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Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Calcium-independent phospholipase A2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-independent phospholipase A2


(Homo sapiens)
BDBM50046270
PNG
((E)-6-Iodomethylene-3-naphthalen-1-yl-tetrahydro-p...)
Show SMILES I\C=C1/CCC(C(=O)O1)c1cccc2ccccc12
Show InChI InChI=1S/C16H13IO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+
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n/an/a 30n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2 .


J Med Chem 36: 95-100 (1993)

More data for this
Ligand-Target Pair
Calcium-independent phospholipase A2


(Homo sapiens)
BDBM50046271
PNG
((E)-3-(naphthalen-1-yl)-6-(prop-2-yn-1-ylidene)tet...)
Show SMILES O=C1O\C(CCC1c1cccc2ccccc12)=C\C#C
Show InChI InChI=1S/C18H14O2/c1-2-6-14-11-12-17(18(19)20-14)16-10-5-8-13-7-3-4-9-15(13)16/h1,3-10,17H,11-12H2/b14-6+
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n/an/a 95n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2 .


J Med Chem 36: 95-100 (1993)

More data for this
Ligand-Target Pair
Calcium-independent phospholipase A2


(Homo sapiens)
BDBM50046268
PNG
(6-Bromomethylene-3-naphthalen-1-yl-tetrahydro-pyra...)
Show SMILES Br\C=C1/CCC(C(=O)O1)c1cccc2ccccc12
Show InChI InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+
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PubMed
n/an/a>100n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2 .


J Med Chem 36: 95-100 (1993)

More data for this
Ligand-Target Pair
Calcium-independent phospholipase A2


(Homo sapiens)
BDBM50046268
PNG
(6-Bromomethylene-3-naphthalen-1-yl-tetrahydro-pyra...)
Show SMILES Br\C=C1/CCC(C(=O)O1)c1cccc2ccccc12
Show InChI InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+
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CHEMBL
PC cid
PC sid
UniChem

Patents


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PubMed
n/an/a 140n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2 .


J Med Chem 36: 95-100 (1993)

More data for this
Ligand-Target Pair
Calcium-independent phospholipase A2


(Homo sapiens)
BDBM50046269
PNG
((Z)-6-(iodomethylene)-3-(naphthalen-1-yl)tetrahydr...)
Show SMILES I\C=C1\CCC(C(=O)O1)c1cccc2ccccc12
Show InChI InChI=1S/C16H13IO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10-
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PC sid
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PubMed
n/an/a 190n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2 .


J Med Chem 36: 95-100 (1993)

More data for this
Ligand-Target Pair
Patatin-like phospholipase domain-containing protein 2


(Homo sapiens)
BDBM50185419
PNG
(CHEMBL3823931)
Show SMILES CN(C)C(=O)Nc1cccc(c1)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
UniProtKB/TrEMBL

GoogleScholar
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PC cid
PC sid
UniChem

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PubMed
n/an/a 700n/an/an/an/an/an/a



Universit£ de Moncton

Curated by ChEMBL


Assay Description
Inhibition of ATGL (unknown origin) overexpressed in Escherichia coli XL-1 cells using [9,10-3H(N)]triolein as substrate incubated for 60 mins by liq...


Eur J Med Chem 118: 290-8 (2016)

More data for this
Ligand-Target Pair