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Compile Data Set for Download or QSAR

Found 385 hits Enz. Inhib. hit(s) with Target = 'CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329437
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CNC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C16H15N5O/c1-18-15(22)11-9-13(12-7-8-19-16(17)21-12)20-14(11)10-5-3-2-4-6-10/h2-9,20H,1H3,(H,18,22)(H2,17,19,21)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329435
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES Nc1nccc(n1)-c1cc(C(=O)NCc2ccccc2)c([nH]1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O/c23-22-24-12-11-18(27-22)19-13-17(20(26-19)16-9-5-2-6-10-16)21(28)25-14-15-7-3-1-4-8-15/h1-13,26H,14H2,(H,25,28)(H2,23,24,27)
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Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329436
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CC(C)NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C18H19N5O/c1-11(2)21-17(24)13-10-15(14-8-9-20-18(19)23-14)22-16(13)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H,21,24)(H2,19,20,23)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123148
PNG
(US8742113, 242)
Show SMILES Cc1ccsc1CN=C1CC(=O)C(O1)=Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C18H15N3O2S/c1-11-4-6-24-16(11)10-20-17-8-14(22)15(23-17)7-12-9-21-18-13(12)3-2-5-19-18/h2-7,9H,8,10H2,1H3,(H,19,21)/b15-7-,20-17-
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n/an/a 1n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329439
PNG
(4-(3-Carbamoyl-5-pyridin-4-yl-1H-pyrrol-2-yl)-pipe...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C20H26N4O3/c1-20(2,3)27-19(26)24-10-6-14(7-11-24)17-15(18(21)25)12-16(23-17)13-4-8-22-9-5-13/h4-5,8-9,12,14,23H,6-7,10-11H2,1-3H3,(H2,21,25)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM27344
PNG
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
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n/an/a 1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123147
PNG
(US8742113, 239)
Show SMILES O=C1CC(OC1=Cc1c[nH]c2ncccc12)=Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C19H13N5O2/c25-16-8-18(23-13-3-4-15-12(6-13)10-22-24-15)26-17(16)7-11-9-21-19-14(11)2-1-5-20-19/h1-7,9-10H,8H2,(H,20,21)(H,22,24)/b17-7-,23-18+
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n/an/a 1n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50272192
PNG
(4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(1...)
Show SMILES Cc1cc(ccc1O)-c1cc(nc(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H14N2O2/c1-11-9-13(7-8-16(11)20)15-10-14(18-17(21)19-15)12-5-3-2-4-6-12/h2-10,20H,1H3,(H,18,19,21)
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n/an/a 1.40n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329419
PNG
(5-(2-amino-5-bromopyrimidin-4-yl)-2-p-tolyl-1H-pyr...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1Br
Show InChI InChI=1S/C15H12BrN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
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n/an/a 2n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123146
PNG
(US8742113, 233)
Show SMILES Cc1cc(F)ccc1N=C1CC(=O)C(O1)=Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C19H14FN3O2/c1-11-7-13(20)4-5-15(11)23-18-9-16(24)17(25-18)8-12-10-22-19-14(12)3-2-6-21-19/h2-8,10H,9H2,1H3,(H,21,22)/b17-8-,23-18+
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n/an/a 2n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123131
PNG
(US8742113, 15)
Show SMILES CCOC(=O)C1C(=O)C(OC1=Nc1ccccc1Cl)=Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C21H16ClN3O4/c1-2-28-21(27)17-18(26)16(10-12-11-24-19-13(12)6-5-9-23-19)29-20(17)25-15-8-4-3-7-14(15)22/h3-11,17H,2H2,1H3,(H,23,24)/b16-10-,25-20-
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n/an/a 2n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329434
PNG
(2,5-Dipyridin-4-yl-1H-pyrrole-3-carboxamide | CHEM...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccncc1)-c1ccncc1
Show InChI InChI=1S/C15H12N4O/c16-15(20)12-9-13(10-1-5-17-6-2-10)19-14(12)11-3-7-18-8-4-11/h1-9,19H,(H2,16,20)
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n/an/a 2n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50272192
PNG
(4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(1...)
Show SMILES Cc1cc(ccc1O)-c1cc(nc(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H14N2O2/c1-11-9-13(7-8-16(11)20)15-10-14(18-17(21)19-15)12-5-3-2-4-6-12/h2-10,20H,1H3,(H,18,19,21)
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n/an/a 3n/an/an/an/an/an/a



Novartis Institutes of Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of CDC7-DBF4 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123144
PNG
(US8742113, 173)
Show SMILES COCCOC(=O)C1C(=O)C(OC1=Nc1ccccc1Cl)=Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C22H18ClN3O5/c1-29-9-10-30-22(28)18-19(27)17(11-13-12-25-20-14(13)5-4-8-24-20)31-21(18)26-16-7-3-2-6-15(16)23/h2-8,11-12,18H,9-10H2,1H3,(H,24,25)/b17-11-,26-21-
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n/an/a 3n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123142
PNG
(US8742113, 142)
Show SMILES CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=NN1CCOCC1
Show InChI InChI=1S/C19H20N4O5/c1-2-27-19(25)15-16(24)14(28-18(15)22-23-6-8-26-9-7-23)10-12-11-21-17-13(12)4-3-5-20-17/h3-5,10-11,15H,2,6-9H2,1H3,(H,20,21)/b14-10-,22-18-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123140
PNG
(US8742113, 126)
Show SMILES CCOC(=O)C1C(=O)C(OC1=Nc1ccc(NCCO)cc1C)=Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C24H24N4O5/c1-3-32-24(31)20-21(30)19(12-15-13-27-22-17(15)5-4-8-26-22)33-23(20)28-18-7-6-16(11-14(18)2)25-9-10-29/h4-8,11-13,20,25,29H,3,9-10H2,1-2H3,(H,26,27)/b19-12-,28-23+
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123143
PNG
(US8742113, 157)
Show SMILES CC(C)OC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc(OCCO)cc1C
Show InChI InChI=1S/C25H25N3O6/c1-14(2)33-25(31)21-22(30)20(12-16-13-27-23-18(16)5-4-8-26-23)34-24(21)28-19-7-6-17(11-15(19)3)32-10-9-29/h4-8,11-14,21,29H,9-10H2,1-3H3,(H,26,27)/b20-12-,28-24+
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123137
PNG
(US8742113, 89)
Show SMILES OCCCOC(=O)C1C(=O)C(OC1=Nc1ccc(F)cc1)=Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C22H18FN3O5/c23-14-4-6-15(7-5-14)26-21-18(22(29)30-10-2-9-27)19(28)17(31-21)11-13-12-25-20-16(13)3-1-8-24-20/h1,3-8,11-12,18,27H,2,9-10H2,(H,24,25)/b17-11-,26-21-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383714
PNG
(CHEMBL2030402)
Show SMILES Clc1ccc2oc3c(nc([nH]c3=O)[C@@H]3CCCN3)c2c1
Show InChI InChI=1S/C14H12ClN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383736
PNG
(CHEMBL2030400)
Show SMILES F[C@H]1CN[C@@H](C1)c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C14H11BrFN3O2/c15-6-1-2-10-8(3-6)11-12(21-10)14(20)19-13(18-11)9-4-7(16)5-17-9/h1-3,7,9,17H,4-5H2,(H,18,19,20)/t7-,9+/m1/s1
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n/an/a 3.70n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383727
PNG
(CHEMBL2030389)
Show SMILES Brc1ccc2oc3c(nc(CN4CCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C15H14BrN3O2/c16-9-3-4-11-10(7-9)13-14(21-11)15(20)18-12(17-13)8-19-5-1-2-6-19/h3-4,7H,1-2,5-6,8H2,(H,17,18,20)
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n/an/a 3.70n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383740
PNG
(CHEMBL2030405)
Show SMILES COc1ccc2oc3c(nc([nH]c3=O)[C@@H]3C[C@@H](F)CN3)c2c1
Show InChI InChI=1S/C15H14FN3O3/c1-21-8-2-3-11-9(5-8)12-13(22-11)15(20)19-14(18-12)10-4-7(16)6-17-10/h2-3,5,7,10,17H,4,6H2,1H3,(H,18,19,20)/t7-,10+/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50279340
PNG
((Z)-2-[(Furan-2-ylmethyl)-amino]-5-[1-(1H-pyrrolo[...)
Show SMILES O=C1N=C(NCc2ccco2)SC1=Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C16H12N4O2S/c21-15-13(7-10-8-18-14-12(10)4-1-5-17-14)23-16(20-15)19-9-11-3-2-6-22-11/h1-8H,9H2,(H,17,18)(H,19,20,21)
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n/an/a 4n/an/an/an/an/an/a



Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2


Citation and Details
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329422
PNG
(5-(2-Amino-pyrimidin-4-yl)-1-ethyl-2-phenyl-1H-pyr...)
Show SMILES CCn1c(cc(C(N)=O)c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H17N5O/c1-2-22-14(13-8-9-20-17(19)21-13)10-12(16(18)23)15(22)11-6-4-3-5-7-11/h3-10H,2H2,1H3,(H2,18,23)(H2,19,20,21)
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n/an/a 4n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123134
PNG
(US8742113, 68)
Show SMILES CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc2c[nH]nc2c1
Show InChI InChI=1S/C22H17N5O4/c1-2-30-22(29)18-19(28)17(8-13-10-24-20-15(13)4-3-7-23-20)31-21(18)26-14-6-5-12-11-25-27-16(12)9-14/h3-11,18H,2H2,1H3,(H,23,24)(H,25,27)/b17-8-,26-21?
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n/an/a 4n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383739
PNG
(CHEMBL2030404)
Show SMILES F[C@H]1CN[C@@H](C1)c1nc2c3cc(Cl)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C14H11ClFN3O2/c15-6-1-2-10-8(3-6)11-12(21-10)14(20)19-13(18-11)9-4-7(16)5-17-9/h1-3,7,9,17H,4-5H2,(H,18,19,20)/t7-,9+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123149
PNG
(US8742113, 244)
Show SMILES CCOC(=O)C1=C(OC(=Cc2c[nH]c3ncccc23)C1=O)N1CCc2ccc(OC)cc2C1
Show InChI InChI=1S/C25H23N3O5/c1-3-32-25(30)21-22(29)20(12-16-13-27-23-19(16)5-4-9-26-23)33-24(21)28-10-8-15-6-7-18(31-2)11-17(15)14-28/h4-7,9,11-13H,3,8,10,14H2,1-2H3,(H,26,27)/b20-12-
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n/an/a 4n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123138
PNG
(US8742113, 91)
Show SMILES CN(C)CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc(F)cc1F
Show InChI InChI=1S/C23H20F2N4O4/c1-29(2)8-9-32-23(31)19-20(30)18(10-13-12-27-21-15(13)4-3-7-26-21)33-22(19)28-17-6-5-14(24)11-16(17)25/h3-7,10-12,19H,8-9H2,1-2H3,(H,26,27)/b18-10-,28-22-
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n/an/a 4n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123139
PNG
(US8742113, 102)
Show SMILES CCOC(=O)C1=C(OC(=Cc2c[nH]c3ncccc23)C1=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C24H21N3O4/c1-2-30-24(29)20-21(28)19(12-17-13-26-22-18(17)8-5-10-25-22)31-23(20)27-11-9-15-6-3-4-7-16(15)14-27/h3-8,10,12-13H,2,9,11,14H2,1H3,(H,25,26)/b19-12-
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n/an/a 4n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123145
PNG
(US8742113, 226)
Show SMILES O=C1CC(OC1=Cc1c[nH]c2ncccc12)=NC1CCCCCC1
Show InChI InChI=1S/C19H21N3O2/c23-16-11-18(22-14-6-3-1-2-4-7-14)24-17(16)10-13-12-21-19-15(13)8-5-9-20-19/h5,8-10,12,14H,1-4,6-7,11H2,(H,20,21)/b17-10-,22-18+
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n/an/a 4n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383730
PNG
(CHEMBL2030393)
Show SMILES Brc1ccc2oc3c(nc([nH]c3=O)[C@@H]3CCCN3)c2c1
Show InChI InChI=1S/C14H12BrN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m0/s1
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n/an/a 4.80n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50272242
PNG
(6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(...)
Show SMILES Clc1cccc(c1)-c1cc(nc(=O)[nH]1)-c1ccc2n[nH]cc2c1
Show InChI InChI=1S/C17H11ClN4O/c18-13-3-1-2-10(7-13)15-8-16(21-17(23)20-15)11-4-5-14-12(6-11)9-19-22-14/h1-9H,(H,19,22)(H,20,21,23)
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n/an/a 5n/an/an/an/an/an/a



Novartis Institutes of Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of CDC7-DBF4 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123136
PNG
(US8742113, 81)
Show SMILES CCOC(=O)C1C(C=C(Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc(OCCO)cc1F
Show InChI InChI=1S/C24H22FN3O5/c1-2-32-24(31)21-20(28-19-6-5-16(12-18(19)25)33-9-8-29)11-14(22(21)30)10-15-13-27-23-17(15)4-3-7-26-23/h3-7,11-13,21,29H,2,8-10H2,1H3,(H,26,27)/b28-20-
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n/an/a 5n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329420
PNG
(5-(2-amino-5-chloropyrimidin-4-yl)-2-p-tolyl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1Cl
Show InChI InChI=1S/C15H12ClN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
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n/an/a 5n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50272244
PNG
(6-(3-(benzyloxy)phenyl)-4-(1H-indazol-5-yl)pyrimid...)
Show SMILES O=c1nc(cc([nH]1)-c1cccc(OCc2ccccc2)c1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C24H18N4O2/c29-24-26-22(13-23(27-24)18-9-10-21-19(11-18)14-25-28-21)17-7-4-8-20(12-17)30-15-16-5-2-1-3-6-16/h1-14H,15H2,(H,25,28)(H,26,27,29)
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n/an/a 6n/an/an/an/an/an/a



Novartis Institutes of Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of CDC7-DBF4 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329431
PNG
(5-Pyridin-4-yl-2-p-tolyl-1H-pyrrole-3-carboxamide ...)
Show SMILES Cc1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O/c1-11-2-4-13(5-3-11)16-14(17(18)21)10-15(20-16)12-6-8-19-9-7-12/h2-10,20H,1H3,(H2,18,21)
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n/an/a 6n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123133
PNG
(US8742113, 63)
Show SMILES CCOC(=O)C1=C(OC(=Cc2c[nH]c3ncccc23)C1=O)N1CCCCCC1
Show InChI InChI=1S/C21H23N3O4/c1-2-27-21(26)17-18(25)16(28-20(17)24-10-5-3-4-6-11-24)12-14-13-23-19-15(14)8-7-9-22-19/h7-9,12-13H,2-6,10-11H2,1H3,(H,22,23)/b16-12-
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n/an/a 6n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383738
PNG
(CHEMBL2030403)
Show SMILES COc1ccc2oc3c(nc([nH]c3=O)[C@@H]3CCCN3)c2c1
Show InChI InChI=1S/C15H15N3O3/c1-20-8-4-5-11-9(7-8)12-13(21-11)15(19)18-14(17-12)10-3-2-6-16-10/h4-5,7,10,16H,2-3,6H2,1H3,(H,17,18,19)/t10-/m0/s1
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n/an/a 6.10n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383733
PNG
(CHEMBL2030396)
Show SMILES Brc1ccc2oc3c(nc([nH]c3=O)C3CCNCC3)c2c1
Show InChI InChI=1S/C15H14BrN3O2/c16-9-1-2-11-10(7-9)12-13(21-11)15(20)19-14(18-12)8-3-5-17-6-4-8/h1-2,7-8,17H,3-6H2,(H,18,19,20)
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n/an/a 6.20n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50432336
PNG
(CHEMBL2348154)
Show SMILES Nc1nccc(n1)-n1cc(-c2cccnc2Cl)c2cnccc12
Show InChI InChI=1S/C16H11ClN6/c17-15-10(2-1-5-20-15)12-9-23(13-3-6-19-8-11(12)13)14-4-7-21-16(18)22-14/h1-9H,(H2,18,21,22)
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDC7 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383734
PNG
(CHEMBL2030398)
Show SMILES CN1CCC[C@H]1c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C15H14BrN3O2/c1-19-6-2-3-10(19)14-17-12-9-7-8(16)4-5-11(9)21-13(12)15(20)18-14/h4-5,7,10H,2-3,6H2,1H3,(H,17,18,20)/t10-/m0/s1
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n/an/a 7.30n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383715
PNG
(CHEMBL2030376)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m0/s1
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n/an/a 7.70n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383712
PNG
(CHEMBL2030392)
Show SMILES Brc1ccc2oc3c(nc([nH]c3=O)C3CNC3)c2c1
Show InChI InChI=1S/C13H10BrN3O2/c14-7-1-2-9-8(3-7)10-11(19-9)13(18)17-12(16-10)6-4-15-5-6/h1-3,6,15H,4-5H2,(H,16,17,18)
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n/an/a 7.70n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383713
PNG
(CHEMBL2030397)
Show SMILES CC(N)c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C12H10BrN3O2/c1-5(14)11-15-9-7-4-6(13)2-3-8(7)18-10(9)12(17)16-11/h2-5H,14H2,1H3,(H,15,16,17)
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n/an/a 7.90n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Citation and Details
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329417
PNG
(5-(3-Fluoro-pyridin-4-yl)-2-phenyl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccncc1F
Show InChI InChI=1S/C16H12FN3O/c17-13-9-19-7-6-11(13)14-8-12(16(18)21)15(20-14)10-4-2-1-3-5-10/h1-9,20H,(H2,18,21)
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n/an/a 8n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123151
PNG
(US8742113, 246)
Show SMILES CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=NN1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C21H22F3N5O4/c1-2-32-20(31)16-17(30)15(10-13-11-26-18-14(13)4-3-5-25-18)33-19(16)27-29-8-6-28(7-9-29)12-21(22,23)24/h3-5,10-11,16H,2,6-9,12H2,1H3,(H,25,26)/b15-10-,27-19+
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US Patent
n/an/a 8n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123150
PNG
(US8742113, 245)
Show SMILES CC(C)OC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=NN1CCOCC1
Show InChI InChI=1S/C20H22N4O5/c1-12(2)28-20(26)16-17(25)15(29-19(16)23-24-6-8-27-9-7-24)10-13-11-22-18-14(13)4-3-5-21-18/h3-5,10-12,16H,6-9H2,1-2H3,(H,21,22)/b15-10-,23-19-
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US Patent
n/an/a 8n/an/an/an/an/an/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)

More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329416
PNG
(2-(2-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1F)-c1ccncc1
Show InChI InChI=1S/C16H12FN3O/c17-13-4-2-1-3-11(13)15-12(16(18)21)9-14(20-15)10-5-7-19-8-6-10/h1-9,20H,(H2,18,21)
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n/an/a 8n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


Citation and Details
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50279338
PNG
((Z)-2-(Benzylamino)-5-(1H-pyrrolo[2,3-b]pyridin-3-...)
Show SMILES O=C1N=C(NCc2ccccc2)SC1=Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C18H14N4OS/c23-17-15(9-13-11-20-16-14(13)7-4-8-19-16)24-18(22-17)21-10-12-5-2-1-3-6-12/h1-9,11H,10H2,(H,19,20)(H,21,22,23)
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n/an/a 9n/an/an/an/an/an/a



Nerviano Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2


Citation and Details
More data for this
Ligand-Target Pair
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