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Found 61 hits Enz. Inhib. hit(s) with Target = 'Carnitine palmitoyltransferase 1A'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50024430
PNG
((R) (R) -2-Tetradecyl-oxirane-2-carboxylic acid-Co...)
Show SMILES CCCCCCCCCCCCCC[C@@]1(CO1)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C38H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-17-38(23-58-38)36(50)67-20-19-40-27(46)16-18-41-34(49)31(48)37(2,3)22-60-66(56,57)63-65(54,55)59-21-26-30(62-64(51,52)53)29(47)35(61-26)45-25-44-28-32(39)42-24-43-33(28)45/h24-26,29-31,35,47-48H,4-23H2,1-3H3,(H,40,46)(H,41,49)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t26-,29-,30-,31?,35-,38-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondria


J Med Chem 30: 1094-7 (1987)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50024434
PNG
((+/-) 2-Tetradecyl-oxirane-2-carboxylic acid-Coenz...)
Show SMILES CCCCCCCCCCCCCCC1(CO1)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C38H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-17-38(23-58-38)36(50)67-20-19-40-27(46)16-18-41-34(49)31(48)37(2,3)22-60-66(56,57)63-65(54,55)59-21-26-30(62-64(51,52)53)29(47)35(61-26)45-25-44-28-32(39)42-24-43-33(28)45/h24-26,29-31,35,47-48H,4-23H2,1-3H3,(H,40,46)(H,41,49)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t26-,29-,30-,31?,35-,38?/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondria


J Med Chem 30: 1094-7 (1987)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50024429
PNG
((R)-(+)2-Tetradecyl-oxirane-2-carboxylic acid meth...)
Show SMILES CCCCCCCCCCCCCC[C@@]1(CO1)C(=O)OC
Show InChI InChI=1S/C18H34O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18(16-21-18)17(19)20-2/h3-16H2,1-2H3/t18-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondria


J Med Chem 30: 1094-7 (1987)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50024431
PNG
((+/-)2-Tetradecyl-oxirane-2-carboxylic acid | 2-Te...)
Show SMILES CCCCCCCCCCCCCCC1(CO1)C(O)=O
Show InChI InChI=1S/C17H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(15-20-17)16(18)19/h2-15H2,1H3,(H,18,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondria


J Med Chem 30: 1094-7 (1987)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50024433
PNG
((+/-) 2-Tetradecyl-oxirane-2-carboxylic acid methy...)
Show SMILES CCCCCCCCCCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C18H34O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18(16-21-18)17(19)20-2/h3-16H2,1-2H3
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n/an/a 90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of carnitine palmitoyl transferase (CPT), assessed with isolated rat liver mitochondria


J Med Chem 30: 1094-7 (1987)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50024433
PNG
((+/-) 2-Tetradecyl-oxirane-2-carboxylic acid methy...)
Show SMILES CCCCCCCCCCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C18H34O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18(16-21-18)17(19)20-2/h3-16H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50025256
PNG
(2-Tridecyl-oxirane-2-carboxylic acid methyl ester ...)
Show SMILES CCCCCCCCCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C17H32O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-17(15-20-17)16(18)19-2/h3-15H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50025263
PNG
(2-Dodecyl-oxirane-2-carboxylic acid methyl ester |...)
Show SMILES CCCCCCCCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C16H30O3/c1-3-4-5-6-7-8-9-10-11-12-13-16(14-19-16)15(17)18-2/h3-14H2,1-2H3
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50025257
PNG
(2-Decyl-oxirane-2-carboxylic acid methyl ester | C...)
Show SMILES CCCCCCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C14H26O3/c1-3-4-5-6-7-8-9-10-11-14(12-17-14)13(15)16-2/h3-12H2,1-2H3
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n/an/a 680n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50025254
PNG
(2-Hexadec-10-enyl-oxirane-2-carboxylic acid methyl...)
Show SMILES CCCCC\C=C\CCCCCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C20H36O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(18-23-20)19(21)22-2/h7-8H,3-6,9-18H2,1-2H3/b8-7+
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n/an/a 680n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101604
PNG
(CHEMBL309568 | [3-Carboxy-2-(dodecane-1-sulfonylam...)
Show SMILES CCCCCCCCCCCCS(=O)(=O)N[C@@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C19H40N2O4S/c1-5-6-7-8-9-10-11-12-13-14-15-26(24,25)20-18(16-19(22)23)17-21(2,3)4/h18,20H,5-17H2,1-4H3/t18-/m0/s1
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n/an/a 700n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101598
PNG
(CHEMBL307495 | [3-Carboxy-2-(dodecane-1-sulfonylam...)
Show SMILES CCCCCCCCCCCCS(=O)(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C19H40N2O4S/c1-5-6-7-8-9-10-11-12-13-14-15-26(24,25)20-18(16-19(22)23)17-21(2,3)4/h18,20H,5-17H2,1-4H3/t18-/m1/s1
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n/an/a 700n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50403029
PNG
(CHEMBL2216792)
Show SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)cnnc12)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)[C@@]1(CCCCCCOc2ccc(Cl)cc2)CO1
Show InChI InChI=1S/C36H53ClN7O19P3S/c1-35(2,30(47)32(48)40-13-11-26(45)39-14-16-67-34(49)36(20-58-36)12-5-3-4-6-15-57-23-9-7-22(37)8-10-23)19-60-66(55,56)63-65(53,54)59-18-25-29(62-64(50,51)52)28(46)33(61-25)44-21-41-27-24(38)17-42-43-31(27)44/h7-10,17,21,25,28-30,33,46-47H,3-6,11-16,18-20H2,1-2H3,(H2,38,43)(H,39,45)(H,40,48)(H,53,54)(H,55,56)(H2,50,51,52)/t25-,28-,29-,30+,33-,36-/m1/s1
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n/an/a 700n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat CPT1A expressed in intact Saccharomyces cerevisiae using [methyl-3H]carnitine by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101591
PNG
(CHEMBL105377 | CHEMBL308869 | R-[3-Carboxy-2-(unde...)
Show SMILES CCCCCCCCCCCNS(=O)(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C18H39N3O4S/c1-5-6-7-8-9-10-11-12-13-14-19-26(24,25)20-17(15-18(22)23)16-21(2,3)4/h17,19-20H,5-16H2,1-4H3/t17-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101591
PNG
(CHEMBL105377 | CHEMBL308869 | R-[3-Carboxy-2-(unde...)
Show SMILES CCCCCCCCCCCNS(=O)(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C18H39N3O4S/c1-5-6-7-8-9-10-11-12-13-14-19-26(24,25)20-17(15-18(22)23)16-21(2,3)4/h17,19-20H,5-16H2,1-4H3/t17-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50024431
PNG
((+/-)2-Tetradecyl-oxirane-2-carboxylic acid | 2-Te...)
Show SMILES CCCCCCCCCCCCCCC1(CO1)C(O)=O
Show InChI InChI=1S/C17H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(15-20-17)16(18)19/h2-15H2,1H3,(H,18,19)
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n/an/a 900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50025262
PNG
(2-Hexadec-10-enyl-oxirane-2-carboxylic acid methyl...)
Show SMILES CCCCCCCCCCCCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C20H38O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(18-23-20)19(21)22-2/h3-18H2,1-2H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122839
PNG
(CHEMBL106227 | [3-Carboxy-2-(3-tetradecyl-ureido)-...)
Show SMILES CCCCCCCCCCCCCCNC(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C22H45N3O3/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-23-22(28)24-20(18-21(26)27)19-25(2,3)4/h20H,5-19H2,1-4H3,(H2-,23,24,26,27,28)/t20-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50025258
PNG
(2-Undecyl-oxirane-2-carboxylic acid methyl ester |...)
Show SMILES CCCCCCCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C15H28O3/c1-3-4-5-6-7-8-9-10-11-12-15(13-18-15)14(16)17-2/h3-13H2,1-2H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101594
PNG
(CHEMBL80493 | [3-Carboxy-2-(decane-1-sulfonylamino...)
Show SMILES CCCCCCCCCCS(=O)(=O)NC(CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C17H36N2O4S/c1-5-6-7-8-9-10-11-12-13-24(22,23)18-16(14-17(20)21)15-19(2,3)4/h16,18H,5-15H2,1-4H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122834
PNG
(CHEMBL105314 | [3-Carboxy-2-(3-dodecyl-ureido)-pro...)
Show SMILES CCCCCCCCCCCCNC(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C20H41N3O3/c1-5-6-7-8-9-10-11-12-13-14-15-21-20(26)22-18(16-19(24)25)17-23(2,3)4/h18H,5-17H2,1-4H3,(H2-,21,22,24,25,26)/t18-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101589
PNG
(CHEMBL77174 | [3-Carboxy-2-(nonylaminosulphonyl-am...)
Show SMILES CCCCCCCCCNS(=O)(=O)NC(CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C16H35N3O4S/c1-5-6-7-8-9-10-11-12-17-24(22,23)18-15(13-16(20)21)14-19(2,3)4/h15,17-18H,5-14H2,1-4H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122828
PNG
(CHEMBL106274 | [3-Carboxy-2-(3-undecyl-ureido)-pro...)
Show SMILES CCCCCCCCCCCNC(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C19H39N3O3/c1-5-6-7-8-9-10-11-12-13-14-20-19(25)21-17(15-18(23)24)16-22(2,3)4/h17H,5-16H2,1-4H3,(H2-,20,21,23,24,25)/t17-/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101598
PNG
(CHEMBL307495 | [3-Carboxy-2-(dodecane-1-sulfonylam...)
Show SMILES CCCCCCCCCCCCS(=O)(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C19H40N2O4S/c1-5-6-7-8-9-10-11-12-13-14-15-26(24,25)20-18(16-19(22)23)17-21(2,3)4/h18,20H,5-17H2,1-4H3/t18-/m1/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101604
PNG
(CHEMBL309568 | [3-Carboxy-2-(dodecane-1-sulfonylam...)
Show SMILES CCCCCCCCCCCCS(=O)(=O)N[C@@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C19H40N2O4S/c1-5-6-7-8-9-10-11-12-13-14-15-26(24,25)20-18(16-19(22)23)17-21(2,3)4/h18,20H,5-17H2,1-4H3/t18-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101600
PNG
(CHEMBL107027 | CHEMBL305897 | [3-Carboxy-2-(undeca...)
Show SMILES CCCCCCCCCCCNS(=O)(=O)N[C@@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C18H39N3O4S/c1-5-6-7-8-9-10-11-12-13-14-19-26(24,25)20-17(15-18(22)23)16-21(2,3)4/h17,19-20H,5-16H2,1-4H3/t17-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101600
PNG
(CHEMBL107027 | CHEMBL305897 | [3-Carboxy-2-(undeca...)
Show SMILES CCCCCCCCCCCNS(=O)(=O)N[C@@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C18H39N3O4S/c1-5-6-7-8-9-10-11-12-13-14-19-26(24,25)20-17(15-18(22)23)16-21(2,3)4/h17,19-20H,5-16H2,1-4H3/t17-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122833
PNG
((3-Carboxy-2-octyloxycarbonylamino-propyl)-trimeth...)
Show SMILES CCCCCCCCOC(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C16H32N2O4/c1-5-6-7-8-9-10-11-22-16(21)17-14(12-15(19)20)13-18(2,3)4/h14H,5-13H2,1-4H3,(H-,17,19,20,21)/t14-/m1/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50403046
PNG
(CHEMBL2216772)
Show SMILES CCCCc1ccc(NC(=O)OCCN2CCCCC2CC(C2CCCCC2)C2CCCCC2)cc1
Show InChI InChI=1S/C32H52N2O2/c1-2-3-12-26-18-20-29(21-19-26)33-32(35)36-24-23-34-22-11-10-17-30(34)25-31(27-13-6-4-7-14-27)28-15-8-5-9-16-28/h18-21,27-28,30-31H,2-17,22-25H2,1H3,(H,33,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat CPT1A


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50046145
PNG
(2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...)
Show SMILES CCCCCCCCCCCCCCC[C@@]1(O)C[N+](C)(C)C[C@@H](CC([O-])=O)O1
Show InChI InChI=1S/C23H45NO4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(27)20-24(2,3)19-21(28-23)18-22(25)26/h21,27H,4-20H2,1-3H3/t21-,23+/m1/s1
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n/an/a 1.55E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat CPT1A using [3H]carnitine by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101590
PNG
(CHEMBL78921 | [3-Carboxy-2-(3-nonyl-ureido)-propyl...)
Show SMILES CCCCCCCCCNC(=O)NC(CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C17H35N3O3/c1-5-6-7-8-9-10-11-12-18-17(23)19-15(13-16(21)22)14-20(2,3)4/h15H,5-14H2,1-4H3,(H2-,18,19,21,22,23)
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n/an/a 1.95E+4n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101593
PNG
((3-Carboxy-2-octyloxycarbonylamino-propyl)-trimeth...)
Show SMILES CCCCCCCCOC(=O)NC(CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C16H32N2O4/c1-5-6-7-8-9-10-11-22-16(21)17-14(12-15(19)20)13-18(2,3)4/h14H,5-13H2,1-4H3,(H-,17,19,20,21)
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n/an/a 2.23E+4n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122827
PNG
(CHEMBL105330 | [3-Carboxy-2-(3-nonyl-ureido)-propy...)
Show SMILES CCCCCCCCCNC(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C17H35N3O3/c1-5-6-7-8-9-10-11-12-18-17(23)19-15(13-16(21)22)14-20(2,3)4/h15H,5-14H2,1-4H3,(H2-,18,19,21,22,23)/t15-/m1/s1
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n/an/a 3.13E+4n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50046145
PNG
(2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...)
Show SMILES CCCCCCCCCCCCCCC[C@@]1(O)C[N+](C)(C)C[C@@H](CC([O-])=O)O1
Show InChI InChI=1S/C23H45NO4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(27)20-24(2,3)19-21(28-23)18-22(25)26/h21,27H,4-20H2,1-3H3/t21-,23+/m1/s1
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n/an/a 3.85E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat CPT1A using [3H]carnitine by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122837
PNG
(CHEMBL319635 | [3-Carboxy-2-(3-heptyl-ureido)-prop...)
Show SMILES CCCCCCCNC(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C15H31N3O3/c1-5-6-7-8-9-10-16-15(21)17-13(11-14(19)20)12-18(2,3)4/h13H,5-12H2,1-4H3,(H2-,16,17,19,20,21)/t13-/m1/s1
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n/an/a 4.36E+4n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101597
PNG
((3-Carboxy-2-tetradecyloxy-propyl)-trimethyl-ammon...)
Show SMILES CCCCCCCCCCCCCCOC(CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C21H43NO3/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-25-20(18-21(23)24)19-22(2,3)4/h20H,5-19H2,1-4H3
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n/an/a 4.70E+4n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122836
PNG
(CHEMBL102993 | [3-Carboxy-2-(3-tetradecyl-ureido)-...)
Show SMILES CCCCCCCCCCCCCCNC(=O)N[C@@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C22H45N3O3/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-23-22(28)24-20(18-21(26)27)19-25(2,3)4/h20H,5-19H2,1-4H3,(H2-,23,24,26,27,28)/t20-/m0/s1
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n/an/a 5.88E+4n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM61402
PNG
((Z)-2-butenedioic acid;2-(2,2-dicyclohexylethyl)pi...)
Show SMILES C(C(C1CCCCC1)C1CCCCC1)C1CCCCN1
Show InChI InChI=1S/C19H35N/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18/h16-20H,1-15H2
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n/an/a 7.70E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CPT1 in rat cardiac mitochondria using [3H]carnitine by radiometric method


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101607
PNG
(CHEMBL80353 | [3-Carboxy-2-(3-nonyl-thioureido)-pr...)
Show SMILES CCCCCCCCCNC(=S)NC(CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C17H35N3O2S/c1-5-6-7-8-9-10-11-12-18-17(23)19-15(13-16(21)22)14-20(2,3)4/h15H,5-14H2,1-4H3,(H2-,18,19,21,22,23)
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n/an/a 1.22E+5n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50284163
PNG
((S)-4-Hexadecyl-2,6,6-trimethyl-2-oxo-2lambda*5*-[...)
Show SMILES CCCCCCCCCCCCCCCCC1C[N+](C)(C)CCO[P@](C)(=O)O1
Show InChI InChI=1S/C23H49NO3P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-22-24(2,3)20-21-26-28(4,25)27-23/h23H,5-22H2,1-4H3/q+1/t23?,28-/m0/s1
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n/an/a 1.28E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory potency of the compound against Carnitine Palmitoyltransferase (CPT-II)


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Sus scrofa)
BDBM50025259
PNG
(2-Hexyl-oxirane-2-carboxylic acid methyl ester | C...)
Show SMILES CCCCCCC1(CO1)C(=O)OC
Show InChI InChI=1S/C10H18O3/c1-3-4-5-6-7-10(8-13-10)9(11)12-2/h3-8H2,1-2H3
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n/an/a 1.36E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against carnitine palmitoyl transferase-A (CPT-A)


J Med Chem 29: 2184-90 (1986)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM61402
PNG
((Z)-2-butenedioic acid;2-(2,2-dicyclohexylethyl)pi...)
Show SMILES C(C(C1CCCCC1)C1CCCCC1)C1CCCCN1
Show InChI InChI=1S/C19H35N/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18/h16-20H,1-15H2
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n/an/a 1.48E+5n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CPT1 in rat liver mitochondria using [3H]carnitine by radiometric method


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101608
PNG
((3-Carboxy-2-tetradecylamino-propyl)-trimethyl-amm...)
Show SMILES CCCCCCCCCCCCCCNC(CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C21H44N2O2/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22-20(18-21(24)25)19-23(2,3)4/h20,22H,5-19H2,1-4H3
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n/an/a 2.30E+5n/an/an/an/an/an/a



Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM22984
PNG
((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Show SMILES COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
Show InChI InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
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n/an/a 2.50E+5n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat CPT1 in rat mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101588
PNG
((3-Carboxy-2-nonyloxycarbonyloxy-propyl)-trimethyl...)
Show SMILES CCCCCCCCCOC(=O)OC(CC(O)=O)C[N+](C)(C)C
Show InChI InChI=1S/C17H33NO5/c1-5-6-7-8-9-10-11-12-22-17(21)23-15(13-16(19)20)14-18(2,3)4/h15H,5-14H2,1-4H3/p+1
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Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101592
PNG
((3-Carboxy-2-nonylcarbamoyloxy-propyl)-trimethyl-a...)
Show SMILES CCCCCCCCCNC(=O)OC(CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C17H34N2O4/c1-5-6-7-8-9-10-11-12-18-17(22)23-15(13-16(20)21)14-19(2,3)4/h15H,5-14H2,1-4H3,(H-,18,20,21,22)
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Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122835
PNG
(CHEMBL105727 | [3-Carboxy-2-(3-nonyl-ureido)-propy...)
Show SMILES CCCCCCCCCNC(=O)N[C@@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C17H35N3O3/c1-5-6-7-8-9-10-11-12-18-17(23)19-15(13-16(21)22)14-20(2,3)4/h15H,5-14H2,1-4H3,(H2-,18,19,21,22,23)/t15-/m0/s1
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Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101596
PNG
(1-(3-Carboxy-2-tetradecyloxycarbonyloxy-propyl)-1-...)
Show SMILES CCCCCCCCCCCCCCOC(=O)OC(CC([O-])=O)C[N+]12CCC(CC1)CC2
Show InChI InChI=1S/C26H47NO5/c1-2-3-4-5-6-7-8-9-10-11-12-13-20-31-26(30)32-24(21-25(28)29)22-27-17-14-23(15-18-27)16-19-27/h23-24H,2-22H2,1H3
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Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50122829
PNG
((3-Carboxy-2-octyloxycarbonylamino-propyl)-trimeth...)
Show SMILES CCCCCCCCOC(=O)N[C@@H](CC([O-])=O)C[N+](C)(C)C
Show InChI InChI=1S/C16H32N2O4/c1-5-6-7-8-9-10-11-22-16(21)17-14(12-15(19)20)13-18(2,3)4/h14H,5-13H2,1-4H3,(H-,17,19,20,21)/t14-/m0/s1
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Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of [14C]-palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria


Citation and Details
More data for this
Ligand-Target Pair
Carnitine palmitoyltransferase 1A


(Rattus norvegicus)
BDBM50101605
PNG
(1-(3-Phosphono-2-tetradecyloxycarbonyloxy-propyl)-...)
Show SMILES CCCCCCCCCCCCCCOC(=O)OC(C[N+]12CCC(CC1)CC2)CP(O)([O-])=O
Show InChI InChI=1S/C25H48NO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-20-31-25(27)32-24(22-33(28,29)30)21-26-17-14-23(15-18-26)16-19-26/h23-24H,2-22H2,1H3,(H-,28,29,30)
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Sigma Tau Pharmaceutical Industries S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of rat liver mitochondrial carnitine palmitoyltransferase 1 using [14C]-palmitoyl-CoA radioligand


J Med Chem 44: 2383-6 (2001)

More data for this
Ligand-Target Pair
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