2O8S/c1-7-4-15(13(19)14-12(7)18)10-3-8(16)9(23-10)5-24(20,21)6-11(17)22-2/h4,8-10,16H,3,5-6H2,1-2H3,(H,14,18,19)/t8-,9+,10+/m0/s1
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2.02E+5n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50292718
PNG
(5'-deoxy-5'-N-pyrrolidinouridine | CHEMBL513623)
Show SMILES O[C@@H]1[C@@H](CN2CCCC2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C13H19N3O5/c17-9-3-6-16(13(20)14-9)12-11(19)10(18)8(21-12)7-15-4-1-2-5-15/h3,6,8,10-12,18-19H,1-2,4-5,7H2,(H,14,17,20)/t8-,10-,11-,12-/m1/s1
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2.03E+5n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A by spectrophotometric method


J Med Chem 52: 932-42 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50342008
PNG
(1-[2,5-Dideoxy-5-(4-carboxypiperidinyl)-beta-D-thr...)
Show SMILES Cc1cn([C@H]2C[C@@H](O)[C@@H](CN3CCC(CC3)C(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H23N3O6/c1-9-7-19(16(24)17-14(9)21)13-6-11(20)12(25-13)8-18-4-2-10(3-5-18)15(22)23/h7,10-13,20H,2-6,8H2,1H3,(H,22,23)(H,17,21,24)/t11-,12-,13-/m1/s1
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2.29E+5n/an/an/an/an/an/an/an/a



Indian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Lineweaver-Burk analysis


Bioorg Med Chem 19: 2478-84 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
CAM-RNase A


(Bison bison (American bison))
BDBM50438446
PNG
(CHEMBL2414515)
Show SMILES COC(=O)CS(=O)(=O)C[C@H]1O[C@H](C[C@H]1S(=O)(=O)CC(=O)OC)n1cc(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H22N2O11S2/c1-9-5-18(16(22)17-15(9)21)12-4-11(31(25,26)8-14(20)28-3)10(29-12)6-30(23,24)7-13(19)27-2/h5,10-12H,4,6-8H2,1-3H3,(H,17,21,22)/t10-,11-,12-/m1/s1
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2.42E+5n/an/an/an/an/an/an/an/a



Institute of Technology Kharagpur

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem 21: 4634-45 (2013)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM50342009
PNG
(5'-N-(4-Carboxypiperidinyl)-2',3'-didehydro-3',5'-...)
Show SMILES Cc1cn([C@@H]2O[C@H](CN3CCC(CC3)C(O)=O)C=C2)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H21N3O5/c1-10-8-19(16(23)17-14(10)20)13-3-2-12(24-13)9-18-6-4-11(5-7-18)15(21)22/h2-3,8,11-13H,4-7,9H2,1H3,(H,21,22)(H,17,20,23)/t12-,13+/m0/s1
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2.50E+5n/an/an/an/an/an/an/an/a



Indian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Lineweaver-Burk analysis


Bioorg Med Chem 19: 2478-84 (2011)

More data for this
Ligand-Target Pair
CAM-RNase A


(Bison bison (American bison))
BDBM173609
PNG
(1-[3'-[4-[(Adenine-9-yl)methyl]-1,2,3-triazol-...)
Show SMILES Nc1ncnc2n(Cc3cn(nn3)[C@H]3[C@@H](CO)O[C@H](C3O)n3cc(F)c(=O)[nH]c3=O)cnc12
Show InChI InChI=1/C17H17FN10O5/c18-8-3-27(17(32)23-15(8)31)16-12(30)11(9(4-29)33-16)28-2-7(24-25-28)1-26-6-22-10-13(19)20-5-21-14(10)26/h2-3,5-6,9,11-12,16,29-30H,1,4H2,(H2,19,20,21)(H,23,31,32)/t9-,11+,12?,16-/s2
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2.65E+5n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...


Bioorg Chem 63: 152-65 (2015)

More data for this
Ligand-Target Pair
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