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Compile Data Set for Download or QSAR

Found 2446 hits Enz. Inhib. hit(s) with Target = 'Cathepsin S'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin S


(Homo sapiens (Human))
BDBM2678
PNG
(US8524710, 79)
Show SMILES FC(F)(F)c1ccc(CNC(=O)c2cnc(nc2N2CC[C@@H](C2)S(=O)(=O)c2ccccc2C(F)(F)F)C#N)cc1
Show InChI InChI=1S/C25H19F6N5O3S/c26-24(27,28)16-7-5-15(6-8-16)12-34-23(37)18-13-33-21(11-32)35-22(18)36-10-9-17(14-36)40(38,39)20-4-2-1-3-19(20)25(29,30)31/h1-8,13,17H,9-10,12,14H2,(H,34,37)/t17-/m0/s1
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US Patent
n/an/a 0.0290n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101469
PNG
(US8524710, 47)
Show SMILES FC(F)(F)c1cc(nc(n1)C#N)N1CC[C@@H](C1)S(=O)(=O)c1ccc(cc1Cl)-n1cccn1
Show InChI InChI=1S/C19H14ClF3N6O2S/c20-14-8-12(29-6-1-5-25-29)2-3-15(14)32(30,31)13-4-7-28(11-13)18-9-16(19(21,22)23)26-17(10-24)27-18/h1-3,5-6,8-9,13H,4,7,11H2/t13-/m0/s1
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US Patent
n/an/a 0.0520n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101470
PNG
(US8524710, 48)
Show SMILES FC(F)(F)c1cc(nc(n1)C#N)N1CC[C@@H](C1)S(=O)(=O)c1ccc(cc1Cl)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C23H24ClF3N6O2S/c24-18-11-16(32-9-7-31(8-10-32)15-1-2-15)3-4-19(18)36(34,35)17-5-6-33(14-17)22-12-20(23(25,26)27)29-21(13-28)30-22/h3-4,11-12,15,17H,1-2,5-10,14H2/t17-/m0/s1
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n/an/a 0.0560n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM2718
PNG
(US8524710, 78 | US8524710, 85 | US8524710, 86)
Show SMILES CC(CNC(=O)c1cnc(nc1N1CC[C@@H](C1)S(=O)(=O)c1ccccc1C(F)(F)F)C#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H23ClF3N5O3S/c1-16(17-6-8-18(27)9-7-17)13-33-25(36)20-14-32-23(12-31)34-24(20)35-11-10-19(15-35)39(37,38)22-5-3-2-4-21(22)26(28,29)30/h2-9,14,16,19H,10-11,13,15H2,1H3,(H,33,36)/t16?,19-/m0/s1
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n/an/a 0.0560n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM2724
PNG
(US8524710, 83)
Show SMILES FC(F)(F)CNC(=O)c1cnc(nc1N1CC[C@@H](C1)S(=O)(=O)c1ccccc1C(F)(F)F)C#N
Show InChI InChI=1S/C19H15F6N5O3S/c20-18(21,22)10-28-17(31)12-8-27-15(7-26)29-16(12)30-6-5-11(9-30)34(32,33)14-4-2-1-3-13(14)19(23,24)25/h1-4,8,11H,5-6,9-10H2,(H,28,31)/t11-/m0/s1
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n/an/a 0.0610n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM50401763
PNG
(CHEMBL2207565)
Show SMILES C[C@H]1CC[C@@H](CC1)[C@](C)(NC(=O)c1ccsc1)c1cn(CC#N)nn1
Show InChI InChI=1S/C18H23N5OS/c1-13-3-5-15(6-4-13)18(2,16-11-23(9-8-19)22-21-16)20-17(24)14-7-10-25-12-14/h7,10-13,15H,3-6,9H2,1-2H3,(H,20,24)/t13-,15-,18-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM50401764
PNG
(CHEMBL2207564)
Show SMILES C[C@H](C#N)n1cc(nn1)[C@@](C)(NC(=O)c1ccsc1)[C@H]1CC[C@H](C)CC1
Show InChI InChI=1S/C19H25N5OS/c1-13-4-6-16(7-5-13)19(3,21-18(25)15-8-9-26-12-15)17-11-24(23-22-17)14(2)10-20/h8-9,11-14,16H,4-7H2,1-3H3,(H,21,25)/t13-,14-,16-,19+/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM2726
PNG
(US8524710, 50)
Show SMILES FC(F)(F)c1cc(nc(n1)C#N)N1CC[C@@H](C1)S(=O)(=O)c1ccc(cc1Cl)-n1ccnc1
Show InChI InChI=1S/C19H14ClF3N6O2S/c20-14-7-12(29-6-4-25-11-29)1-2-15(14)32(30,31)13-3-5-28(10-13)18-8-16(19(21,22)23)26-17(9-24)27-18/h1-2,4,6-8,11,13H,3,5,10H2/t13-/m0/s1
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n/an/a 0.110n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19731
PNG
(2-Cyano-pyrimidine, 16a | 2-cyano-4-(cyclohexylami...)
Show SMILES O=C(NCCc1ccccc1)c1cnc(nc1NC1CCCCC1)C#N
Show InChI InChI=1S/C20H23N5O/c21-13-18-23-14-17(19(25-18)24-16-9-5-2-6-10-16)20(26)22-12-11-15-7-3-1-4-8-15/h1,3-4,7-8,14,16H,2,5-6,9-12H2,(H,22,26)(H,23,24,25)
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n/an/a 0.130n/an/an/an/a7.022



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101473
PNG
(US8524710, 51)
Show SMILES COCCOc1ccc(c(Cl)c1)S(=O)(=O)[C@H]1CCN(C1)c1cc(nc(n1)C#N)C(F)(F)F
Show InChI InChI=1S/C19H18ClF3N4O4S/c1-30-6-7-31-12-2-3-15(14(20)8-12)32(28,29)13-4-5-27(11-13)18-9-16(19(21,22)23)25-17(10-24)26-18/h2-3,8-9,13H,4-7,11H2,1H3/t13-/m0/s1
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n/an/a 0.130n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101466
PNG
(US8524710, 44)
Show SMILES CC(C)(C)N1CCN(CC1)c1ccc(c(Cl)c1)S(=O)(=O)[C@H]1CCN(C1)c1cc(nc(n1)C#N)C(F)(F)F
Show InChI InChI=1S/C24H28ClF3N6O2S/c1-23(2,3)34-10-8-32(9-11-34)16-4-5-19(18(25)12-16)37(35,36)17-6-7-33(15-17)22-13-20(24(26,27)28)30-21(14-29)31-22/h4-5,12-13,17H,6-11,15H2,1-3H3/t17-/m0/s1
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n/an/a 0.150n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM2736
PNG
(US8524710, 80)
Show SMILES FC(F)(F)c1ccc(CNC(=O)c2cnc(nc2N2CC[C@@H](C2)S(=O)(=O)c2cccc(Cl)c2Cl)C#N)cc1
Show InChI InChI=1S/C24H18Cl2F3N5O3S/c25-18-2-1-3-19(21(18)26)38(36,37)16-8-9-34(13-16)22-17(12-31-20(10-30)33-22)23(35)32-11-14-4-6-15(7-5-14)24(27,28)29/h1-7,12,16H,8-9,11,13H2,(H,32,35)/t16-/m0/s1
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n/an/a 0.155n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101462
PNG
(US8524710, 40)
Show SMILES FC(F)(F)c1cc(nc(n1)C#N)N1CC[C@@H](C1)S(=O)(=O)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C17H12F6N4O2S/c18-16(19,20)11-3-1-2-4-12(11)30(28,29)10-5-6-27(9-10)15-7-13(17(21,22)23)25-14(8-24)26-15/h1-4,7,10H,5-6,9H2/t10-/m0/s1
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n/an/a 0.167n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Mus musculus)
BDBM50444314
PNG
(CHEMBL3093935)
Show SMILES Clc1ccccc1S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1CCCCC1)C(=O)NC1(CC1)C#N
Show InChI InChI=1S/C22H26ClN3O4S/c23-17-8-4-5-9-19(17)31(29,30)16-12-18(20(27)25-22(14-24)10-11-22)26(13-16)21(28)15-6-2-1-3-7-15/h4-5,8-9,15-16,18H,1-3,6-7,10-13H2,(H,25,27)/t16-,18+/m1/s1
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n/an/a 0.200n/an/an/an/an/an/a



Pharma Research and Early

Curated by ChEMBL


Assay Description
Inhibition of mouse cathepsin-S using Z-Val-Val-Arg-AMC as substrate up to 20 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19511
PNG
((2R)-3-[(3-bromobenzene)sulfonyl]-N-(1-cyanocyclop...)
Show SMILES FC(F)(F)[C@@H](N[C@@H](CS(=O)(=O)c1cccc(Br)c1)C(=O)NC1(CC1)C#N)c1ccccc1
Show InChI InChI=1S/C21H19BrF3N3O3S/c22-15-7-4-8-16(11-15)32(30,31)12-17(19(29)28-20(13-26)9-10-20)27-18(21(23,24)25)14-5-2-1-3-6-14/h1-8,11,17-18,27H,9-10,12H2,(H,28,29)/t17-,18-/m0/s1
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n/an/a 0.200n/an/an/an/a6.522



Merck Frosst Centre for Therapeutic Research



Assay Description
Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19515
PNG
((2R)-N-(1-cyanocyclopropyl)-3-[(3,4-dichlorobenzen...)
Show SMILES Fc1ccc(cc1)[C@H](N[C@@H](CS(=O)(=O)c1ccc(Cl)c(Cl)c1)C(=O)NC1(CC1)C#N)C(F)(F)F
Show InChI InChI=1S/C21H17Cl2F4N3O3S/c22-15-6-5-14(9-16(15)23)34(32,33)10-17(19(31)30-20(11-28)7-8-20)29-18(21(25,26)27)12-1-3-13(24)4-2-12/h1-6,9,17-18,29H,7-8,10H2,(H,30,31)/t17-,18-/m0/s1
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n/an/a 0.200n/an/an/an/a6.522



Merck Frosst Centre for Therapeutic Research



Assay Description
Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19514
PNG
((2R)-N-(1-cyanocyclopropyl)-3-[(3,4-dichlorobenzen...)
Show SMILES FC(F)(F)[C@@H](N[C@@H](CS(=O)(=O)c1ccc(Cl)c(Cl)c1)C(=O)NC1(CC1)C#N)c1ccccc1
Show InChI InChI=1S/C21H18Cl2F3N3O3S/c22-15-7-6-14(10-16(15)23)33(31,32)11-17(19(30)29-20(12-27)8-9-20)28-18(21(24,25)26)13-4-2-1-3-5-13/h1-7,10,17-18,28H,8-9,11H2,(H,29,30)/t17-,18-/m0/s1
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n/an/a 0.200n/an/an/an/a6.522



Merck Frosst Centre for Therapeutic Research



Assay Description
Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101460
PNG
(US8524710, 38)
Show SMILES FC(F)(F)c1ccccc1S(=O)(=O)[C@H]1CCN(C1)c1nc(nc2CCCc12)C#N
Show InChI InChI=1S/C19H17F3N4O2S/c20-19(21,22)14-5-1-2-7-16(14)29(27,28)12-8-9-26(11-12)18-13-4-3-6-15(13)24-17(10-23)25-18/h1-2,5,7,12H,3-4,6,8-9,11H2/t12-/m0/s1
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n/an/a 0.205n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19783
PNG
((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Show SMILES CCCC[C@H](NC(=O)O[C@H](Cn1ccc(n1)-c1ccc(cc1)C(F)(F)F)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1
Show InChI InChI=1S/C27H33F3N6O4/c1-5-6-7-20(23(37)24(38)33-22-12-14-31-34-22)32-25(39)40-21(26(2,3)4)16-36-15-13-19(35-36)17-8-10-18(11-9-17)27(28,29)30/h8-15,20-21H,5-7,16H2,1-4H3,(H,32,39)(H2,31,33,34,38)/t20-,21+/m0/s1
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n/an/a 0.210n/an/an/an/a5.522



GSK



Assay Description
Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19733
PNG
(2-Cyano-pyrimidine, 16c | 2-cyano-4-(cyclohexylami...)
Show SMILES COc1cccc(CCNC(=O)c2cnc(nc2NC2CCCCC2)C#N)c1
Show InChI InChI=1S/C21H25N5O2/c1-28-17-9-5-6-15(12-17)10-11-23-21(27)18-14-24-19(13-22)26-20(18)25-16-7-3-2-4-8-16/h5-6,9,12,14,16H,2-4,7-8,10-11H2,1H3,(H,23,27)(H,24,25,26)
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n/an/a 0.230n/an/an/an/a7.022



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM122478
PNG
(US8729061, 8)
Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CC1
Show InChI InChI=1S/C29H31Cl2N3O6S/c1-2-22(25(35)27(37)32-19-11-12-19)33-26(36)23-15-20(41(39,40)24-6-4-3-5-21(24)31)16-34(23)28(38)29(13-14-29)17-7-9-18(30)10-8-17/h3-10,19-20,22-23H,2,11-16H2,1H3,(H,32,37)(H,33,36)/t20-,22+,23+/m1/s1
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US Patent
n/an/a 0.296n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19504
PNG
((2R)-N-(1-cyanocyclopropyl)-3-{[(2,3-difluoropheny...)
Show SMILES Fc1cccc(CS(=O)(=O)C[C@H](N[C@@H](c2ccccc2)C(F)(F)F)C(=O)NC2(CC2)C#N)c1F
Show InChI InChI=1S/C22H20F5N3O3S/c23-16-8-4-7-15(18(16)24)11-34(32,33)12-17(20(31)30-21(13-28)9-10-21)29-19(22(25,26)27)14-5-2-1-3-6-14/h1-8,17,19,29H,9-12H2,(H,30,31)/t17-,19-/m0/s1
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n/an/a 0.300n/an/an/an/a6.522



Merck Frosst Centre for Therapeutic Research



Assay Description
Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19510
PNG
((2R)-3-[(4-bromobenzene)sulfonyl]-N-(1-cyanocyclop...)
Show SMILES FC(F)(F)[C@@H](N[C@@H](CS(=O)(=O)c1ccc(Br)cc1)C(=O)NC1(CC1)C#N)c1ccccc1
Show InChI InChI=1S/C21H19BrF3N3O3S/c22-15-6-8-16(9-7-15)32(30,31)12-17(19(29)28-20(13-26)10-11-20)27-18(21(23,24)25)14-4-2-1-3-5-14/h1-9,17-18,27H,10-12H2,(H,28,29)/t17-,18-/m0/s1
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n/an/a 0.300n/an/an/an/a6.522



Merck Frosst Centre for Therapeutic Research



Assay Description
Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM129710
PNG
(US8802665, 43)
Show SMILES Clc1cccc(c1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)N1CCCCC1)C(=O)NC1(CC1)C#N
Show InChI InChI=1S/C24H29ClN4O4S/c25-17-5-4-6-18(13-17)34(32,33)19-14-20(21(30)27-23(16-26)7-8-23)29(15-19)22(31)24(9-10-24)28-11-2-1-3-12-28/h4-6,13,19-20H,1-3,7-12,14-15H2,(H,27,30)/t19-,20+/m1/s1
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n/an/a 0.300n/an/an/an/a6.5n/a



Genentech, Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8802665 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM129694
PNG
(US8802665, 27)
Show SMILES Clc1ccccc1S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)N1CCSCC1)C(=O)NC1(CC1)C#N
Show InChI InChI=1S/C23H27ClN4O4S2/c24-17-3-1-2-4-19(17)34(31,32)16-13-18(20(29)26-22(15-25)5-6-22)28(14-16)21(30)23(7-8-23)27-9-11-33-12-10-27/h1-4,16,18H,5-14H2,(H,26,29)/t16-,18+/m1/s1
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n/an/a 0.300n/an/an/an/a6.5n/a



Genentech, Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8802665 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM50401766
PNG
(CHEMBL2207562)
Show SMILES CCCC[C@H](C#N)n1cc(nn1)[C@@](C)(NC(=O)c1ccsc1)[C@H]1CC[C@H](C)CC1
Show InChI InChI=1S/C22H31N5OS/c1-4-5-6-19(13-23)27-14-20(25-26-27)22(3,18-9-7-16(2)8-10-18)24-21(28)17-11-12-29-15-17/h11-12,14-16,18-19H,4-10H2,1-3H3,(H,24,28)/t16-,18-,19-,22+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19505
PNG
((2R)-N-(1-cyanocyclopropyl)-3-{[(2,3-difluoropheny...)
Show SMILES Fc1ccc(cc1)[C@H](N[C@@H](CS(=O)(=O)Cc1cccc(F)c1F)C(=O)NC1(CC1)C#N)C(F)(F)F
Show InChI InChI=1S/C22H19F6N3O3S/c23-15-6-4-13(5-7-15)19(22(26,27)28)30-17(20(32)31-21(12-29)8-9-21)11-35(33,34)10-14-2-1-3-16(24)18(14)25/h1-7,17,19,30H,8-11H2,(H,31,32)/t17-,19-/m0/s1
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n/an/a 0.300n/an/an/an/a6.522



Merck Frosst Centre for Therapeutic Research



Assay Description
Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM2738
PNG
(US8524710, 87)
Show SMILES FC(F)(F)c1ccccc1S(=O)(=O)[C@H]1CCN(C1)c1nc(ncc1C(=O)NCC1(CC1)c1ccc(Cl)cc1)C#N
Show InChI InChI=1S/C27H23ClF3N5O3S/c28-18-7-5-17(6-8-18)26(10-11-26)16-34-25(37)20-14-33-23(13-32)35-24(20)36-12-9-19(15-36)40(38,39)22-4-2-1-3-21(22)27(29,30)31/h1-8,14,19H,9-12,15-16H2,(H,34,37)/t19-/m0/s1
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n/an/a 0.305n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101437
PNG
(US8524710, 14)
Show SMILES FC(F)(F)c1ccccc1S(=O)(=O)[C@H]1CCN(C1)c1ccnc(n1)C#N
Show InChI InChI=1S/C16H13F3N4O2S/c17-16(18,19)12-3-1-2-4-13(12)26(24,25)11-6-8-23(10-11)15-5-7-21-14(9-20)22-15/h1-5,7,11H,6,8,10H2/t11-/m0/s1
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n/an/a 0.310n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM3521
PNG
(US8524710, 84)
Show SMILES FC(F)(F)CNC(=O)c1cnc(nc1N1CC[C@@H](C1)S(=O)(=O)c1cccc(Cl)c1Cl)C#N
Show InChI InChI=1S/C18H14Cl2F3N5O3S/c19-12-2-1-3-13(15(12)20)32(30,31)10-4-5-28(8-10)16-11(7-25-14(6-24)27-16)17(29)26-9-18(21,22)23/h1-3,7,10H,4-5,8-9H2,(H,26,29)/t10-/m0/s1
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n/an/a 0.320n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM122498
PNG
(US8729061, 28)
Show SMILES CC(C)[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CC1
Show InChI InChI=1S/C30H33Cl2N3O6S/c1-17(2)25(26(36)28(38)33-20-11-12-20)34-27(37)23-15-21(42(40,41)24-6-4-3-5-22(24)32)16-35(23)29(39)30(13-14-30)18-7-9-19(31)10-8-18/h3-10,17,20-21,23,25H,11-16H2,1-2H3,(H,33,38)(H,34,37)/t21-,23+,25+/m1/s1
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n/an/a 0.328n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101464
PNG
(US8524710, 42)
Show SMILES Fc1ccc(c(Cl)c1)S(=O)(=O)[C@H]1CCN(C1)c1cc(nc(n1)C#N)C(F)(F)F
Show InChI InChI=1S/C16H11ClF4N4O2S/c17-11-5-9(18)1-2-12(11)28(26,27)10-3-4-25(8-10)15-6-13(16(19,20)21)23-14(7-22)24-15/h1-2,5-6,10H,3-4,8H2/t10-/m0/s1
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n/an/a 0.335n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM122508
PNG
(US8729061, 38)
Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccc(Cl)cc1Cl)C(=O)C(=O)NC1CC1
Show InChI InChI=1S/C29H30Cl3N3O6S/c1-2-22(25(36)27(38)33-19-8-9-19)34-26(37)23-14-20(42(40,41)24-10-7-18(31)13-21(24)32)15-35(23)28(39)29(11-12-29)16-3-5-17(30)6-4-16/h3-7,10,13,19-20,22-23H,2,8-9,11-12,14-15H2,1H3,(H,33,38)(H,34,37)/t20-,22+,23+/m1/s1
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n/an/a 0.340n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101467
PNG
(US8524710, 45)
Show SMILES FC(F)(F)c1cc(nc(n1)C#N)N1CC[C@@H](C1)S(=O)(=O)c1ccc(cc1Cl)N1CCN2CCC[C@H]2C1
Show InChI InChI=1S/C23H24ClF3N6O2S/c24-18-10-15(32-9-8-31-6-1-2-16(31)13-32)3-4-19(18)36(34,35)17-5-7-33(14-17)22-11-20(23(25,26)27)29-21(12-28)30-22/h3-4,10-11,16-17H,1-2,5-9,13-14H2/t16-,17-/m0/s1
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n/an/a 0.355n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM2718
PNG
(US8524710, 78 | US8524710, 85 | US8524710, 86)
Show SMILES CC(CNC(=O)c1cnc(nc1N1CC[C@@H](C1)S(=O)(=O)c1ccccc1C(F)(F)F)C#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H23ClF3N5O3S/c1-16(17-6-8-18(27)9-7-17)13-33-25(36)20-14-32-23(12-31)34-24(20)35-11-10-19(15-35)39(37,38)22-5-3-2-4-21(22)26(28,29)30/h2-9,14,16,19H,10-11,13,15H2,1H3,(H,33,36)/t16?,19-/m0/s1
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n/an/a 0.365n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM122479
PNG
(US8729061, 9)
Show SMILES CCC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CC1
Show InChI InChI=1S/C30H33Cl2N3O6S/c1-2-5-23(26(36)28(38)33-20-12-13-20)34-27(37)24-16-21(42(40,41)25-7-4-3-6-22(25)32)17-35(24)29(39)30(14-15-30)18-8-10-19(31)11-9-18/h3-4,6-11,20-21,23-24H,2,5,12-17H2,1H3,(H,33,38)(H,34,37)/t21-,23+,24+/m1/s1
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n/an/a 0.367n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM130419
PNG
(US8822505, 21 | US8822505, 23 | US8822505, 24)
Show SMILES CC(C)(C)OC(=O)N1CCC1(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccc(F)cc1Cl)c1ncc(Cl)cc1F
Show InChI InChI=1S/C29H29Cl2F2N5O6S/c1-27(2,3)44-26(41)38-9-8-29(38,23-20(33)10-16(30)13-35-23)25(40)37-14-18(12-21(37)24(39)36-28(15-34)6-7-28)45(42,43)22-5-4-17(32)11-19(22)31/h4-5,10-11,13,18,21H,6-9,12,14H2,1-3H3,(H,36,39)/t18-,21+,29?/m1/s1
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n/an/a 0.377n/an/an/an/a6.5n/a



Genentech, Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8822505 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM129693
PNG
(US8802665, 26)
Show SMILES CC1CCCN(C1)C1(CC1)C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C25H31ClN4O4S/c1-17-5-4-12-29(14-17)25(10-11-25)23(32)30-15-18(35(33,34)21-7-3-2-6-19(21)26)13-20(30)22(31)28-24(16-27)8-9-24/h2-3,6-7,17-18,20H,4-5,8-15H2,1H3,(H,28,31)/t17?,18-,20+/m1/s1
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n/an/a 0.400n/an/an/an/a6.5n/a



Genentech, Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8802665 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM129709
PNG
(US8802665, 42)
Show SMILES Fc1ccc(c(Cl)c1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)N1CCCCC1)C(=O)NC1(CC1)C#N
Show InChI InChI=1S/C24H28ClFN4O4S/c25-18-12-16(26)4-5-20(18)35(33,34)17-13-19(21(31)28-23(15-27)6-7-23)30(14-17)22(32)24(8-9-24)29-10-2-1-3-11-29/h4-5,12,17,19H,1-3,6-11,13-14H2,(H,28,31)/t17-,19+/m1/s1
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n/an/a 0.400n/an/an/an/a6.5n/a



Genentech, Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8802665 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM129711
PNG
(US8802665, 44)
Show SMILES Cc1ccc(cc1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)N1CCCCC1)C(=O)NC1(CC1)C#N
Show InChI InChI=1S/C25H32N4O4S/c1-18-5-7-19(8-6-18)34(32,33)20-15-21(22(30)27-24(17-26)9-10-24)29(16-20)23(31)25(11-12-25)28-13-3-2-4-14-28/h5-8,20-21H,2-4,9-16H2,1H3,(H,27,30)/t20-,21+/m1/s1
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n/an/a 0.400n/an/an/an/a6.5n/a



Genentech, Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8802665 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM129713
PNG
(US8802665, 46)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)N1CCCCC1)C(=O)NC1(CC1)C#N
Show InChI InChI=1S/C25H29F3N4O4S/c26-25(27,28)17-5-4-6-18(13-17)37(35,36)19-14-20(21(33)30-23(16-29)7-8-23)32(15-19)22(34)24(9-10-24)31-11-2-1-3-12-31/h4-6,13,19-20H,1-3,7-12,14-15H2,(H,30,33)/t19-,20+/m1/s1
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n/an/a 0.400n/an/an/an/a6.5n/a



Genentech, Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8802665 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19509
PNG
((2R)-N-(1-cyanocyclopropyl)-3-[(4-fluorobenzene)su...)
Show SMILES Fc1ccc(cc1)[C@H](N[C@@H](CS(=O)(=O)c1ccc(F)cc1)C(=O)NC1(CC1)C#N)C(F)(F)F
Show InChI InChI=1S/C21H18F5N3O3S/c22-14-3-1-13(2-4-14)18(21(24,25)26)28-17(19(30)29-20(12-27)9-10-20)11-33(31,32)16-7-5-15(23)6-8-16/h1-8,17-18,28H,9-11H2,(H,29,30)/t17-,18-/m0/s1
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n/an/a 0.400n/an/an/an/a6.522



Merck Frosst Centre for Therapeutic Research



Assay Description
Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19500
PNG
((2R)-N-(1-cyanocyclopropyl)-3-[(2-methylpropane)su...)
Show SMILES CC(C)CS(=O)(=O)C[C@H](N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(=O)NC1(CC1)C#N
Show InChI InChI=1S/C19H23F4N3O3S/c1-12(2)9-30(28,29)10-15(17(27)26-18(11-24)7-8-18)25-16(19(21,22)23)13-3-5-14(20)6-4-13/h3-6,12,15-16,25H,7-10H2,1-2H3,(H,26,27)/t15-,16-/m0/s1
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n/an/a 0.400n/an/an/an/a6.522



Merck Frosst Centre for Therapeutic Research



Assay Description
Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19502
PNG
((2R)-N-(1-cyanocyclopropyl)-3-(cyclopropylmethane)...)
Show SMILES Fc1ccc(cc1)[C@H](N[C@@H](CS(=O)(=O)CC1CC1)C(=O)NC1(CC1)C#N)C(F)(F)F
Show InChI InChI=1S/C19H21F4N3O3S/c20-14-5-3-13(4-6-14)16(19(21,22)23)25-15(10-30(28,29)9-12-1-2-12)17(27)26-18(11-24)7-8-18/h3-6,12,15-16,25H,1-2,7-10H2,(H,26,27)/t15-,16-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM122495
PNG
(US8729061, 25)
Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ncc(Cl)cc1F)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CC1
Show InChI InChI=1S/C28H29Cl2FN4O6S/c1-2-20(23(36)26(38)33-16-7-8-16)34-25(37)21-12-17(42(40,41)22-6-4-3-5-18(22)30)14-35(21)27(39)28(9-10-28)24-19(31)11-15(29)13-32-24/h3-6,11,13,16-17,20-21H,2,7-10,12,14H2,1H3,(H,33,38)(H,34,37)/t17-,20+,21+/m1/s1
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n/an/a 0.403n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM101465
PNG
(US8524710, 43)
Show SMILES CN1CCN(CC1)c1ccc(c(Cl)c1)S(=O)(=O)[C@H]1CCN(C1)c1cc(nc(n1)C#N)C(F)(F)F
Show InChI InChI=1S/C21H22ClF3N6O2S/c1-29-6-8-30(9-7-29)14-2-3-17(16(22)10-14)34(32,33)15-4-5-31(13-15)20-11-18(21(23,24)25)27-19(12-26)28-20/h2-3,10-11,15H,4-9,13H2,1H3/t15-/m0/s1
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n/an/a 0.415n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8524710 (2013)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM122486
PNG
(US8729061, 16)
Show SMILES CCC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Br)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CC1
Show InChI InChI=1S/C30H33BrClN3O6S/c1-2-5-23(26(36)28(38)33-20-12-13-20)34-27(37)24-16-21(42(40,41)25-7-4-3-6-22(25)32)17-35(24)29(39)30(14-15-30)18-8-10-19(31)11-9-18/h3-4,6-11,20-21,23-24H,2,5,12-17H2,1H3,(H,33,38)(H,34,37)/t21-,23+,24+/m1/s1
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n/an/a 0.442n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM122528
PNG
(US8729061, 58)
Show SMILES CC(C)[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ncc(Cl)cc1F)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CC1
Show InChI InChI=1S/C29H31Cl2FN4O6S/c1-15(2)23(24(37)27(39)34-17-7-8-17)35-26(38)21-12-18(43(41,42)22-6-4-3-5-19(22)31)14-36(21)28(40)29(9-10-29)25-20(32)11-16(30)13-33-25/h3-6,11,13,15,17-18,21,23H,7-10,12,14H2,1-2H3,(H,34,39)(H,35,38)/t18-,21+,23+/m1/s1
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n/an/a 0.478n/an/an/an/a6.5n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8729061 (2014)

More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM19735
PNG
(2-Cyano-pyrimidine, 16e | 2-cyano-4-(cyclohexylami...)
Show SMILES CN1CCN(CC1)c1ccc(CCNC(=O)c2cnc(nc2NC2CCCCC2)C#N)cc1
Show InChI InChI=1S/C25H33N7O/c1-31-13-15-32(16-14-31)21-9-7-19(8-10-21)11-12-27-25(33)22-18-28-23(17-26)30-24(22)29-20-5-3-2-4-6-20/h7-10,18,20H,2-6,11-16H2,1H3,(H,27,33)(H,28,29,30)
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n/an/a 0.480n/an/an/an/a7.022



Novartis Pharmaceuticals



Assay Description
The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM130420
PNG
(US8822505, 22 | US8822505, 25 | US8822505, 26)
Show SMILES CC(C)(C)OC(=O)N1CCC1(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccc(F)cc1Cl)c1ncc(Br)cc1F
Show InChI InChI=1S/C29H29BrClF2N5O6S/c1-27(2,3)44-26(41)38-9-8-29(38,23-20(33)10-16(30)13-35-23)25(40)37-14-18(12-21(37)24(39)36-28(15-34)6-7-28)45(42,43)22-5-4-17(32)11-19(22)31/h4-5,10-11,13,18,21H,6-9,12,14H2,1-3H3,(H,36,39)/t18-,21+,29?/m1/s1
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n/an/a 0.492n/an/an/an/a6.5n/a



Genentech, Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...


US Patent US8822505 (2014)

More data for this
Ligand-Target Pair
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