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Found 100 hits Enz. Inhib. hit(s) with Target = 'Class I phosphodiesterase B1 (TbrPDEB1)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148195
PNG
(CHEMBL3765188)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn(C)n1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C34H42N6O4/c1-39-37-33(35-38-39)24-15-18-27(19-16-24)43-21-9-10-22-44-31-23-25(17-20-30(31)42-2)32-28-13-7-8-14-29(28)34(41)40(36-32)26-11-5-3-4-6-12-26/h7-8,15-20,23,26,28-29H,3-6,9-14,21-22H2,1-2H3/t28-,29+/s2
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n/an/a 3.20n/an/an/an/an/an/a



Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50427452
PNG
(CHEMBL2326941)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1S/C33H40N6O4/c1-41-29-19-16-24(31-27-12-6-7-13-28(27)33(40)39(36-31)25-10-4-2-3-5-11-25)22-30(29)43-21-9-8-20-42-26-17-14-23(15-18-26)32-34-37-38-35-32/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,34,35,37,38)/t27-,28+/m0/s1
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VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei full length PDEB1 expressed in insect SF21 cells using cAMP as substrate by scintillation proximity assay


J Med Chem 56: 2087-96 (2013)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50441529
PNG
(CHEMBL2436771)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)[C@H]2CC=CC[C@@H]12
Show InChI InChI=1S/C33H40N6O4/c1-41-29-19-16-24(31-27-12-6-7-13-28(27)33(40)39(36-31)25-10-4-2-3-5-11-25)22-30(29)43-21-9-8-20-42-26-17-14-23(15-18-26)32-34-37-38-35-32/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,34,35,37,38)/t27-,28+/m1/s1
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Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei PDEB1


Bioorg Med Chem Lett 23: 5971-4 (2013)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397108
PNG
(CHEMBL85005)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)C2CC=CCC12
Show InChI InChI=1S/C33H40N6O4/c1-41-29-19-16-24(31-27-12-6-7-13-28(27)33(40)39(36-31)25-10-4-2-3-5-11-25)22-30(29)43-21-9-8-20-42-26-17-14-23(15-18-26)32-34-37-38-35-32/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,34,35,37,38)
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VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei TbrPDEB1


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50427452
PNG
(CHEMBL2326941)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1S/C33H40N6O4/c1-41-29-19-16-24(31-27-12-6-7-13-28(27)33(40)39(36-31)25-10-4-2-3-5-11-25)22-30(29)43-21-9-8-20-42-26-17-14-23(15-18-26)32-34-37-38-35-32/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,34,35,37,38)/t27-,28+/m0/s1
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50427452
PNG
(CHEMBL2326941)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1S/C33H40N6O4/c1-41-29-19-16-24(31-27-12-6-7-13-28(27)33(40)39(36-31)25-10-4-2-3-5-11-25)22-30(29)43-21-9-8-20-42-26-17-14-23(15-18-26)32-34-37-38-35-32/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,34,35,37,38)/t27-,28+/m0/s1
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148237
PNG
(CHEMBL3763233)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnnn1C)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C34H42N6O4/c1-39-33(35-37-38-39)24-15-18-27(19-16-24)43-21-9-10-22-44-31-23-25(17-20-30(31)42-2)32-28-13-7-8-14-29(28)34(41)40(36-32)26-11-5-3-4-6-12-26/h7-8,15-20,23,26,28-29H,3-6,9-14,21-22H2,1-2H3/t28-,29+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148238
PNG
(CHEMBL3765037)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-n1ccnc1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C35H42N4O4/c1-41-32-19-14-26(34-30-12-6-7-13-31(30)35(40)39(37-34)28-10-4-2-3-5-11-28)24-33(32)43-23-9-8-22-42-29-17-15-27(16-18-29)38-21-20-36-25-38/h6-7,14-21,24-25,28,30-31H,2-5,8-13,22-23H2,1H3/t30-,31+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148239
PNG
(CHEMBL3764370)
Show SMILES COc1ccc(cc1OCCCCn1cnc2ncncc12)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C31H38N6O3/c1-39-27-15-14-22(18-28(27)40-17-9-8-16-36-21-34-30-26(36)19-32-20-33-30)29-24-12-6-7-13-25(24)31(38)37(35-29)23-10-4-2-3-5-11-23/h6-7,14-15,18-21,23-25H,2-5,8-13,16-17H2,1H3/t24-,25+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397078
PNG
(CHEMBL2171452)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C30H38N6O4/c1-30(2)27(33-36(29(30)37)23-10-6-4-5-7-11-23)22-14-17-25(38-3)26(20-22)40-19-9-8-18-39-24-15-12-21(13-16-24)28-31-34-35-32-28/h12-17,20,23H,4-11,18-19H2,1-3H3,(H,31,32,34,35)
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n/an/a 49n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397078
PNG
(CHEMBL2171452)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C30H38N6O4/c1-30(2)27(33-36(29(30)37)23-10-6-4-5-7-11-23)22-14-17-25(38-3)26(20-22)40-19-9-8-18-39-24-15-12-21(13-16-24)28-31-34-35-32-28/h12-17,20,23H,4-11,18-19H2,1-3H3,(H,31,32,34,35)
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VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei His-tagged catalytic domains of TbrPDEB1 expressed in Escherichia coli BL21 assessed as conversion of cAMP to AMP af...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148247
PNG
(CHEMBL3765010)
Show SMILES COc1ccc(cc1OCCCCCc1ccccc1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C33H42N2O3/c1-37-30-22-21-26(24-31(30)38-23-13-5-8-16-25-14-6-4-7-15-25)32-28-19-11-12-20-29(28)33(36)35(34-32)27-17-9-2-3-10-18-27/h4,6-7,11-12,14-15,21-22,24,27-29H,2-3,5,8-10,13,16-20,23H2,1H3/t28-,29+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148254
PNG
(CHEMBL3765606)
Show SMILES COc1ccc(cc1OCCc1ccc(cc1)N(C)C)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C32H41N3O3/c1-34(2)25-17-14-23(15-18-25)20-21-38-30-22-24(16-19-29(30)37-3)31-27-12-8-9-13-28(27)32(36)35(33-31)26-10-6-4-5-7-11-26/h8-9,14-19,22,26-28H,4-7,10-13,20-21H2,1-3H3/t27-,28+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148255
PNG
(CHEMBL3765786)
Show SMILES COc1ccc(CCOc2cc(ccc2OC)C2=NN(C3CCCCCC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1
Show InChI InChI=1/C31H38N2O4/c1-35-25-16-13-22(14-17-25)19-20-37-29-21-23(15-18-28(29)36-2)30-26-11-7-8-12-27(26)31(34)33(32-30)24-9-5-3-4-6-10-24/h7-8,13-18,21,24,26-27H,3-6,9-12,19-20H2,1-2H3/t26-,27+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148250
PNG
(CHEMBL3765222)
Show SMILES COc1ccc(cc1OCc1cccc(OC)c1OC)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C31H38N2O5/c1-35-26-18-17-21(19-28(26)38-20-22-11-10-16-27(36-2)30(22)37-3)29-24-14-8-9-15-25(24)31(34)33(32-29)23-12-6-4-5-7-13-23/h8-11,16-19,23-25H,4-7,12-15,20H2,1-3H3/t24-,25+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148249
PNG
(CHEMBL3763352)
Show SMILES COCCOc1cc(ccc1OC)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C25H34N2O4/c1-29-15-16-31-23-17-18(13-14-22(23)30-2)24-20-11-7-8-12-21(20)25(28)27(26-24)19-9-5-3-4-6-10-19/h7-8,13-14,17,19-21H,3-6,9-12,15-16H2,1-2H3/t20-,21+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148248
PNG
(CHEMBL3765581)
Show SMILES COc1ccc(cc1OCCO)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C24H32N2O4/c1-29-21-13-12-17(16-22(21)30-15-14-27)23-19-10-6-7-11-20(19)24(28)26(25-23)18-8-4-2-3-5-9-18/h6-7,12-13,16,18-20,27H,2-5,8-11,14-15H2,1H3/t19-,20+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148252
PNG
(CHEMBL3764909)
Show SMILES COc1ccc(cc1OCc1ccccn1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C28H33N3O3/c1-33-25-16-15-20(18-26(25)34-19-21-10-8-9-17-29-21)27-23-13-6-7-14-24(23)28(32)31(30-27)22-11-4-2-3-5-12-22/h6-10,15-18,22-24H,2-5,11-14,19H2,1H3/t23-,24+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148251
PNG
(CHEMBL3765225)
Show SMILES COc1cc(COc2cc(ccc2OC)C2=NN(C3CCCCCC3)C(=O)[C@@H]3CC=CC[C@H]23)cc(OC)c1
Show InChI InChI=1/C31H38N2O5/c1-35-24-16-21(17-25(19-24)36-2)20-38-29-18-22(14-15-28(29)37-3)30-26-12-8-9-13-27(26)31(34)33(32-30)23-10-6-4-5-7-11-23/h8-9,14-19,23,26-27H,4-7,10-13,20H2,1-3H3/t26-,27+/s2
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Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148253
PNG
(CHEMBL3765733)
Show SMILES COc1ccc(cc1OCc1ccncc1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C28H33N3O3/c1-33-25-13-12-21(18-26(25)34-19-20-14-16-29-17-15-20)27-23-10-6-7-11-24(23)28(32)31(30-27)22-8-4-2-3-5-9-22/h6-7,12-18,22-24H,2-5,8-11,19H2,1H3/t23-,24+/s2
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n/an/a 158n/an/an/an/an/an/a



Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397079
PNG
(CHEMBL2171451)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)C#N)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C30H37N3O4/c1-30(2)28(32-33(29(30)34)24-10-6-4-5-7-11-24)23-14-17-26(35-3)27(20-23)37-19-9-8-18-36-25-15-12-22(21-31)13-16-25/h12-17,20,24H,4-11,18-19H2,1-3H3
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n/an/a 160n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397082
PNG
(CHEMBL2171460)
Show SMILES COc1ccc(cc1OCc1cccc2ccccc12)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C30H34N2O3/c1-30(2)28(31-32(29(30)33)24-14-6-4-5-7-15-24)22-17-18-26(34-3)27(19-22)35-20-23-13-10-12-21-11-8-9-16-25(21)23/h8-13,16-19,24H,4-7,14-15,20H2,1-3H3
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n/an/a 250n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50441528
PNG
(CHEMBL2436772)
Show SMILES COc1ccc(cc1OC1CCCC1)C1=NN(C[C@H]2CC=CC[C@@H]12)C1CCCC1
Show InChI InChI=1S/C25H34N2O2/c1-28-23-15-14-18(16-24(23)29-21-11-5-6-12-21)25-22-13-7-2-8-19(22)17-27(26-25)20-9-3-4-10-20/h2,7,14-16,19-22H,3-6,8-13,17H2,1H3/t19-,22-/m1/s1
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n/an/a 278n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei PDEB1


Bioorg Med Chem Lett 23: 5971-4 (2013)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148194
PNG
(CHEMBL3763456)
Show SMILES COc1ccc(cc1OC)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C23H30N2O3/c1-27-20-14-13-16(15-21(20)28-2)22-18-11-7-8-12-19(18)23(26)25(24-22)17-9-5-3-4-6-10-17/h7-8,13-15,17-19H,3-6,9-12H2,1-2H3/t18-,19+/s2
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n/an/a 316n/an/an/an/an/an/a



Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148240
PNG
(CHEMBL3763271)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)C(O)=O)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
Show InChI InChI=1/C33H40N2O6/c1-39-29-19-16-24(22-30(29)41-21-9-8-20-40-26-17-14-23(15-18-26)33(37)38)31-27-12-6-7-13-28(27)32(36)35(34-31)25-10-4-2-3-5-11-25/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,37,38)/t27-,28+/s2
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n/an/a 316n/an/an/an/an/an/a



Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397086
PNG
(CHEMBL2171456)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C(C)C)C(=O)C1(C)C
Show InChI InChI=1S/C26H32N6O4/c1-17(2)32-25(33)26(3,4)23(29-32)19-10-13-21(34-5)22(16-19)36-15-7-6-14-35-20-11-8-18(9-12-20)24-27-30-31-28-24/h8-13,16-17H,6-7,14-15H2,1-5H3,(H,27,28,30,31)
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n/an/a 400n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397106
PNG
(CHEMBL2171660)
Show SMILES COc1ccc(cc1OC1CCCC1)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C24H34N2O3/c1-24(2)22(25-26(23(24)27)18-10-6-4-5-7-11-18)17-14-15-20(28-3)21(16-17)29-19-12-8-9-13-19/h14-16,18-19H,4-13H2,1-3H3
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n/an/a 410n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397081
PNG
(CHEMBL2171461)
Show SMILES COc1ccc(cc1OCc1ccccn1)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C25H31N3O3/c1-25(2)23(27-28(24(25)29)20-11-6-4-5-7-12-20)18-13-14-21(30-3)22(16-18)31-17-19-10-8-9-15-26-19/h8-10,13-16,20H,4-7,11-12,17H2,1-3H3
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n/an/a 500n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397102
PNG
(CHEMBL2171664)
Show SMILES COc1ccc(cc1OCc1ccccc1)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C26H32N2O3/c1-26(2)24(27-28(25(26)29)21-13-9-4-5-10-14-21)20-15-16-22(30-3)23(17-20)31-18-19-11-7-6-8-12-19/h6-8,11-12,15-17,21H,4-5,9-10,13-14,18H2,1-3H3
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n/an/a 500n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397083
PNG
(CHEMBL2171459)
Show SMILES COc1ccc(CCOc2cc(ccc2OC)C2=NN(C3CCCCCC3)C(=O)C2(C)C)cc1
Show InChI InChI=1S/C28H36N2O4/c1-28(2)26(29-30(27(28)31)22-9-7-5-6-8-10-22)21-13-16-24(33-4)25(19-21)34-18-17-20-11-14-23(32-3)15-12-20/h11-16,19,22H,5-10,17-18H2,1-4H3
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n/an/a 630n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397080
PNG
(CHEMBL2171462)
Show SMILES COc1ccc(cc1OCc1cc(C)on1)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C24H31N3O4/c1-16-13-18(26-31-16)15-30-21-14-17(11-12-20(21)29-4)22-24(2,3)23(28)27(25-22)19-9-7-5-6-8-10-19/h11-14,19H,5-10,15H2,1-4H3
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n/an/a 630n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397084
PNG
(CHEMBL2171458)
Show SMILES COc1ccc(COc2cc(ccc2OC)C2=NN(C3CCCCCC3)C(=O)C2(C)C)cc1
Show InChI InChI=1S/C27H34N2O4/c1-27(2)25(28-29(26(27)30)21-9-7-5-6-8-10-21)20-13-16-23(32-4)24(17-20)33-18-19-11-14-22(31-3)15-12-19/h11-17,21H,5-10,18H2,1-4H3
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n/an/a 790n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397090
PNG
(CHEMBL2171658)
Show SMILES COc1ccc(cc1OCc1cccc2ccccc12)C1=NN(C(C)C)C(=O)C1(C)C
Show InChI InChI=1S/C26H28N2O3/c1-17(2)28-25(29)26(3,4)24(27-28)19-13-14-22(30-5)23(15-19)31-16-20-11-8-10-18-9-6-7-12-21(18)20/h6-15,17H,16H2,1-5H3
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n/an/a 790n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397091
PNG
(CHEMBL2171657)
Show SMILES COc1ccc(CCOc2cc(ccc2OC)C2=NN(C(C)C)C(=O)C2(C)C)cc1
Show InChI InChI=1S/C24H30N2O4/c1-16(2)26-23(27)24(3,4)22(25-26)18-9-12-20(29-6)21(15-18)30-14-13-17-7-10-19(28-5)11-8-17/h7-12,15-16H,13-14H2,1-6H3
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n/an/a 830n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50058062
PNG
(CHEMBL3323128)
Show SMILES COc1ccc(cc1OCCCCOc1ccccc1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N
Show InChI InChI=1/C25H29NO5/c1-29-22-10-9-20(25(18-26)13-11-19(12-14-25)24(27)28)17-23(22)31-16-6-5-15-30-21-7-3-2-4-8-21/h2-4,7-10,17,19H,5-6,11-16H2,1H3,(H,27,28)/t19-,25-
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n/an/a 950n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate addition


Bioorg Med Chem Lett 24: 4084-9 (2014)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397103
PNG
(CHEMBL2171663)
Show SMILES COc1ccc(cc1OCc1ccccc1)C1=NN(C(C)C)C(=O)C1(C)C
Show InChI InChI=1S/C22H26N2O3/c1-15(2)24-21(25)22(3,4)20(23-24)17-11-12-18(26-5)19(13-17)27-14-16-9-7-6-8-10-16/h6-13,15H,14H2,1-5H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397085
PNG
(CHEMBL2171457)
Show SMILES COc1ccc(cc1OCc1ccc(cc1)C#N)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C27H31N3O3/c1-27(2)25(29-30(26(27)31)22-8-6-4-5-7-9-22)21-14-15-23(32-3)24(16-21)33-18-20-12-10-19(17-28)11-13-20/h10-16,22H,4-9,18H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148244
PNG
(CHEMBL3763547)
Show SMILES COc1ccc(cc1OC)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CCCC[C@H]12
Show InChI InChI=1/C23H32N2O3/c1-27-20-14-13-16(15-21(20)28-2)22-18-11-7-8-12-19(18)23(26)25(24-22)17-9-5-3-4-6-10-17/h13-15,17-19H,3-12H2,1-2H3/t18-,19+/s2
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n/an/a 1.59E+3n/an/an/an/an/an/a



Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50148246
PNG
(CHEMBL3764415)
Show SMILES COc1ccc(cc1OC)C1=NN(C(C)C)C(=O)[C@@H]2CCCC[C@H]12
Show InChI InChI=1/C19H26N2O3/c1-12(2)21-19(22)15-8-6-5-7-14(15)18(20-21)13-9-10-16(23-3)17(11-13)24-4/h9-12,14-15H,5-8H2,1-4H3/t14-,15+/s2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Mercachem

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay


Bioorg Med Chem 24: 1573-81 (2016)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397092
PNG
(CHEMBL2171656)
Show SMILES COc1ccc(COc2cc(ccc2OC)C2=NN(C(C)C)C(=O)C2(C)C)cc1
Show InChI InChI=1S/C23H28N2O4/c1-15(2)25-22(26)23(3,4)21(24-25)17-9-12-19(28-6)20(13-17)29-14-16-7-10-18(27-5)11-8-16/h7-13,15H,14H2,1-6H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397093
PNG
(CHEMBL2171655)
Show SMILES COc1ccc(cc1OCc1ccc(cc1)C#N)C1=NN(C(C)C)C(=O)C1(C)C
Show InChI InChI=1S/C23H25N3O3/c1-15(2)26-22(27)23(3,4)21(25-26)18-10-11-19(28-5)20(12-18)29-14-17-8-6-16(13-24)7-9-17/h6-12,15H,14H2,1-5H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397097
PNG
(CHEMBL2171651)
Show SMILES COc1ccc(cc1Cl)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C19H25ClN2O2/c1-19(2)17(13-10-11-16(24-3)15(20)12-13)21-22(18(19)23)14-8-6-4-5-7-9-14/h10-12,14H,4-9H2,1-3H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397094
PNG
(CHEMBL2171654)
Show SMILES COc1ccc(cc1Br)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C19H25BrN2O2/c1-19(2)17(13-10-11-16(24-3)15(20)12-13)21-22(18(19)23)14-8-6-4-5-7-9-14/h10-12,14H,4-9H2,1-3H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50397089
PNG
(CHEMBL2171453)
Show SMILES COc1ccc(cc1OCc1ccccn1)C1=NN(C(C)C)C(=O)C1(C)C
Show InChI InChI=1S/C21H25N3O3/c1-14(2)24-20(25)21(3,4)19(23-24)15-9-10-17(26-5)18(12-15)27-13-16-8-6-7-11-22-16/h6-12,14H,13H2,1-5H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM153391
PNG
(3-(3-carbamoyl-4-(3-methoxyphenylamino)-8-methylqu...)
Show SMILES COc1cccc(Nc2c(cnc3c(C)cc(cc23)S(=O)(=O)c2cccc(c2)C(O)=O)C(N)=O)c1
Show InChI InChI=1S/C25H21N3O6S/c1-14-9-19(35(32,33)18-8-3-5-15(10-18)25(30)31)12-20-22(14)27-13-21(24(26)29)23(20)28-16-6-4-7-17(11-16)34-2/h3-13H,1-2H3,(H2,26,29)(H,27,28)(H,30,31)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Northeastern University



Assay Description
In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...


Chem Biol Drug Des 85: 549-64 (2015)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM153402
PNG
(4-((3-Methoxyphenyl)amino)-8-methyl-6-(1-methyl-1H...)
Show SMILES COc1cccc(Nc2c(cnc3c(C)cc(cc23)-c2ccc3cnn(C)c3c2)C(N)=O)c1
Show InChI InChI=1S/C26H23N5O2/c1-15-9-18(16-7-8-17-13-29-31(2)23(17)11-16)10-21-24(15)28-14-22(26(27)32)25(21)30-19-5-4-6-20(12-19)33-3/h4-14H,1-3H3,(H2,27,32)(H,28,30)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Northeastern University



Assay Description
In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...


Chem Biol Drug Des 85: 549-64 (2015)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM153408
PNG
(8-Methyl-6-(1-methyl-1H-indazol-6-yl)-4-(m-tolylam...)
Show SMILES Cc1cccc(Nc2c(cnc3c(C)cc(cc23)-c2ccc3cnn(C)c3c2)C(N)=O)c1
Show InChI InChI=1S/C26H23N5O/c1-15-5-4-6-20(9-15)30-25-21-11-19(10-16(2)24(21)28-14-22(25)26(27)32)17-7-8-18-13-29-31(3)23(18)12-17/h4-14H,1-3H3,(H2,27,32)(H,28,30)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Northeastern University



Assay Description
In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...


Chem Biol Drug Des 85: 549-64 (2015)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM153390
PNG
(Methyl 3-(3-carbamoyl-4-(3-methoxyphenylamino)-8-m...)
Show SMILES COC(=O)c1cccc(c1)S(=O)(=O)c1cc(C)c2ncc(C(N)=O)c(Nc3cccc(OC)c3)c2c1
Show InChI InChI=1S/C26H23N3O6S/c1-15-10-20(36(32,33)19-9-4-6-16(11-19)26(31)35-3)13-21-23(15)28-14-22(25(27)30)24(21)29-17-7-5-8-18(12-17)34-2/h4-14H,1-3H3,(H2,27,30)(H,28,29)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Northeastern University



Assay Description
In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...


Chem Biol Drug Des 85: 549-64 (2015)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM153407
PNG
(4-(3-Ethylphenylamino)-8-methyl-6-(1-methyl-1H-ind...)
Show SMILES CCc1cccc(Nc2c(cnc3c(C)cc(cc23)-c2ccc3cnn(C)c3c2)C(N)=O)c1
Show InChI InChI=1S/C27H25N5O/c1-4-17-6-5-7-21(11-17)31-26-22-12-20(10-16(2)25(22)29-15-23(26)27(28)33)18-8-9-19-14-30-32(3)24(19)13-18/h5-15H,4H2,1-3H3,(H2,28,33)(H,29,31)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Northeastern University



Assay Description
In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...


Chem Biol Drug Des 85: 549-64 (2015)

More data for this
Ligand-Target Pair
Class I phosphodiesterase B1 (TbrPDEB1)


(Trypanosoma brucei)
BDBM50058066
PNG
(CHEMBL3323131)
Show SMILES COc1ccc(OCCCCOc2cc(ccc2OC)[C@]2(CC[C@@H](CC2)C(O)=O)C#N)cc1
Show InChI InChI=1/C26H31NO6/c1-30-21-6-8-22(9-7-21)32-15-3-4-16-33-24-17-20(5-10-23(24)31-2)26(18-27)13-11-19(12-14-26)25(28)29/h5-10,17,19H,3-4,11-16H2,1-2H3,(H,28,29)/t19-,26-
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n/an/a 3.50E+3n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate addition


Bioorg Med Chem Lett 24: 4084-9 (2014)

More data for this
Ligand-Target Pair
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