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Compile Data Set for Download or QSAR

Found 411 hits Enz. Inhib. hit(s) with Target = 'Cathepsin G'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin G


(Homo sapiens)
BDBM50101132
PNG
(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Show SMILES O=C1N(Cc2ccccc2)C(=O)N1Cc1ccccc1
Show InChI InChI=1S/C16H14N2O2/c19-15-17(11-13-7-3-1-4-8-13)16(20)18(15)12-14-9-5-2-6-10-14/h1-10H,11-12H2
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n/an/a 0.390n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against human cathepsin G


Bioorg Med Chem Lett 11: 1691-4 (2001)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063048
PNG
(CHEMBL3398147)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C=O
Show InChI InChI=1S/C18H19NO5S/c1-18(2,3)17(21)24-14-8-10-15(11-9-14)25(22,23)19-16-7-5-4-6-13(16)12-20/h4-12,19H,1-3H3
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50084637
PNG
(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O
Show InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50118029
PNG
(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Show SMILES Cl.CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)\C=C\CN2CCCCC2)N(C1=O)S(C)(=O)=O
Show InChI InChI=1S/C19H31N3O4S/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3/b8-7+/t15-,17+,18-/m1/s1
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GSK

Curated by ChEMBL


Assay Description
The compound was evaluated for its inhibitory activity against cathepsin G using selectivity assay


J Med Chem 45: 3878-90 (2002)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063047
PNG
(CHEMBL3398148)
Show SMILES C\C(=N\O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C19H22N2O5S/c1-13(20-23)16-7-5-6-8-17(16)21-27(24,25)15-11-9-14(10-12-15)26-18(22)19(2,3)4/h5-12,21,23H,1-4H3/b20-13-
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063046
PNG
(CHEMBL3398149)
Show SMILES CC\C(=N\O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H24N2O5S/c1-5-17(21-24)16-8-6-7-9-18(16)22-28(25,26)15-12-10-14(11-13-15)27-19(23)20(2,3)4/h6-13,22,24H,5H2,1-4H3/b21-17-
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101980
PNG
(CHEMBL3398150)
Show SMILES CCC\C(=N\O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C21H26N2O5S/c1-5-8-18(22-25)17-9-6-7-10-19(17)23-29(26,27)16-13-11-15(12-14-16)28-20(24)21(2,3)4/h6-7,9-14,23,25H,5,8H2,1-4H3/b22-18-
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM166437
PNG
(US9073833, 5)
Show SMILES CO\N=C(/C)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H24N2O5S/c1-14(21-26-5)17-8-6-7-9-18(17)22-28(24,25)16-12-10-15(11-13-16)27-19(23)20(2,3)4/h6-13,22H,1-5H3/b21-14+
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM166438
PNG
(US9073833, 6)
Show SMILES CO\N=C(\C)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H24N2O5S/c1-14(21-26-5)17-8-6-7-9-18(17)22-28(24,25)16-12-10-15(11-13-16)27-19(23)20(2,3)4/h6-13,22H,1-5H3/b21-14-
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063052
PNG
(CHEMBL3398143)
Show SMILES CC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C19H21NO5S/c1-13(21)16-7-5-6-8-17(16)20-26(23,24)15-11-9-14(10-12-15)25-18(22)19(2,3)4/h5-12,20H,1-4H3
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063051
PNG
(CHEMBL3398144)
Show SMILES CCC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H23NO5S/c1-5-18(22)16-8-6-7-9-17(16)21-27(24,25)15-12-10-14(11-13-15)26-19(23)20(2,3)4/h6-13,21H,5H2,1-4H3
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063054
PNG
(CHEMBL3398165)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)OCCO
Show InChI InChI=1S/C20H23NO7S/c1-20(2,3)19(24)28-14-8-10-15(11-9-14)29(25,26)21-17-7-5-4-6-16(17)18(23)27-13-12-22/h4-11,21-22H,12-13H2,1-3H3
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063053
PNG
(CHEMBL3398164)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCCO
Show InChI InChI=1S/C20H24N2O6S/c1-20(2,3)19(25)28-14-8-10-15(11-9-14)29(26,27)22-17-7-5-4-6-16(17)18(24)21-12-13-23/h4-11,22-23H,12-13H2,1-3H3,(H,21,24)
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101987
PNG
(CHEMBL3398163)
Show SMILES CC(C)(C)S(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccccc1C=O
Show InChI InChI=1/C17H20N2O4S2/c1-17(2,3)24(21)18-14-8-10-15(11-9-14)25(22,23)19-16-7-5-4-6-13(16)12-20/h4-12,18-19H,1-3H3
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101985
PNG
(CHEMBL3398157)
Show SMILES COC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C20H18F3NO5/c1-19(2,20(21,22)23)18(27)29-13-10-8-12(9-11-13)16(25)24-15-7-5-4-6-14(15)17(26)28-3/h4-11H,1-3H3,(H,24,25)
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101984
PNG
(CHEMBL3398156)
Show SMILES CCCOC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C22H25NO5/c1-5-14-27-20(25)17-8-6-7-9-18(17)23-19(24)15-10-12-16(13-11-15)28-21(26)22(2,3)4/h6-13H,5,14H2,1-4H3,(H,23,24)
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101983
PNG
(CHEMBL3398155)
Show SMILES CCOC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C21H23NO5/c1-5-26-19(24)16-8-6-7-9-17(16)22-18(23)14-10-12-15(13-11-14)27-20(25)21(2,3)4/h6-13H,5H2,1-4H3,(H,22,23)
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101989
PNG
(CHEMBL3398154)
Show SMILES COC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H21NO5/c1-20(2,3)19(24)26-14-11-9-13(10-12-14)17(22)21-16-8-6-5-7-15(16)18(23)25-4/h5-12H,1-4H3,(H,21,22)
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101988
PNG
(CHEMBL3398153)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1\C=N/O
Show InChI InChI=1S/C18H20N2O5S/c1-18(2,3)17(21)25-14-8-10-15(11-9-14)26(23,24)20-16-7-5-4-6-13(16)12-19-22/h4-12,20,22H,1-3H3/b19-12-
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101982
PNG
(CHEMBL3398162)
Show SMILES CC(=O)c1ccccc1NS(=O)(=O)c1ccc(NS(=O)C(C)(C)C)cc1
Show InChI InChI=1/C18H22N2O4S2/c1-13(21)16-7-5-6-8-17(16)20-26(23,24)15-11-9-14(10-12-15)19-25(22)18(2,3)4/h5-12,19-20H,1-4H3
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101981
PNG
(CHEMBL3398161)
Show SMILES COC(=O)c1ccccc1NS(=O)(=O)c1ccc(NC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C19H22N2O5S/c1-19(2,3)18(23)20-13-9-11-14(12-10-13)27(24,25)21-16-8-6-5-7-15(16)17(22)26-4/h5-12,21H,1-4H3,(H,20,23)
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Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101978
PNG
(CHEMBL3398160)
Show SMILES COC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C19H18F3NO6S/c1-18(2,19(20,21)22)17(25)29-12-8-10-13(11-9-12)30(26,27)23-15-7-5-4-6-14(15)16(24)28-3/h4-11,23H,1-3H3
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101977
PNG
(CHEMBL3398159)
Show SMILES CCCOC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C22H22F3NO5/c1-4-13-30-19(28)16-7-5-6-8-17(16)26-18(27)14-9-11-15(12-10-14)31-20(29)21(2,3)22(23,24)25/h5-12H,4,13H2,1-3H3,(H,26,27)
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101986
PNG
(CHEMBL3398158)
Show SMILES CCOC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C21H20F3NO5/c1-4-29-18(27)15-7-5-6-8-16(15)25-17(26)13-9-11-14(12-10-13)30-19(28)20(2,3)21(22,23)24/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063049
PNG
(CHEMBL3398146)
Show SMILES CCCCC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C22H27NO5S/c1-5-6-11-20(24)18-9-7-8-10-19(18)23-29(26,27)17-14-12-16(13-15-17)28-21(25)22(2,3)4/h7-10,12-15,23H,5-6,11H2,1-4H3
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50063050
PNG
(CHEMBL3398145)
Show SMILES CCCC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C21H25NO5S/c1-5-8-19(23)17-9-6-7-10-18(17)22-28(25,26)16-13-11-15(12-14-16)27-20(24)21(2,3)4/h6-7,9-14,22H,5,8H2,1-4H3
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50073139
PNG
(2-(4-cyanophenylcarboxamido)-1,1-dimethyl-4-phenyl...)
Show SMILES CC(C)(C(CCc1ccccc1)NC(=O)c1ccc(cc1)C#N)C(=O)OC(=O)C(C)(C)C(CCc1ccccc1)NC(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C42H42N4O5/c1-41(2,35(25-19-29-11-7-5-8-12-29)45-37(47)33-21-15-31(27-43)16-22-33)39(49)51-40(50)42(3,4)36(26-20-30-13-9-6-10-14-30)46-38(48)34-23-17-32(28-44)18-24-34/h5-18,21-24,35-36H,19-20,25-26H2,1-4H3,(H,45,47)(H,46,48)
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n/an/a 1.40n/an/an/an/an/an/a



Nippon Steel Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against human leukocyte cathepsin G (h-CG)


Bioorg Med Chem Lett 9: 413-8 (1999)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349174
PNG
(CHEMBL1807526)
Show SMILES Cc1cccc2scc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c12
Show InChI InChI=1S/C20H18N2O3S/c1-13-5-4-8-17-19(13)14(12-26-17)11-22-16-7-3-2-6-15(16)21(20(22)25)10-9-18(23)24/h2-8,12H,9-11H2,1H3,(H,23,24)
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n/an/a 2.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50101131
PNG
(1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione | CHEMBL...)
Show SMILES Cc1ccc(cc1)N1C(=O)N(C1=O)c1ccc(C)cc1
Show InChI InChI=1S/C16H14N2O2/c1-11-3-7-13(8-4-11)17-15(19)18(16(17)20)14-9-5-12(2)6-10-14/h3-10H,1-2H3
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n/an/a 2.30n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against human cathepsin G


Bioorg Med Chem Lett 11: 1691-4 (2001)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349176
PNG
(CHEMBL1807531)
Show SMILES Cc1cccc2n(C)cc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c12
Show InChI InChI=1S/C21H21N3O3/c1-14-6-5-9-18-20(14)15(12-22(18)2)13-24-17-8-4-3-7-16(17)23(21(24)27)11-10-19(25)26/h3-9,12H,10-11,13H2,1-2H3,(H,25,26)
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n/an/a 4.80n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50075109
PNG
(1,1-dimethyl-2-phenylcarboxamidoheptanoic anhydrid...)
Show SMILES CCCCC(NC(=O)c1ccccc1)C(C)(C)C(=O)OC(=O)C(C)(C)C(CCCC)NC(=O)c1ccccc1
Show InChI InChI=1S/C32H44N2O5/c1-7-9-21-25(33-27(35)23-17-13-11-14-18-23)31(3,4)29(37)39-30(38)32(5,6)26(22-10-8-2)34-28(36)24-19-15-12-16-20-24/h11-20,25-26H,7-10,21-22H2,1-6H3,(H,33,35)(H,34,36)
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n/an/a 6.40n/an/an/an/an/an/a



Nippon Steel Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against human leukocyte cathepsin G (h-CG)


Bioorg Med Chem Lett 9: 413-8 (1999)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349173
PNG
(CHEMBL1807638)
Show SMILES Cc1c(C)c2cc(C)cc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c2n1C
Show InChI InChI=1S/C23H25N3O3/c1-14-11-17(22-18(12-14)15(2)16(3)24(22)4)13-26-20-8-6-5-7-19(20)25(23(26)29)10-9-21(27)28/h5-8,11-12H,9-10,13H2,1-4H3,(H,27,28)
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n/an/a 7n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50073123
PNG
((S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonan...)
Show SMILES CCCCCCC(NC(=O)c1ccc(cc1)C#N)C(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC
Show InChI InChI=1S/C30H39N3O4/c1-5-7-8-12-15-26(33-27(34)24-18-16-23(21-31)17-19-24)30(3,4)29(36)32-25(28(35)37-6-2)20-22-13-10-9-11-14-22/h9-11,13-14,16-19,25-26H,5-8,12,15,20H2,1-4H3,(H,32,36)(H,33,34)/t25-,26?/m0/s1
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n/an/a 8.40n/an/an/an/an/an/a



Nippon Steel Corporation

Curated by ChEMBL


Assay Description
Compound was tested by chromogenic assay for the inhibition of serine proteases like Human cathepsin G


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50073123
PNG
((S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonan...)
Show SMILES CCCCCCC(NC(=O)c1ccc(cc1)C#N)C(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC
Show InChI InChI=1S/C30H39N3O4/c1-5-7-8-12-15-26(33-27(34)24-18-16-23(21-31)17-19-24)30(3,4)29(36)32-25(28(35)37-6-2)20-22-13-10-9-11-14-22/h9-11,13-14,16-19,25-26H,5-8,12,15,20H2,1-4H3,(H,32,36)(H,33,34)/t25-,26?/m0/s1
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n/an/a 8.70n/an/an/an/an/an/a



Nippon Steel Corporation

Curated by ChEMBL


Assay Description
Compound was tested by chromogenic assay for the inhibition of serine proteases like Human cathepsin G


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349183
PNG
(CHEMBL1807538)
Show SMILES Cc1cn(C)c2c(Cn3c4ccccc4n(CCC(O)=O)c3=O)cccc12
Show InChI InChI=1S/C21H21N3O3/c1-14-12-22(2)20-15(6-5-7-16(14)20)13-24-18-9-4-3-8-17(18)23(21(24)27)11-10-19(25)26/h3-9,12H,10-11,13H2,1-2H3,(H,25,26)
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n/an/a 8.80n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349178
PNG
(CHEMBL1807535)
Show SMILES Cc1cc(C)c2c(Cn3c4ccccc4n(CCC(O)=O)c3=O)nsc2c1
Show InChI InChI=1S/C20H19N3O3S/c1-12-9-13(2)19-14(21-27-17(19)10-12)11-23-16-6-4-3-5-15(16)22(20(23)26)8-7-18(24)25/h3-6,9-10H,7-8,11H2,1-2H3,(H,24,25)
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n/an/a 9.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349185
PNG
(CHEMBL1807529)
Show SMILES Cn1cc(Cn2c3ccccc3n(CCC(O)=O)c2=O)c2ccccc12
Show InChI InChI=1S/C20H19N3O3/c1-21-12-14(15-6-2-3-7-16(15)21)13-23-18-9-5-4-8-17(18)22(20(23)26)11-10-19(24)25/h2-9,12H,10-11,13H2,1H3,(H,24,25)
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n/an/a>10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50073123
PNG
((S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonan...)
Show SMILES CCCCCCC(NC(=O)c1ccc(cc1)C#N)C(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC
Show InChI InChI=1S/C30H39N3O4/c1-5-7-8-12-15-26(33-27(34)24-18-16-23(21-31)17-19-24)30(3,4)29(36)32-25(28(35)37-6-2)20-22-13-10-9-11-14-22/h9-11,13-14,16-19,25-26H,5-8,12,15,20H2,1-4H3,(H,32,36)(H,33,34)/t25-,26?/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Nippon Steel Corporation

Curated by ChEMBL


Assay Description
Compound was tested by chromogenic assay for the inhibition of serine proteases like Human cathepsin G


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349184
PNG
(CHEMBL1807527)
Show SMILES OC(=O)CCn1c2ccccc2n(Cc2csc3ccccc23)c1=O
Show InChI InChI=1S/C19H16N2O3S/c22-18(23)9-10-20-15-6-2-3-7-16(15)21(19(20)24)11-13-12-25-17-8-4-1-5-14(13)17/h1-8,12H,9-11H2,(H,22,23)
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n/an/a>10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349187
PNG
(CHEMBL1807528)
Show SMILES OC(=O)CCn1c2ccccc2n(Cc2nsc3ccccc23)c1=O
Show InChI InChI=1S/C18H15N3O3S/c22-17(23)9-10-20-14-6-2-3-7-15(14)21(18(20)24)11-13-12-5-1-4-8-16(12)25-19-13/h1-8H,9-11H2,(H,22,23)
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n/an/a>10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349180
PNG
(CHEMBL1807530)
Show SMILES OC(=O)CCn1c2ccccc2n(Cc2cccc3ccccc23)c1=O
Show InChI InChI=1S/C21H18N2O3/c24-20(25)12-13-22-18-10-3-4-11-19(18)23(21(22)26)14-16-8-5-7-15-6-1-2-9-17(15)16/h1-11H,12-14H2,(H,24,25)
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n/an/a>10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349188
PNG
(CHEMBL1807532)
Show SMILES Cc1cccc2ncc(Cn3c4ccccc4n(CCC(O)=O)c3=O)n12
Show InChI InChI=1S/C19H18N4O3/c1-13-5-4-8-17-20-11-14(23(13)17)12-22-16-7-3-2-6-15(16)21(19(22)26)10-9-18(24)25/h2-8,11H,9-10,12H2,1H3,(H,24,25)
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Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349189
PNG
(CHEMBL1807533)
Show SMILES Cc1cccn2ncc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c12
Show InChI InChI=1S/C19H18N4O3/c1-13-5-4-9-23-18(13)14(11-20-23)12-22-16-7-3-2-6-15(16)21(19(22)26)10-8-17(24)25/h2-7,9,11H,8,10,12H2,1H3,(H,24,25)
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Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349182
PNG
(CHEMBL1807534)
Show SMILES Cc1cccc2c(cc(Cn3c4ccccc4n(CCC(O)=O)c3=O)n12)C#N
Show InChI InChI=1S/C21H18N4O3/c1-14-5-4-8-17-15(12-22)11-16(25(14)17)13-24-19-7-3-2-6-18(19)23(21(24)28)10-9-20(26)27/h2-8,11H,9-10,13H2,1H3,(H,26,27)
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n/an/a>10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349181
PNG
(CHEMBL1807536)
Show SMILES Cn1ccc2cccc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c12
Show InChI InChI=1S/C20H19N3O3/c1-21-11-9-14-5-4-6-15(19(14)21)13-23-17-8-3-2-7-16(17)22(20(23)26)12-10-18(24)25/h2-9,11H,10,12-13H2,1H3,(H,24,25)
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Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349179
PNG
(CHEMBL1807537)
Show SMILES Cc1cc2cccc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c2n1C
Show InChI InChI=1S/C21H21N3O3/c1-14-12-15-6-5-7-16(20(15)22(14)2)13-24-18-9-4-3-8-17(18)23(21(24)27)11-10-19(25)26/h3-9,12H,10-11,13H2,1-2H3,(H,25,26)
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Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349186
PNG
(CHEMBL1807539)
Show SMILES Cc1cn(C)c2cccc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c12
Show InChI InChI=1S/C21H21N3O3/c1-14-12-22(2)18-9-5-6-15(20(14)18)13-24-17-8-4-3-7-16(17)23(21(24)27)11-10-19(25)26/h3-9,12H,10-11,13H2,1-2H3,(H,25,26)
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Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349175
PNG
(CHEMBL1807637)
Show SMILES Cc1c(C)c2cccc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c2n1C
Show InChI InChI=1S/C22H23N3O3/c1-14-15(2)23(3)21-16(7-6-8-17(14)21)13-25-19-10-5-4-9-18(19)24(22(25)28)12-11-20(26)27/h4-10H,11-13H2,1-3H3,(H,26,27)
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Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349190
PNG
(CHEMBL1807641)
Show SMILES Cc1c(C)c2ccc(Cl)c(Cn3c4ccccc4n(CCC(O)=O)c3=O)c2n1C
Show InChI InChI=1S/C22H22ClN3O3/c1-13-14(2)24(3)21-15(13)8-9-17(23)16(21)12-26-19-7-5-4-6-18(19)25(22(26)29)11-10-20(27)28/h4-9H,10-12H2,1-3H3,(H,27,28)
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Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50349177
PNG
(CHEMBL1807639)
Show SMILES COc1cc(Cn2c3ccccc3n(CCC(O)=O)c2=O)c2n(C)c(C)c(C)c2c1
Show InChI InChI=1S/C23H25N3O4/c1-14-15(2)24(3)22-16(11-17(30-4)12-18(14)22)13-26-20-8-6-5-7-19(20)25(23(26)29)10-9-21(27)28/h5-8,11-12H,9-10,13H2,1-4H3,(H,27,28)
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Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
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