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Compile Data Set for Download or QSAR

Found 100 hits Enz. Inhib. hit(s) with Target = 'Cdc25C'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cdc25C


(Homo sapiens (Human))
BDBM50208827
PNG
(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
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n/an/a 56.9n/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25C


Bioorg Med Chem 19: 2145-55 (2011)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175216
PNG
(5-(2-(dimethylamino)ethylamino)-2-ethylbenzo[d]oxa...)
Show SMILES CCc1nc2c(O)c(cc(O)c2o1)N=CCN(C)C
Show InChI InChI=1S/C13H17N3O3/c1-4-10-15-11-12(18)8(14-5-6-16(2)3)7-9(17)13(11)19-10/h5,7,17-18H,4,6H2,1-3H3
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n/an/a 130n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175215
PNG
(6-(2-(dimethylamino)ethylamino)-2-ethylbenzo[d]oxa...)
Show SMILES CCc1nc2c(O)cc(N=CCN(C)C)c(O)c2o1
Show InChI InChI=1S/C13H17N3O3/c1-4-10-15-11-9(17)7-8(12(18)13(11)19-10)14-5-6-16(2)3/h5,7,17-18H,4,6H2,1-3H3
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n/an/a 130n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175218
PNG
(5-(2-(dimethylamino)ethylamino)-2-methylbenzo[d]th...)
Show SMILES CN(C)CC=Nc1cc(O)c2sc(C)nc2c1O
Show InChI InChI=1S/C12H15N3O2S/c1-7-14-10-11(17)8(13-4-5-15(2)3)6-9(16)12(10)18-7/h4,6,16-17H,5H2,1-3H3
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n/an/a 150n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50341995
PNG
(5-(2-(dimethylamino)ethylamino)-2,6-dimethylbenzo[...)
Show SMILES CN(C)CC=Nc1c(C)c(O)c2sc(C)nc2c1O
Show InChI InChI=1S/C13H17N3O2S/c1-7-9(14-5-6-16(3)4)12(18)10-13(11(7)17)19-8(2)15-10/h5,17-18H,6H2,1-4H3
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n/an/a 170n/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25C


Bioorg Med Chem 19: 2145-55 (2011)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175219
PNG
(6-(2-(dimethylamino)ethylamino)-2-phenylbenzo[d]ox...)
Show SMILES CN(C)CC=Nc1cc(O)c2nc(oc2c1O)-c1ccccc1
Show InChI InChI=1S/C17H17N3O3/c1-20(2)9-8-18-12-10-13(21)14-16(15(12)22)23-17(19-14)11-6-4-3-5-7-11/h3-8,10,21-22H,9H2,1-2H3
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n/an/a 230n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175217
PNG
(5-(2-(dimethylamino)ethylamino)-2-phenylbenzo[d]ox...)
Show SMILES CN(C)CC=Nc1cc(O)c2oc(nc2c1O)-c1ccccc1
Show InChI InChI=1S/C17H17N3O3/c1-20(2)9-8-18-12-10-13(21)16-14(15(12)22)19-17(23-16)11-6-4-3-5-7-11/h3-8,10,21-22H,9H2,1-2H3
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n/an/a 230n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50106497
PNG
(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Show SMILES Oc1c(Cl)c(N=CCN2CCOCC2)c(O)c2ncccc12
Show InChI InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-4,20-21H,5-9H2
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n/an/a 250n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50177318
PNG
(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Show SMILES CCCCCCCCCCCCCCc1ccc(cc1)C(=O)c1ccc2c(nocc12)-c1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C36H43NO5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-15-17-29(18-16-27)36(40)32-24-23-31-33(32)25-42-37-35(31)28-19-21-30(22-20-28)41-26-34(38)39/h15-25H,2-14,26H2,1H3,(H,38,39)
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n/an/a 2.27E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against cdc25C phosphatase


Bioorg Med Chem Lett 16: 499-502 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129579
PNG
(2,5-Dihydroxy-3-[7-(2-methyl-benzyl)-1H-indol-3-yl...)
Show SMILES Cc1ccccc1Cc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C22H17NO4/c1-12-5-2-3-6-13(12)9-14-7-4-8-15-16(11-23-20(14)15)19-21(26)17(24)10-18(25)22(19)27/h2-8,11,19,23H,9-10H2,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129576
PNG
(2,5-Dihydroxy-3-[7-(3,7,11-trimethyl-dodeca-2,6,10...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\Cc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C29H33NO4/c1-18(2)8-5-9-19(3)10-6-11-20(4)14-15-21-12-7-13-22-23(17-30-27(21)22)26-28(33)24(31)16-25(32)29(26)34/h7-8,10,12-14,17,26,30H,5-6,9,11,15-16H2,1-4H3/b19-10+,20-14+
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n/an/a 3.50E+3n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50155597
PNG
(4-Dimethylamino-2-{[2-(4-nitro-phenyl)-ethylamino]...)
Show SMILES CN(C)c1ccc(O)c(CNCCc2ccc(cc2)[N+]([O-])=O)c1
Show InChI InChI=1S/C17H21N3O3/c1-19(2)16-7-8-17(21)14(11-16)12-18-10-9-13-3-5-15(6-4-13)20(22)23/h3-8,11,18,21H,9-10,12H2,1-2H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory concentration for human cell division cycle 25 degree C phosphatase


Bioorg Med Chem Lett 14: 5809-12 (2004)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50155595
PNG
(4-Dimethylamino-2-methoxy-6-{[2-(4-nitro-phenyl)-e...)
Show SMILES COc1cc(cc(CNCCc2ccc(cc2)[N+]([O-])=O)c1O)N(C)C
Show InChI InChI=1S/C18H23N3O4/c1-20(2)16-10-14(18(22)17(11-16)25-3)12-19-9-8-13-4-6-15(7-5-13)21(23)24/h4-7,10-11,19,22H,8-9,12H2,1-3H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory concentration for human cell division cycle 25 degree C phosphatase


Bioorg Med Chem Lett 14: 5809-12 (2004)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50197854
PNG
(3-(4-heptadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Show SMILES CCCCCCCCCCCCCCCCCC1=C(CCC(O)=O)C(=O)OC1=O
Show InChI InChI=1S/C24H40O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-21(18-19-22(25)26)24(28)29-23(20)27/h2-19H2,1H3,(H,25,26)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Université Paul Verlaine-Metz

Curated by ChEMBL


Assay Description
Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)


Eur J Med Chem 42: 243-7 (2007)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50197854
PNG
(3-(4-heptadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Show SMILES CCCCCCCCCCCCCCCCCC1=C(CCC(O)=O)C(=O)OC1=O
Show InChI InChI=1S/C24H40O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-21(18-19-22(25)26)24(28)29-23(20)27/h2-19H2,1H3,(H,25,26)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25C


Bioorg Med Chem 19: 2145-55 (2011)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50370437
PNG
(BN-82002 | CHEMBL1258871)
Show SMILES COc1cc(cc(CN(C)CCc2ccc(cc2)[N+]([O-])=O)c1C)N(C)C
Show InChI InChI=1S/C20H27N3O3/c1-15-17(12-19(21(2)3)13-20(15)26-5)14-22(4)11-10-16-6-8-18(9-7-16)23(24)25/h6-9,12-13H,10-11,14H2,1-5H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory concentration for human cell division cycle 25 degree C phosphatase


Bioorg Med Chem Lett 14: 5809-12 (2004)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50155599
PNG
(4-Dimethylamino-2-({methyl-[2-(4-nitro-phenyl)-eth...)
Show SMILES CN(C)c1ccc(O)c(CN(C)CCc2ccc(cc2)[N+]([O-])=O)c1
Show InChI InChI=1S/C18H23N3O3/c1-19(2)17-8-9-18(22)15(12-17)13-20(3)11-10-14-4-6-16(7-5-14)21(23)24/h4-9,12,22H,10-11,13H2,1-3H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory concentration for human cell division cycle 25 degree C phosphatase


Bioorg Med Chem Lett 14: 5809-12 (2004)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50197848
PNG
(3-(4-tridecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)prop...)
Show SMILES CCCCCCCCCCCCCC1=C(CCC(O)=O)C(=O)OC1=O
Show InChI InChI=1S/C20H32O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-17(14-15-18(21)22)20(24)25-19(16)23/h2-15H2,1H3,(H,21,22)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Université Paul Verlaine-Metz

Curated by ChEMBL


Assay Description
Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)


Eur J Med Chem 42: 243-7 (2007)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50068031
PNG
(CHEMBL142455 | [(1R,3aS,4R,5S,7aR)-5-(5-Cyano-1-me...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H](CC(O)=O)[C@H](CC[C@]12C)C(=C)CCCCC#N
Show InChI InChI=1S/C27H45NO2/c1-19(2)10-9-12-21(4)24-13-14-25-23(18-26(29)30)22(15-16-27(24,25)5)20(3)11-7-6-8-17-28/h19,21-25H,3,6-16,18H2,1-2,4-5H3,(H,29,30)/t21-,22-,23-,24-,25+,27-/m1/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human cell division cycle 25 degree C


J Med Chem 44: 834-48 (2001)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129584
PNG
(3-(7-Benzyloxy-1H-indol-3-yl)-2,5-dihydroxy-[1,4]b...)
Show SMILES O=C1CC(=O)C(=O)C(c2c[nH]c3c(OCc4ccccc4)cccc23)C1=O
Show InChI InChI=1S/C21H15NO5/c23-15-9-16(24)21(26)18(20(15)25)14-10-22-19-13(14)7-4-8-17(19)27-11-12-5-2-1-3-6-12/h1-8,10,18,22H,9,11H2
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n/an/a 6.90E+3n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50197856
PNG
(3-(4-pentadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Show SMILES CCCCCCCCCCCCCCCC1=C(CCC(O)=O)C(=O)OC1=O
Show InChI InChI=1S/C22H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-19(16-17-20(23)24)22(26)27-21(18)25/h2-17H2,1H3,(H,23,24)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Université Paul Verlaine-Metz

Curated by ChEMBL


Assay Description
Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)


Eur J Med Chem 42: 243-7 (2007)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50197852
PNG
((Z )-3-(4-(heptadec-8-enyl)-2,5-dioxo-2,5-dihydrof...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC1=C(CCC(O)=O)C(=O)OC1=O
Show InChI InChI=1S/C24H38O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-21(18-19-22(25)26)24(28)29-23(20)27/h9-10H,2-8,11-19H2,1H3,(H,25,26)/b10-9-
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n/an/a 8.80E+3n/an/an/an/an/an/a



Université Paul Verlaine-Metz

Curated by ChEMBL


Assay Description
Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)


Eur J Med Chem 42: 243-7 (2007)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129580
PNG
(3-[4,6-Dichloro-7-(3-methyl-but-2-enyl)-1H-indol-3...)
Show SMILES CC(C)=CCc1c(Cl)cc(Cl)c2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C19H15Cl2NO4/c1-8(2)3-4-9-11(20)5-12(21)15-10(7-22-17(9)15)16-18(25)13(23)6-14(24)19(16)26/h3,5,7,16,22H,4,6H2,1-2H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM26613
PNG
((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Show SMILES OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H7O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-7H,(H,10,11);2*1H2;;/q;;;;+2/p-2/b7-6+;;;;
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n/an/a>1.00E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Cdc25c catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...


Bioorg Med Chem 20: 4371-6 (2012)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50177316
PNG
(2-(4-(7-(4-(aminomethyl)benzoyl)cyclopenta[d][1,2]...)
Show SMILES NCc1ccc(cc1)C(=O)c1ccc2c(nocc12)-c1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C23H18N2O5/c24-11-14-1-3-16(4-2-14)23(28)19-10-9-18-20(19)12-30-25-22(18)15-5-7-17(8-6-15)29-13-21(26)27/h1-10,12H,11,13,24H2,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against cdc25C phosphatase


Bioorg Med Chem Lett 16: 499-502 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129583
PNG
(3-[7-(3,7-Dimethyl-octa-2,6-dienyl)-1H-indol-3-yl]...)
Show SMILES CC(C)=CCC\C(C)=C\Cc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C24H25NO4/c1-14(2)6-4-7-15(3)10-11-16-8-5-9-17-18(13-25-22(16)17)21-23(28)19(26)12-20(27)24(21)29/h5-6,8-10,13,21,25H,4,7,11-12H2,1-3H3/b15-10+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129581
PNG
(3-[6-Chloro-7-(3-methyl-but-2-enyl)-1H-indol-3-yl]...)
Show SMILES CC(C)=CCc1c(Cl)ccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C19H16ClNO4/c1-9(2)3-4-11-13(20)6-5-10-12(8-21-17(10)11)16-18(24)14(22)7-15(23)19(16)25/h3,5-6,8,16,21H,4,7H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175223
PNG
(5-(2-(dimethylamino)ethylamino)-2-phenyl-2H-indazo...)
Show SMILES CN(C)CC=Nc1cc(O)c2nn(cc2c1O)-c1ccccc1
Show InChI InChI=1S/C17H18N4O2/c1-20(2)9-8-18-14-10-15(22)16-13(17(14)23)11-21(19-16)12-6-4-3-5-7-12/h3-8,10-11,22-23H,9H2,1-2H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175222
PNG
(6-(2-(dimethylamino)ethylamino)-2-phenyl-2H-indazo...)
Show SMILES CN(C)CC=Nc1cc(O)c2cn(nc2c1O)-c1ccccc1
Show InChI InChI=1S/C17H18N4O2/c1-20(2)9-8-18-14-10-15(22)13-11-21(19-16(13)17(14)23)12-6-4-3-5-7-12/h3-8,10-11,22-23H,9H2,1-2H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175220
PNG
(5-(2-(dimethylamino)ethylamino)-2-ethyl-1H-benzo[d...)
Show SMILES CCc1nc2c(O)cc(N=CCN(C)C)c(O)c2[nH]1
Show InChI InChI=1S/C13H18N4O2/c1-4-10-15-11-9(18)7-8(13(19)12(11)16-10)14-5-6-17(2)3/h5,7,18-19H,4,6H2,1-3H3,(H,15,16)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50197855
PNG
(3-(4-tetradecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Show SMILES CCCCCCCCCCCCCCC1=C(CCC(O)=O)C(=O)OC1=O
Show InChI InChI=1S/C21H34O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17-18(15-16-19(22)23)21(25)26-20(17)24/h2-16H2,1H3,(H,22,23)
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n/an/a 1.26E+4n/an/an/an/an/an/a



Université Paul Verlaine-Metz

Curated by ChEMBL


Assay Description
Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)


Eur J Med Chem 42: 243-7 (2007)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129574
PNG
(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Show SMILES CC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C19H17NO4/c1-10(2)6-7-11-4-3-5-12-13(9-20-17(11)12)16-18(23)14(21)8-15(22)19(16)24/h3-6,9,16,20H,7-8H2,1-2H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129585
PNG
(3-(7-Benzyl-1H-indol-3-yl)-2,5-dihydroxy-[1,4]benz...)
Show SMILES O=C1CC(=O)C(=O)C(c2c[nH]c3c(Cc4ccccc4)cccc23)C1=O
Show InChI InChI=1S/C21H15NO4/c23-16-10-17(24)21(26)18(20(16)25)15-11-22-19-13(7-4-8-14(15)19)9-12-5-2-1-3-6-12/h1-8,11,18,22H,9-10H2
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n/an/a 1.50E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129572
PNG
(3-(1H-Benzo[g]indol-3-yl)-2,5-dihydroxy-[1,4]benzo...)
Show SMILES O=C1CC(=O)C(=O)C(c2c[nH]c3c2ccc2ccccc32)C1=O
Show InChI InChI=1S/C18H11NO4/c20-13-7-14(21)18(23)15(17(13)22)12-8-19-16-10-4-2-1-3-9(10)5-6-11(12)16/h1-6,8,15,19H,7H2
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n/an/a 1.50E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50175221
PNG
(5-(2-(dimethylamino)ethylamino)-2-phenyl-1H-benzo[...)
Show SMILES CN(C)CC=Nc1cc(O)c2nc([nH]c2c1O)-c1ccccc1
Show InChI InChI=1S/C17H18N4O2/c1-21(2)9-8-18-12-10-13(22)14-15(16(12)23)20-17(19-14)11-6-4-3-5-7-11/h3-8,10,22-23H,9H2,1-2H3,(H,19,20)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM24778
PNG
(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Show SMILES CC1=CC(=O)c2ccccc2C1=O
Show InChI InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
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n/an/a 1.88E+4n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory concentration for human cell division cycle 25 degree C phosphatase


Bioorg Med Chem Lett 14: 5809-12 (2004)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM24778
PNG
(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Show SMILES CC1=CC(=O)c2ccccc2C1=O
Show InChI InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant CDC25C


Bioorg Med Chem Lett 16: 171-5 (2005)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50155594
PNG
(2-Dimethylamino-6-methoxy-4-({methyl-[2-(4-nitro-p...)
Show SMILES COc1cc(CN(C)CCc2ccc(cc2)[N+]([O-])=O)cc(N(C)C)c1O
Show InChI InChI=1S/C19H25N3O4/c1-20(2)17-11-15(12-18(26-4)19(17)23)13-21(3)10-9-14-5-7-16(8-6-14)22(24)25/h5-8,11-12,23H,9-10,13H2,1-4H3
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n/an/a 2.07E+4n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibitory concentration for human cell division cycle 25 degree C phosphatase


Bioorg Med Chem Lett 14: 5809-12 (2004)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50327448
PNG
(7-methyl-2-methylene-4-(3-phenylbuta-1,3-dienyl)-1...)
Show SMILES Oc1ccc2c(\C=C\C(=O)c3ccccc3)cc(=O)oc2c1
Show InChI InChI=1S/C18H12O4/c19-14-7-8-15-13(10-18(21)22-17(15)11-14)6-9-16(20)12-4-2-1-3-5-12/h1-11,19H/b9-6+
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n/an/a 2.60E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129577
PNG
(2,5-Dihydroxy-3-(7-phenyl-1H-indol-3-yl)-[1,4]benz...)
Show SMILES O=C1CC(=O)C(=O)C(c2c[nH]c3c(cccc23)-c2ccccc2)C1=O
Show InChI InChI=1S/C20H13NO4/c22-15-9-16(23)20(25)17(19(15)24)14-10-21-18-12(7-4-8-13(14)18)11-5-2-1-3-6-11/h1-8,10,17,21H,9H2
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n/an/a 2.70E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129575
PNG
(2,5-Dihydroxy-3-(1H-indol-3-yl)-[1,4]benzoquinone ...)
Show SMILES O=C1CC(=O)C(=O)C(c2c[nH]c3ccccc23)C1=O
Show InChI InChI=1S/C14H9NO4/c16-10-5-11(17)14(19)12(13(10)18)8-6-15-9-4-2-1-3-7(8)9/h1-4,6,12,15H,5H2
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n/an/a 3.00E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50080994
PNG
(CHEMBL85943 | sodium tungstate)
Show SMILES [O-][W]([O-])(=O)=O
Show InChI InChI=1S/4O.W/q;;2*-1;
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n/an/a 3.00E+4n/an/an/an/an/an/a



Mitotix, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against human Cell division cycle 25 degree C


Bioorg Med Chem Lett 9: 2537-8 (1999)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129573
PNG
(6-Chloro-7-[2-(3,5-dibromo-4-hydroxy-cyclohexyl)-e...)
Show SMILES OC1C(Br)CC(CC=Nc2c(O)c3ncccc3c(O)c2Cl)CC1Br
Show InChI InChI=1S/C17H17Br2ClN2O3/c18-10-6-8(7-11(19)16(10)24)3-5-22-14-12(20)15(23)9-2-1-4-21-13(9)17(14)25/h1-2,4-5,8,10-11,16,23-25H,3,6-7H2
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n/an/a 3.50E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50342001
PNG
(1-(biphenyl-4-yl)-3,4-bis(2-hydroxyethylthio)-1H-p...)
Show SMILES OCCSC1=C(SCCO)C(=O)N(C1=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H19NO4S2/c22-10-12-26-17-18(27-13-11-23)20(25)21(19(17)24)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,22-23H,10-13H2
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n/an/a 4.00E+4n/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25C


Bioorg Med Chem 19: 2145-55 (2011)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50129586
PNG
(3-(6-Chloro-1H-indol-3-yl)-2,5-dihydroxy-[1,4]benz...)
Show SMILES Clc1ccc2c(c[nH]c2c1)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C14H8ClNO4/c15-6-1-2-7-8(5-16-9(7)3-6)12-13(19)10(17)4-11(18)14(12)20/h1-3,5,12,16H,4H2
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n/an/a 4.00E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Eight point inhibitory concentration against Cell division cycle 25 degree C was determined


J Med Chem 46: 2580-8 (2003)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50388812
PNG
(CHEMBL2062707)
Show SMILES CCCCCCCCCCCCCCCC(NCc1ccc(O)cc1)=C1C(=O)OC(CO)C1=O
Show InChI InChI=1S/C28H43NO5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(26-27(32)25(21-30)34-28(26)33)29-20-22-16-18-23(31)19-17-22/h16-19,25,29-31H,2-15,20-21H2,1H3
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n/an/a 4.41E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of CDC25C


Citation and Details
More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50327446
PNG
(7-methoxy-4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)...)
Show SMILES COc1ccc(cc1)C(=O)\C=C\c1cc(=O)oc2cc(OC)ccc12
Show InChI InChI=1S/C20H16O5/c1-23-15-6-3-13(4-7-15)18(21)10-5-14-11-20(22)25-19-12-16(24-2)8-9-17(14)19/h3-12H,1-2H3/b10-5+
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n/an/a 4.70E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50388817
PNG
(CHEMBL2062711)
Show SMILES CCCCCCCCCCCCCCCC(NCc1ccccc1F)=C1C(=O)OC(CO)C1=O
Show InChI InChI=1S/C28H42FNO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-24(26-27(32)25(21-31)34-28(26)33)30-20-22-17-15-16-18-23(22)29/h15-18,25,30-31H,2-14,19-21H2,1H3
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n/an/a 4.71E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of CDC25C


Citation and Details
More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50327445
PNG
(7-methoxy-4-(3-oxo-3-phenylprop-1-enyl)-2H-chromen...)
Show SMILES COc1ccc2c(\C=C\C(=O)c3ccccc3)cc(=O)oc2c1
Show InChI InChI=1S/C19H14O4/c1-22-15-8-9-16-14(11-19(21)23-18(16)12-15)7-10-17(20)13-5-3-2-4-6-13/h2-12H,1H3/b10-7+
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n/an/a 4.90E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50341996
PNG
((2R,3R)-2,3-Dibromo-3-methyl-1,1-dioxo-1lambda*6*-...)
Show SMILES C[C@]1(Br)[C@@H](Br)S(=O)(=O)c2ccccc2C1=O
Show InChI InChI=1S/C10H8Br2O3S/c1-10(12)8(13)6-4-2-3-5-7(6)16(14,15)9(10)11/h2-5,9H,1H3/t9-,10+/m0/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25C


Bioorg Med Chem 19: 2145-55 (2011)

More data for this
Ligand-Target Pair
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