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Compile Data Set for Download or QSAR

Found 100 hits Enz. Inhib. hit(s) with Target = 'Calpain 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179750
PNG
((S)-2-((S)-2-(benzyloxycarbonyl)-4-methylpentanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H30N2O5/c1-13(2)10-16(18(23)21-17(19(24)25)11-14(3)4)22-20(26)27-12-15-8-6-5-7-9-15/h5-9,13-14,16-17H,10-12H2,1-4H3,(H,21,23)(H,22,26)(H,24,25)/t16-,17-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50114340
PNG
((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C)C=O
Show InChI InChI=1S/C17H25FN2O4S/c1-11(2)9-14(10-21)19-17(22)16(12(3)4)20-25(23,24)15-7-5-13(18)6-8-15/h5-8,10-12,14,16,20H,9H2,1-4H3,(H,19,22)/t14-,16-/m0/s1
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n/an/a 7.5n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179749
PNG
((S)-2-(2-(2-(10H-phenothiazin-2-yloxy)acetamido)ac...)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C26H32N4O6S/c1-15(2)11-20(25(33)30-18-9-10-35-26(18)34)29-23(31)13-27-24(32)14-36-16-7-8-22-19(12-16)28-17-5-3-4-6-21(17)37-22/h3-8,12,15,18,20,26,28,34H,9-11,13-14H2,1-2H3,(H,27,32)(H,29,31)(H,30,33)/t18-,20-,26?/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358131
PNG
(CHEMBL1923954)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)C(C)C)C=O
Show InChI InChI=1S/C21H28N2O4S/c1-14(2)11-18(13-24)22-21(25)20(15(3)4)23-28(26,27)19-10-9-16-7-5-6-8-17(16)12-19/h5-10,12-15,18,20,23H,11H2,1-4H3,(H,22,25)/t18-,20-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358138
PNG
(CHEMBL1923961)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C22H24ClN3O4S/c1-14(2)21(26-31(29,30)18-9-7-16(23)8-10-18)22(28)25-17(13-27)11-15-12-24-20-6-4-3-5-19(15)20/h3-10,12-14,17,21,24,26H,11H2,1-2H3,(H,25,28)/t17-,21-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358137
PNG
(CHEMBL1923960)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C20H23ClN2O4S/c1-14(2)19(23-28(26,27)18-10-8-16(21)9-11-18)20(25)22-17(13-24)12-15-6-4-3-5-7-15/h3-11,13-14,17,19,23H,12H2,1-2H3,(H,22,25)/t17-,19-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358132
PNG
(CHEMBL1923955)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C24H26N2O4S/c1-17(2)23(24(28)25-21(16-27)14-18-8-4-3-5-9-18)26-31(29,30)22-13-12-19-10-6-7-11-20(19)15-22/h3-13,15-17,21,23,26H,14H2,1-2H3,(H,25,28)/t21-,23-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358140
PNG
(CHEMBL1923963)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(C)cc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C21H26N2O4S/c1-15(2)20(23-28(26,27)19-11-9-16(3)10-12-19)21(25)22-18(14-24)13-17-7-5-4-6-8-17/h4-12,14-15,18,20,23H,13H2,1-3H3,(H,22,25)/t18-,20-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286446
PNG
(CHEMBL341222 | {(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-...)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O
Show InChI InChI=1S/C23H28N2O5/c1-16(2)12-21(25-23(29)30-15-18-6-4-3-5-7-18)22(28)24-19(14-26)13-17-8-10-20(27)11-9-17/h3-11,14,16,19,21,27H,12-13,15H2,1-2H3,(H,24,28)(H,25,29)/t19-,21-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358134
PNG
(CHEMBL1923957)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C22H24FN3O4S/c1-14(2)21(26-31(29,30)18-9-7-16(23)8-10-18)22(28)25-17(13-27)11-15-12-24-20-6-4-3-5-19(15)20/h3-10,12-14,17,21,24,26H,11H2,1-2H3,(H,25,28)/t17-,21-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179745
PNG
((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C27H34N4O6S/c1-15(2)12-21(26(34)30-19-10-11-36-27(19)35)31-25(33)16(3)28-24(32)14-37-17-8-9-23-20(13-17)29-18-6-4-5-7-22(18)38-23/h4-9,13,15-16,19,21,27,29,35H,10-12,14H2,1-3H3,(H,28,32)(H,30,34)(H,31,33)/t16-,19-,21-,27?/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286452
PNG
(CHEMBL340020 | {(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-...)
Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O
Show InChI InChI=1S/C22H26N2O5/c1-15(2)20(24-22(28)29-14-17-6-4-3-5-7-17)21(27)23-18(13-25)12-16-8-10-19(26)11-9-16/h3-11,13,15,18,20,26H,12,14H2,1-2H3,(H,23,27)(H,24,28)/t18-,20-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358133
PNG
(CHEMBL1923956)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C20H23FN2O4S/c1-14(2)19(23-28(26,27)18-10-8-16(21)9-11-18)20(25)22-17(13-24)12-15-6-4-3-5-7-15/h3-11,13-14,17,19,23H,12H2,1-2H3,(H,22,25)/t17-,19-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358139
PNG
(CHEMBL1923962)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(C)cc1)C(C)C)C=O
Show InChI InChI=1S/C18H28N2O4S/c1-12(2)10-15(11-21)19-18(22)17(13(3)4)20-25(23,24)16-8-6-14(5)7-9-16/h6-9,11-13,15,17,20H,10H2,1-5H3,(H,19,22)/t15-,17-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286449
PNG
(CHEMBL338859 | {(S)-1-[(S)-1-(4-Methoxy-benzyl)-2-...)
Show SMILES COc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C)C=O)cc1
Show InChI InChI=1S/C23H28N2O5/c1-16(2)21(25-23(28)30-15-18-7-5-4-6-8-18)22(27)24-19(14-26)13-17-9-11-20(29-3)12-10-17/h4-12,14,16,19,21H,13,15H2,1-3H3,(H,24,27)(H,25,28)/t19-,21-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358136
PNG
(CHEMBL1923959)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)C(C)C)C=O
Show InChI InChI=1S/C17H25ClN2O4S/c1-11(2)9-14(10-21)19-17(22)16(12(3)4)20-25(23,24)15-7-5-13(18)6-8-15/h5-8,10-12,14,16,20H,9H2,1-4H3,(H,19,22)/t14-,16-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50137397
PNG
(CHEMBL341014 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C23H28N2O4/c1-17(2)13-21(25-23(28)29-16-19-11-7-4-8-12-19)22(27)24-20(15-26)14-18-9-5-3-6-10-18/h3-12,15,17,20-21H,13-14,16H2,1-2H3,(H,24,27)(H,25,28)/t20-,21-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179747
PNG
((S)-2-((2S,3S)-2-(2-(10H-phenothiazin-2-yloxy)acet...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(C)O)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C28H36N4O7S/c1-15(2)12-21(26(35)30-19-10-11-38-28(19)37)31-27(36)25(16(3)33)32-24(34)14-39-17-8-9-23-20(13-17)29-18-6-4-5-7-22(18)40-23/h4-9,13,15-16,19,21,25,28-29,33,37H,10-12,14H2,1-3H3,(H,30,35)(H,31,36)(H,32,34)/t16?,19-,21-,25-,28?/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50014577
PNG
(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50073850
PNG
((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O
Show InChI InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179743
PNG
((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C27H34N4O7S/c1-15(2)11-20(25(34)30-18-9-10-37-27(18)36)31-26(35)21(13-32)29-24(33)14-38-16-7-8-23-19(12-16)28-17-5-3-4-6-22(17)39-23/h3-8,12,15,18,20-21,27-28,32,36H,9-11,13-14H2,1-2H3,(H,29,33)(H,30,34)(H,31,35)/t18-,20-,21-,27?/m0/s1
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n/an/a 48.7n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286453
PNG
(CHEMBL419423 | {(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-...)
Show SMILES CCC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O
Show InChI InChI=1S/C23H28N2O5/c1-3-16(2)21(25-23(29)30-15-18-7-5-4-6-8-18)22(28)24-19(14-26)13-17-9-11-20(27)12-10-17/h4-12,14,16,19,21,27H,3,13,15H2,1-2H3,(H,24,28)(H,25,29)/t16?,19-,21-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179744
PNG
((S)-4-Methyl-2-[(S)-4-methyl-2-(2-10H-phenothiazin...)
Show SMILES CC(C)C[C@H](NC(=O)Cc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C30H40N4O5S/c1-17(2)13-23(28(36)34-24(14-18(3)4)29(37)33-21-11-12-39-30(21)38)32-27(35)16-19-9-10-26-22(15-19)31-20-7-5-6-8-25(20)40-26/h5-10,15,17-18,21,23-24,30-31,38H,11-14,16H2,1-4H3,(H,32,35)(H,33,37)(H,34,36)/t21-,23-,24-,30?/m0/s1
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n/an/a 55.4n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179741
PNG
((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(C)C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C29H38N4O6S/c1-16(2)13-22(27(35)31-20-11-12-38-29(20)37)32-28(36)26(17(3)4)33-25(34)15-39-18-9-10-24-21(14-18)30-19-7-5-6-8-23(19)40-24/h5-10,14,16-17,20,22,26,29-30,37H,11-13,15H2,1-4H3,(H,31,35)(H,32,36)(H,33,34)/t20-,22-,26-,29?/m0/s1
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n/an/a 75.9n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179738
PNG
(CHEMBL203244 | N-((S)-1-((S)-1-((3S)-2-hydroxy-tet...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)c1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C29H38N4O5S/c1-16(2)13-22(28(36)33-23(14-17(3)4)27(35)31-20-11-12-38-29(20)37)32-26(34)18-9-10-25-21(15-18)30-19-7-5-6-8-24(19)39-25/h5-10,15-17,20,22-23,29-30,37H,11-14H2,1-4H3,(H,31,35)(H,32,34)(H,33,36)/t20-,22-,23-,29?/m0/s1
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n/an/a 85.5n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179746
PNG
((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Show SMILES CC[C@H](NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C28H36N4O6S/c1-4-18(26(34)32-22(13-16(2)3)27(35)31-20-11-12-37-28(20)36)30-25(33)15-38-17-9-10-24-21(14-17)29-19-7-5-6-8-23(19)39-24/h5-10,14,16,18,20,22,28-29,36H,4,11-13,15H2,1-3H3,(H,30,33)(H,31,35)(H,32,34)/t18-,20-,22-,28?/m0/s1
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n/an/a 88.6n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286445
PNG
(CHEMBL127613 | [((S)-1-Benzyl-2-oxo-ethylcarbamoyl...)
Show SMILES O=C[C@H](Cc1ccccc1)NC(=O)C(NC(=O)OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H24N2O4/c28-17-22(16-19-10-4-1-5-11-19)26-24(29)23(21-14-8-3-9-15-21)27-25(30)31-18-20-12-6-2-7-13-20/h1-15,17,22-23H,16,18H2,(H,26,29)(H,27,30)/t22-,23?/m0/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286454
PNG
(CHEMBL129657 | [(S)-1-((S)-1-Formyl-2-naphthalen-1...)
Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cccc2ccccc12)C=O
Show InChI InChI=1S/C26H28N2O4/c1-18(2)24(28-26(31)32-17-19-9-4-3-5-10-19)25(30)27-22(16-29)15-21-13-8-12-20-11-6-7-14-23(20)21/h3-14,16,18,22,24H,15,17H2,1-2H3,(H,27,30)(H,28,31)/t22-,24-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286455
PNG
(CHEMBL128775 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Show SMILES CC(C)(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C24H30N2O4/c1-24(2,3)15-21(26-23(29)30-17-19-12-8-5-9-13-19)22(28)25-20(16-27)14-18-10-6-4-7-11-18/h4-13,16,20-21H,14-15,17H2,1-3H3,(H,25,28)(H,26,29)/t20-,21-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286444
PNG
(CHEMBL339000 | [(S)-1-((S)-1-Formyl-3-phenyl-propy...)
Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)C=O
Show InChI InChI=1S/C23H28N2O4/c1-17(2)21(25-23(28)29-16-19-11-7-4-8-12-19)22(27)24-20(15-26)14-13-18-9-5-3-6-10-18/h3-12,15,17,20-21H,13-14,16H2,1-2H3,(H,24,27)(H,25,28)/t20-,21-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179739
PNG
((S)-4-Methyl-2-{(S)-4-methyl-2-[2-(10H-phenothiazi...)
Show SMILES CC(C)C[C@H](NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C30H40N4O6S/c1-17(2)13-23(28(36)34-24(14-18(3)4)29(37)33-21-11-12-39-30(21)38)32-27(35)16-40-19-9-10-26-22(15-19)31-20-7-5-6-8-25(20)41-26/h5-10,15,17-18,21,23-24,30-31,38H,11-14,16H2,1-4H3,(H,32,35)(H,33,37)(H,34,36)/t21-,23-,24-,30?/m0/s1
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n/an/a 105n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358142
PNG
(CHEMBL1923965)
Show SMILES CCC[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](CC(C)C)C=O
Show InChI InChI=1S/C17H25FN2O4S/c1-4-5-16(17(22)19-14(11-21)10-12(2)3)20-25(23,24)15-8-6-13(18)7-9-15/h6-9,11-12,14,16,20H,4-5,10H2,1-3H3,(H,19,22)/t14-,16-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179754
PNG
((S)-2-(2-(2-(10H-phenothiazin-2-yloxy)acetamido)-2...)
Show SMILES CC(C)C[C@H](NC(=O)C(C)(C)NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C28H36N4O6S/c1-16(2)13-21(25(34)30-19-11-12-37-26(19)35)31-27(36)28(3,4)32-24(33)15-38-17-9-10-23-20(14-17)29-18-7-5-6-8-22(18)39-23/h5-10,14,16,19,21,26,29,35H,11-13,15H2,1-4H3,(H,30,34)(H,31,36)(H,32,33)/t19-,21-,26?/m0/s1
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n/an/a 138n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286443
PNG
(CHEMBL128776 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Show SMILES C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C20H22N2O4/c1-15(21-20(25)26-14-17-10-6-3-7-11-17)19(24)22-18(13-23)12-16-8-4-2-5-9-16/h2-11,13,15,18H,12,14H2,1H3,(H,21,25)(H,22,24)/t15-,18-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179748
PNG
((S)-4-methyl-2-[(S)-4-methyl-2-(3-10H-phenothiazin...)
Show SMILES CC(C)C[C@H](NC(=O)CCc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C31H42N4O5S/c1-18(2)15-24(29(37)35-25(16-19(3)4)30(38)34-22-13-14-40-31(22)39)33-28(36)12-10-20-9-11-27-23(17-20)32-21-7-5-6-8-26(21)41-27/h5-9,11,17-19,22,24-25,31-32,39H,10,12-16H2,1-4H3,(H,33,36)(H,34,38)(H,35,37)/t22-,24-,25-,31?/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179753
PNG
((S)-4-Methyl-2-{(S)-2-[2-(10H-phenothiazin-2-yloxy...)
Show SMILES CCC[C@H](NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C29H38N4O6S/c1-4-7-20(27(35)33-23(14-17(2)3)28(36)32-21-12-13-38-29(21)37)31-26(34)16-39-18-10-11-25-22(15-18)30-19-8-5-6-9-24(19)40-25/h5-6,8-11,15,17,20-21,23,29-30,37H,4,7,12-14,16H2,1-3H3,(H,31,34)(H,32,36)(H,33,35)/t20-,21-,23-,29?/m0/s1
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n/an/a 151n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179740
PNG
((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)COc1ccc2Sc3ccccc3Nc2c1)c1ccccc1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C32H36N4O6S/c1-19(2)16-25(30(38)34-23-14-15-41-32(23)40)35-31(39)29(20-8-4-3-5-9-20)36-28(37)18-42-21-12-13-27-24(17-21)33-22-10-6-7-11-26(22)43-27/h3-13,17,19,23,25,29,32-33,40H,14-16,18H2,1-2H3,(H,34,38)(H,35,39)(H,36,37)/t23-,25-,29-,32?/m0/s1
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n/an/a 222n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358143
PNG
(CHEMBL1923966)
Show SMILES CCCC[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](CC(C)C)C=O
Show InChI InChI=1S/C18H27FN2O4S/c1-4-5-6-17(18(23)20-15(12-22)11-13(2)3)21-26(24,25)16-9-7-14(19)8-10-16/h7-10,12-13,15,17,21H,4-6,11H2,1-3H3,(H,20,23)/t15-,17-/m0/s1
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n/an/a 260n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286456
PNG
(CHEMBL129458 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Show SMILES O=C[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H28N2O4/c30-19-24(18-22-12-6-2-7-13-22)28-26(31)25(17-16-21-10-4-1-5-11-21)29-27(32)33-20-23-14-8-3-9-15-23/h1-15,19,24-25H,16-18,20H2,(H,28,31)(H,29,32)/t24-,25-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179751
PNG
((S)-2-((S)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(C)(C)C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C30H40N4O6S/c1-17(2)14-22(27(36)32-20-12-13-39-29(20)38)33-28(37)26(30(3,4)5)34-25(35)16-40-18-10-11-24-21(15-18)31-19-8-6-7-9-23(19)41-24/h6-11,15,17,20,22,26,29,31,38H,12-14,16H2,1-5H3,(H,32,36)(H,33,37)(H,34,35)/t20-,22-,26+,29?/m0/s1
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n/an/a 354n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286450
PNG
(CHEMBL128135 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Show SMILES O=C[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C26H26N2O4/c29-18-23(16-20-10-4-1-5-11-20)27-25(30)24(17-21-12-6-2-7-13-21)28-26(31)32-19-22-14-8-3-9-15-22/h1-15,18,23-24H,16-17,19H2,(H,27,30)(H,28,31)/t23-,24-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286451
PNG
(CHEMBL129823 | [1-((S)-1-Benzyl-2-oxo-ethylcarbamo...)
Show SMILES CC(C)(C)C(NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C23H28N2O4/c1-23(2,3)20(25-22(28)29-16-18-12-8-5-9-13-18)21(27)24-19(15-26)14-17-10-6-4-7-11-17/h4-13,15,19-20H,14,16H2,1-3H3,(H,24,27)(H,25,28)/t19-,20?/m0/s1
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179752
PNG
((S)-2-((R)-2-(2-(10H-phenothiazin-2-yloxy)acetamid...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](NC(=O)COc1ccc2Sc3ccccc3Nc2c1)C(C)C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C29H38N4O6S/c1-16(2)13-22(27(35)31-20-11-12-38-29(20)37)32-28(36)26(17(3)4)33-25(34)15-39-18-9-10-24-21(14-18)30-19-7-5-6-8-23(19)40-24/h5-10,14,16-17,20,22,26,29-30,37H,11-13,15H2,1-4H3,(H,31,35)(H,32,36)(H,33,34)/t20-,22-,26+,29?/m0/s1
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n/an/a 553n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358135
PNG
(CHEMBL1923958)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](C)C=O
Show InChI InChI=1S/C14H19FN2O4S/c1-9(2)13(14(19)16-10(3)8-18)17-22(20,21)12-6-4-11(15)5-7-12/h4-10,13,17H,1-3H3,(H,16,19)/t10-,13-/m0/s1
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n/an/a 630n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50358141
PNG
(CHEMBL1923964)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NS(C)(=O)=O)C(C)C)C=O
Show InChI InChI=1S/C12H24N2O4S/c1-8(2)6-10(7-15)13-12(16)11(9(3)4)14-19(5,17)18/h7-11,14H,6H2,1-5H3,(H,13,16)/t10-,11-/m0/s1
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n/an/a 830n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50179742
PNG
((3S)-3-((S)-4-methyl-2-((S)-4-methyl-2-(10H-phenot...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)c1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@H]1CCOC1OC(C)=O
Show InChI InChI=1S/C31H40N4O6S/c1-17(2)14-24(34-28(37)20-10-11-27-23(16-20)32-21-8-6-7-9-26(21)42-27)30(39)35-25(15-18(3)4)29(38)33-22-12-13-40-31(22)41-19(5)36/h6-11,16-18,22,24-25,31-32H,12-15H2,1-5H3,(H,33,38)(H,34,37)(H,35,39)/t22-,24-,25-,31?/m0/s1
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n/an/a 905n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286447
PNG
(CHEMBL2370670 | [1-(2-Formyl-pyrrolidine-1-carbony...)
Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C=O
Show InChI InChI=1S/C18H24N2O4/c1-13(2)16(17(22)20-10-6-9-15(20)11-21)19-18(23)24-12-14-7-4-3-5-8-14/h3-5,7-8,11,13,15-16H,6,9-10,12H2,1-2H3,(H,19,23)/t15-,16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50286448
PNG
(CHEMBL127663 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Show SMILES O=C[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C30H28N2O4/c33-20-26(18-22-10-3-1-4-11-22)31-29(34)28(32-30(35)36-21-23-12-5-2-6-13-23)19-25-16-9-15-24-14-7-8-17-27(24)25/h1-17,20,26,28H,18-19,21H2,(H,31,34)(H,32,35)/t26-,28-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay


Citation and Details
More data for this
Ligand-Target Pair
Calpain 1/small subunit 1


(Homo sapiens-Homo sapiens (Human))
BDBM50069792
PNG
((2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-N-[(...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C=O
Show InChI InChI=1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



CV Therapeutics Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Calpain I


Bioorg Med Chem Lett 8: 209-14 (1999)

More data for this
Ligand-Target Pair
Calpain 1


(Rattus norvegicus)
BDBM50124010
PNG
(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C)C=O
Show InChI InChI=1S/C17H25FN2O4S/c1-11(2)9-14(10-21)19-17(22)16(12(3)4)20-25(23,24)15-7-5-13(18)6-8-15/h5-8,10-12,14,16,20H,9H2,1-4H3,(H,19,22)/t14-,16+/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
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