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Compile Data Set for Download or QSAR

Found 172 hits Enz. Inhib. hit(s) with Target = 'Cathepsin H'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin (H and K)


(Homo sapiens)
BDBM50255753
PNG
(CHEMBL481611 | MK-0822 | Odanacatib)
Show SMILES CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N
Show InChI InChI=1S/C25H27F4N3O3S/c1-23(2,26)14-20(22(33)32-24(15-30)12-13-24)31-21(25(27,28)29)18-6-4-16(5-7-18)17-8-10-19(11-9-17)36(3,34)35/h4-11,20-21,31H,12-14H2,1-3H3,(H,32,33)/t20-,21-/m0/s1
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n/an/a>10n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of cathepsin H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50148298
PNG
(((S)-1-Formyl-pentyl)-carbamic acid (R)-1-benzyl-2...)
Show SMILES CCCC[C@H](NC(=O)O[C@H](Cc1ccccc1)C(C)C)C=O
Show InChI InChI=1S/C18H27NO3/c1-4-5-11-16(13-20)19-18(21)22-17(14(2)3)12-15-9-7-6-8-10-15/h6-10,13-14,16-17H,4-5,11-12H2,1-3H3,(H,19,21)/t16-,17+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50148296
PNG
(((S)-1-Formyl-pentyl)-carbamic acid (S)-1-methyl-2...)
Show SMILES CCCC[C@H](NC(=O)O[C@@H](C)Cc1ccccc1)C=O
Show InChI InChI=1S/C16H23NO3/c1-3-4-10-15(12-18)17-16(19)20-13(2)11-14-8-6-5-7-9-14/h5-9,12-13,15H,3-4,10-11H2,1-2H3,(H,17,19)/t13-,15-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50163831
PNG
((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Show SMILES C[C@@H](CC1CCCCC1)OC(=O)C1CCN1C#N
Show InChI InChI=1S/C14H22N2O2/c1-11(9-12-5-3-2-4-6-12)18-14(17)13-7-8-16(13)10-15/h11-13H,2-9H2,1H3/t11-,13?/m0/s1
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n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50250152
PNG
(3-acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroq...)
Show SMILES CC(=O)c1c(Nc2ccc(Cl)cc2)nc2c(Cl)cc(cc2c1O)[N+]([O-])=O
Show InChI InChI=1S/C17H11Cl2N3O4/c1-8(23)14-16(24)12-6-11(22(25)26)7-13(19)15(12)21-17(14)20-10-4-2-9(18)3-5-10/h2-7H,1H3,(H2,20,21,24)
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n/an/a 145n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50157741
PNG
(CHEMBL374508 | E-64 | E64)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCN=C(N)N
Show InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin H after 10 mins


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50177501
PNG
(CHEMBL203663 | {(S)-1-[(morpholine-4-carbonyl)-hyd...)
Show SMILES CCCC[C@H](NC(=O)O[C@H](Cc1ccccc1)C(C)C)C=NNC(=O)N1CCOCC1
Show InChI InChI=1S/C23H36N4O4/c1-4-5-11-20(17-24-26-22(28)27-12-14-30-15-13-27)25-23(29)31-21(18(2)3)16-19-9-7-6-8-10-19/h6-10,17-18,20-21H,4-5,11-16H2,1-3H3,(H,25,29)(H,26,28)/t20-,21+/m0/s1
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n/an/a 190n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50177494
PNG
(CHEMBL204605 | {(S)-1-[(morpholine-4-carbonyl)-hyd...)
Show SMILES CCCC[C@H](NC(=O)O[C@@H](C)Cc1ccccc1)C=NNC(=O)N1CCOCC1
Show InChI InChI=1S/C21H32N4O4/c1-3-4-10-19(16-22-24-20(26)25-11-13-28-14-12-25)23-21(27)29-17(2)15-18-8-6-5-7-9-18/h5-9,16-17,19H,3-4,10-15H2,1-2H3,(H,23,27)(H,24,26)/t17-,19-/m0/s1
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n/an/a 230n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165424
PNG
((S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,...)
Show SMILES CCCC[C@H](NC(=O)O[C@@H]1C(=O)OCC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C22H30N2O6/c1-5-6-12-16(24-21(28)30-18-20(27)29-13-22(18,3)4)17(25)19(26)23-14(2)15-10-8-7-9-11-15/h7-11,14,16,18H,5-6,12-13H2,1-4H3,(H,23,26)(H,24,28)/t14-,16+,18-/m1/s1
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n/an/a>500n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152524
PNG
((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Show SMILES CCCC[C@H](NC(=O)OCC1(Cc2ccc(F)cc2)CCC1)C(=O)C(=O)Nc1ccn[nH]1
Show InChI InChI=1S/C23H29FN4O4/c1-2-3-5-18(20(29)21(30)27-19-10-13-25-28-19)26-22(31)32-15-23(11-4-12-23)14-16-6-8-17(24)9-7-16/h6-10,13,18H,2-5,11-12,14-15H2,1H3,(H,26,31)(H2,25,27,28,30)/t18-/m0/s1
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n/an/a>500n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50163832
PNG
((1S)-2-cyclohexyl-1-methylethyl (2S)-1-cyanopyrrol...)
Show SMILES C[C@@H](CC1CCCCC1)OC(=O)C1CCCN1C#N
Show InChI InChI=1S/C15H24N2O2/c1-12(10-13-6-3-2-4-7-13)19-15(18)14-8-5-9-17(14)11-16/h12-14H,2-10H2,1H3/t12-,14?/m0/s1
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n/an/a 580n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165425
PNG
(CHEMBL195963 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)O[C@H]1CCCc2ccccc12)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C26H32N2O4/c1-3-4-16-22(24(29)25(30)27-18(2)19-11-6-5-7-12-19)28-26(31)32-23-17-10-14-20-13-8-9-15-21(20)23/h5-9,11-13,15,18,22-23H,3-4,10,14,16-17H2,1-2H3,(H,27,30)(H,28,31)/t18-,22+,23+/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152526
PNG
((1-(3-phenylpropyl)cyclobutyl)methyl(S)-1,2-dioxo-...)
Show SMILES CCCC[C@H](NC(=O)OCC1(CCCc2ccccc2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C30H40N2O4/c1-3-4-18-26(27(33)28(34)31-23(2)25-16-9-6-10-17-25)32-29(35)36-22-30(20-12-21-30)19-11-15-24-13-7-5-8-14-24/h5-10,13-14,16-17,23,26H,3-4,11-12,15,18-22H2,1-2H3,(H,31,34)(H,32,35)/t23-,26+/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152521
PNG
((1-phenethylcyclobutyl)methyl(S)-1,2-dioxo-1-((R)-...)
Show SMILES CCCC[C@H](NC(=O)OCC1(CCc2ccccc2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C29H38N2O4/c1-3-4-16-25(26(32)27(33)30-22(2)24-14-9-6-10-15-24)31-28(34)35-21-29(18-11-19-29)20-17-23-12-7-5-8-13-23/h5-10,12-15,22,25H,3-4,11,16-21H2,1-2H3,(H,30,33)(H,31,34)/t22-,25+/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50201701
PNG
(CHEMBL390474 | cis-4-(2,3-dimethylphenoxy)-6-oxa-1...)
Show SMILES Cc1cccc(O[C@H]2CCN3C[C@H]2OC3=O)c1C
Show InChI InChI=1S/C14H17NO3/c1-9-4-3-5-11(10(9)2)17-12-6-7-15-8-13(12)18-14(15)16/h3-5,12-13H,6-8H2,1-2H3/t12-,13+/m0/s1
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n/an/a 2.65E+3n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152522
PNG
(2-methyl-2-phenylpropyl(S)-1,2-dioxo-1-((R)-1-phen...)
Show SMILES CCCC[C@H](NC(=O)OCC(C)(C)c1ccccc1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C26H34N2O4/c1-5-6-17-22(23(29)24(30)27-19(2)20-13-9-7-10-14-20)28-25(31)32-18-26(3,4)21-15-11-8-12-16-21/h7-16,19,22H,5-6,17-18H2,1-4H3,(H,27,30)(H,28,31)/t19-,22+/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152532
PNG
(2,2-dimethyl-3-phenylpropyl(S)-1,2-dioxo-1-((R)-1-...)
Show SMILES CCCC[C@H](NC(=O)OCC(C)(C)Cc1ccccc1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C27H36N2O4/c1-5-6-17-23(24(30)25(31)28-20(2)22-15-11-8-12-16-22)29-26(32)33-19-27(3,4)18-21-13-9-7-10-14-21/h7-16,20,23H,5-6,17-19H2,1-4H3,(H,28,31)(H,29,32)/t20-,23+/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152530
PNG
(CHEMBL186650 | P2,P3 Ketoamide derivative)
Show SMILES CN(C)S(=O)(=O)NCCCC[C@H](NC(=O)OCC1(Cc2ccc(F)cc2)CCC1)C(=O)C(=O)NCc1cccnc1
Show InChI InChI=1S/C28H38FN5O6S/c1-34(2)41(38,39)32-16-4-3-8-24(25(35)26(36)31-19-22-7-5-15-30-18-22)33-27(37)40-20-28(13-6-14-28)17-21-9-11-23(29)12-10-21/h5,7,9-12,15,18,24,32H,3-4,6,8,13-14,16-17,19-20H2,1-2H3,(H,31,36)(H,33,37)/t24-/m0/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152525
PNG
(CHEMBL184403 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)OCC1(Cc2ccccc2)CCCC1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C29H38N2O4/c1-3-4-17-25(26(32)27(33)30-22(2)24-15-9-6-10-16-24)31-28(34)35-21-29(18-11-12-19-29)20-23-13-7-5-8-14-23/h5-10,13-16,22,25H,3-4,11-12,17-21H2,1-2H3,(H,30,33)(H,31,34)/t22-,25+/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165420
PNG
(CHEMBL197509 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C26H36N2O4/c1-3-4-10-22(23(29)25(30)27-16(2)19-8-6-5-7-9-19)28-26(31)32-24-20-12-17-11-18(14-20)15-21(24)13-17/h5-9,16-18,20-22,24H,3-4,10-15H2,1-2H3,(H,27,30)(H,28,31)/t16-,17?,18?,20?,21?,22+,24?/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152523
PNG
(CHEMBL180528 | [(S)-5-[(Morpholine-4-carbonyl)-ami...)
Show SMILES C[C@@H](NC(=O)C(=O)[C@H](CCCCNC(=O)N1CCOCC1)NC(=O)OCC1(Cc2ccc(F)cc2)CCC1)c1ccccc1
Show InChI InChI=1S/C33H43FN4O6/c1-24(26-8-3-2-4-9-26)36-30(40)29(39)28(10-5-6-17-35-31(41)38-18-20-43-21-19-38)37-32(42)44-23-33(15-7-16-33)22-25-11-13-27(34)14-12-25/h2-4,8-9,11-14,24,28H,5-7,10,15-23H2,1H3,(H,35,41)(H,36,40)(H,37,42)/t24-,28+/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152527
PNG
((1-benzylcyclobutyl)methyl(S)-1,2-dioxo-1-((R)-1-p...)
Show SMILES CCCC[C@H](NC(=O)OCC1(Cc2ccccc2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C28H36N2O4/c1-3-4-16-24(25(31)26(32)29-21(2)23-14-9-6-10-15-23)30-27(33)34-20-28(17-11-18-28)19-22-12-7-5-8-13-22/h5-10,12-15,21,24H,3-4,11,16-20H2,1-2H3,(H,29,32)(H,30,33)/t21-,24+/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Capra hircus (Goat))
BDBM50045441
PNG
(CHEMBL3309617)
Show SMILES Clc1ccc(\C=C\C(=N/Nc2ccccc2)\c2ccccc2)cc1
Show InChI InChI=1S/C21H17ClN2/c22-19-14-11-17(12-15-19)13-16-21(18-7-3-1-4-8-18)24-23-20-9-5-2-6-10-20/h1-16,23H/b16-13+,24-21+
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n/an/a 5.70E+3n/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Inhibition of goat liver cathepsin H using Leu-betaNA substrate pre-incubated 30 mins before substrate addition by colorimetry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Capra hircus (Goat))
BDBM91551
PNG
(3-(4-chlorophenyl)-2,5-diphenyl-3,4-dihydropyrazol...)
Show SMILES Clc1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H17ClN2/c22-18-13-11-17(12-14-18)21-15-20(16-7-3-1-4-8-16)23-24(21)19-9-5-2-6-10-19/h1-14,21H,15H2
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n/an/a 6.25E+3n/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Inhibition of goat liver cathepsin H using Leu-betaNA substrate pre-incubated 30 mins before substrate addition by colorimetry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50201700
PNG
((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-...)
Show SMILES O=C1O[C@@H]2CN1CC[C@@H]2Oc1ccccc1
Show InChI InChI=1S/C12H13NO3/c14-12-13-7-6-10(11(8-13)16-12)15-9-4-2-1-3-5-9/h1-5,10-11H,6-8H2/t10-,11+/m0/s1
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n/an/a 6.59E+3n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Rattus norvegicus)
BDBM36325
PNG
(Cathepsin Inhibitor III)
Show SMILES COc1ccc(cc1)C(=O)ONC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H27N3O7/c1-35-22-14-12-21(13-15-22)26(33)37-30-24(31)17-28-25(32)23(16-19-8-4-2-5-9-19)29-27(34)36-18-20-10-6-3-7-11-20/h2-15,23H,16-18H2,1H3,(H,28,32)(H,29,34)(H,30,31)
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n/an/a 6.60E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Capra hircus (Goat))
BDBM50045443
PNG
(CHEMBL3309799)
Show SMILES Clc1ccc(cc1)C1CC(=NN1)c1ccccc1
Show InChI InChI=1/C15H13ClN2/c16-13-8-6-12(7-9-13)15-10-14(17-18-15)11-4-2-1-3-5-11/h1-9,15,18H,10H2
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n/an/a 7.00E+3n/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Inhibition of goat liver cathepsin H using Leu-betaNA substrate pre-incubated 30 mins before substrate addition by colorimetry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Capra hircus (Goat))
BDBM50045444
PNG
(CHEMBL3309804)
Show SMILES Clc1ccc(cc1)-c1cc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15ClN2/c22-18-13-11-17(12-14-18)21-15-20(16-7-3-1-4-8-16)23-24(21)19-9-5-2-6-10-19/h1-15H
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n/an/a 7.10E+3n/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Inhibition of goat liver cathepsin H using Leu-betaNA substrate pre-incubated 30 mins before substrate addition by colorimetry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Rattus norvegicus)
BDBM36330
PNG
(AC-YFG-AMOK 10a)
Show SMILES CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)COC(=O)c1c(C)cccc1C
Show InChI InChI=1S/C32H35N3O7/c1-20-8-7-9-21(2)29(20)32(41)42-19-26(38)18-33-30(39)27(16-23-10-5-4-6-11-23)35-31(40)28(34-22(3)36)17-24-12-14-25(37)15-13-24/h4-15,27-28,37H,16-19H2,1-3H3,(H,33,39)(H,34,36)(H,35,40)/t27-,28-/m0/s1
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n/an/a 7.90E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Rattus norvegicus)
BDBM36329
PNG
(Z-LG-AOMK 9c)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)COC(=O)c1c(C)cccc1C
Show InChI InChI=1S/C26H32N2O6/c1-17(2)13-22(28-26(32)34-15-20-11-6-5-7-12-20)24(30)27-14-21(29)16-33-25(31)23-18(3)9-8-10-19(23)4/h5-12,17,22H,13-16H2,1-4H3,(H,27,30)(H,28,32)/t22-/m0/s1
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n/an/a 7.90E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50163838
PNG
((1-Cyano-pyrrolidin-3-yl)-carbamic acid (S)-2-cycl...)
Show SMILES C[C@@H](CC1CCCCC1)OC(=O)N[C@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H25N3O2/c1-12(9-13-5-3-2-4-6-13)20-15(19)17-14-7-8-18(10-14)11-16/h12-14H,2-10H2,1H3,(H,17,19)/t12-,14-/m0/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Capra hircus (Goat))
BDBM50045442
PNG
(CHEMBL332286)
Show SMILES CC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C17H15ClN2O/c1-12(21)20-17(14-7-9-15(18)10-8-14)11-16(19-20)13-5-3-2-4-6-13/h2-10,17H,11H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Inhibition of goat liver cathepsin H using Leu-betaNA substrate pre-incubated 30 mins before substrate addition by colorimetry


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50270029
PNG
(2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-pro...)
Show SMILES NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)[CH-][N+]#N
Show InChI InChI=1S/C12H13IN4O2/c13-9-3-1-8(2-4-9)5-10(11(18)7-16-15)17-12(19)6-14/h1-4,7,10H,5-6,14H2,(H,17,19)/t10-/m0/s1
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n/an/a 9.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin H after 10 mins


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50186088
PNG
((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Show SMILES CC[C@H](N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N
Show InChI InChI=1S/C19H21N3O/c1-2-18(21)19(23)22-17(13-20)12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,17-18H,2,12,21H2,1H3,(H,22,23)/t17-,18-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Arpida A/S

Curated by ChEMBL


Assay Description
Inhibition of Cathepsin H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50201699
PNG
((1R,2S)-2-isobutoxy-7-oxa-5-aza-bicyclo[3.2.1]octa...)
Show SMILES CC(C)CO[C@H]1CCN2C[C@H]1OC2=O
Show InChI InChI=1S/C10H17NO3/c1-7(2)6-13-8-3-4-11-5-9(8)14-10(11)12/h7-9H,3-6H2,1-2H3/t8-,9+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50302107
PNG
(CHEMBL567893 | Grassystatin A)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](OC(=O)[C@@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@@H](C)O
Show InChI InChI=1S/C58H95N9O16/c1-30(2)25-38(43(69)29-45(71)64-46(36(12)68)52(74)60-35(11)54(76)66(15)42(27-37-21-18-17-19-22-37)55(77)67-24-20-23-41(67)56(78)81-16)61-51(73)40(28-44(59)70)62-50(72)39(26-31(3)4)63-53(75)48(33(7)8)82-58(80)49(34(9)10)83-57(79)47(32(5)6)65(13)14/h17-19,21-22,30-36,38-43,46-49,68-69H,20,23-29H2,1-16H3,(H2,59,70)(H,60,74)(H,61,73)(H,62,72)(H,63,75)(H,64,71)/t35-,36+,38-,39-,40-,41-,42+,43-,46-,47-,48+,49-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of cathepsin H after 10 to 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50201705
PNG
((1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]oc...)
Show SMILES O=C1O[C@@H]2CN1CC[C@@H]2OCc1ccccc1
Show InChI InChI=1S/C13H15NO3/c15-13-14-7-6-11(12(8-14)17-13)16-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9H2/t11-,12+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50152520
PNG
(1-benzylcyclopentyl(S)-1,2-dioxo-1-((R)-1-phenylet...)
Show SMILES CCCC[C@H](NC(=O)OC1(Cc2ccccc2)CCCC1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C28H36N2O4/c1-3-4-17-24(25(31)26(32)29-21(2)23-15-9-6-10-16-23)30-27(33)34-28(18-11-12-19-28)20-22-13-7-5-8-14-22/h5-10,13-16,21,24H,3-4,11-12,17-20H2,1-2H3,(H,29,32)(H,30,33)/t21-,24+/m1/s1
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n/an/a>1.20E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin H


(Rattus norvegicus)
BDBM36331
PNG
(Ac-YFR-AMOK 10b)
Show SMILES CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)COC(=O)c1c(C)cccc1C
Show InChI InChI=1S/C36H44N6O7/c1-22-9-7-10-23(2)32(22)35(48)49-21-31(45)28(13-8-18-39-36(37)38)41-34(47)30(19-25-11-5-4-6-12-25)42-33(46)29(40-24(3)43)20-26-14-16-27(44)17-15-26/h4-7,9-12,14-17,28-30,44H,8,13,18-21H2,1-3H3,(H,40,43)(H,41,47)(H,42,46)(H4,37,38,39)/t28-,29-,30-/m0/s1
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n/an/a 1.20E+4n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50177491
PNG
(CHEMBL205173 | {(S)-1-[(morpholine-4-carbonyl)-hyd...)
Show SMILES CCCC[C@H](NC(=O)OC(C)(C)C)C=NNC(=O)N1CCOCC1
Show InChI InChI=1S/C16H30N4O4/c1-5-6-7-13(18-15(22)24-16(2,3)4)12-17-19-14(21)20-8-10-23-11-9-20/h12-13H,5-11H2,1-4H3,(H,18,22)(H,19,21)/t13-/m0/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50148292
PNG
(((S)-1-Formyl-pentyl)-carbamic acid 1-benzyl-cyclo...)
Show SMILES CCCC[C@H](NC(=O)OC1(Cc2ccccc2)CCCC1)C=O
Show InChI InChI=1S/C19H27NO3/c1-2-3-11-17(15-21)20-18(22)23-19(12-7-8-13-19)14-16-9-5-4-6-10-16/h4-6,9-10,15,17H,2-3,7-8,11-14H2,1H3,(H,20,22)/t17-/m0/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50177495
PNG
(CHEMBL381715 | {(S)-1-[(2,3-dihydro-indole-1-carbo...)
Show SMILES CCCC[C@H](NC(=O)OC(C)(C)C)C=NN=C(O)N1CCc2ccccc12
Show InChI InChI=1S/C20H30N4O3/c1-5-6-10-16(22-19(26)27-20(2,3)4)14-21-23-18(25)24-13-12-15-9-7-8-11-17(15)24/h7-9,11,14,16H,5-6,10,12-13H2,1-4H3,(H,22,26)(H,23,25)/t16-/m0/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50177503
PNG
(CHEMBL426308 | {(S)-1-[(2,3-dihydro-indole-1-carbo...)
Show SMILES CCCC[C@H](NC(=O)OC1(Cc2ccccc2)CCCC1)C=NN=C(O)N1CCc2ccccc12
Show InChI InChI=1S/C28H36N4O3/c1-2-3-14-24(21-29-31-26(33)32-19-16-23-13-7-8-15-25(23)32)30-27(34)35-28(17-9-10-18-28)20-22-11-5-4-6-12-22/h4-8,11-13,15,21,24H,2-3,9-10,14,16-20H2,1H3,(H,30,34)(H,31,33)/t24-/m0/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50137790
PNG
(((S)-1-Formyl-pentyl)-carbamic acid tert-butyl est...)
Show SMILES CCCC[C@H](NC(=O)OC(C)(C)C)C=O
Show InChI InChI=1S/C11H21NO3/c1-5-6-7-9(8-13)12-10(14)15-11(2,3)4/h8-9H,5-7H2,1-4H3,(H,12,14)/t9-/m0/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human cathepsin H in a fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165428
PNG
(CHEMBL196240 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)O[C@H]1CCc2ccccc12)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C25H30N2O4/c1-3-4-14-21(23(28)24(29)26-17(2)18-10-6-5-7-11-18)27-25(30)31-22-16-15-19-12-8-9-13-20(19)22/h5-13,17,21-22H,3-4,14-16H2,1-2H3,(H,26,29)(H,27,30)/t17-,21+,22+/m1/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165426
PNG
(CHEMBL196298 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)OC1CC2CCC1C2)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C23H32N2O4/c1-3-4-10-19(25-23(28)29-20-14-16-11-12-18(20)13-16)21(26)22(27)24-15(2)17-8-6-5-7-9-17/h5-9,15-16,18-20H,3-4,10-14H2,1-2H3,(H,24,27)(H,25,28)/t15-,16?,18?,19+,20?/m1/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165427
PNG
(CHEMBL194068 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)O[C@@H]1C(=O)NCC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C22H31N3O5/c1-5-6-12-16(25-21(29)30-18-20(28)23-13-22(18,3)4)17(26)19(27)24-14(2)15-10-8-7-9-11-15/h7-11,14,16,18H,5-6,12-13H2,1-4H3,(H,23,28)(H,24,27)(H,25,29)/t14-,16+,18-/m1/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165422
PNG
(CHEMBL195301 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)OC1C[C@H](C)C[C@@H](C)C1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C24H36N2O4/c1-5-6-12-21(26-24(29)30-20-14-16(2)13-17(3)15-20)22(27)23(28)25-18(4)19-10-8-7-9-11-19/h7-11,16-18,20-21H,5-6,12-15H2,1-4H3,(H,25,28)(H,26,29)/t16-,17-,18-,21+/m1/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165421
PNG
(CHEMBL371749 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)O[C@H]1C[C@@H](C)C[C@@H](C)C1)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C24H36N2O4/c1-5-6-12-21(26-24(29)30-20-14-16(2)13-17(3)15-20)22(27)23(28)25-18(4)19-10-8-7-9-11-19/h7-11,16-18,20-21H,5-6,12-15H2,1-4H3,(H,25,28)(H,26,29)/t16-,17+,18-,20-,21+/m1/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens)
BDBM50165423
PNG
(CHEMBL193582 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Show SMILES CCCC[C@H](NC(=O)OC1C2(C)CCC(C2)C1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C26H38N2O4/c1-6-7-13-20(21(29)22(30)27-17(2)18-11-9-8-10-12-18)28-24(31)32-23-25(3,4)19-14-15-26(23,5)16-19/h8-12,17,19-20,23H,6-7,13-16H2,1-5H3,(H,27,30)(H,28,31)/t17-,19?,20+,23?,26?/m1/s1
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n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamide


Citation and Details
More data for this
Ligand-Target Pair
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