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Compile Data Set for Download or QSAR

Found 2446 hits Enz. Inhib. hit(s) with Target = 'CCKBR'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50454480
PNG
(CHEMBL2093059)
Show SMILES CN(c1nn[nH]n1)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1
Show InChI InChI=1S/C25H29N9O2/c1-33(24-29-31-32-30-24)18-12-8-11-17(15-18)26-25(36)28-22-23(35)34(2)20-14-7-6-13-19(20)21(27-22)16-9-4-3-5-10-16/h6-8,11-16,22H,3-5,9-10H2,1-2H3,(H2,26,28,36)(H,29,30,31,32)/t22-/m0/s1
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n/an/a 0.0540n/an/an/an/an/an/a



Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes


J Med Chem 39: 842-9 (1996)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50286892
PNG
(1-[(R)-1-(2-Cyclopentyl-2-oxo-ethyl)-2-oxo-5-pheny...)
Show SMILES Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1
Show InChI InChI=1S/C30H30N4O3/c1-20-10-9-15-23(18-20)31-30(37)33-28-29(36)34(19-26(35)21-11-5-6-12-21)25-17-8-7-16-24(25)27(32-28)22-13-3-2-4-14-22/h2-4,7-10,13-18,21,28H,5-6,11-12,19H2,1H3,(H2,31,33,37)/t28-/m0/s1
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n/an/a 0.0700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to displace [125I]-CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain


Bioorg Med Chem Lett 6: 51-54 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50454481
PNG
(CHEMBL2110201)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(C)c(Nc3nn[nH]n3)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C25H29N9O2/c1-15-12-13-17(14-19(15)27-24-30-32-33-31-24)26-25(36)29-22-23(35)34(2)20-11-7-6-10-18(20)21(28-22)16-8-4-3-5-9-16/h6-7,10-14,16,22H,3-5,8-9H2,1-2H3,(H2,26,29,36)(H2,27,30,31,32,33)/t22-/m0/s1
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n/an/a 0.0740n/an/an/an/an/an/a



Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes


J Med Chem 39: 842-9 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50070467
PNG
(1-[1-[2-(3-Aza-bicyclo[3.2.2]non-3-yl)-2-oxo-ethyl...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)Nc2cccc(c2)-c2nnn[nH]2)C(=O)N(CC(=O)N2CC3CCC(CC3)C2)c2ccccc12
Show InChI InChI=1S/C33H32FN9O3/c34-26-10-3-1-8-24(26)29-25-9-2-4-11-27(25)43(19-28(44)42-17-20-12-13-21(18-42)15-14-20)32(45)31(36-29)37-33(46)35-23-7-5-6-22(16-23)30-38-40-41-39-30/h1-11,16,20-21,31H,12-15,17-19H2,(H2,35,37,46)(H,38,39,40,41)
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n/an/a 0.0870n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes


Bioorg Med Chem Lett 8: 1449-54 (1999)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50290398
PNG
(1-[1-[2-(3-Aza-bicyclo[3.2.2]non-3-yl)-2-oxo-ethyl...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1
Show InChI InChI=1S/C33H34FN5O3/c1-21-7-6-8-24(17-21)35-33(42)37-31-32(41)39(20-29(40)38-18-22-13-14-23(19-38)16-15-22)28-12-5-3-10-26(28)30(36-31)25-9-2-4-11-27(25)34/h2-12,17,22-23,31H,13-16,18-20H2,1H3,(H2,35,37,42)
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n/an/a 0.0870n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes


Bioorg Med Chem Lett 7: 169-174 (1997)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50059319
PNG
(1-[(R)-5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-2...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)N1CC2CCC(CC2)C1
Show InChI InChI=1S/C26H31N5O2/c1-17-6-5-7-20(14-17)27-26(33)29-23-25(32)30(2)22-9-4-3-8-21(22)24(28-23)31-15-18-10-11-19(16-31)13-12-18/h3-9,14,18-19,23H,10-13,15-16H2,1-2H3,(H2,27,29,33)/t18?,19?,23-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex


Bioorg Med Chem Lett 5: 3023-3026 (1995)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50286884
PNG
(1-{1-[2-(1-Methyl-cyclopentyl)-2-oxo-ethyl]-2-oxo-...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1
Show InChI InChI=1S/C31H32N4O3/c1-21-11-10-14-23(19-21)32-30(38)34-28-29(37)35(20-26(36)31(2)17-8-9-18-31)25-16-7-6-15-24(25)27(33-28)22-12-4-3-5-13-22/h3-7,10-16,19,28H,8-9,17-18,20H2,1-2H3,(H2,32,34,38)
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TBA

Curated by ChEMBL


Assay Description
Ability to displace [125I]-CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain


Bioorg Med Chem Lett 6: 51-54 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50285009
PNG
(3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-5-cyc...)
Show SMILES Cc1ccc2[C@H](C[C@@H](NC(=O)Nc3cccc(c3)C(O)=O)C(=O)N(CC(=O)NC(C)(C)C)c2c1)C1CCCCC1
Show InChI InChI=1S/C31H40N4O5/c1-19-13-14-23-24(20-9-6-5-7-10-20)17-25(33-30(40)32-22-12-8-11-21(16-22)29(38)39)28(37)35(26(23)15-19)18-27(36)34-31(2,3)4/h8,11-16,20,24-25H,5-7,9-10,17-18H2,1-4H3,(H,34,36)(H,38,39)(H2,32,33,40)/t24-,25-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex


Bioorg Med Chem Lett 5: 1933-1936 (1995)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056102
PNG
((R)-1-(1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(pyridi...)
Show SMILES CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C28H30N6O3/c1-28(2,3)23(35)17-34-22-14-6-5-12-20(22)24(21-13-7-8-15-30-21)32-25(26(34)36)33-27(37)31-19-11-9-10-18(16-19)29-4/h5-16,25,29H,17H2,1-4H3,(H2,31,33,37)/t25-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50059319
PNG
(1-[(R)-5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-2...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)N1CC2CCC(CC2)C1
Show InChI InChI=1S/C26H31N5O2/c1-17-6-5-7-20(14-17)27-26(33)29-23-25(32)30(2)22-9-4-3-8-21(22)24(28-23)31-15-18-10-11-19(16-31)13-12-18/h3-9,14,18-19,23H,10-13,15-16H2,1-2H3,(H2,27,29,33)/t18?,19?,23-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.


J Med Chem 40: 2491-501 (1997)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50040667
PNG
(1-[(R)-5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-2...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)N1CC2CCC(CC2)C1
Show InChI InChI=1S/C26H31N5O2/c1-17-6-5-7-20(14-17)27-26(33)29-23-25(32)30(2)22-9-4-3-8-21(22)24(28-23)31-15-18-10-11-19(16-31)13-12-18/h3-9,14,18-19,23H,10-13,15-16H2,1-2H3,(H2,27,29,33)/t18?,19?,23-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.


J Med Chem 37: 719-21 (1994)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056101
PNG
(1-[(R)-2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-phenyl-2,...)
Show SMILES Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1
Show InChI InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1
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n/an/a 0.110n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to displace [125I]-CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain


Bioorg Med Chem Lett 6: 51-54 (1996)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056101
PNG
(1-[(R)-2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-phenyl-2,...)
Show SMILES Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1
Show InChI InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]-CCK-8 as the radioligand


Bioorg Med Chem Lett 6: 55-58 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50049783
PNG
(1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc3CCN(c4nnn[nH]4)c3c2)C1=O)c1ccccc1
Show InChI InChI=1S/C26H23N9O2/c1-34-20-10-6-5-9-19(20)22(17-7-3-2-4-8-17)28-23(24(34)36)29-26(37)27-18-12-11-16-13-14-35(21(16)15-18)25-30-32-33-31-25/h2-12,15,23H,13-14H2,1H3,(H2,27,29,37)(H,30,31,32,33)/t23-/m0/s1
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Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes


J Med Chem 39: 842-9 (1996)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056103
PNG
(1-(3-Diethylamino-phenyl)-3-[(R)-1-(3,3-dimethyl-2...)
Show SMILES CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C31H36N6O3/c1-6-36(7-2)22-14-12-13-21(19-22)33-30(40)35-28-29(39)37(20-26(38)31(3,4)5)25-17-9-8-15-23(25)27(34-28)24-16-10-11-18-32-24/h8-19,28H,6-7,20H2,1-5H3,(H2,33,35,40)/t28-/m0/s1
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Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056099
PNG
(1-[(R)-1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-pyridi...)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(c2)N2CCCC2)C1=O)c1ccccn1
Show InChI InChI=1S/C31H34N6O3/c1-31(2,3)26(38)20-37-25-15-5-4-13-23(25)27(24-14-6-7-16-32-24)34-28(29(37)39)35-30(40)33-21-11-10-12-22(19-21)36-17-8-9-18-36/h4-7,10-16,19,28H,8-9,17-18,20H2,1-3H3,(H2,33,35,40)/t28-/m0/s1
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Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056093
PNG
(1-[(R)-1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-phenyl...)
Show SMILES CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C29H31N5O3/c1-29(2,3)24(35)18-34-23-16-9-8-15-22(23)25(19-11-6-5-7-12-19)32-26(27(34)36)33-28(37)31-21-14-10-13-20(17-21)30-4/h5-17,26,30H,18H2,1-4H3,(H2,31,33,37)/t26-/m0/s1
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Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056101
PNG
(1-[(R)-2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-phenyl-2,...)
Show SMILES Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1
Show InChI InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1
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Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50286903
PNG
(1-[1-(2-Cyclopentyl-2-oxo-ethyl)-2-oxo-5-pyridin-2...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1
Show InChI InChI=1S/C29H29N5O3/c1-19-9-8-12-21(17-19)31-29(37)33-27-28(36)34(18-25(35)20-10-2-3-11-20)24-15-5-4-13-22(24)26(32-27)23-14-6-7-16-30-23/h4-9,12-17,20,27H,2-3,10-11,18H2,1H3,(H2,31,33,37)
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n/an/a 0.120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]-CCK-8 as the radioligand


Bioorg Med Chem Lett 6: 55-58 (1996)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50286897
PNG
(1-[2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-pyridin-2-yl-...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1
Show InChI InChI=1S/C31H27N5O3/c1-20-10-9-12-22(18-20)33-31(39)35-29-30(38)36(19-27(37)23-13-4-3-11-21(23)2)26-16-6-5-14-24(26)28(34-29)25-15-7-8-17-32-25/h3-18,29H,19H2,1-2H3,(H2,33,35,39)
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n/an/a 0.130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]-CCK-8 as the radioligand


Bioorg Med Chem Lett 6: 55-58 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 0.138n/an/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells


J Med Chem 38: 3384-90 (1995)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056092
PNG
(1-(3-Diethylamino-phenyl)-3-[(R)-1-(3,3-dimethyl-2...)
Show SMILES CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C32H37N5O3/c1-6-36(7-2)24-17-13-16-23(20-24)33-31(40)35-29-30(39)37(21-27(38)32(3,4)5)26-19-12-11-18-25(26)28(34-29)22-14-9-8-10-15-22/h8-20,29H,6-7,21H2,1-5H3,(H2,33,35,40)/t29-/m0/s1
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n/an/a 0.140n/an/an/an/an/an/a



Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50040674
PNG
(1-((S)-1-Isobutyl-2-oxo-5-phenyl-2,3-dihydro-1H-be...)
Show SMILES CC(C)CN1c2ccccc2C(=N[C@H](NC(=O)Nc2ccc(cc2)-c2nnn[nH]2)C1=O)c1ccccc1
Show InChI InChI=1S/C27H26N8O2/c1-17(2)16-35-22-11-7-6-10-21(22)23(18-8-4-3-5-9-18)29-25(26(35)36)30-27(37)28-20-14-12-19(13-15-20)24-31-33-34-32-24/h3-15,17,25H,16H2,1-2H3,(H2,28,30,37)(H,31,32,33,34)/t25-/m1/s1
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n/an/a 0.142n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand


J Med Chem 37: 722-4 (1994)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056091
PNG
(1-[1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-phenyl-2,3...)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(c2)[N+]([O-])=O)C1=O)c1ccccc1
Show InChI InChI=1S/C28H27N5O5/c1-28(2,3)23(34)17-32-22-15-8-7-14-21(22)24(18-10-5-4-6-11-18)30-25(26(32)35)31-27(36)29-19-12-9-13-20(16-19)33(37)38/h4-16,25H,17H2,1-3H3,(H2,29,31,36)
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n/an/a 0.160n/an/an/an/an/an/a



Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056089
PNG
(1-[(R)-1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-phenyl...)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(c2)N2CCCC2)C1=O)c1ccccc1
Show InChI InChI=1S/C32H35N5O3/c1-32(2,3)27(38)21-37-26-17-8-7-16-25(26)28(22-12-5-4-6-13-22)34-29(30(37)39)35-31(40)33-23-14-11-15-24(20-23)36-18-9-10-19-36/h4-8,11-17,20,29H,9-10,18-19,21H2,1-3H3,(H2,33,35,40)/t29-/m0/s1
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n/an/a 0.170n/an/an/an/an/an/a



Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50016425
PNG
((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C52H69N9O15S/c1-6-8-18-37(57-48(68)40(61-51(71)75-52(3,4)5)26-32-21-23-34(24-22-32)76-77(72,73)74)46(66)55-30-43(62)56-41(27-33-29-54-36-20-14-13-17-35(33)36)49(69)58-38(19-9-7-2)47(67)60-42(28-44(63)64)50(70)59-39(45(53)65)25-31-15-11-10-12-16-31/h10-17,20-24,29,37-42,54H,6-9,18-19,25-28,30H2,1-5H3,(H2,53,65)(H,55,66)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,61,71)(H,63,64)(H,72,73,74)/t37-,38-,39-,40-,41-,42-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



EP CNRS 51

Curated by ChEMBL


Assay Description
Inhibition of [125I]-BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells


J Med Chem 36: 3021-8 (1993)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50285009
PNG
(3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-5-cyc...)
Show SMILES Cc1ccc2[C@H](C[C@@H](NC(=O)Nc3cccc(c3)C(O)=O)C(=O)N(CC(=O)NC(C)(C)C)c2c1)C1CCCCC1
Show InChI InChI=1S/C31H40N4O5/c1-19-13-14-23-24(20-9-6-5-7-10-20)17-25(33-30(40)32-22-12-8-11-21(16-22)29(38)39)28(37)35(26(23)15-19)18-27(36)34-31(2,3)4/h8,11-16,20,24-25H,5-7,9-10,17-18H2,1-4H3,(H,34,36)(H,38,39)(H2,32,33,40)/t24-,25-/m1/s1
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n/an/a 0.200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex


Bioorg Med Chem Lett 5: 1933-1936 (1995)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056095
PNG
(1-(3-Dimethylamino-phenyl)-3-[(R)-1-(3,3-dimethyl-...)
Show SMILES CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C29H32N6O3/c1-29(2,3)24(36)18-35-23-15-7-6-13-21(23)25(22-14-8-9-16-30-22)32-26(27(35)37)33-28(38)31-19-11-10-12-20(17-19)34(4)5/h6-17,26H,18H2,1-5H3,(H2,31,33,38)/t26-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50049789
PNG
(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(Nc3nnn[nH]3)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C24H27N9O2/c1-33-19-13-6-5-12-18(19)20(15-8-3-2-4-9-15)27-21(22(33)34)28-24(35)26-17-11-7-10-16(14-17)25-23-29-31-32-30-23/h5-7,10-15,21H,2-4,8-9H2,1H3,(H2,26,28,35)(H2,25,29,30,31,32)/t21-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes


J Med Chem 39: 842-9 (1996)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50056098
PNG
(1-(3-Dimethylamino-phenyl)-3-[(R)-1-(3,3-dimethyl-...)
Show SMILES CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C30H33N5O3/c1-30(2,3)25(36)19-35-24-17-10-9-16-23(24)26(20-12-7-6-8-13-20)32-27(28(35)37)33-29(38)31-21-14-11-15-22(18-21)34(4)5/h6-18,27H,19H2,1-5H3,(H2,31,33,38)/t27-/m0/s1
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n/an/a 0.210n/an/an/an/an/an/a



Ferring Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]-CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain


J Med Chem 40: 331-41 (1997)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50043556
PNG
(CHEMBL137516 | N,N-Diethyl-2-{3-[3-(3-methoxy-phen...)
Show SMILES CCN(CC)C(=O)CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(OC)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C29H31N5O4/c1-4-33(5-2)25(35)19-34-24-17-10-9-16-23(24)26(20-12-7-6-8-13-20)31-27(28(34)36)32-29(37)30-21-14-11-15-22(18-21)38-3/h6-18,27H,4-5,19H2,1-3H3,(H2,30,32,37)
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n/an/a 0.220n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor


J Med Chem 36: 4276-92 (1994)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50285019
PNG
(CHEMBL294161 | N-tert-Butyl-2-((3R,5R)-5-cyclohexy...)
Show SMILES Cc1ccc2[C@H](C[C@@H](NC(=O)Nc3cccc(c3)-c3nnn[nH]3)C(=O)N(CC(=O)NC(C)(C)C)c2c1)C1CCCCC1
Show InChI InChI=1S/C31H40N8O3/c1-19-13-14-23-24(20-9-6-5-7-10-20)17-25(29(41)39(26(23)15-19)18-27(40)34-31(2,3)4)33-30(42)32-22-12-8-11-21(16-22)28-35-37-38-36-28/h8,11-16,20,24-25H,5-7,9-10,17-18H2,1-4H3,(H,34,40)(H2,32,33,42)(H,35,36,37,38)/t24-,25-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex


Bioorg Med Chem Lett 5: 1933-1936 (1995)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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n/an/a 0.229n/an/an/an/an/an/a



Glaxo Wellcome Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8


J Med Chem 39: 2655-8 (1996)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50286882
PNG
(1-[(S)-1-(2-Cyclopentyl-2-oxo-ethyl)-2-oxo-5-pheny...)
Show SMILES Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1
Show InChI InChI=1S/C30H30N4O3/c1-20-10-9-15-23(18-20)31-30(37)33-28-29(36)34(19-26(35)21-11-5-6-12-21)25-17-8-7-16-24(25)27(32-28)22-13-3-2-4-14-22/h2-4,7-10,13-18,21,28H,5-6,11-12,19H2,1H3,(H2,31,33,37)/t28-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]-CCK-8 as the radioligand


Bioorg Med Chem Lett 6: 55-58 (1996)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50286882
PNG
(1-[(S)-1-(2-Cyclopentyl-2-oxo-ethyl)-2-oxo-5-pheny...)
Show SMILES Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1
Show InChI InChI=1S/C30H30N4O3/c1-20-10-9-15-23(18-20)31-30(37)33-28-29(36)34(19-26(35)21-11-5-6-12-21)25-17-8-7-16-24(25)27(32-28)22-13-3-2-4-14-22/h2-4,7-10,13-18,21,28H,5-6,11-12,19H2,1H3,(H2,31,33,37)/t28-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Ability to displace [125I]-CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain


Bioorg Med Chem Lett 6: 51-54 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50285466
PNG
(CHEMBL75490 | N-Benzoyl-3-[3-(5-cyclohexyl-1-methy...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(c2)S(=O)(=O)NC(=O)c2ccccc2)C1=O)C1CCCCC1
Show InChI InChI=1S/C30H31N5O5S/c1-35-25-18-9-8-17-24(25)26(20-11-4-2-5-12-20)32-27(29(35)37)33-30(38)31-22-15-10-16-23(19-22)41(39,40)34-28(36)21-13-6-3-7-14-21/h3,6-10,13-20,27H,2,4-5,11-12H2,1H3,(H,34,36)(H2,31,33,38)
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n/an/a 0.240n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]-CCK from guinea pig cortical membranes


Bioorg Med Chem Lett 5: 2303-2308 (1995)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50043546
PNG
(1-(3-Methoxy-phenyl)-3-[2-oxo-1-(2-oxo-2-pyrrolidi...)
Show SMILES COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1
Show InChI InChI=1S/C29H29N5O4/c1-38-22-13-9-12-21(18-22)30-29(37)32-27-28(36)34(19-25(35)33-16-7-8-17-33)24-15-6-5-14-23(24)26(31-27)20-10-3-2-4-11-20/h2-6,9-15,18,27H,7-8,16-17,19H2,1H3,(H2,30,32,37)
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n/an/a 0.240n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor


J Med Chem 36: 4276-92 (1994)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50004490
PNG
(CCK7 analogue | CHEMBL412238 | N-(1-Carbamoyl-2-ph...)
Show SMILES CCCC[C@H](NC(=O)CCc1ccc(OS(O)(=O)=O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C48H62N8O13S/c1-5-6-15-36(52-41(57)22-19-30-17-20-33(21-18-30)69-70(66,67)68)45(62)51-28-42(58)53-39(25-32-27-50-35-16-11-10-14-34(32)35)48(65)56(4)40(23-29(2)3)47(64)55-38(26-43(59)60)46(63)54-37(44(49)61)24-31-12-8-7-9-13-31/h7-14,16-18,20-21,27,29,36-40,50H,5-6,15,19,22-26,28H2,1-4H3,(H2,49,61)(H,51,62)(H,52,57)(H,53,58)(H,54,63)(H,55,64)(H,59,60)(H,66,67,68)/t36-,37-,38-,39-,40-/m0/s1
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n/an/a 0.240n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex


J Med Chem 35: 2919-28 (1992)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50288462
PNG
((R)-2-{(2R,5S)-2-[(R)-3-((R)-2-Carboxy-pyrrolidine...)
Show SMILES CC(C)(C)OC(=O)N1[C@H](Cc2ccccc12)C(=O)N1[C@H](CC[C@H]1c1ccccc1)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C40H44N4O7/c1-40(2,3)51-39(50)44-29-17-10-9-15-27(29)23-34(44)37(47)43-30(25-12-5-4-6-13-25)19-20-31(43)35(45)42-24-28-16-8-7-14-26(28)22-33(42)36(46)41-21-11-18-32(41)38(48)49/h4-10,12-17,30-34H,11,18-24H2,1-3H3,(H,48,49)/t30-,31+,32+,33+,34+/m0/s1
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n/an/a 0.25n/an/an/an/an/an/a


TBA

Assay Description
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50285011
PNG
(CHEMBL294252 | N-tert-Butyl-2-{(3R,5R)-5-cyclohexy...)
Show SMILES Cc1ccc2[C@H](C[C@@H](NC(=O)Nc3cccc(c3)C(=O)NS(C)(=O)=O)C(=O)N(CC(=O)NC(C)(C)C)c2c1)C1CCCCC1
Show InChI InChI=1S/C32H43N5O6S/c1-20-14-15-24-25(21-10-7-6-8-11-21)18-26(30(40)37(27(24)16-20)19-28(38)35-32(2,3)4)34-31(41)33-23-13-9-12-22(17-23)29(39)36-44(5,42)43/h9,12-17,21,25-26H,6-8,10-11,18-19H2,1-5H3,(H,35,38)(H,36,39)(H2,33,34,41)/t25-,26-/m1/s1
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n/an/a 0.260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex


Bioorg Med Chem Lett 5: 1933-1936 (1995)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50040678
PNG
(1-((S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)Nc2ccc(cc2)-c2nc(=O)o[nH]2)C1=O)c1ccccc1
Show InChI InChI=1S/C25H20N6O4/c1-31-19-10-6-5-9-18(19)20(15-7-3-2-4-8-15)27-22(23(31)32)28-24(33)26-17-13-11-16(12-14-17)21-29-25(34)35-30-21/h2-14,22H,1H3,(H2,26,28,33)(H,29,30,34)/t22-/m1/s1
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n/an/a 0.266n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand


J Med Chem 37: 722-4 (1994)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50285462
PNG
(CHEMBL305649 | L-736309 | N-{3-[3-((R)-5-Cyclohexy...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(c2)C(=O)NS(=O)(=O)c2ccccc2C)C1=O)C1CCCCC1
Show InChI InChI=1S/C31H33N5O5S/c1-20-11-6-9-18-26(20)42(40,41)35-29(37)22-14-10-15-23(19-22)32-31(39)34-28-30(38)36(2)25-17-8-7-16-24(25)27(33-28)21-12-4-3-5-13-21/h6-11,14-19,21,28H,3-5,12-13H2,1-2H3,(H,35,37)(H2,32,34,39)/t28-/m0/s1
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n/an/a 0.270n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]-CCK from guinea pig cortical membranes


Bioorg Med Chem Lett 5: 2303-2308 (1995)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50040666
PNG
(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C24H28N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h6-9,12-15,17,22H,3-5,10-11H2,1-2H3,(H2,25,27,30)/t22-/m0/s1
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n/an/a 0.280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]-CCK from guinea pig cortical membranes


Bioorg Med Chem Lett 5: 2303-2308 (1995)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50286886
PNG
(1-[1-(3-Cyclohexyl-2-oxo-propyl)-2-oxo-5-phenyl-2,...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1
Show InChI InChI=1S/C32H34N4O3/c1-22-11-10-16-25(19-22)33-32(39)35-30-31(38)36(21-26(37)20-23-12-4-2-5-13-23)28-18-9-8-17-27(28)29(34-30)24-14-6-3-7-15-24/h3,6-11,14-19,23,30H,2,4-5,12-13,20-21H2,1H3,(H2,33,35,39)
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n/an/a 0.280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to displace [125I]-CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain


Bioorg Med Chem Lett 6: 51-54 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50020270
PNG
((RS)-1-(4-Chloro-phenyl)-3-[2-oxo-1-(2-oxo-2-pyrro...)
Show SMILES Clc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)cc1
Show InChI InChI=1S/C28H26ClN5O3/c29-20-12-14-21(15-13-20)30-28(37)32-26-27(36)34(18-24(35)33-16-6-7-17-33)23-11-5-4-10-22(23)25(31-26)19-8-2-1-3-9-19/h1-5,8-15,26H,6-7,16-18H2,(H2,30,32,37)
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n/an/a 0.280n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex


J Med Chem 32: 13-6 (1989)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50040666
PNG
(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C24H28N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h6-9,12-15,17,22H,3-5,10-11H2,1-2H3,(H2,25,27,30)/t22-/m0/s1
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n/an/a 0.280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro test for inhibition of [125I]-CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined


Bioorg Med Chem Lett 3: 1919-1924 (1993)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50454482
PNG
(CHEMBL2110202)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C25H29N9O2/c1-34-20-13-6-5-12-19(20)21(17-9-3-2-4-10-17)28-22(23(34)35)29-25(36)27-18-11-7-8-16(14-18)15-26-24-30-32-33-31-24/h5-8,11-14,17,22H,2-4,9-10,15H2,1H3,(H2,27,29,36)(H2,26,30,31,32,33)/t22-/m0/s1
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n/an/a 0.280n/an/an/an/an/an/a



Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes


J Med Chem 39: 842-9 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50040666
PNG
(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C24H28N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h6-9,12-15,17,22H,3-5,10-11H2,1-2H3,(H2,25,27,30)/t22-/m0/s1
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n/an/a 0.280n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.


J Med Chem 37: 719-21 (1994)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50040666
PNG
(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C24H28N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h6-9,12-15,17,22H,3-5,10-11H2,1-2H3,(H2,25,27,30)/t22-/m0/s1
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n/an/a 0.280n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.


J Med Chem 40: 2491-501 (1997)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50020270
PNG
((RS)-1-(4-Chloro-phenyl)-3-[2-oxo-1-(2-oxo-2-pyrro...)
Show SMILES Clc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)cc1
Show InChI InChI=1S/C28H26ClN5O3/c29-20-12-14-21(15-13-20)30-28(37)32-26-27(36)34(18-24(35)33-16-6-7-17-33)23-11-5-4-10-22(23)25(31-26)19-8-2-1-3-9-19/h1-5,8-15,26H,6-7,16-18H2,(H2,30,32,37)
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n/an/a 0.280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [125I]-CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.


Bioorg Med Chem Lett 3: 871-874 (1993)

More data for this
Ligand-Target Pair
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