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Compile Data Set for Download or QSAR

Found 732 hits Enz. Inhib. hit(s) with Target = 'CaM Kinase II'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CAMK2B


(Homo sapiens)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of CAMK2B


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM139540
PNG
(US8889696, Staurosporine | US9051313, Staurosporin...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/s2
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US Patent
n/an/a 0.700n/an/an/an/an/an/a



Temple University—Of The Commonwealth System Of Higher Education

US Patent


Assay Description
The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...


US Patent US8889696 (2014)

More data for this
Ligand-Target Pair
CAMK2A


(Homo sapiens)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of CamK2alpha


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149450
PNG
(US8975250, 32)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(cc3OC)N3CCC(CC3)N3CCOCC3)nc12
Show InChI InChI=1S/C26H34N8O4/c1-3-34-23(27)21(24(28)36)22(35)18-15-29-26(31-25(18)34)30-19-5-4-17(14-20(19)37-2)32-8-6-16(7-9-32)33-10-12-38-13-11-33/h4-5,14-16H,3,6-13,27H2,1-2H3,(H2,28,36)(H,29,30,31)
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n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50361927
PNG
(CHEMBL1939161)
Show SMILES CN1CCCC1CCNc1nc(Nc2ccc(Cl)c(Cl)c2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H22Cl3N5/c1-29-10-2-3-15(29)8-9-25-20-16-11-13(22)4-7-19(16)27-21(28-20)26-14-5-6-17(23)18(24)12-14/h4-7,11-12,15H,2-3,8-10H2,1H3,(H2,25,26,27,28)
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n/an/a 2n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CAMK2delta using tetramethylbenzidine as substrate by spectrophotometry analysis


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149454
PNG
(US8975250, 61)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(N4CCC(CC4)N4CCCC4)c(Cl)c3)nc12
Show InChI InChI=1S/C25H31ClN8O2/c1-2-34-22(27)20(23(28)36)21(35)17-14-29-25(31-24(17)34)30-15-5-6-19(18(26)13-15)33-11-7-16(8-12-33)32-9-3-4-10-32/h5-6,13-14,16H,2-4,7-12,27H2,1H3,(H2,28,36)(H,29,30,31)
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n/an/a 8n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374977
PNG
(CHEMBL270849)
Show SMILES Clc1cccc(Nc2nccc(n2)-c2cccc(c2)N2CCNCC2)c1
Show InChI InChI=1S/C20H20ClN5/c21-16-4-2-5-17(14-16)24-20-23-8-7-19(25-20)15-3-1-6-18(13-15)26-11-9-22-10-12-26/h1-8,13-14,22H,9-12H2,(H,23,24,25)
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n/an/a 9n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375063
PNG
(CHEMBL255607)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc12
Show InChI InChI=1S/C22H17ClN4O2/c23-13-5-6-17-15(9-13)16(10-25-17)19-20(22(29)26-21(19)28)27-11-12(7-8-24)14-3-1-2-4-18(14)27/h1-6,9-11,25H,7-8,24H2,(H,26,28,29)
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n/an/a 10n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374956
PNG
(CHEMBL272978)
Show SMILES NCCNc1cccc(c1)-c1ccnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5/c19-14-4-2-6-16(12-14)23-18-22-9-7-17(24-18)13-3-1-5-15(11-13)21-10-8-20/h1-7,9,11-12,21H,8,10,20H2,(H,22,23,24)
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n/an/a 12n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375073
PNG
(CHEMBL402340)
Show SMILES CNCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc12
Show InChI InChI=1S/C23H19ClN4O2/c1-25-9-8-13-12-28(19-5-3-2-4-15(13)19)21-20(22(29)27-23(21)30)17-11-26-18-7-6-14(24)10-16(17)18/h2-7,10-12,25-26H,8-9H2,1H3,(H,27,29,30)
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n/an/a 13n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149449
PNG
(US8975250, 29)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(cc3OC)C3CCN(CC3)C3CC3)nc12
Show InChI InChI=1S/C25H31N7O3/c1-3-32-22(26)20(23(27)34)21(33)17-13-28-25(30-24(17)32)29-18-7-4-15(12-19(18)35-2)14-8-10-31(11-9-14)16-5-6-16/h4,7,12-14,16H,3,5-6,8-11,26H2,1-2H3,(H2,27,34)(H,28,29,30)
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n/an/a 17n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375061
PNG
(CHEMBL271648)
Show SMILES CNCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(cc23)C(=O)OC)c2ccccc12
Show InChI InChI=1S/C25H22N4O4/c1-26-10-9-15-13-29(20-6-4-3-5-16(15)20)22-21(23(30)28-24(22)31)18-12-27-19-8-7-14(11-17(18)19)25(32)33-2/h3-8,11-13,26-27H,9-10H2,1-2H3,(H,28,30,31)
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n/an/a 21n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149451
PNG
(US8975250, 35)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(cc3OC)C3CCN(CCC(F)(F)F)CC3)nc12
Show InChI InChI=1S/C25H30F3N7O3/c1-3-35-21(29)19(22(30)37)20(36)16-13-31-24(33-23(16)35)32-17-5-4-15(12-18(17)38-2)14-6-9-34(10-7-14)11-8-25(26,27)28/h4-5,12-14H,3,6-11,29H2,1-2H3,(H2,30,37)(H,31,32,33)
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n/an/a 22n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6838
PNG
(1-(2-{18-methyl-12,14-dioxo-3,13,18-triazahexacycl...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCN6CCC(CC6)C(N)=O)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C29H27N5O3/c1-33-11-7-16-5-6-19-21(26(16)33)23-22(28(36)32-29(23)37)20-18-4-2-3-15(24(18)31-25(19)20)8-12-34-13-9-17(10-14-34)27(30)35/h2-7,11,17,31H,8-10,12-14H2,1H3,(H2,30,35)(H,32,36,37)
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n/an/a 25n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CAMK2A


(Homo sapiens)
BDBM50430016
PNG
(CHEMBL2335444)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(C)C)C(C)C)C(O)=O
Show InChI InChI=1S/C197H335N67O41S2/c1-17-109(11)156(184(297)233-104-153(272)235-123(64-43-86-223-193(212)213)164(277)234-113(15)160(273)238-124(58-29-36-79-199)165(278)243-132(67-46-89-226-196(218)219)174(287)257-154(107(7)8)185(298)258-155(108(9)10)186(299)262-159(191(304)305)112(14)20-4)259-176(289)133(71-74-146(206)265)236-152(271)103-232-163(276)138(94-106(5)6)252-171(284)128(62-33-40-83-203)249-183(296)144-69-48-91-263(144)190(303)145-70-49-92-264(145)189(302)137(68-47-90-227-197(220)221)251-169(282)126(60-31-38-81-201)246-182(295)143(105-306)237-151(270)102-230-150(269)101-231-162(275)122(57-28-35-78-198)240-166(279)125(59-30-37-80-200)244-179(292)140(96-115-99-228-120-55-26-24-52-117(115)120)254-170(283)127(61-32-39-82-202)241-173(286)136(77-93-307-16)248-168(281)130(65-44-87-224-194(214)215)242-167(280)131(66-45-88-225-195(216)217)245-181(294)142(98-149(209)268)255-172(285)134(72-75-147(207)266)247-178(291)139(95-114-50-22-21-23-51-114)253-180(293)141(97-116-100-229-121-56-27-25-53-118(116)121)256-188(301)158(111(13)19-3)260-175(288)129(63-34-41-84-204)250-187(300)157(110(12)18-2)261-177(290)135(73-76-148(208)267)239-161(274)119(205)54-42-85-222-192(210)211/h21-27,50-53,55-56,99-100,106-113,119,122-145,154-159,228-229,306H,17-20,28-49,54,57-98,101-105,198-205H2,1-16H3,(H2,206,265)(H2,207,266)(H2,208,267)(H2,209,268)(H,230,269)(H,231,275)(H,232,276)(H,233,297)(H,234,277)(H,235,272)(H,236,271)(H,237,270)(H,238,273)(H,239,274)(H,240,279)(H,241,286)(H,242,280)(H,243,278)(H,244,292)(H,245,294)(H,246,295)(H,247,291)(H,248,281)(H,249,296)(H,250,300)(H,251,282)(H,252,284)(H,253,293)(H,254,283)(H,255,285)(H,256,301)(H,257,287)(H,258,298)(H,259,289)(H,260,288)(H,261,290)(H,262,299)(H,304,305)(H4,210,211,222)(H4,212,213,223)(H4,214,215,224)(H4,216,217,225)(H4,218,219,226)(H4,220,221,227)/t109-,110-,111-,112-,113-,119-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,154-,155-,156-,157-,158-,159-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375062
PNG
(CHEMBL402533)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(cc23)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)13-5-6-17-15(9-13)16(10-28-17)19-20(22(32)29-21(19)31)30-11-12(7-8-27)14-3-1-2-4-18(14)30/h1-6,9-11,28H,7-8,27H2,(H,29,31,32)
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n/an/a 32n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374982
PNG
(CHEMBL403446)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Br)cc23)c2ccccc12
Show InChI InChI=1S/C23H19BrN4O2/c24-13-6-7-18-15(10-13)16(11-26-18)20-21(23(30)27-22(20)29)17-12-28(9-3-8-25)19-5-2-1-4-14(17)19/h1-2,4-7,10-12,26H,3,8-9,25H2,(H,27,29,30)
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n/an/a 34n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374982
PNG
(CHEMBL403446)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Br)cc23)c2ccccc12
Show InChI InChI=1S/C23H19BrN4O2/c24-13-6-7-18-15(10-13)16(11-26-18)20-21(23(30)27-22(20)29)17-12-28(9-3-8-25)19-5-2-1-4-14(17)19/h1-2,4-7,10-12,26H,3,8-9,25H2,(H,27,29,30)
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n/an/a 34n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149455
PNG
(US8975250, 75)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc4CNCCc4c3)nc12
Show InChI InChI=1S/C19H21N7O2/c1-2-26-16(20)14(17(21)28)15(27)13-9-23-19(25-18(13)26)24-12-4-3-11-8-22-6-5-10(11)7-12/h3-4,7,9,22H,2,5-6,8,20H2,1H3,(H2,21,28)(H,23,24,25)
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n/an/a 37n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375072
PNG
(CHEMBL403337)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(F)cc23)c2ccccc12
Show InChI InChI=1S/C22H17FN4O2/c23-13-5-6-17-15(9-13)16(10-25-17)19-20(22(29)26-21(19)28)27-11-12(7-8-24)14-3-1-2-4-18(14)27/h1-6,9-11,25H,7-8,24H2,(H,26,28,29)
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n/an/a 38n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149459
PNG
(US8975250, 113)
Show SMILES COc1cc(ccc1Nc1ncc2c(n1)n(c(N)c(C(N)=O)c2=O)-c1ccccc1)C1CCNCC1
Show InChI InChI=1S/C26H27N7O3/c1-36-20-13-16(15-9-11-29-12-10-15)7-8-19(20)31-26-30-14-18-22(34)21(24(28)35)23(27)33(25(18)32-26)17-5-3-2-4-6-17/h2-8,13-15,29H,9-12,27H2,1H3,(H2,28,35)(H,30,31,32)
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n/an/a 39n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CAMK2A


(Homo sapiens)
BDBM50430015
PNG
(CHEMBL2335442)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCN=C(N)N)[C@@H](C)CC)C(C)C)C(C)C)C(O)=O
Show InChI InChI=1S/C157H289N65O34S/c1-12-86(9)119(141(248)195-81-116(227)197-90(43-25-67-186-150(169)170)124(231)196-88(11)121(228)199-91(38-14-19-61-158)125(232)206-100(48-30-72-191-155(179)180)136(243)215-117(84(5)6)142(249)216-118(85(7)8)143(250)218-120(148(255)256)87(10)13-2)217-137(244)101(55-58-112(164)223)198-115(226)80-194-123(230)106(79-83(3)4)213-133(240)95(42-18-23-65-162)209-139(246)108-51-33-75-219(108)146(253)110-53-35-77-221(110)144(251)104(49-31-73-192-156(181)182)211-131(238)94(41-17-22-64-161)207-138(245)107(82-257)214-135(242)103(57-60-114(166)225)210-140(247)109-52-34-76-220(109)147(254)111-54-36-78-222(111)145(252)105(50-32-74-193-157(183)184)212-132(239)99(47-29-71-190-154(177)178)204-129(236)97(45-27-69-188-152(173)174)205-134(241)102(56-59-113(165)224)208-130(237)98(46-28-70-189-153(175)176)203-128(235)96(44-26-68-187-151(171)172)202-127(234)93(40-16-21-63-160)201-126(233)92(39-15-20-62-159)200-122(229)89(163)37-24-66-185-149(167)168/h83-111,117-120,257H,12-82,158-163H2,1-11H3,(H2,164,223)(H2,165,224)(H2,166,225)(H,194,230)(H,195,248)(H,196,231)(H,197,227)(H,198,226)(H,199,228)(H,200,229)(H,201,233)(H,202,234)(H,203,235)(H,204,236)(H,205,241)(H,206,232)(H,207,245)(H,208,237)(H,209,246)(H,210,247)(H,211,238)(H,212,239)(H,213,240)(H,214,242)(H,215,243)(H,216,249)(H,217,244)(H,218,250)(H,255,256)(H4,167,168,185)(H4,169,170,186)(H4,171,172,187)(H4,173,174,188)(H4,175,176,189)(H4,177,178,190)(H4,179,180,191)(H4,181,182,192)(H4,183,184,193)/t86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,117-,118-,119-,120-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374954
PNG
(CHEMBL271045)
Show SMILES OC(=O)c1ccc(cc1)-c1ccnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H12ClN3O2/c18-13-2-1-3-14(10-13)20-17-19-9-8-15(21-17)11-4-6-12(7-5-11)16(22)23/h1-10H,(H,22,23)(H,19,20,21)
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n/an/a 42n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375071
PNG
(CHEMBL270032)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(cc23)C#N)c2ccccc12
Show InChI InChI=1S/C23H17N5O2/c24-8-7-14-12-28(19-4-2-1-3-15(14)19)21-20(22(29)27-23(21)30)17-11-26-18-6-5-13(10-25)9-16(17)18/h1-6,9,11-12,26H,7-8,24H2,(H,27,29,30)
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n/an/a 46n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6840
PNG
(5-[2-(4-hydroxypiperidin-1-yl)ethyl]-18-methyl-3,1...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCN6CCC(O)CC6)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C28H26N4O3/c1-31-11-7-16-5-6-19-21(26(16)31)23-22(27(34)30-28(23)35)20-18-4-2-3-15(24(18)29-25(19)20)8-12-32-13-9-17(33)10-14-32/h2-7,11,17,29,33H,8-10,12-14H2,1H3,(H,30,34,35)
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n/an/a 46n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6846
PNG
(5-{2-[(4-hydroxycyclohexyl)amino]ethyl}-18-methyl-...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCN[C@H]6CC[C@H](O)CC6)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C29H28N4O3/c1-33-14-12-16-5-10-20-22(27(16)33)24-23(28(35)32-29(24)36)21-19-4-2-3-15(25(19)31-26(20)21)11-13-30-17-6-8-18(34)9-7-17/h2-5,10,12,14,17-18,30-31,34H,6-9,11,13H2,1H3,(H,32,35,36)/t17-,18-
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n/an/a 49n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CAMK2A


(Homo sapiens)
BDBM50430014
PNG
(CHEMBL2335479)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C136H240N44O39/c1-18-72(14)105(176-117(203)82(45-47-94(142)181)159-95(182)65-155-110(196)86(59-67(4)5)167-113(199)79(37-23-27-51-139)163-123(209)92-43-33-57-179(92)131(217)93-44-34-58-180(93)130(216)84(42-32-56-154-136(149)150)165-109(195)76(141)35-21-25-49-137)124(210)156-66-96(183)158-77(39-29-53-151-133(143)144)111(197)157-75(17)108(194)160-78(36-22-26-50-138)112(198)161-80(40-30-54-152-134(145)146)115(201)173-103(70(10)11)126(212)175-104(71(12)13)127(213)178-107(74(16)20-3)128(214)164-83(46-48-97(184)185)114(200)168-89(62-99(188)189)120(206)169-88(61-98(186)187)119(205)162-81(41-31-55-153-135(147)148)116(202)177-106(73(15)19-2)129(215)172-90(63-100(190)191)121(207)170-91(64-101(192)193)122(208)174-102(69(8)9)125(211)171-87(60-68(6)7)118(204)166-85(132(218)219)38-24-28-52-140/h67-93,102-107H,18-66,137-141H2,1-17H3,(H2,142,181)(H,155,196)(H,156,210)(H,157,197)(H,158,183)(H,159,182)(H,160,194)(H,161,198)(H,162,205)(H,163,209)(H,164,214)(H,165,195)(H,166,204)(H,167,199)(H,168,200)(H,169,206)(H,170,207)(H,171,211)(H,172,215)(H,173,201)(H,174,208)(H,175,212)(H,176,203)(H,177,202)(H,178,213)(H,184,185)(H,186,187)(H,188,189)(H,190,191)(H,192,193)(H,218,219)(H4,143,144,151)(H4,145,146,152)(H4,147,148,153)(H4,149,150,154)/t72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,102-,103-,104-,105-,106-,107-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149460
PNG
(US8975250, 114)
Show SMILES COc1cc(ccc1Nc1ncc2c(n1)n(CCO)c(N)c(C(N)=O)c2=O)C1CCNCC1
Show InChI InChI=1S/C22H27N7O4/c1-33-16-10-13(12-4-6-25-7-5-12)2-3-15(16)27-22-26-11-14-18(31)17(20(24)32)19(23)29(8-9-30)21(14)28-22/h2-3,10-12,25,30H,4-9,23H2,1H3,(H2,24,32)(H,26,27,28)
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n/an/a 57n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6858
PNG
(8-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Show SMILES Brc1cccc2[nH]c3c4[nH]c5ccccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C20H10BrN3O2/c21-9-5-3-7-11-13(9)14-16-15(19(25)24-20(16)26)12-8-4-1-2-6-10(8)22-17(12)18(14)23-11/h1-7,22-23H,(H,24,25,26)
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n/an/a 58n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6842
PNG
(18-methyl-5-[2-(piperidin-1-yl)ethyl]-3,13,18-tria...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCN6CCCCC6)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C28H26N4O2/c1-31-14-10-17-8-9-19-21(26(17)31)23-22(27(33)30-28(23)34)20-18-7-5-6-16(24(18)29-25(19)20)11-15-32-12-3-2-4-13-32/h5-10,14,29H,2-4,11-13,15H2,1H3,(H,30,33,34)
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n/an/a 62n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374963
PNG
(CHEMBL402428)
Show SMILES OC(=O)c1ccc(cc1)-c1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C17H13N3O2/c21-16(22)13-8-6-12(7-9-13)15-10-11-18-17(20-15)19-14-4-2-1-3-5-14/h1-11H,(H,21,22)(H,18,19,20)
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n/an/a 64n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374965
PNG
(CHEMBL255617)
Show SMILES Nc1cc(Nc2nccc(n2)-c2ccc(cc2)C(O)=O)ccn1
Show InChI InChI=1S/C16H13N5O2/c17-14-9-12(5-7-18-14)20-16-19-8-6-13(21-16)10-1-3-11(4-2-10)15(22)23/h1-9H,(H,22,23)(H3,17,18,19,20,21)
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n/an/a 66n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6837
PNG
(indolocarbazole deriv. 13a | methyl 1-(2-{18-methy...)
Show SMILES COC(=O)C1CCN(CCc2cccc3c2[nH]c2c3c3C(=O)NC(=O)c3c3c4n(C)ccc4ccc23)CC1
Show InChI InChI=1S/C30H28N4O4/c1-33-12-8-17-6-7-20-22(27(17)33)24-23(28(35)32-29(24)36)21-19-5-3-4-16(25(19)31-26(20)21)9-13-34-14-10-18(11-15-34)30(37)38-2/h3-8,12,18,31H,9-11,13-15H2,1-2H3,(H,32,35,36)
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n/an/a 81n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50361928
PNG
(CHEMBL1939162)
Show SMILES CCN1CCCC(C1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H22Cl3N5/c1-2-29-7-3-4-16(12-29)25-20-18-11-13(22)5-6-19(18)27-21(28-20)26-17-9-14(23)8-15(24)10-17/h5-6,8-11,16H,2-4,7,12H2,1H3,(H2,25,26,27,28)
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n/an/a 82n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CAMK2delta using tetramethylbenzidine as substrate by spectrophotometry analysis


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6864
PNG
(6-methyl-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0...)
Show SMILES Cc1ccc2c(c1)[nH]c1c3[nH]c4ccccc4c3c3C(=O)NC(=O)c3c21
Show InChI InChI=1S/C21H13N3O2/c1-9-6-7-11-13(8-9)23-19-15(11)17-16(20(25)24-21(17)26)14-10-4-2-3-5-12(10)22-18(14)19/h2-8,22-23H,1H3,(H,24,25,26)
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n/an/a 82n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CAMK2B


(Homo sapiens)
BDBM50363167
PNG
(CHEMBL1945559)
Show SMILES Cn1c2c(C(C#N)C3(CCNCC3)NC2=O)c2ccc(Cl)c(Cl)c12
Show InChI InChI=1S/C17H16Cl2N4O/c1-23-14-9(2-3-11(18)13(14)19)12-10(8-20)17(4-6-21-7-5-17)22-16(24)15(12)23/h2-3,10,21H,4-7H2,1H3,(H,22,24)
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n/an/a 83n/an/an/an/an/an/a



Ludwig-Maximilians University of Munich

Curated by ChEMBL


Assay Description
Inhibition of CaMK2 using ATP as substrate


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6841
PNG
(5-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl}...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCN6CCC[C@H]6CO)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C28H26N4O3/c1-31-12-9-16-7-8-19-21(26(16)31)23-22(27(34)30-28(23)35)20-18-6-2-4-15(24(18)29-25(19)20)10-13-32-11-3-5-17(32)14-33/h2,4,6-9,12,17,29,33H,3,5,10-11,13-14H2,1H3,(H,30,34,35)/t17-/m0/s1
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n/an/a 90n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6862
PNG
(6-fluoro-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0...)
Show SMILES Fc1ccc2c(c1)[nH]c1c3[nH]c4ccccc4c3c3C(=O)NC(=O)c3c21
Show InChI InChI=1S/C20H10FN3O2/c21-8-5-6-10-12(7-8)23-18-14(10)16-15(19(25)24-20(16)26)13-9-3-1-2-4-11(9)22-17(13)18/h1-7,22-23H,(H,24,25,26)
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n/an/a 92n/a 40n/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6843
PNG
(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCNCCO)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C25H22N4O3/c1-29-11-8-14-5-6-16-18(23(14)29)20-19(24(31)28-25(20)32)17-15-4-2-3-13(7-9-26-10-12-30)21(15)27-22(16)17/h2-6,8,11,26-27,30H,7,9-10,12H2,1H3,(H,28,31,32)
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n/an/a 95n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375070
PNG
(CHEMBL411724)
Show SMILES CCc1ccc2[nH]cc(C3=C(C(=O)NC3=O)n3cc(CCNC)c4ccccc34)c2c1
Show InChI InChI=1S/C25H24N4O2/c1-3-15-8-9-20-18(12-15)19(13-27-20)22-23(25(31)28-24(22)30)29-14-16(10-11-26-2)17-6-4-5-7-21(17)29/h4-9,12-14,26-27H,3,10-11H2,1-2H3,(H,28,30,31)
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n/an/a 110n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375077
PNG
(CHEMBL430412)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18N4O2/c23-10-9-13-12-26(18-8-4-2-5-14(13)18)20-19(21(27)25-22(20)28)16-11-24-17-7-3-1-6-15(16)17/h1-8,11-12,24H,9-10,23H2,(H,25,27,28)
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n/an/a 110n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374956
PNG
(CHEMBL272978)
Show SMILES NCCNc1cccc(c1)-c1ccnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5/c19-14-4-2-6-16(12-14)23-18-22-9-7-17(24-18)13-3-1-5-15(11-13)21-10-8-20/h1-7,9,11-12,21H,8,10,20H2,(H,22,23,24)
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n/an/a 110n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta-mediated vimentin phosphorylation in human HL2 cells after 1 hr by ELISA


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149456
PNG
(US8975250, 76)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(OC4CCN(C)CC4)cc3)nc12
Show InChI InChI=1S/C22H27N7O3/c1-3-29-19(23)17(20(24)31)18(30)16-12-25-22(27-21(16)29)26-13-4-6-14(7-5-13)32-15-8-10-28(2)11-9-15/h4-7,12,15H,3,8-11,23H2,1-2H3,(H2,24,31)(H,25,26,27)
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n/an/a 118n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM2672
PNG
(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25)
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n/an/a<125n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149452
PNG
(US8975250, 52)
Show SMILES CC(C)Cn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(CCN4CCOCC4)cc3)nc12
Show InChI InChI=1S/C24H31N7O3/c1-15(2)14-31-21(25)19(22(26)33)20(32)18-13-27-24(29-23(18)31)28-17-5-3-16(4-6-17)7-8-30-9-11-34-12-10-30/h3-6,13,15H,7-12,14,25H2,1-2H3,(H2,26,33)(H,27,28,29)
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n/an/a 139n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)

More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375064
PNG
(CHEMBL402152)
Show SMILES CNCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20N4O2/c1-24-11-10-14-13-27(19-9-5-3-6-15(14)19)21-20(22(28)26-23(21)29)17-12-25-18-8-4-2-7-16(17)18/h2-9,12-13,24-25H,10-11H2,1H3,(H,26,28,29)
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n/an/a 150n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50361934
PNG
(CHEMBL1939328)
Show SMILES CCCCCNc1nc(Nc2ccc(cc2)[N+]([O-])=O)nc(n1)N1CCN(CCN(C)C)CC1
Show InChI InChI=1S/C22H35N9O2/c1-4-5-6-11-23-20-25-21(24-18-7-9-19(10-8-18)31(32)33)27-22(26-20)30-16-14-29(15-17-30)13-12-28(2)3/h7-10H,4-6,11-17H2,1-3H3,(H2,23,24,25,26,27)
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n/an/a 154n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CAMK2delta using tetramethylbenzidine as substrate by spectrophotometry analysis


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375069
PNG
(CHEMBL271426)
Show SMILES COc1ccc2[nH]cc(C3=C(C(=O)NC3=O)n3cc(CCN)c4ccccc34)c2c1
Show InChI InChI=1S/C23H20N4O3/c1-30-14-6-7-18-16(10-14)17(11-25-18)20-21(23(29)26-22(20)28)27-12-13(8-9-24)15-4-2-3-5-19(15)27/h2-7,10-12,25H,8-9,24H2,1H3,(H,26,28,29)
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n/an/a 170n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374966
PNG
(CHEMBL402524)
Show SMILES C[C@H](Nc1cc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NO)ccn1)c1ccccc1
Show InChI InChI=1S/C24H22N6O2/c1-16(17-5-3-2-4-6-17)27-22-15-20(11-13-25-22)28-24-26-14-12-21(29-24)18-7-9-19(10-8-18)23(31)30-32/h2-16,32H,1H3,(H,30,31)(H2,25,26,27,28,29)/t16-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Citation and Details
More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6850
PNG
(5-[3-(diethylamino)propyl]-18-methyl-3,13,18-triaz...)
Show SMILES CCN(CC)CCCc1cccc2c1[nH]c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12
Show InChI InChI=1S/C28H28N4O2/c1-4-32(5-2)14-7-9-16-8-6-10-18-20-22-23(28(34)30-27(22)33)21-19(25(20)29-24(16)18)12-11-17-13-15-31(3)26(17)21/h6,8,10-13,15,29H,4-5,7,9,14H2,1-3H3,(H,30,33,34)
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n/an/a 174n/an/an/an/a7.522



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Citation and Details
More data for this
Ligand-Target Pair
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