Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cathepsin V (Homo sapiens (human)) | BDBM50414641![]() (CHEMBL554065) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414640![]() (CHEMBL562844) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414638![]() (CHEMBL549378) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414639![]() (CHEMBL550872) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414642![]() (CHEMBL549791) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50331557![]() (2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 16.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human cathepsin V by fluorescence assay | Bioorg Med Chem Lett 20: 6890-4 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414637![]() (CHEMBL562915) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 19.9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414636![]() (CHEMBL559880) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50331769![]() ((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human Cat V | Bioorg Med Chem Lett 20: 7444-9 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50165427![]() (CHEMBL194068 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 15: 2209-13 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50331555![]() (CHEMBL1289305 | N-(1-(1H-pyrazol-3-ylamino)-1,2-di...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 29.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human cathepsin V by fluorescence assay | Bioorg Med Chem Lett 20: 6890-4 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50331556![]() (2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 36.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human cathepsin V by fluorescence assay | Bioorg Med Chem Lett 20: 6890-4 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414643![]() (CHEMBL557455) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 39.8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414633![]() (CHEMBL556436) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50331768![]() ((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human Cat V | Bioorg Med Chem Lett 20: 7444-9 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM12311![]() ((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human Cathepsin V | Antimicrob Agents Chemother 54: 305-11 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50165424![]() ((S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 15: 2209-13 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50331767![]() (1-(4'-((S)-1-((S)-1-((S)-1-cyano-2-(4-cyano-2-fluo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human Cat V | Bioorg Med Chem Lett 20: 7444-9 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414644![]() (CHEMBL555122) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50169493![]() ((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of 2 lM Cbz-Phe-Arg-AMC binding to human cathepsin V activity in fluorescence assay with 100 mM NaOAc | Bioorg Med Chem Lett 15: 3540-6 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50201701![]() (CHEMBL390474 | cis-4-(2,3-dimethylphenoxy)-6-oxa-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of human recombinant cathepsin V | Bioorg Med Chem Lett 17: 1254-9 (2007) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50201700![]() ((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of human recombinant cathepsin V | Bioorg Med Chem Lett 17: 1254-9 (2007) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414629![]() (CHEMBL563471) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50414635![]() (CHEMBL564626) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM19783![]() ((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of 2 lM Cbz-Phe-Arg-AMC binding to human cathepsin V activity in fluorescence assay with 100 mM NaOAc | Bioorg Med Chem Lett 15: 3540-6 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50165423![]() (CHEMBL193582 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 15: 2209-13 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50165426![]() (CHEMBL196298 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 15: 2209-13 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31992![]() (Dipeptidyl nitrile inhibitor, 25) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31977![]() (Dipeptidyl nitrile inhibitor, 10) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31980![]() (Dipeptidyl nitrile inhibitor, 13) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31992![]() (Dipeptidyl nitrile inhibitor, 25) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31988![]() (Dipeptidyl nitrile inhibitor, 21) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50165428![]() (CHEMBL196240 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 15: 2209-13 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50165425![]() (CHEMBL195963 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 15: 2209-13 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50165420![]() (CHEMBL197509 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 15: 2209-13 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31972![]() (Dipeptidyl nitrile inhibitor, 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | 398 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31993![]() (Dipeptidyl nitrile inhibitor, 26) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31993![]() (Dipeptidyl nitrile inhibitor, 26) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50169495![]() ((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of 2 lM Cbz-Phe-Arg-AMC binding to human cathepsin V activity in fluorescence assay with 100 mM NaOAc | Bioorg Med Chem Lett 15: 3540-6 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31991![]() (Dipeptidyl nitrile inhibitor, 24) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31990![]() (Dipeptidyl nitrile inhibitor, 23) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31989![]() (Dipeptidyl nitrile inhibitor, 22) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50255753![]() (CHEMBL481611 | MK-0822 | Odanacatib) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 762 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Inhibition of cathepsin V | Bioorg Med Chem Lett 18: 923-8 (2008) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31970![]() (Dipeptidyl nitrile inhibitor, 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 794 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31975![]() (Dipeptidyl nitrile inhibitor, 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 794 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31970![]() (Dipeptidyl nitrile inhibitor, 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage | Bioorg Med Chem Lett 19: 4622-5 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM93444![]() (Flavonid, 6[3,1]) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | 5.5 | 27 |
Universidade Federal de São Carlo | Assay Description Recombinant human cathepsin V was expressed and purified as described previously. | J Comb Chem 12: 687-95 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM50201699![]() ((1R,2S)-2-isobutoxy-7-oxa-5-aza-bicyclo[3.2.1]octa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | 894 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of human recombinant cathepsin V | Bioorg Med Chem Lett 17: 1254-9 (2007) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31984![]() (Dipeptidyl nitrile inhibitor, 17) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin V (Homo sapiens (human)) | BDBM31974![]() (Dipeptidyl nitrile inhibitor, 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) | |||||||||||
More data for this Ligand-Target Pair |
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