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Found 259 hits Enz. Inhib. hit(s) with Target = 'Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191929
PNG
(2-(4-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2...)
Show SMILES Cc1cc(CCO)ccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C20H19N5O/c1-13-11-14(7-10-26)4-5-17(13)24-20-22-9-6-18(25-20)16-12-23-19-15(16)3-2-8-21-19/h2-6,8-9,11-12,26H,7,10H2,1H3,(H,21,23)(H,22,24,25)
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n/an/a 0.600n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191913
PNG
(CHEMBL384350 | N-(2-methyl-4-(2-(pyrrolidin-1-yl)e...)
Show SMILES Cc1cc(CCN2CCCC2)ccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C24H26N6/c1-17-15-18(9-14-30-12-2-3-13-30)6-7-21(17)28-24-26-11-8-22(29-24)20-16-27-23-19(20)5-4-10-25-23/h4-8,10-11,15-16H,2-3,9,12-14H2,1H3,(H,25,27)(H,26,28,29)
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n/an/a 0.600n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191918
PNG
(CHEMBL212552 | N-(2-methyl-4-(2-(piperidin-1-yl)et...)
Show SMILES Cc1cc(CCN2CCCCC2)ccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C25H28N6/c1-18-16-19(10-15-31-13-3-2-4-14-31)7-8-22(18)29-25-27-12-9-23(30-25)21-17-28-24-20(21)6-5-11-26-24/h5-9,11-12,16-17H,2-4,10,13-15H2,1H3,(H,26,28)(H,27,29,30)
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n/an/a 1n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191924
PNG
(CHEMBL377449 | N-(2-methyl-4-(2-morpholinoethyl)ph...)
Show SMILES Cc1cc(CCN2CCOCC2)ccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C24H26N6O/c1-17-15-18(7-10-30-11-13-31-14-12-30)4-5-21(17)28-24-26-9-6-22(29-24)20-16-27-23-19(20)3-2-8-25-23/h2-6,8-9,15-16H,7,10-14H2,1H3,(H,25,27)(H,26,28,29)
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n/an/a 1.90n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191922
PNG
(CHEMBL212299 | trans-N1-(4-(1H-pyrrolo[2,3-b]pyrid...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H20N6/c18-11-3-5-12(6-4-11)22-17-20-9-7-15(23-17)14-10-21-16-13(14)2-1-8-19-16/h1-2,7-12H,3-6,18H2,(H,19,21)(H,20,22,23)/t11-,12-
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n/an/a 2n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2.5n/an/an/an/an/an/a



Hanyang University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B (unknown origin) after 40 mins by scintillation counting analysis


Eur J Med Chem 102: 600-10 (2015)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191925
PNG
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-o-tolylpyrimid...)
Show SMILES Cc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H15N5/c1-12-5-2-3-7-15(12)22-18-20-10-8-16(23-18)14-11-21-17-13(14)6-4-9-19-17/h2-11H,1H3,(H,19,21)(H,20,22,23)
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n/an/a 3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50338873
PNG
(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)
Show SMILES COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)ccc3C)c2N)cc1
Show InChI InChI=1S/C27H24ClF3N6O3/c1-15-3-6-17(34-26(39)35-18-7-10-22(28)21(12-18)27(29,30)31)11-20(15)25(38)36-23-13-33-37(24(23)32)14-16-4-8-19(40-2)9-5-16/h3-13H,14,32H2,1-2H3,(H,36,38)(H2,34,35,39)
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n/an/a 3.20n/an/an/an/an/an/a



Hanyang University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B


Bioorg Med Chem 19: 1915-23 (2011)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 3.20n/an/an/an/an/an/a



Georgetown University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B


AAPS J 8: 204-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM27216
PNG
((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Show SMILES CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of Cyclin B-cyclin-dependent kinase 1


J Med Chem 45: 2366-78 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7478
PNG
(2-chloro-4-[(2-{[(1R)-1-(hydroxymethyl)-2-methylpr...)
Show SMILES CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of cyclin dependent kinase 1-cyclinB


J Med Chem 45: 2366-78 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



The Rockefeller University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB


Trends Pharmacol Sci 25: 471-80 (2004)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191914
PNG
(CHEMBL212833 | N-(2-chlorophenyl)-4-(1H-pyrrolo[2,...)
Show SMILES Clc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H12ClN5/c18-13-5-1-2-6-15(13)23-17-20-9-7-14(22-17)12-10-21-16-11(12)4-3-8-19-16/h1-10H,(H,19,21)(H,20,22,23)
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n/an/a 9n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Lilly Spain S.A.

Curated by ChEMBL


Assay Description
Inhibition of Cyclin B-cyclin-dependent kinase 1


Bioorg Med Chem Lett 13: 3835-9 (2003)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191919
PNG
(CHEMBL380301 | N-(2-bromophenyl)-4-(1H-pyrrolo[2,3...)
Show SMILES Brc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H12BrN5/c18-13-5-1-2-6-15(13)23-17-20-9-7-14(22-17)12-10-21-16-11(12)4-3-8-19-16/h1-10H,(H,19,21)(H,20,22,23)
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n/an/a 13n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191912
PNG
(CHEMBL385478 | N-cyclohexyl-4-(1H-pyrrolo[2,3-b]py...)
Show SMILES C1CCC(CC1)Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H19N5/c1-2-5-12(6-3-1)21-17-19-10-8-15(22-17)14-11-20-16-13(14)7-4-9-18-16/h4,7-12H,1-3,5-6H2,(H,18,20)(H,19,21,22)
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n/an/a 14n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132003
PNG
((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Show SMILES Oc1[nH]c2ccccc2c1-c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17-18,20H
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n/an/a 18n/an/an/an/an/an/a



The Rockefeller University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB


Trends Pharmacol Sci 25: 471-80 (2004)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50366800
PNG
(OLOMOUCINE II)
Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2O)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-7-5-6-8-15(13)27)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)/t14-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 12: 3283-6 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 21n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B


J Med Chem 48: 4535-46 (2005)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7491
PNG
((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Show SMILES NC1=NC(=O)C(N1)=C1CCNC(=O)c2[nH]c(Br)cc12
Show InChI InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)
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n/an/a 22n/an/an/an/an/an/a



The Rockefeller University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB


Trends Pharmacol Sci 25: 471-80 (2004)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7238
PNG
((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...)
Show SMILES COc1ccc2NC(=O)C(=Cc3cnc[nH]3)c2c1
Show InChI InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)
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n/an/a 22n/an/an/an/an/an/a



The Rockefeller University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB


Trends Pharmacol Sci 25: 471-80 (2004)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7263
PNG
(9-cyanopaullone | 9-oxo-8,18-diazatetracyclo[9.7.0...)
Show SMILES O=C1Cc2c([nH]c3ccc(cc23)C#N)-c2ccccc2N1
Show InChI InChI=1S/C17H11N3O/c18-9-10-5-6-15-12(7-10)13-8-16(21)19-14-4-2-1-3-11(14)17(13)20-15/h1-7,20H,8H2,(H,19,21)
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n/an/a 24n/an/an/an/an/an/a



Technische Universit£t Braunschweig

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B expressed in M phase starfish oocyte


Eur J Med Chem 45: 335-42 (2010)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191928
PNG
(1-(3-(2-(cyclohexylamino)pyrimidin-4-yl)-1H-pyrrol...)
Show SMILES CC(=O)n1cc(-c2ccnc(NC3CCCCC3)n2)c2cccnc12
Show InChI InChI=1S/C19H21N5O/c1-13(25)24-12-16(15-8-5-10-20-18(15)24)17-9-11-21-19(23-17)22-14-6-3-2-4-7-14/h5,8-12,14H,2-4,6-7H2,1H3,(H,21,22,23)
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n/an/a 31n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50329427
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20)
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n/an/a 31n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdk1/cyclin B


J Med Chem 53: 7296-315 (2010)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7262
PNG
(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
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n/an/a 35n/an/an/an/an/an/a



Technische Universit£t Braunschweig

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B expressed in M phase starfish oocyte


Eur J Med Chem 45: 335-42 (2010)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7262
PNG
(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
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n/an/a 35n/an/an/an/an/an/a



The Rockefeller University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB


Trends Pharmacol Sci 25: 471-80 (2004)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191916
PNG
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-p-tolylpyrimid...)
Show SMILES Cc1ccc(Nc2nccc(n2)-c2c[nH]c3ncccc23)cc1
Show InChI InChI=1S/C18H15N5/c1-12-4-6-13(7-5-12)22-18-20-10-8-16(23-18)15-11-21-17-14(15)3-2-9-19-17/h2-11H,1H3,(H,19,21)(H,20,22,23)
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n/an/a 40n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7265
PNG
(4,5-dimethoxy-9-oxo-8,18-diazatetracyclo[9.7.0.0^{...)
Show SMILES COc1cc2NC(=O)Cc3c([nH]c4ccc(cc34)C#N)-c2cc1OC
Show InChI InChI=1S/C19H15N3O3/c1-24-16-6-13-15(8-17(16)25-2)21-18(23)7-12-11-5-10(9-20)3-4-14(11)22-19(12)13/h3-6,8,22H,7H2,1-2H3,(H,21,23)
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n/an/a 44n/an/an/an/an/an/a



Technische Universit£t Braunschweig

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B expressed in M phase starfish oocyte


Eur J Med Chem 45: 335-42 (2010)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191923
PNG
(CHEMBL213023 | N-(2-methoxyphenyl)-4-(1H-pyrrolo[2...)
Show SMILES COc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H15N5O/c1-24-16-7-3-2-6-15(16)23-18-20-10-8-14(22-18)13-11-21-17-12(13)5-4-9-19-17/h2-11H,1H3,(H,19,21)(H,20,22,23)
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n/an/a 44n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191932
PNG
(CHEMBL377048 | N-(2-fluorophenyl)-4-(1H-pyrrolo[2,...)
Show SMILES Fc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H12FN5/c18-13-5-1-2-6-15(13)23-17-20-9-7-14(22-17)12-10-21-16-11(12)4-3-8-19-16/h1-10H,(H,19,21)(H,20,22,23)
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n/an/a 46n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7269
PNG
(3-(6-oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-ind...)
Show SMILES FC(F)(F)c1ccc2[nH]c-3c(CC(=O)Nc4ccc(CCC#N)cc-34)c2c1
Show InChI InChI=1S/C20H14F3N3O/c21-20(22,23)12-4-6-16-13(9-12)14-10-18(27)25-17-5-3-11(2-1-7-24)8-15(17)19(14)26-16/h3-6,8-9,26H,1-2,10H2,(H,25,27)
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n/an/a 47n/an/an/an/an/an/a



Universität Hamburg

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 1-cyclin B from Starfish oocytes


Bioorg Med Chem Lett 10: 567-9 (2000)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM27216
PNG
((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Show SMILES CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 12: 3283-6 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191917
PNG
(CHEMBL378768 | N-phenyl-4-(1H-pyrrolo[2,3-b]pyridi...)
Show SMILES N(c1ccccc1)c1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H13N5/c1-2-5-12(6-3-1)21-17-19-10-8-15(22-17)14-11-20-16-13(14)7-4-9-18-16/h1-11H,(H,18,20)(H,19,21,22)
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n/an/a 54n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50335638
PNG
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
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n/an/a 56n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK1/Cyclin B by radiometric assay


J Med Chem 54: 635-54 (2011)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191926
PNG
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2-(trifluorom...)
Show SMILES FC(F)(F)c1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H12F3N5/c19-18(20,21)13-5-1-2-6-15(13)26-17-23-9-7-14(25-17)12-10-24-16-11(12)4-3-8-22-16/h1-10H,(H,22,24)(H,23,25,26)
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n/an/a 56n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191920
PNG
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-m-tolylpyrimid...)
Show SMILES Cc1cccc(Nc2nccc(n2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C18H15N5/c1-12-4-2-5-13(10-12)22-18-20-9-7-16(23-18)15-11-21-17-14(15)6-3-8-19-17/h2-11H,1H3,(H,19,21)(H,20,22,23)
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n/an/a 57n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191915
PNG
(CHEMBL213277 | N-(2-ethylphenyl)-4-(1H-pyrrolo[2,3...)
Show SMILES CCc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C19H17N5/c1-2-13-6-3-4-8-16(13)23-19-21-11-9-17(24-19)15-12-22-18-14(15)7-5-10-20-18/h3-12H,2H2,1H3,(H,20,22)(H,21,23,24)
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n/an/a 68n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM10642
PNG
(2-[({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(pr...)
Show SMILES CC(C)C(CO)Nc1nc(NCc2ccccc2O)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C20H28N6O2/c1-12(2)15(10-27)23-20-24-18(21-9-14-7-5-6-8-16(14)28)17-19(25-20)26(11-22-17)13(3)4/h5-8,11-13,15,27-28H,9-10H2,1-4H3,(H2,21,23,24,25)
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n/an/a 80n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 12: 3283-6 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50120508
PNG
(2-(3-hydroxypropylamino)-6-(o -hydroxybenzylamino)...)
Show SMILES CC(C)n1cnc2c(NCc3ccccc3O)nc(NCCCO)nc12
Show InChI InChI=1S/C18H24N6O2/c1-12(2)24-11-21-15-16(20-10-13-6-3-4-7-14(13)26)22-18(23-17(15)24)19-8-5-9-25/h3-4,6-7,11-12,25-26H,5,8-10H2,1-2H3,(H2,19,20,22,23)
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n/an/a 100n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 12: 3283-6 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM10635
PNG
(3-[({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(pr...)
Show SMILES CC(C)C(CO)Nc1nc(NCc2cccc(O)c2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C20H28N6O2/c1-12(2)16(10-27)23-20-24-18(21-9-14-6-5-7-15(28)8-14)17-19(25-20)26(11-22-17)13(3)4/h5-8,11-13,16,27-28H,9-10H2,1-4H3,(H2,21,23,24,25)
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n/an/a 120n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 12: 3283-6 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191921
PNG
(CHEMBL215048 | N-cyclohexyl-4-(1-(methylsulfonyl)-...)
Show SMILES CS(=O)(=O)n1cc(-c2ccnc(NC3CCCCC3)n2)c2cccnc12
Show InChI InChI=1S/C18H21N5O2S/c1-26(24,25)23-12-15(14-8-5-10-19-17(14)23)16-9-11-20-18(22-16)21-13-6-3-2-4-7-13/h5,8-13H,2-4,6-7H2,1H3,(H,20,21,22)
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n/an/a 128n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191931
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl...)
Show SMILES Oc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H13N5O/c23-15-6-2-1-5-14(15)22-17-19-9-7-13(21-17)12-10-20-16-11(12)4-3-8-18-16/h1-10,23H,(H,18,20)(H,19,21,22)
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n/an/a 139n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7377
PNG
(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Show SMILES CCCCc1c([nH]c2nccnc12)-c1ccc(O)cc1
Show InChI InChI=1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
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n/an/a 150n/an/an/an/an/an/a



The Rockefeller University

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB


Trends Pharmacol Sci 25: 471-80 (2004)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50120510
PNG
(4-{[2-(1-Hydroxymethyl-2-methyl-propylamino)-9-iso...)
Show SMILES CC(C)C(CO)Nc1nc(NCc2ccc(O)cc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C20H28N6O2/c1-12(2)16(10-27)23-20-24-18(21-9-14-5-7-15(28)8-6-14)17-19(25-20)26(11-22-17)13(3)4/h5-8,11-13,16,27-28H,9-10H2,1-4H3,(H2,21,23,24,25)
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n/an/a 150n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 12: 3283-6 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50191930
PNG
(CHEMBL213207 | N-(cyclohexylmethyl)-4-(1H-pyrrolo[...)
Show SMILES C(Nc1nccc(n1)-c1c[nH]c2ncccc12)C1CCCCC1
Show InChI InChI=1S/C18H21N5/c1-2-5-13(6-3-1)11-22-18-20-10-8-16(23-18)15-12-21-17-14(15)7-4-9-19-17/h4,7-10,12-13H,1-3,5-6,11H2,(H,19,21)(H,20,22,23)
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n/an/a 151n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclinB by Flashplate assay


Bioorg Med Chem Lett 16: 4818-21 (2006)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50147458
PNG
((3-{3-[4-(2-Methoxy-phenyl)-2,5-dioxo-2,5-dihydro-...)
Show SMILES COc1ccccc1C1=C(C(=O)NC1=O)c1cn(CCCNC(=O)OC(C)(C)C)c2ncccc12
Show InChI InChI=1S/C26H28N4O5/c1-26(2,3)35-25(33)28-13-8-14-30-15-18(16-10-7-12-27-22(16)30)21-20(23(31)29-24(21)32)17-9-5-6-11-19(17)34-4/h5-7,9-12,15H,8,13-14H2,1-4H3,(H,28,33)(H,29,31,32)
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n/an/a 170n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 14: 3245-50 (2004)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7273
PNG
(14-bromo-4,5-dimethoxy-8,18-diazatetracyclo[9.7.0....)
Show SMILES COc1cc2NC(=O)Cc3c([nH]c4ccc(Br)cc34)-c2cc1OC
Show InChI InChI=1S/C18H15BrN2O3/c1-23-15-6-12-14(8-16(15)24-2)20-17(22)7-11-10-5-9(19)3-4-13(10)21-18(11)12/h3-6,8,21H,7H2,1-2H3,(H,20,22)
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n/an/a 200n/an/an/an/an/an/a



Technische Universit£t Braunschweig

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B expressed in M phase starfish oocyte


Eur J Med Chem 45: 335-42 (2010)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM5655
PNG
(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Show SMILES CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 1-cyclin B from M phase starfish (Marthasterias glacialis) oocytes


J Med Chem 46: 876-9 (2003)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50120512
PNG
(3-{[2-(1-Hydroxymethyl-propylamino)-9-isopropyl-9H...)
Show SMILES CCC(CO)Nc1nc(NCc2cccc(O)c2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-6-5-7-15(27)8-13)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)
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n/an/a 200n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 12: 3283-6 (2002)

More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50113281
PNG
(AT-7519)
Show SMILES Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1
Show InChI InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B (unknown origin) by radiometric filter binding assay


Bioorg Med Chem Lett 25: 3420-35 (2015)

More data for this
Ligand-Target Pair
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