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Compile Data Set for Download or QSAR

Found 2469 hits Enz. Inhib. hit(s) with Target = 'Cathepsin L'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin L1


(Homo sapiens (human))
BDBM50121902
PNG
(CHEMBL287630 | [(S)-1-((2S,3R)-2-Benzenesulfonyl-4...)
Show SMILES O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H]1[C@@H](NC1=O)S(=O)(=O)c1ccccc1)OCc1ccccc1
Show InChI InChI=1S/C26H25N3O6S/c30-23(28-22-24(31)29-25(22)36(33,34)20-14-8-3-9-15-20)21(16-18-10-4-1-5-11-18)27-26(32)35-17-19-12-6-2-7-13-19/h1-15,21-22,25H,16-17H2,(H,27,32)(H,28,30)(H,29,31)/t21-,22+,25-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



currently NAEJA Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cathepsin L


Bioorg Med Chem Lett 13: 139-41 (2002)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50121907
PNG
(CHEMBL31788 | [(S)-1-((3R,4S)-2-Oxo-4-phenylsulfan...)
Show SMILES O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H]1[C@@H](NC1=O)Sc1ccccc1)OCc1ccccc1
Show InChI InChI=1S/C26H25N3O4S/c30-23(28-22-24(31)29-25(22)34-20-14-8-3-9-15-20)21(16-18-10-4-1-5-11-18)27-26(32)33-17-19-12-6-2-7-13-19/h1-15,21-22,25H,16-17H2,(H,27,32)(H,28,30)(H,29,31)/t21-,22+,25-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



currently NAEJA Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cathepsin L


Bioorg Med Chem Lett 13: 139-41 (2002)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19732
PNG
(2-Cyano-pyrimidine, 16b | 2-cyano-4-(cyclohexylami...)
Show SMILES COc1ccc(CCNC(=O)c2cnc(nc2NC2CCCCC2)C#N)cc1
Show InChI InChI=1S/C21H25N5O2/c1-28-17-9-7-15(8-10-17)11-12-23-21(27)18-14-24-19(13-22)26-20(18)25-16-5-3-2-4-6-16/h7-10,14,16H,2-6,11-12H2,1H3,(H,23,27)(H,24,25,26)
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n/an/a 0.170n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19733
PNG
(2-Cyano-pyrimidine, 16c | 2-cyano-4-(cyclohexylami...)
Show SMILES COc1cccc(CCNC(=O)c2cnc(nc2NC2CCCCC2)C#N)c1
Show InChI InChI=1S/C21H25N5O2/c1-28-17-9-5-6-15(12-17)10-11-23-21(27)18-14-24-19(13-22)26-20(18)25-16-7-3-2-4-8-16/h5-6,9,12,14,16H,2-4,7-8,10-11H2,1H3,(H,23,27)(H,24,25,26)
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n/an/a 0.310n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19741
PNG
(2-Cyano-pyrimidine, 17f | 2-cyano-4-[(2,2-dimethyl...)
Show SMILES CN1CCN(Cc2ccc(CCNC(=O)c3cnc(nc3NCC(C)(C)C)C#N)cc2)CC1
Show InChI InChI=1S/C25H35N7O/c1-25(2,3)18-29-23-21(16-28-22(15-26)30-23)24(33)27-10-9-19-5-7-20(8-6-19)17-32-13-11-31(4)12-14-32/h5-8,16H,9-14,17-18H2,1-4H3,(H,27,33)(H,28,29,30)
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n/an/a 0.330n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19736
PNG
(2-Cyano-pyrimidine, 17a | 2-cyano-4-[(2,2-dimethyl...)
Show SMILES COc1ccc(CCNC(=O)c2cnc(nc2NCC(C)(C)C)C#N)cc1
Show InChI InChI=1S/C20H25N5O2/c1-20(2,3)13-24-18-16(12-23-17(11-21)25-18)19(26)22-10-9-14-5-7-15(27-4)8-6-14/h5-8,12H,9-10,13H2,1-4H3,(H,22,26)(H,23,24,25)
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n/an/a 0.340n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50250152
PNG
(3-acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroq...)
Show SMILES CC(=O)c1c(Nc2ccc(Cl)cc2)nc2c(Cl)cc(cc2c1O)[N+]([O-])=O
Show InChI InChI=1S/C17H11Cl2N3O4/c1-8(23)14-16(24)12-6-11(22(25)26)7-13(19)15(12)21-17(14)20-10-4-2-9(18)3-5-10/h2-7H,1H3,(H2,20,21,24)
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n/an/a 0.437n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L after 30 mins by fluorometric end-point assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19735
PNG
(2-Cyano-pyrimidine, 16e | 2-cyano-4-(cyclohexylami...)
Show SMILES CN1CCN(CC1)c1ccc(CCNC(=O)c2cnc(nc2NC2CCCCC2)C#N)cc1
Show InChI InChI=1S/C25H33N7O/c1-31-13-15-32(16-14-31)21-9-7-19(8-10-21)11-12-27-25(33)22-18-28-23(17-26)30-24(22)29-20-5-3-2-4-6-20/h7-10,18,20H,2-6,11-16H2,1H3,(H,27,33)(H,28,29,30)
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n/an/a 0.450n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19743
PNG
(2-Cyano-pyrimidine, 17h | 2-cyano-4-[(2,2-dimethyl...)
Show SMILES CC(C)(C)CNc1nc(ncc1C(=O)NCCc1ccc(OCCn2ccnc2)cc1)C#N
Show InChI InChI=1S/C24H29N7O2/c1-24(2,3)16-29-22-20(15-28-21(14-25)30-22)23(32)27-9-8-18-4-6-19(7-5-18)33-13-12-31-11-10-26-17-31/h4-7,10-11,15,17H,8-9,12-13,16H2,1-3H3,(H,27,32)(H,28,29,30)
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n/an/a 0.520n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50349198
PNG
(CHEMBL1807649)
Show SMILES CC(C)C[C@H](NC(=O)c1ccco1)C(=O)N[C@H]1CC[C@@H](C)N(CC1=O)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C23H30N4O6S/c1-15(2)13-18(26-23(30)20-7-6-12-33-20)22(29)25-17-10-9-16(3)27(14-19(17)28)34(31,32)21-8-4-5-11-24-21/h4-8,11-12,15-18H,9-10,13-14H2,1-3H3,(H,25,29)(H,26,30)/t16-,17+,18+/m1/s1
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n/an/a 0.530n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19745
PNG
(2-Cyano-pyrimidine, 17j | 2-cyano-4-[(2,2-dimethyl...)
Show SMILES COc1ccc(CCNC(=O)c2cnc(nc2NCC(C)(C)C)C#N)cc1OCCn1ccnc1
Show InChI InChI=1S/C25H31N7O3/c1-25(2,3)16-30-23-19(15-29-22(14-26)31-23)24(33)28-8-7-18-5-6-20(34-4)21(13-18)35-12-11-32-10-9-27-17-32/h5-6,9-10,13,15,17H,7-8,11-12,16H2,1-4H3,(H,28,33)(H,29,30,31)
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n/an/a 0.580n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19744
PNG
(2-Cyano-pyrimidine, 17i | 2-cyano-4-[(2,2-dimethyl...)
Show SMILES CC(C)(C)CNc1nc(ncc1C(=O)NCCc1cccc(OCCn2ccnc2)c1)C#N
Show InChI InChI=1S/C24H29N7O2/c1-24(2,3)16-29-22-20(15-28-21(14-25)30-22)23(32)27-8-7-18-5-4-6-19(13-18)33-12-11-31-10-9-26-17-31/h4-6,9-10,13,15,17H,7-8,11-12,16H2,1-3H3,(H,27,32)(H,28,29,30)
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n/an/a 0.680n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L


(Rattus norvegicus)
BDBM50121039
PNG
(CHEMBL114410 | [(S)-2-Cyclohexyl-1-((5S,6R)-4,4,7-...)
Show SMILES O=C(N[C@@H](CC1CCCCC1)C(=O)N[C@H]1[C@H]2N(CCS2(=O)=O)C1=O)OCc1ccccc1
Show InChI InChI=1S/C22H29N3O6S/c26-19(24-18-20(27)25-11-12-32(29,30)21(18)25)17(13-15-7-3-1-4-8-15)23-22(28)31-14-16-9-5-2-6-10-16/h2,5-6,9-10,15,17-18,21H,1,3-4,7-8,11-14H2,(H,23,28)(H,24,26)/t17-,18+,21-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



currently NAEJA Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease


Bioorg Med Chem Lett 12: 3417-9 (2002)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50163831
PNG
((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Show SMILES C[C@@H](CC1CCCCC1)OC(=O)C1CCN1C#N
Show InChI InChI=1S/C14H22N2O2/c1-11(9-12-5-3-2-4-6-12)18-14(17)13-7-8-16(13)10-15/h11-13H,2-9H2,1H3/t11-,13?/m0/s1
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n/an/a 0.710n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cathepsin L using 5 uM Cbz-Phe-Arg-AMC


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50084674
PNG
(CHEMBL115394 | [1-(1-Formyl-2-phenyl-ethylcarbamoy...)
Show SMILES O=CC(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C26H26N2O4/c29-18-23(16-20-10-4-1-5-11-20)27-25(30)24(17-21-12-6-2-7-13-21)28-26(31)32-19-22-14-8-3-9-15-22/h1-15,18,23-24H,16-17,19H2,(H,27,30)(H,28,31)
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n/an/a 0.740n/an/an/an/an/an/a



University of Queensland

Curated by ChEMBL


Assay Description
Inhibitory activity against cathepsin L, lysosomal cysteine protease


J Med Chem 43: 305-41 (2000)

Checked by Author
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50067612
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](C=O)C(C)C
Show InChI InChI=1S/C21H28N2O4S/c1-5-15(4)20(21(25)22-18(13-24)14(2)3)23-28(26,27)19-12-8-10-16-9-6-7-11-17(16)19/h6-15,18,20,23H,5H2,1-4H3,(H,22,25)/t15?,18-,20+/m1/s1
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n/an/a 0.740n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19740
PNG
(2-Cyano-pyrimidine, 17e | 2-cyano-4-[(2,2-dimethyl...)
Show SMILES CN1CCN(CC1)c1cccc(CCNC(=O)c2cnc(nc2NCC(C)(C)C)C#N)c1
Show InChI InChI=1S/C24H33N7O/c1-24(2,3)17-28-22-20(16-27-21(15-25)29-22)23(32)26-9-8-18-6-5-7-19(14-18)31-12-10-30(4)11-13-31/h5-7,14,16H,8-13,17H2,1-4H3,(H,26,32)(H,27,28,29)
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n/an/a 0.820n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50084650
PNG
(CHEMBL177914 | {(S)-1-[(S)-1-Formyl-2-(4-hydroxy-p...)
Show SMILES Oc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C=O)cc1
Show InChI InChI=1S/C26H26N2O5/c29-17-22(15-20-11-13-23(30)14-12-20)27-25(31)24(16-19-7-3-1-4-8-19)28-26(32)33-18-21-9-5-2-6-10-21/h1-14,17,22,24,30H,15-16,18H2,(H,27,31)(H,28,32)/t22-,24-/m0/s1
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n/an/a 0.850n/an/an/an/an/an/a



University of Queensland

Curated by ChEMBL


Assay Description
Inhibitory activity against cathepsin L, lysosomal cysteine protease


J Med Chem 43: 305-41 (2000)

Checked by Author
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM122528
PNG
(US8729061, 58)
Show SMILES CC(C)[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ncc(Cl)cc1F)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CC1
Show InChI InChI=1S/C29H31Cl2FN4O6S/c1-15(2)23(24(37)27(39)34-17-7-8-17)35-26(38)21-12-18(43(41,42)22-6-4-3-5-19(22)31)14-36(21)28(40)29(9-10-29)25-20(32)11-16(30)13-33-25/h3-6,11,13,15,17-18,21,23H,7-10,12,14H2,1-2H3,(H,34,39)(H,35,38)/t18-,21+,23+/m1/s1
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US Patent
n/an/a 0.900n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50067608
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C25H28N2O4S/c1-3-18(2)24(25(29)26-21(17-28)16-19-10-5-4-6-11-19)27-32(30,31)23-15-9-13-20-12-7-8-14-22(20)23/h4-15,17-18,21,24,27H,3,16H2,1-2H3,(H,26,29)/t18?,21-,24-/m0/s1
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n/an/a 0.950n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50067606
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(C)C)C=O
Show InChI InChI=1S/C22H30N2O4S/c1-5-16(4)21(22(26)23-18(14-25)13-15(2)3)24-29(27,28)20-12-8-10-17-9-6-7-11-19(17)20/h6-12,14-16,18,21,24H,5,13H2,1-4H3,(H,23,26)/t16?,18-,21-/m0/s1
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n/an/a 0.950n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50067604
PNG
((S)-N-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethyl]-3-met...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C26H27N3O4S/c1-17(2)25(29-34(32,33)24-13-7-9-18-8-3-4-11-22(18)24)26(31)28-20(16-30)14-19-15-27-23-12-6-5-10-21(19)23/h3-13,15-17,20,25,27,29H,14H2,1-2H3,(H,28,31)/t20-,25+/m1/s1
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n/an/a 0.970n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50349203
PNG
(CHEMBL1807698)
Show SMILES CC1CCC(C[C@H](NC(=O)c2ccco2)C(=O)N[C@H]2CC[C@@H](C)N(CC2=O)S(=O)(=O)c2ccccn2)CC1
Show InChI InChI=1S/C27H36N4O6S/c1-18-8-11-20(12-9-18)16-22(30-27(34)24-6-5-15-37-24)26(33)29-21-13-10-19(2)31(17-23(21)32)38(35,36)25-7-3-4-14-28-25/h3-7,14-15,18-22H,8-13,16-17H2,1-2H3,(H,29,33)(H,30,34)/t18?,19-,20?,21+,22+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19731
PNG
(2-Cyano-pyrimidine, 16a | 2-cyano-4-(cyclohexylami...)
Show SMILES O=C(NCCc1ccccc1)c1cnc(nc1NC1CCCCC1)C#N
Show InChI InChI=1S/C20H23N5O/c21-13-18-23-14-17(19(25-18)24-16-9-5-2-6-10-16)20(26)22-12-11-15-7-3-1-4-8-15/h1,3-4,7-8,14,16H,2,5-6,9-12H2,(H,22,26)(H,23,24,25)
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n/an/a 1.10n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19737
PNG
(2-Cyano-pyrimidine, 17b | 2-cyano-4-[(2,2-dimethyl...)
Show SMILES COc1cccc(CCNC(=O)c2cnc(nc2NCC(C)(C)C)C#N)c1
Show InChI InChI=1S/C20H25N5O2/c1-20(2,3)13-24-18-16(12-23-17(11-21)25-18)19(26)22-9-8-14-6-5-7-15(10-14)27-4/h5-7,10,12H,8-9,13H2,1-4H3,(H,22,26)(H,23,24,25)
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n/an/a 1.20n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50349197
PNG
(CHEMBL1807647)
Show SMILES C[C@@H]1CC[C@H](NC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C26H34N4O6S/c1-18-12-13-20(22(31)17-30(18)37(34,35)24-11-5-6-14-27-24)28-25(32)21(16-19-8-3-2-4-9-19)29-26(33)23-10-7-15-36-23/h5-7,10-11,14-15,18-21H,2-4,8-9,12-13,16-17H2,1H3,(H,28,32)(H,29,33)/t18-,20+,21+/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50414644
PNG
(CHEMBL555122)
Show SMILES Cn1nc(cc1C(=O)NC(Cc1cccc(c1)-c1nnc(CCN)o1)C(=O)NCC#N)C(C)(C)C
Show InChI InChI=1S/C24H30N8O3/c1-24(2,3)19-14-18(32(4)31-19)22(34)28-17(21(33)27-11-10-26)13-15-6-5-7-16(12-15)23-30-29-20(35-23)8-9-25/h5-7,12,14,17H,8-9,11,13,25H2,1-4H3,(H,27,33)(H,28,34)
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n/an/a 1.26n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavage


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L


(Rattus norvegicus)
BDBM50121041
PNG
(CHEMBL326093 | [(S)-1-((R)-4,7-Dioxo-4-(S)-oxo-4la...)
Show SMILES O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H]1[C@H]2N(CCS2(=O)=O)C1=O)OCc1ccccc1
Show InChI InChI=1S/C22H23N3O6S/c26-19(24-18-20(27)25-11-12-32(29,30)21(18)25)17(13-15-7-3-1-4-8-15)23-22(28)31-14-16-9-5-2-6-10-16/h1-10,17-18,21H,11-14H2,(H,23,28)(H,24,26)/t17-,18+,21-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



currently NAEJA Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease


Bioorg Med Chem Lett 12: 3417-9 (2002)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50067613
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O
Show InChI InChI=1S/C25H28N2O5S/c1-3-17(2)24(25(30)26-20(16-28)15-18-11-13-21(29)14-12-18)27-33(31,32)23-10-6-8-19-7-4-5-9-22(19)23/h4-14,16-17,20,24,27,29H,3,15H2,1-2H3,(H,26,30)/t17?,20-,24-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM210877
PNG
(US9290467, 47)
Show SMILES CSc1ccc2OC\C=C\COc3ccc(C[C@H](NC(=O)c2c1)C(=O)NC1(CC1)C#N)cc3Cl
Show InChI InChI=1/C25H24ClN3O4S/c1-34-17-5-7-21-18(14-17)23(30)28-20(24(31)29-25(15-27)8-9-25)13-16-4-6-22(19(26)12-16)33-11-3-2-10-32-21/h2-7,12,14,20H,8-11,13H2,1H3,(H,28,30)(H,29,31)/b3-2+/t20-/s2
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US Patent
n/an/a 1.60n/an/an/an/an/an/a



HOFFMANN—LA ROCHE INC.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US9290467 (2016)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM210881
PNG
(US9290467, 51)
Show SMILES CSc1ccc2OCCCCOc3ccc(C[C@H](NC(=O)c2c1)C(=O)NC1(CC1)C#N)cc3Cl
Show InChI InChI=1/C25H26ClN3O4S/c1-34-17-5-7-21-18(14-17)23(30)28-20(24(31)29-25(15-27)8-9-25)13-16-4-6-22(19(26)12-16)33-11-3-2-10-32-21/h4-7,12,14,20H,2-3,8-11,13H2,1H3,(H,28,30)(H,29,31)/t20-/s2
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n/an/a 1.60n/an/an/an/an/an/a



HOFFMANN—LA ROCHE INC.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US9290467 (2016)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM16510
PNG
((2S,3S)-3-[[(1S)-1-(isoamylcarbamoyl)-3-methyl-but...)
Show SMILES CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(O)=O
Show InChI InChI=1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1
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n/an/a<1.63n/an/an/an/an/an/a



PCMD

Curated by PubChem BioAssay


Assay Description
Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50250190
PNG
(3-acetyl-6-chloro-2-(2-chloro-4-methylphenylamino)...)
Show SMILES CC(=O)c1c(Nc2ccc(C)cc2Cl)nc2c(cc(Cl)cc2c1O)[N+]([O-])=O
Show InChI InChI=1S/C18H13Cl2N3O4/c1-8-3-4-13(12(20)5-8)21-18-15(9(2)24)17(25)11-6-10(19)7-14(23(26)27)16(11)22-18/h3-7H,1-2H3,(H2,21,22,25)
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n/an/a 1.66n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L after 30 mins by fluorometric end-point assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L


(Rattus norvegicus)
BDBM50121040
PNG
(CHEMBL117928 | [(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,...)
Show SMILES O=C(N[C@@H](Cc1cccnc1)C(=O)N[C@H]1[C@H]2N(CCS2(=O)=O)C1=O)OCc1ccccc1
Show InChI InChI=1S/C21H22N4O6S/c26-18(24-17-19(27)25-9-10-32(29,30)20(17)25)16(11-15-7-4-8-22-12-15)23-21(28)31-13-14-5-2-1-3-6-14/h1-8,12,16-17,20H,9-11,13H2,(H,23,28)(H,24,26)/t16-,17+,20-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



currently NAEJA Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease


Bioorg Med Chem Lett 12: 3417-9 (2002)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM122523
PNG
(US8729061, 53)
Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CCOCC1
Show InChI InChI=1S/C31H35Cl2N3O7S/c1-2-24(27(37)29(39)34-21-11-15-43-16-12-21)35-28(38)25-17-22(44(41,42)26-6-4-3-5-23(26)33)18-36(25)30(40)31(13-14-31)19-7-9-20(32)10-8-19/h3-10,21-22,24-25H,2,11-18H2,1H3,(H,34,39)(H,35,38)/t22-,24+,25+/m1/s1
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US Patent
n/an/a 1.70n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19742
PNG
(2-Cyano-pyrimidine, 17g | 2-cyano-4-[(2,2-dimethyl...)
Show SMILES CN1CCC(CC1)Oc1ccc(CCNC(=O)c2cnc(nc2NCC(C)(C)C)C#N)cc1
Show InChI InChI=1S/C25H34N6O2/c1-25(2,3)17-29-23-21(16-28-22(15-26)30-23)24(32)27-12-9-18-5-7-19(8-6-18)33-20-10-13-31(4)14-11-20/h5-8,16,20H,9-14,17H2,1-4H3,(H,27,32)(H,28,29,30)
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n/an/a 1.70n/an/an/an/a5.522



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50369397
PNG
(CHEMBL1790993)
Show SMILES CC[C@@H](C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C27H29N3O4S/c1-3-18(2)26(30-35(33,34)25-14-8-10-19-9-4-5-12-23(19)25)27(32)29-21(17-31)15-20-16-28-24-13-7-6-11-22(20)24/h4-14,16-18,21,26,28,30H,3,15H2,1-2H3,(H,29,32)/t18-,21-,26+/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50084677
PNG
(3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C27H29N3O4S/c1-3-18(2)26(30-35(33,34)25-14-8-10-19-9-4-5-12-23(19)25)27(32)29-21(17-31)15-20-16-28-24-13-7-6-11-22(20)24/h4-14,16-18,21,26,28,30H,3,15H2,1-2H3,(H,29,32)/t18?,21-,26-/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



University of Queensland

Curated by ChEMBL


Assay Description
Inhibitory activity against cathepsin L


J Med Chem 43: 305-41 (2000)

Checked by Author
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM122519
PNG
(US8729061, 49)
Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C34H35Cl2N3O6S/c1-2-27(30(40)32(42)37-19-16-22-8-4-3-5-9-22)38-31(41)28-20-25(46(44,45)29-11-7-6-10-26(29)36)21-39(28)33(43)34(17-18-34)23-12-14-24(35)15-13-23/h3-15,25,27-28H,2,16-21H2,1H3,(H,37,42)(H,38,41)/t25-,27+,28+/m1/s1
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US Patent
n/an/a 2n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50369405
PNG
(CHEMBL1790991)
Show SMILES CC[C@@H](C)[C@H](NC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C25H27F3N4O3/c1-3-15(2)22(32-24(35)31-21-11-7-5-9-19(21)25(26,27)28)23(34)30-17(14-33)12-16-13-29-20-10-6-4-8-18(16)20/h4-11,13-15,17,22,29H,3,12H2,1-2H3,(H,30,34)(H2,31,32,35)/t15-,17-,22+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50369397
PNG
(CHEMBL1790993)
Show SMILES CC[C@@H](C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C27H29N3O4S/c1-3-18(2)26(30-35(33,34)25-14-8-10-19-9-4-5-12-23(19)25)27(32)29-21(17-31)15-20-16-28-24-13-7-6-11-22(20)24/h4-14,16-18,21,26,28,30H,3,15H2,1-2H3,(H,29,32)/t18-,21-,26+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Compound was measured for inhibition of collagenolytic of human Cathepsin L


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50414643
PNG
(CHEMBL557455)
Show SMILES Cn1nc(cc1C(=O)NC(Cc1cccc(c1)-c1nnc(CN)o1)C(=O)NCC#N)C(C)(C)C
Show InChI InChI=1S/C23H28N8O3/c1-23(2,3)18-12-17(31(4)30-18)21(33)27-16(20(32)26-9-8-24)11-14-6-5-7-15(10-14)22-29-28-19(13-25)34-22/h5-7,10,12,16H,9,11,13,25H2,1-4H3,(H,26,32)(H,27,33)
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n/an/a 2n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavage


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50369410
PNG
(CHEMBL1790989)
Show SMILES CC[C@@H](C)[C@H](NC(=O)Nc1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C28H30N4O3/c1-3-18(2)26(32-28(35)31-25-14-8-10-19-9-4-5-11-22(19)25)27(34)30-21(17-33)15-20-16-29-24-13-7-6-12-23(20)24/h4-14,16-18,21,26,29H,3,15H2,1-2H3,(H,30,34)(H2,31,32,35)/t18-,21-,26+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM19778
PNG
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Show SMILES CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CC[C@@H](C)N(CC1=O)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C27H32N4O6S/c1-17(2)14-21(30-27(34)24-15-19-8-4-5-9-23(19)37-24)26(33)29-20-12-11-18(3)31(16-22(20)32)38(35,36)25-10-6-7-13-28-25/h4-10,13,15,17-18,20-21H,11-12,14,16H2,1-3H3,(H,29,33)(H,30,34)/t18-,20+,21+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of cathepsin L in human HepG2 cells


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50369402
PNG
(CHEMBL1790996)
Show SMILES CC[C@@H](C)[C@H](NC(=O)c1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C24H27N3O3/c1-3-16(2)22(27-23(29)17-9-5-4-6-10-17)24(30)26-19(15-28)13-18-14-25-21-12-8-7-11-20(18)21/h4-12,14-16,19,22,25H,3,13H2,1-2H3,(H,26,30)(H,27,29)/t16-,19-,22+/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50369398
PNG
(CHEMBL1790999)
Show SMILES CC[C@@H](C)[C@H](NS(=O)(=O)c1ccc(C)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C24H29N3O4S/c1-4-17(3)23(27-32(30,31)20-11-9-16(2)10-12-20)24(29)26-19(15-28)13-18-14-25-22-8-6-5-7-21(18)22/h5-12,14-15,17,19,23,25,27H,4,13H2,1-3H3,(H,26,29)/t17-,19-,23+/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50067597
PNG
((S)-4-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CC(C)C[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C27H29N3O4S/c1-18(2)14-25(30-35(33,34)26-13-7-9-19-8-3-4-11-23(19)26)27(32)29-21(17-31)15-20-16-28-24-12-6-5-10-22(20)24/h3-13,16-18,21,25,28,30H,14-15H2,1-2H3,(H,29,32)/t21-,25+/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50369403
PNG
(CHEMBL1790995)
Show SMILES CC[C@@H](C)[C@H](NC(=S)NCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C25H30N4O2S/c1-3-17(2)23(29-25(32)27-14-18-9-5-4-6-10-18)24(31)28-20(16-30)13-19-15-26-22-12-8-7-11-21(19)22/h4-12,15-17,20,23,26H,3,13-14H2,1-2H3,(H,28,31)(H2,27,29,32)/t17-,20-,23+/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50369400
PNG
(CHEMBL1791000)
Show SMILES CC[C@@H](C)[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C24H28N4O2S/c1-3-16(2)22(28-24(31)27-18-9-5-4-6-10-18)23(30)26-19(15-29)13-17-14-25-21-12-8-7-11-20(17)21/h4-12,14-16,19,22,25H,3,13H2,1-2H3,(H,26,30)(H2,27,28,31)/t16-,19-,22+/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50286441
PNG
((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C20H38N6O5/c1-11(2)9-15(24-13(5)27)17(28)26-16(10-12(3)4)18(29)25-14(19(30)31)7-6-8-23-20(21)22/h11-12,14-16H,6-10H2,1-5H3,(H,24,27)(H,25,29)(H,26,28)(H,30,31)(H4,21,22,23)/t14-,15-,16-/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Compound was measured for inhibition of collagenolytic of human Cathepsin L


Citation and Details
More data for this
Ligand-Target Pair
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