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Compile Data Set for Download or QSAR

Found 31 hits Enz. Inhib. hit(s) with Target = 'Carboxypeptidase N, catalytic subunit'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201438
PNG
((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Show SMILES NC(N)=NCCCC(CS)C(O)=O
Show InChI InChI=1S/C7H15N3O2S/c8-7(9)10-3-1-2-5(4-13)6(11)12/h5,13H,1-4H2,(H,11,12)(H4,8,9,10)
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n/an/a 2n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201439
PNG
(2-(2-chloro-5-guanidinophenyl)-3-mercaptopropanoic...)
Show SMILES NC(N)=Nc1ccc(Cl)c(c1)C(CS)C(O)=O
Show InChI InChI=1S/C10H12ClN3O2S/c11-8-2-1-5(14-10(12)13)3-6(8)7(4-17)9(15)16/h1-3,7,17H,4H2,(H,15,16)(H4,12,13,14)
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n/an/a 7n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201427
PNG
(2-(3-guanidinophenyl)-3-mercaptopropanoic acid | C...)
Show SMILES NC(N)=Nc1cccc(c1)C(CS)C(O)=O
Show InChI InChI=1S/C10H13N3O2S/c11-10(12)13-7-3-1-2-6(4-7)8(5-16)9(14)15/h1-4,8,16H,5H2,(H,14,15)(H4,11,12,13)
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n/an/a 8n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201427
PNG
(2-(3-guanidinophenyl)-3-mercaptopropanoic acid | C...)
Show SMILES NC(N)=Nc1cccc(c1)C(CS)C(O)=O
Show InChI InChI=1S/C10H13N3O2S/c11-10(12)13-7-3-1-2-6(4-7)8(5-16)9(14)15/h1-4,8,16H,5H2,(H,14,15)(H4,11,12,13)
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n/an/a 8n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201429
PNG
(2-(1-carbamimidoylpiperidin-3-yl)-3-mercaptopropan...)
Show SMILES NC(=N)N1CCCC(C1)C(CS)C(O)=O
Show InChI InChI=1S/C9H17N3O2S/c10-9(11)12-3-1-2-6(4-12)7(5-15)8(13)14/h6-7,15H,1-5H2,(H3,10,11)(H,13,14)
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n/an/a 58n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201429
PNG
(2-(1-carbamimidoylpiperidin-3-yl)-3-mercaptopropan...)
Show SMILES NC(=N)N1CCCC(C1)C(CS)C(O)=O
Show InChI InChI=1S/C9H17N3O2S/c10-9(11)12-3-1-2-6(4-12)7(5-15)8(13)14/h6-7,15H,1-5H2,(H3,10,11)(H,13,14)
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n/an/a 58n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201428
PNG
(3-mercapto-2-(piperidin-4-yl)propanoic acid | CHEM...)
Show SMILES OC(=O)C(CS)C1CCNCC1
Show InChI InChI=1S/C8H15NO2S/c10-8(11)7(5-12)6-1-3-9-4-2-6/h6-7,9,12H,1-5H2,(H,10,11)
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n/an/a 60n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201435
PNG
(2-(mercaptomethyl)-3-(piperidin-4-yl)propanoic aci...)
Show SMILES OC(=O)C(CS)CC1CCNCC1
Show InChI InChI=1S/C9H17NO2S/c11-9(12)8(6-13)5-7-1-3-10-4-2-7/h7-8,10,13H,1-6H2,(H,11,12)
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n/an/a 61n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201431
PNG
(2-(3-aminophenyl)-3-mercaptopropanoic acid | CHEMB...)
Show SMILES Nc1cccc(c1)C(CS)C(O)=O
Show InChI InChI=1S/C9H11NO2S/c10-7-3-1-2-6(4-7)8(5-13)9(11)12/h1-4,8,13H,5,10H2,(H,11,12)
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n/an/a 357n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201437
PNG
(2-(mercaptomethyl)-3-(piperidin-3-yl)propanoic aci...)
Show SMILES OC(=O)C(CS)CC1CCCNC1
Show InChI InChI=1S/C9H17NO2S/c11-9(12)8(6-13)4-7-2-1-3-10-5-7/h7-8,10,13H,1-6H2,(H,11,12)
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n/an/a 420n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201437
PNG
(2-(mercaptomethyl)-3-(piperidin-3-yl)propanoic aci...)
Show SMILES OC(=O)C(CS)CC1CCCNC1
Show InChI InChI=1S/C9H17NO2S/c11-9(12)8(6-13)4-7-2-1-3-10-5-7/h7-8,10,13H,1-6H2,(H,11,12)
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n/an/a 420n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201430
PNG
(2-(4-carbamimidoylphenyl)-3-mercaptopropanoic acid...)
Show SMILES NC(=N)c1ccc(cc1)C(CS)C(O)=O
Show InChI InChI=1S/C10H12N2O2S/c11-9(12)7-3-1-6(2-4-7)8(5-15)10(13)14/h1-4,8,15H,5H2,(H3,11,12)(H,13,14)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50089687
PNG
(ANABAENOPEPTIN F | Anabaenopeptin F)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C(=O)[C@H](CCc2ccc(O)cc2)NC1=O)NC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1/C42H62N10O9/c1-5-25(2)34-38(57)47-31(21-18-27-16-19-29(53)20-17-27)39(58)52(4)26(3)35(54)48-33(24-28-12-7-6-8-13-28)36(55)45-22-10-9-14-30(37(56)51-34)49-42(61)50-32(40(59)60)15-11-23-46-41(43)44/h6-8,12-13,16-17,19-20,25-26,30-34,53H,5,9-11,14-15,18,21-24H2,1-4H3,(H,45,55)(H,47,57)(H,48,54)(H,51,56)(H,59,60)(H4,43,44,46)(H2,49,50,61)/t25-,26-,30+,31-,32-,33-,34-/s2
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n/an/a 2.70E+3n/an/an/an/an/an/a



Institute for Infection Research

Curated by ChEMBL


Assay Description
Inhibition of CPN (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201433
PNG
(2-(1-carbamimidoylpiperidin-4-yl)-3-mercaptopropan...)
Show SMILES NC(=N)N1CCC(CC1)C(CS)C(O)=O
Show InChI InChI=1S/C9H17N3O2S/c10-9(11)12-3-1-6(2-4-12)7(5-15)8(13)14/h6-7,15H,1-5H2,(H3,10,11)(H,13,14)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201436
PNG
(2-(1-(2-aminoacetyl)piperidin-4-yl)-3-mercaptoprop...)
Show SMILES NCC(=O)N1CCC(CC1)C(CS)C(O)=O
Show InChI InChI=1S/C10H18N2O3S/c11-5-9(13)12-3-1-7(2-4-12)8(6-16)10(14)15/h7-8,16H,1-6,11H2,(H,14,15)
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n/an/a 4.95E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50089688
PNG
(ANABAENOPEPTIN B)
Show SMILES CC(C)[C@@H]1NC(=O)[C@@H](CCCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C(=O)[C@H](CCc2ccc(O)cc2)NC1=O)NC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1/C41H60N10O9/c1-24(2)33-37(56)46-30(20-17-26-15-18-28(52)19-16-26)38(57)51(4)25(3)34(53)47-32(23-27-11-6-5-7-12-27)35(54)44-21-9-8-13-29(36(55)50-33)48-41(60)49-31(39(58)59)14-10-22-45-40(42)43/h5-7,11-12,15-16,18-19,24-25,29-33,52H,8-10,13-14,17,20-23H2,1-4H3,(H,44,54)(H,46,56)(H,47,53)(H,50,55)(H,58,59)(H4,42,43,45)(H2,48,49,60)/t25-,29+,30-,31-,32-,33-/s2
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n/an/a 5.40E+3n/an/an/an/an/an/a



Institute for Infection Research

Curated by ChEMBL


Assay Description
Inhibition of CPN (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50089686
PNG
(CHEMBL3577334)
Show SMILES CC(C)[C@@H]1NC(=O)[C@@H](CCCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C(=O)[C@H](CCc2ccc(O)cc2)NC1=O)NC(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1/C41H60N8O9/c1-25(2)34-38(54)44-31(21-18-27-16-19-29(50)20-17-27)39(55)49(4)26(3)35(51)45-33(24-28-12-6-5-7-13-28)36(52)43-23-11-9-14-30(37(53)48-34)46-41(58)47-32(40(56)57)15-8-10-22-42/h5-7,12-13,16-17,19-20,25-26,30-34,50H,8-11,14-15,18,21-24,42H2,1-4H3,(H,43,52)(H,44,54)(H,45,51)(H,48,53)(H,56,57)(H2,46,47,58)/t26-,30+,31-,32-,33-,34-/s2
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n/an/a 5.70E+3n/an/an/an/an/an/a



Institute for Infection Research

Curated by ChEMBL


Assay Description
Inhibition of CPN (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201434
PNG
(3-mercapto-2-(piperidin-3-yl)propanoic acid | CHEM...)
Show SMILES OC(=O)C(CS)C1CCCNC1
Show InChI InChI=1S/C8H15NO2S/c10-8(11)7(5-12)6-2-1-3-9-4-6/h6-7,9,12H,1-5H2,(H,10,11)
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n/an/a 2.35E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201434
PNG
(3-mercapto-2-(piperidin-3-yl)propanoic acid | CHEM...)
Show SMILES OC(=O)C(CS)C1CCCNC1
Show InChI InChI=1S/C8H15NO2S/c10-8(11)7(5-12)6-2-1-3-9-4-6/h6-7,9,12H,1-5H2,(H,10,11)
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n/an/a 2.35E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201432
PNG
(2-(1-(1-iminoethyl)piperidin-4-yl)-3-mercaptopropa...)
Show SMILES CC(=N)N1CCC(CC1)C(CS)C(O)=O
Show InChI InChI=1S/C10H18N2O2S/c1-7(11)12-4-2-8(3-5-12)9(6-15)10(13)14/h8-9,11,15H,2-6H2,1H3,(H,13,14)
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n/an/a 2.90E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008279
PNG
(CHEMBL3235140)
Show SMILES Cl.NCCC[C@]1(CCn2c(C1)ncc2-c1cccc(c1)-c1ccc(Cl)cc1Cl)C(O)=O
Show InChI InChI=1S/C23H23Cl2N3O2.ClH/c24-17-5-6-18(19(25)12-17)15-3-1-4-16(11-15)20-14-27-21-13-23(22(29)30,7-2-9-26)8-10-28(20)21;/h1,3-6,11-12,14H,2,7-10,13,26H2,(H,29,30);1H/t23-;/m1./s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008278
PNG
(CHEMBL3235139)
Show SMILES NCCC[C@]1(CCn2c(C1)ncc2-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H21N3O2/c18-9-4-7-17(16(21)22)8-10-20-14(12-19-15(20)11-17)13-5-2-1-3-6-13/h1-3,5-6,12H,4,7-11,18H2,(H,21,22)/t17-/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008276
PNG
(CHEMBL3235137)
Show SMILES NCCCC1(CCc2c(C1)ncn2-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H21N3O2/c18-10-4-8-17(16(21)22)9-7-15-14(11-17)19-12-20(15)13-5-2-1-3-6-13/h1-3,5-6,12H,4,7-11,18H2,(H,21,22)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008275
PNG
(CHEMBL3235136)
Show SMILES NCCCC1(CCc2c(C1)ncn2CCC1CCC(CC1)C1CCCCC1)C(O)=O
Show InChI InChI=1S/C25H41N3O2/c26-15-4-13-25(24(29)30)14-11-23-22(17-25)27-18-28(23)16-12-19-7-9-21(10-8-19)20-5-2-1-3-6-20/h18-21H,1-17,26H2,(H,29,30)
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n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008274
PNG
(CHEMBL3235135)
Show SMILES NCCC[C@]1(CCc2c(C1)ncn2Cc1cccc(c1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H27N3O2/c25-13-5-11-24(23(28)29)12-10-22-21(15-24)26-17-27(22)16-18-6-4-9-20(14-18)19-7-2-1-3-8-19/h1-4,6-9,14,17H,5,10-13,15-16,25H2,(H,28,29)/t24-/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008273
PNG
(CHEMBL3235134)
Show SMILES NCCC[C@]1(CCc2c(C1)ncn2C1CCCCC1)C(O)=O
Show InChI InChI=1S/C17H27N3O2/c18-10-4-8-17(16(21)22)9-7-15-14(11-17)19-12-20(15)13-5-2-1-3-6-13/h12-13H,1-11,18H2,(H,21,22)/t17-/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008272
PNG
(CHEMBL3235133)
Show SMILES Cl.CC(C)CCn1cnc2C[C@@](CCCN)(CCc12)C(O)=O
Show InChI InChI=1S/C16H27N3O2.ClH/c1-12(2)5-9-19-11-18-13-10-16(15(20)21,6-3-8-17)7-4-14(13)19;/h11-12H,3-10,17H2,1-2H3,(H,20,21);1H/t16-;/m1./s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008271
PNG
(CHEMBL3235132)
Show SMILES CCCn1cnc2C[C@@](CCCN)(CCc12)C(O)=O
Show InChI InChI=1S/C14H23N3O2/c1-2-8-17-10-16-11-9-14(13(18)19,5-3-7-15)6-4-12(11)17/h10H,2-9,15H2,1H3,(H,18,19)/t14-/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50008277
PNG
(CHEMBL3235138)
Show SMILES CCc1cnc2CC(CCCN)(CCn12)C(O)=O
Show InChI InChI=1S/C13H21N3O2/c1-2-10-9-15-11-8-13(12(17)18,4-3-6-14)5-7-16(10)11/h9H,2-8,14H2,1H3,(H,17,18)
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n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of carboxypeptidase N (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50201438
PNG
((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Show SMILES NC(N)=NCCCC(CS)C(O)=O
Show InChI InChI=1S/C7H15N3O2S/c8-7(9)10-3-1-2-5(4-13)6(11)12/h5,13H,1-4H2,(H,11,12)(H4,8,9,10)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair
Carboxypeptidase N, catalytic subunit


(Homo sapiens)
BDBM50226600
PNG
((2S)-2-[(2-aminoethyl)amino]-3-(1H-imidazol-4-yl)p...)
Show SMILES NCCN[C@@H](Cc1cnc[nH]1)C(O)=O
Show InChI InChI=1S/C8H14N4O2/c9-1-2-11-7(8(13)14)3-6-4-10-5-12-6/h4-5,7,11H,1-3,9H2,(H,10,12)(H,13,14)/t7-/m0/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma carboxypeptidase N


Citation and Details
More data for this
Ligand-Target Pair