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Compile Data Set for Download or QSAR

Found 425 hits Enz. Inhib. hit(s) with Target = 'Coagulation factor IX'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor IX


(Homo sapiens (human))
BDBM150291
PNG
(US8987242, 105)
Show SMILES CS(=O)(=O)c1ccccc1-c1ccc(cc1)N1CCO[C@H]([C@@H](O)C(=O)Nc2ccc(cc2)C(N)=N)C1=O
Show InChI InChI=1S/C26H26N4O6S/c1-37(34,35)21-5-3-2-4-20(21)16-8-12-19(13-9-16)30-14-15-36-23(26(30)33)22(31)25(32)29-18-10-6-17(7-11-18)24(27)28/h2-13,22-23,31H,14-15H2,1H3,(H3,27,28)(H,29,32)/t22-,23-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150295
PNG
(US8987242, aa144)
Show SMILES OC([C@H]1OCCN(C1=O)c1ccc(F)c(c1)C(=O)N1CCOCC1)C(=O)Nc1ccc2C(=N)NCc2c1
Show InChI InChI=1S/C25H26FN5O6/c26-19-4-2-16(12-18(19)24(34)30-5-8-36-9-6-30)31-7-10-37-21(25(31)35)20(32)23(33)29-15-1-3-17-14(11-15)13-28-22(17)27/h1-4,11-12,20-21,32H,5-10,13H2,(H2,27,28)(H,29,33)/t20?,21-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150289
PNG
(US8987242, 15)
Show SMILES NC(=N)c1ccc(NC(=O)[C@H](O)[C@H]2OCCN(C2=O)c2ccc(cc2)C2CCCCC2)cc1
Show InChI InChI=1S/C25H30N4O4/c26-23(27)18-6-10-19(11-7-18)28-24(31)21(30)22-25(32)29(14-15-33-22)20-12-8-17(9-13-20)16-4-2-1-3-5-16/h6-13,16,21-22,30H,1-5,14-15H2,(H3,26,27)(H,28,31)/t21-,22-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150285
PNG
(US8987242, 50)
Show SMILES NC(=N)c1ccc(NC(=O)[C@H](O)[C@H]2OCCN(C2=O)c2cccc(NC(=O)CO)c2)cc1
Show InChI InChI=1/C21H23N5O6/c22-19(23)12-4-6-13(7-5-12)25-20(30)17(29)18-21(31)26(8-9-32-18)15-3-1-2-14(10-15)24-16(28)11-27/h1-7,10,17-18,27,29H,8-9,11H2,(H3,22,23)(H,24,28)(H,25,30)/t17-,18-/s2
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n/an/a 20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150286
PNG
(US8987242, 62)
Show SMILES Cc1ccc(cc1)N1CCO[C@H]([C@@H](O)C(=O)Nc2ccc3c(N)nccc3c2)C1=O
Show InChI InChI=1/C22H22N4O4/c1-13-2-5-16(6-3-13)26-10-11-30-19(22(26)29)18(27)21(28)25-15-4-7-17-14(12-15)8-9-24-20(17)23/h2-9,12,18-19,27H,10-11H2,1H3,(H2,23,24)(H,25,28)/t18-,19-/s2
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n/an/a 20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150293
PNG
(US8987242, 114)
Show SMILES Cc1ccc(cc1)N1CCCO[C@H]([C@@H](O)C(=O)Nc2ccc(cc2)C(N)=N)C1=O
Show InChI InChI=1S/C21H24N4O4/c1-13-3-9-16(10-4-13)25-11-2-12-29-18(21(25)28)17(26)20(27)24-15-7-5-14(6-8-15)19(22)23/h3-10,17-18,26H,2,11-12H2,1H3,(H3,22,23)(H,24,27)/t17-,18-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150290
PNG
(US8987242, 2)
Show SMILES Cc1ccc(cc1)N1CCOC(C(O)C(=O)Nc2ccc(cc2)C(N)=N)C1=O
Show InChI InChI=1/C20H22N4O4/c1-12-2-8-15(9-3-12)24-10-11-28-17(20(24)27)16(25)19(26)23-14-6-4-13(5-7-14)18(21)22/h2-9,16-17,25H,10-11H2,1H3,(H3,21,22)(H,23,26)
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150288
PNG
(US8987242, 1)
Show SMILES Cc1ccc(cc1)N1CCOC(C(O)C(=O)Nc2ccc3c(N)nccc3c2)C1=O
Show InChI InChI=1/C22H22N4O4/c1-13-2-5-16(6-3-13)26-10-11-30-19(22(26)29)18(27)21(28)25-15-4-7-17-14(12-15)8-9-24-20(17)23/h2-9,12,18-19,27H,10-11H2,1H3,(H2,23,24)(H,25,28)
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n/an/a 40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150231
PNG
(US8980916, 6)
Show SMILES CC(C)(C)c1ccc(cc1)-n1cccc(C(O)C(=O)Nc2ccc3c(N)nccc3c2)c1=O
Show InChI InChI=1/C26H26N4O3/c1-26(2,3)17-6-9-19(10-7-17)30-14-4-5-21(25(30)33)22(31)24(32)29-18-8-11-20-16(15-18)12-13-28-23(20)27/h4-15,22,31H,1-3H3,(H2,27,28)(H,29,32)
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n/an/a 54n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd.

US Patent


Assay Description
Inhibitory activity against Factor IXa was tested using the substrate SPECTROFLUOR FIXa (American Diagnostica Inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8980916 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150292
PNG
(US8987242, 109)
Show SMILES CC(=O)N1CCN(C(=O)C1C(O)C(=O)Nc1ccc2c(N)nccc2c1)c1ccc(C)cc1
Show InChI InChI=1/C24H25N5O4/c1-14-3-6-18(7-4-14)29-12-11-28(15(2)30)20(24(29)33)21(31)23(32)27-17-5-8-19-16(13-17)9-10-26-22(19)25/h3-10,13,20-21,31H,11-12H2,1-2H3,(H2,25,26)(H,27,32)
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n/an/a 60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150287
PNG
(US8987242, 67)
Show SMILES CC(C)(C)c1ccc(cc1)N1CCO[C@H]([C@@H](O)C(=O)Nc2ccc(cc2F)C(N)=N)C1=O
Show InChI InChI=1/C23H27FN4O4/c1-23(2,3)14-5-7-15(8-6-14)28-10-11-32-19(22(28)31)18(29)21(30)27-17-9-4-13(20(25)26)12-16(17)24/h4-9,12,18-19,29H,10-11H2,1-3H3,(H3,25,26)(H,27,30)/t18-,19-/s2
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n/an/a 60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150294
PNG
(US8987242, aa142)
Show SMILES OC([C@H]1OCCN(C1=O)c1ccccc1C#N)C(=O)Nc1ccc2C(=N)NCc2c1
Show InChI InChI=1S/C21H19N5O4/c22-10-12-3-1-2-4-16(12)26-7-8-30-18(21(26)29)17(27)20(28)25-14-5-6-15-13(9-14)11-24-19(15)23/h1-6,9,17-18,27H,7-8,11H2,(H2,23,24)(H,25,28)/t17?,18-/m1/s1
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n/an/a 66n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183049
PNG
(US9150544, 83)
Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2C(F)(F)F)C(O)=O)C1=O
Show InChI InChI=1/C24H25F3N6O5S/c1-32(2)20-4-3-15(12-30-20)39(37,38)31-18-6-8-33(22(18)34)19(23(35)36)10-14-9-13-5-7-29-21(28)16(13)11-17(14)24(25,26)27/h3-5,7,9,11-12,18-19,31H,6,8,10H2,1-2H3,(H2,28,29)(H,35,36)/t18-,19+/s2
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n/an/a 69n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182983
PNG
(US9150544, 17)
Show SMILES COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC(F)(F)C2)C1=O)C(O)=O
Show InChI InChI=1/C24H26F2N6O6S2/c1-38-18-10-15-13(2-5-28-20(15)27)8-14(18)9-17(22(34)35)32-6-3-16(21(32)33)30-40(36,37)19-11-29-23(39-19)31-7-4-24(25,26)12-31/h2,5,8,10-11,16-17,30H,3-4,6-7,9,12H2,1H3,(H2,27,28)(H,34,35)/t16-,17+/s2
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n/an/a 70n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183045
PNG
(US9150544, 79)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2C(F)(F)F)C(O)=O)C1=O
Show InChI InChI=1/C22H23F3N6O5S2/c1-30(2)21-28-10-17(37-21)38(35,36)29-15-4-6-31(19(15)32)16(20(33)34)8-12-7-11-3-5-27-18(26)13(11)9-14(12)22(23,24)25/h3,5,7,9-10,15-16,29H,4,6,8H2,1-2H3,(H2,26,27)(H,33,34)/t15-,16+/s2
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n/an/a 70n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183022
PNG
(US9150544, 56)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(OC(F)(F)F)cc12
Show InChI InChI=1/C24H23F5N6O6S2/c25-23(26)3-6-34(11-23)22-32-10-18(42-22)43(39,40)33-15-2-5-35(20(15)36)16(21(37)38)8-13-7-12-1-4-31-19(30)14(12)9-17(13)41-24(27,28)29/h1,4,7,9-10,15-16,33H,2-3,5-6,8,11H2,(H2,30,31)(H,37,38)/t15-,16+/s2
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n/an/a 76n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183061
PNG
(US9150544, 95)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(cc12)C#N
Show InChI InChI=1/C24H25N7O5S2/c25-12-16-10-17-14(3-5-27-21(17)26)9-15(16)11-19(23(33)34)31-8-4-18(22(31)32)29-38(35,36)20-13-28-24(37-20)30-6-1-2-7-30/h3,5,9-10,13,18-19,29H,1-2,4,6-8,11H2,(H2,26,27)(H,33,34)/t18-,19+/s2
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n/an/a 80n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150296
PNG
(US8987242, aa150)
Show SMILES Nc1noc2cc(NC(=O)C(O)[C@H]3OCCN(C3=O)c3cccc(c3)S(F)(F)(F)(F)F)ccc12
Show InChI InChI=1S/C19H17F5N4O5S/c20-34(21,22,23,24)12-3-1-2-11(9-12)28-6-7-32-16(19(28)31)15(29)18(30)26-10-4-5-13-14(8-10)33-27-17(13)25/h1-5,8-9,15-16,29H,6-7H2,(H2,25,27)(H,26,30)/t15?,16-/m1/s1
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n/an/a 83n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183062
PNG
(US9150544, 96)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(OC(F)(F)F)cc12
Show InChI InChI=1/C24H25F3N6O6S2/c25-24(26,27)39-18-11-15-13(3-5-29-20(15)28)9-14(18)10-17(22(35)36)33-8-4-16(21(33)34)31-41(37,38)19-12-30-23(40-19)32-6-1-2-7-32/h3,5,9,11-12,16-17,31H,1-2,4,6-8,10H2,(H2,28,29)(H,35,36)/t16-,17+/s2
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n/an/a 83n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183019
PNG
(US9150544, 53)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(Cl)cc12
Show InChI InChI=1/C23H25ClN6O5S2/c24-16-11-15-13(3-5-26-20(15)25)9-14(16)10-18(22(32)33)30-8-4-17(21(30)31)28-37(34,35)19-12-27-23(36-19)29-6-1-2-7-29/h3,5,9,11-12,17-18,28H,1-2,4,6-8,10H2,(H2,25,26)(H,32,33)/t17-,18+/s2
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n/an/a 84n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183047
PNG
(US9150544, 81)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(cc12)C(F)(F)F
Show InChI InChI=1/C24H25F3N6O5S2/c25-24(26,27)16-11-15-13(3-5-29-20(15)28)9-14(16)10-18(22(35)36)33-8-4-17(21(33)34)31-40(37,38)19-12-30-23(39-19)32-6-1-2-7-32/h3,5,9,11-12,17-18,31H,1-2,4,6-8,10H2,(H2,28,29)(H,35,36)/t17-,18+/s2
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n/an/a 86n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183028
PNG
(US9150544, 62)
Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O
Show InChI InChI=1/C23H25ClN6O5S/c1-29(2)20-4-3-15(12-27-20)36(34,35)28-18-6-8-30(22(18)31)19(23(32)33)10-14-9-13-5-7-26-21(25)16(13)11-17(14)24/h3-5,7,9,11-12,18-19,28H,6,8,10H2,1-2H3,(H2,25,26)(H,32,33)/t18-,19+/s2
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n/an/a 92n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183040
PNG
(US9150544, 74)
Show SMILES CN(C)c1ncc(cc1C)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2OC(F)(F)F)C(O)=O)C1=O
Show InChI InChI=1/C25H27F3N6O6S/c1-13-8-16(12-31-22(13)33(2)3)41(38,39)32-18-5-7-34(23(18)35)19(24(36)37)10-15-9-14-4-6-30-21(29)17(14)11-20(15)40-25(26,27)28/h4,6,8-9,11-12,18-19,32H,5,7,10H2,1-3H3,(H2,29,30)(H,36,37)/t18-,19+/s2
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n/an/a 100n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183006
PNG
(US9150544, 40)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2F)C(O)=O)C1=O
Show InChI InChI=1/C21H23FN6O5S2/c1-27(2)21-25-10-17(34-21)35(32,33)26-15-4-6-28(19(15)29)16(20(30)31)8-12-7-11-3-5-24-18(23)13(11)9-14(12)22/h3,5,7,9-10,15-16,26H,4,6,8H2,1-2H3,(H2,23,24)(H,30,31)/t15-,16+/s2
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n/an/a 100n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182967
PNG
(US9150544, 1)
Show SMILES Nc1nccc2c(F)c(C[C@@H](N3CC[C@H](NS(=O)(=O)c4ccc(nc4)N4CCCC4)C3=O)C(O)=O)ccc12
Show InChI InChI=1/C25H27FN6O5S/c26-22-15(3-5-18-17(22)7-9-28-23(18)27)13-20(25(34)35)32-12-8-19(24(32)33)30-38(36,37)16-4-6-21(29-14-16)31-10-1-2-11-31/h3-7,9,14,19-20,30H,1-2,8,10-13H2,(H2,27,28)(H,34,35)/t19-,20+/s2
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n/an/a 100n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183029
PNG
(US9150544, 63)
Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2F)C(O)=O)C1=O
Show InChI InChI=1/C23H25FN6O5S/c1-29(2)20-4-3-15(12-27-20)36(34,35)28-18-6-8-30(22(18)31)19(23(32)33)10-14-9-13-5-7-26-21(25)16(13)11-17(14)24/h3-5,7,9,11-12,18-19,28H,6,8,10H2,1-2H3,(H2,25,26)(H,32,33)/t18-,19+/s2
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n/an/a 110n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183032
PNG
(US9150544, 66)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(Cl)cc12
Show InChI InChI=1/C23H23ClF2N6O5S2/c24-15-9-14-12(1-4-28-19(14)27)7-13(15)8-17(21(34)35)32-5-2-16(20(32)33)30-39(36,37)18-10-29-22(38-18)31-6-3-23(25,26)11-31/h1,4,7,9-10,16-17,30H,2-3,5-6,8,11H2,(H2,27,28)(H,34,35)/t16-,17+/s2
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n/an/a 110n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182980
PNG
(US9150544, 14)
Show SMILES COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O)C(O)=O
Show InChI InChI=1/C24H28N6O6S2/c1-36-19-12-16-14(4-6-26-21(16)25)10-15(19)11-18(23(32)33)30-9-5-17(22(30)31)28-38(34,35)20-13-27-24(37-20)29-7-2-3-8-29/h4,6,10,12-13,17-18,28H,2-3,5,7-9,11H2,1H3,(H2,25,26)(H,32,33)/t17-,18+/s2
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n/an/a 110n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182973
PNG
(US9150544, 7)
Show SMILES COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(O)=O
Show InChI InChI=1/C22H26N6O6S2/c1-27(2)22-25-11-18(35-22)36(32,33)26-15-5-7-28(20(15)29)16(21(30)31)9-13-8-12-4-6-24-19(23)14(12)10-17(13)34-3/h4,6,8,10-11,15-16,26H,5,7,9H2,1-3H3,(H2,23,24)(H,30,31)/t15-,16+/s2
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n/an/a 110n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183053
PNG
(US9150544, 87)
Show SMILES CN(C)c1ncc(cc1Cl)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2OC(F)(F)F)C(O)=O)C1=O
Show InChI InChI=1/C24H24ClF3N6O6S/c1-33(2)21-16(25)9-14(11-31-21)41(38,39)32-17-4-6-34(22(17)35)18(23(36)37)8-13-7-12-3-5-30-20(29)15(12)10-19(13)40-24(26,27)28/h3,5,7,9-11,17-18,32H,4,6,8H2,1-2H3,(H2,29,30)(H,36,37)/t17-,18+/s2
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n/an/a 110n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183010
PNG
(US9150544, 44)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2OC(F)(F)F)C(O)=O)C1=O
Show InChI InChI=1/C22H23F3N6O6S2/c1-30(2)21-28-10-17(38-21)39(35,36)29-14-4-6-31(19(14)32)15(20(33)34)8-12-7-11-3-5-27-18(26)13(11)9-16(12)37-22(23,24)25/h3,5,7,9-10,14-15,29H,4,6,8H2,1-2H3,(H2,26,27)(H,33,34)/t14-,15+/s2
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n/an/a 120n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182992
PNG
(US9150544, 26)
Show SMILES COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(Cl)c2)C1=O)C(O)=O
Show InChI InChI=1/C24H27ClN6O6S/c1-30(2)22-17(25)10-15(12-28-22)38(35,36)29-18-5-7-31(23(18)32)19(24(33)34)9-14-8-13-4-6-27-21(26)16(13)11-20(14)37-3/h4,6,8,10-12,18-19,29H,5,7,9H2,1-3H3,(H2,26,27)(H,33,34)/t18-,19+/s2
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n/an/a 120n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183058
PNG
(US9150544, 92)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC4)C3=O)C(O)=O)c(Cl)cc12
Show InChI InChI=1/C22H23ClN6O5S2/c23-15-10-14-12(2-4-25-19(14)24)8-13(15)9-17(21(31)32)29-7-3-16(20(29)30)27-36(33,34)18-11-26-22(35-18)28-5-1-6-28/h2,4,8,10-11,16-17,27H,1,3,5-7,9H2,(H2,24,25)(H,31,32)/t16-,17+/s2
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n/an/a 120n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183008
PNG
(US9150544, 42)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(F)cc12
Show InChI InChI=1/C23H23F3N6O5S2/c24-15-9-14-12(1-4-28-19(14)27)7-13(15)8-17(21(34)35)32-5-2-16(20(32)33)30-39(36,37)18-10-29-22(38-18)31-6-3-23(25,26)11-31/h1,4,7,9-10,16-17,30H,2-3,5-6,8,11H2,(H2,27,28)(H,34,35)/t16-,17+/s2
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n/an/a 120n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183057
PNG
(US9150544, 91)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(cc12)C(F)(F)F
Show InChI InChI=1/C24H23F5N6O5S2/c25-23(26)3-6-34(11-23)22-32-10-18(41-22)42(39,40)33-16-2-5-35(20(16)36)17(21(37)38)8-13-7-12-1-4-31-19(30)14(12)9-15(13)24(27,28)29/h1,4,7,9-10,16-17,33H,2-3,5-6,8,11H2,(H2,30,31)(H,37,38)/t16-,17+/s2
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n/an/a 120n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183007
PNG
(US9150544, 41)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(F)cc12
Show InChI InChI=1/C23H25FN6O5S2/c24-16-11-15-13(3-5-26-20(15)25)9-14(16)10-18(22(32)33)30-8-4-17(21(30)31)28-37(34,35)19-12-27-23(36-19)29-6-1-2-7-29/h3,5,9,11-12,17-18,28H,1-2,4,6-8,10H2,(H2,25,26)(H,32,33)/t17-,18+/s2
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n/an/a 120n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183026
PNG
(US9150544, 60)
Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2OC(F)(F)F)C(O)=O)C1=O
Show InChI InChI=1/C24H25F3N6O6S/c1-32(2)20-4-3-15(12-30-20)40(37,38)31-17-6-8-33(22(17)34)18(23(35)36)10-14-9-13-5-7-29-21(28)16(13)11-19(14)39-24(25,26)27/h3-5,7,9,11-12,17-18,31H,6,8,10H2,1-2H3,(H2,28,29)(H,35,36)/t17-,18+/s2
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US Patent
n/an/a 130n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183012
PNG
(US9150544, 46)
Show SMILES CCOc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O)C(O)=O
Show InChI InChI=1/C25H30N6O6S2/c1-2-37-20-13-17-15(5-7-27-22(17)26)11-16(20)12-19(24(33)34)31-10-6-18(23(31)32)29-39(35,36)21-14-28-25(38-21)30-8-3-4-9-30/h5,7,11,13-14,18-19,29H,2-4,6,8-10,12H2,1H3,(H2,26,27)(H,33,34)/t18-,19+/s2
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US Patent
n/an/a 130n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183015
PNG
(US9150544, 49)
Show SMILES CN(C1CCC1)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O
Show InChI InChI=1/C24H27ClN6O5S2/c1-30(15-3-2-4-15)24-28-12-20(37-24)38(35,36)29-18-6-8-31(22(18)32)19(23(33)34)10-14-9-13-5-7-27-21(26)16(13)11-17(14)25/h5,7,9,11-12,15,18-19,29H,2-4,6,8,10H2,1H3,(H2,26,27)(H,33,34)/t18-,19+/s2
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US Patent
n/an/a 130n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM150299
PNG
(US8987242, 21)
Show SMILES Cc1ccc(CN2CCO[C@H]([C@@H](O)C(=O)Nc3ccc(cc3)C(N)=N)C2=O)cc1
Show InChI InChI=1/C21H24N4O4/c1-13-2-4-14(5-3-13)12-25-10-11-29-18(21(25)28)17(26)20(27)24-16-8-6-15(7-9-16)19(22)23/h2-9,17-18,26H,10-12H2,1H3,(H3,22,23)(H,24,27)/t17-,18-/s2
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n/an/a 130n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US8987242 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182987
PNG
(US9150544, 21)
Show SMILES COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CC[C@@H](F)C2)C1=O)C(O)=O
Show InChI InChI=1/C24H27FN6O6S2/c1-37-19-10-16-13(2-5-27-21(16)26)8-14(19)9-18(23(33)34)31-7-4-17(22(31)32)29-39(35,36)20-11-28-24(38-20)30-6-3-15(25)12-30/h2,5,8,10-11,15,17-18,29H,3-4,6-7,9,12H2,1H3,(H2,26,27)(H,33,34)/t15-,17+,18-/s2
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n/an/a 140n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182990
PNG
(US9150544, 24)
Show SMILES COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O)C(O)=O
Show InChI InChI=1/C24H28N6O6S/c1-29(2)21-5-4-16(13-27-21)37(34,35)28-18-7-9-30(23(18)31)19(24(32)33)11-15-10-14-6-8-26-22(25)17(14)12-20(15)36-3/h4-6,8,10,12-13,18-19,28H,7,9,11H2,1-3H3,(H2,25,26)(H,32,33)/t18-,19+/s2
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US Patent
n/an/a 140n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183024
PNG
(US9150544, 58)
Show SMILES Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC4)C3=O)C(O)=O)c(OC(F)(F)F)cc12
Show InChI InChI=1/C23H23F3N6O6S2/c24-23(25,26)38-17-10-14-12(2-4-28-19(14)27)8-13(17)9-16(21(34)35)32-7-3-15(20(32)33)30-40(36,37)18-11-29-22(39-18)31-5-1-6-31/h2,4,8,10-11,15-16,30H,1,3,5-7,9H2,(H2,27,28)(H,34,35)/t15-,16+/s2
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US Patent
n/an/a 140n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182996
PNG
(US9150544, 30)
Show SMILES CCc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(O)=O
Show InChI InChI=1/C23H28N6O5S2/c1-4-13-10-16-14(5-7-25-20(16)24)9-15(13)11-18(22(31)32)29-8-6-17(21(29)30)27-36(33,34)19-12-26-23(35-19)28(2)3/h5,7,9-10,12,17-18,27H,4,6,8,11H2,1-3H3,(H2,24,25)(H,31,32)/t17-,18+/s2
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US Patent
n/an/a 150n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183002
PNG
(US9150544, 36)
Show SMILES CCc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N2CCCC2)C1=O)C(O)=O
Show InChI InChI=1/C27H32N6O5S/c1-2-17-14-21-18(7-9-29-25(21)28)13-19(17)15-23(27(35)36)33-12-8-22(26(33)34)31-39(37,38)20-5-6-24(30-16-20)32-10-3-4-11-32/h5-7,9,13-14,16,22-23,31H,2-4,8,10-12,15H2,1H3,(H2,28,29)(H,35,36)/t22-,23+/s2
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US Patent
n/an/a 150n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182994
PNG
(US9150544, 28)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2C)C(O)=O)C1=O
Show InChI InChI=1/C22H26N6O5S2/c1-12-8-15-13(4-6-24-19(15)23)9-14(12)10-17(21(30)31)28-7-5-16(20(28)29)26-35(32,33)18-11-25-22(34-18)27(2)3/h4,6,8-9,11,16-17,26H,5,7,10H2,1-3H3,(H2,23,24)(H,30,31)/t16-,17+/s2
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n/an/a 150n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182988
PNG
(US9150544, 22)
Show SMILES COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(C)c2)C1=O)C(O)=O
Show InChI InChI=1/C25H30N6O6S/c1-14-9-17(13-28-23(14)30(2)3)38(35,36)29-19-6-8-31(24(19)32)20(25(33)34)11-16-10-15-5-7-27-22(26)18(15)12-21(16)37-4/h5,7,9-10,12-13,19-20,29H,6,8,11H2,1-4H3,(H2,26,27)(H,33,34)/t19-,20+/s2
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n/an/a 150n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM183011
PNG
(US9150544, 45)
Show SMILES CCOc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(O)=O
Show InChI InChI=1/C23H28N6O6S2/c1-4-35-18-11-15-13(5-7-25-20(15)24)9-14(18)10-17(22(31)32)29-8-6-16(21(29)30)27-37(33,34)19-12-26-23(36-19)28(2)3/h5,7,9,11-12,16-17,27H,4,6,8,10H2,1-3H3,(H2,24,25)(H,31,32)/t16-,17+/s2
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US Patent
n/an/a 160n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM182972
PNG
(US9150544, 6)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2ccc3c(N)nccc3c2F)C(O)=O)C1=O
Show InChI InChI=1/C21H23FN6O5S2/c1-27(2)21-25-10-16(34-21)35(32,33)26-14-6-8-28(19(14)29)15(20(30)31)9-11-3-4-13-12(17(11)22)5-7-24-18(13)23/h3-5,7,10,14-15,26H,6,8-9H2,1-2H3,(H2,23,24)(H,30,31)/t14-,15+/s2
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US Patent
n/an/a 160n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention are tested in a range of concentrations (4.9 nM to 5 然 final) and deposited in a proportion of 25 痞 per we...


US Patent US9150544 (2015)

More data for this
Ligand-Target Pair
Coagulation factor IX


(Homo sapiens (human))
BDBM185667
PNG
(US9161924, 37)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(c1)C(O)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1/C25H27N3O2/c1-25(2,3)20-11-7-16(8-12-20)18-5-4-6-19(15-18)22(29)24(30)28-21-13-9-17(10-14-21)23(26)27/h4-15,22,29H,1-3H3,(H3,26,27)(H,28,30)
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US Patent
n/an/a 160n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (American Diagnostica Inc.; 500 West Avenue, Stamford, Conn. ...


US Patent US9161924 (2015)

More data for this
Ligand-Target Pair
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